Redox signaling (Anna-Liisa Levonen group)

Nrf2 is a transcription factor mainly involved in combating cellular stress caused by reactive oxygen and nitrogen species. However, Nrf2 is also involved in cancer and cardiometabolic diseases, making it an essential drug target.

Epigenomics of vitamin D

01.10.2000 -
The scientific interest of our team is on mechanisms of gene regulation and its impact on major common diseases, such as type 2 diabetes, atherosclerosis and cancer. Our investigations use methods of molecular biology, bioinformatics and systems biology.

Genetics of gene regulation in disease

Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic...