Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic...
World leading laboratory in cardiovascular and malignant glioma gene therapy. Main focus of the research is on the development of new gene drugs, translational research and phase I/II human clinical trials.
Assistant Professor
, A.I. Virtanen Institute for Molecular Sciences
*** under construction ***
'From basic science to translational impact.'
The goal of our junior research group is to improve therapeutics and diagnostics of cardiovascular diseases by understanding the biology behind the diseases. The main focus is in studying vascular anomalies and aortic aneurysms. Particularly ...
Our research is based on randomized controlled dietary inervention studies examining the effects of nutrients, diet and lifestyle on metabolism and risk of non-communicable diseases. We concentrate on the health effects of the quality of dietary fat, dietary fiber and dietary patterns. Lately, we...
Gene and cell level understanding the mechanisms driving atherosclerosis and coronary artery disease
Nrf2 is a transcription factor mainly involved in combating cellular stress caused by reactive oxygen and nitrogen species. However, Nrf2 is also involved in cancer and cardiometabolic diseases, making it an essential drug target.
Our research group investigates neurobiological mechanisms underlying memory impairment in Alzheimer’s disease and searches for new treatment options to halt the disease progression.