Allergy Research Group

Allergy and allergens are mysterious

It is not known what is the property of most of the allergenic proteins which make them allergenic. It is neither known why most individuals do not mount a productive immune response against them resulting in IgE production and the immediate-type of allergy.

There is some information, for example, size, solubility, resistance to digestion, and other quite unspecific characteristics which in fact do not explain the allergenic capacity of these proteins, that is, their capacity to induce the T-helper type 2 (Th2) differentiation of CD4+ T lymphocytes. Th2 cells play a pivotal role in the immediate type of allergy, such as pollen-induced rhinitis or animal dust-induced asthma, by secreting interleukin-4 which stimulates IgE production.

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