Allergy Research Group
Allergy and allergens are mysterious
It is not known what is the property of most of the allergenic proteins which make them allergenic. It is neither known why most individuals do not mount a productive immune response against them resulting in IgE production and the immediate-type of allergy.
There is some information, for example, size, solubility, resistance to digestion, and other quite unspecific characteristics which in fact do not explain the allergenic capacity of these proteins, that is, their capacity to induce the T-helper type 2 (Th2) differentiation of CD4+ T lymphocytes. Th2 cells play a pivotal role in the immediate type of allergy, such as pollen-induced rhinitis or animal dust-induced asthma, by secreting interleukin-4 which stimulates IgE production.
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Group members - UEF
Tuomas Virtanen Clinical Lecturer , School of Medicine, Institute of Clinical Medicine
Tuure Kinnunen Professor , School of Medicine, Institute of Clinical Medicine
Marja Rytkönen-Nissinen University Lecturer , School of Medicine, Institute of Clinical Medicine