Tumor-stroma interaction - Pasonen-Seppänen group

01.09.2019 -
Tumor microenvironment (TME) has an active contribution to tumor development and cancer progression. This extremely complex system is composed of multiple cell types, such as fibroblasts and infiltrating immune cells, and structural extracellular matrix (ECM), which is mainly composed of hyaluron...

Redox signaling (Anna-Liisa Levonen group)

Nrf2 is a transcription factor mainly involved in combating cellular stress caused by reactive oxygen and nitrogen species. However, Nrf2 is also involved in cancer and cardiometabolic diseases, making it an essential drug target.