Molecular Pathology and Genetics of Cancer

We study the etiology and pathogenesis of malignant diseases with a special emphasis on the histopathologic, molecular pathologic and genetic/genomic factors. Profound collaboration between several research groups at the UEF and Kuopio University Hospital (KUH) as well as with our national and in...

Genetics of gene regulation in disease

Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic...