Nutrigenomics and molecular nutrition
Closed. 01.08.2018 - 31.12.2021
Project
Nutrigenomics and non-communicable or chronic diseases: Nutrigenomics is an emerging science in nutrition that uses molecular tools to better understand the physiological responses obtained through a certain diet in individuals and population groups.
At the Institute of Public Health and Clinical Nutrition, within the main research interests of the nutrigenomics research line is to study the molecular interactions between metabolites produced by the gut microbiota derived from specific dietary nutrients that protect from type 2 diabetes and non-alcoholic fatty liver disease under this specific project
Project name
• Molecular and metabolic mechanisms for the role of gut microbiota-derived indole propionic acid (IPA) in the prevention of type 2 diabetes
Other projects:
• Studying the gene-pathway associations for IPA both for adipose and liver tissues.
PhD student
Ratika Sehgal, Ratika.Sehgal@uef.fi
Post Doc researcher
Mariana Ilha, Mariana.Ilha@uef.fi
Marjo Tuomainen, Marjo.Tuomainen@uef.fi
Time period
01.08.2018 - 31.12.2021
Group members - UEF
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Vanessa de Mello Laaksonen Senior Researcher , School of Medicine, Institute of Public Health and Clinical Nutrition -
Marjo Tuomainen Postdoctoral Researcher , School of Medicine, Institute of Public Health and Clinical Nutrition -
Maija Vaittinen Postdoctoral Researcher , School of Medicine, Institute of Public Health and Clinical Nutrition
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Mariana Ilha Postdoctoral Researcher , School of Medicine, Institute of Public Health and Clinical Nutrition -
Ratika Sehgal School of Medicine, Institute of Public Health and Clinical Nutrition -
Vanessa de Mello Laaksonen Senior Researcher , School of Medicine, Institute of Public Health and Clinical Nutrition
Leader(s)
Others
Collaboration with UEF research groups
Cooperation partners
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UEF (transcriptomics and epigenetic studies, FADSDIET2 study)
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UEF (PET study)
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UEF (dietary intervention studies)
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Finnish Diabetes Prevention Study
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UEF (non-targeted metabolomics studies)
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(DNA methylation studies)
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(PBMC transcriptomics studies)
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Chalmers University of Technology, Sweden
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UFRGS, Brazil (nutritional, dietary and metabolic aspects in obesity and non-alcoholic fatty liver disease)
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nursing sciences, UNILAB/Fortaleza
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Endocrinology and Nutrology sciences, HCPA/UFRGS, Porto Alegre, Brazil
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Course in Nutrition Genomics in non-communicable chronic diseases, UFRGS, Post-Graduation Program in Nutrition and Health, Brazil
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Nutrition and health, UFV/Viçosa, Brazil
Publications
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Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial Sousa, Danilo Ferreira de; Araújo, Márcio Flávio Moura de; de Mello, Vanessa Derenji; Damasceno, Marta Maria Coelho; Freitas, Roberto Wagner Júnior Freire de. 2020. Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial Journal of the american college of nutrition 2021; 40 8: 679-688. 2020
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Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial Meuronen, Topi; Lankinen, Maria A; Fauland, Alexander; Shimizu, Bun-Ichi; de Mello, Vanessa D; Laaksonen, David E; Wheelock, Craig E; Erkkilä, Arja T; Schwab, Ursula S. 2020. Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial Prostaglandins leukotrienes and essential fatty acids 159: 102143. 2020
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Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. 2020. Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids Liver international 2021; 41 4: 754-763. 2020
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An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study Ulven, SM; Holven, KB; Rundblad, A; Myhrstad, MCW; Leder, L; Dahlman, I; Mello, VD; Schwab, U; Carlberg, C; Pihlajamäki, J; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Rosqvist, F; Hukkanen, J; Herzig, KH; Savolainen, MJ; Risérus, U; et al. [incl. Uusitupa, M]. 2019. An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study Nutrients 11 12: 2932. 2019
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Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism Erkkilä, AT; Lee, JC; Lankinen, M; Manninen, S; Leung ,HH; Oger, C; de Mello, VD; Schwab, US. 2019. Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism Lipids 54 8: 453-464. 2019
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Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study Myhrstad, MC; de Mello, VD; Dahlman, I; Kolehmainen, M; Paananen, J; Rundblad, A; Carlberg, C; Olstad, OK; Pihlajamäki, J; Holven, KB; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Storm, MU; Åkesson, B; Rosqvist, F; Hukkanen, J; et al. (incl. Schwab, U; Uusitupa, M). 2019. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study Molecular nutrition and food research 63 13: 1801405. 2019
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Liver DNA methylation of FADS2 associates with FADS2 genotypex Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. 2019. Liver DNA methylation of FADS2 associates with FADS2 genotypex Clinical epigenetics 11 1: 10. 2019
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The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial de Mello, VD; Dahlman, I; Lankinen, M; Kurl, S; Pitkänen, L; Laaksonen, DE; Schwab, US; Erkkilä, AT. 2019. The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial Nutrition and diabetes 9 1: 1. 2019
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Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression Liver international 39 10: 1895-1905. 2019
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Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals Nutrition and diabetes 8: 35. 2018