Quantitative cell biology

01.10.2020 -

Research group

In the Quantitative Cell Biology laboratory, we study the biology of cells through the prism of quantitative sciences. We use cutting edge quantitative bio-imaging tools to count biomolecules such as proteins or mRNAs, measure their interactions, clustering or quantify their motion in live cells of any organism. We develop our own software tools to analyze this data. We use biochemistry, genetics and molecular/cell biological methods to decipher how genetic or epigenetic perturbations affect our "in cellulo" quantitative measurements. Then, we integrate this wealth of quantitative data to parametrize predictive mathematical models of complex, intricate cellular processes. We are in particular fascinated by the outstanding questions of how a cell takes the decision to divide into two cells, this so peculiar trait of living things. How did evolution shape cell division cycle pathways to adjust the biophysical features of each cell type to its particular functions or environment? And why cells sometimes (often!) decide NOT to divide, but instead remain quiescent, differentiate or commit suicide? Those simple fundamental questions are extremely relevant to many biomedical challenges including the limited efficiency of current anti-cancer therapeutic approaches. In particular, we are studying how the decisions to divide, to differentiate, or to remain quiescent are coordinated at the molecular level in lymphocytes, in collaboration with the Heinäniemi lab (UEF). On the medium term, our goal is to understand in depth how chromosomal translocations common in Acute Lymphoblastic Leukemia (ALL) favor the decision to proliferate, to the detriment of normal differentiation of lymphoid progenitor cells.

Funder(s)

Main funder

Suomen akatemia

Quantitative cell biology funder logo

Other funders

Sigrid Juséliuksen Säätiö

Quantitative cell biology funder logo

Väre lasten syöpä säätiö

Quantitative cell biology funder logo

Keywords

Time period

01.10.2020 -

Group members - UEF

Other group members

  • Nkiruka Osegbe
    Nkiruka Osegbe nkosegbe@student.uef.fi
  • Teemu Mäki-maunus
    Teemu Mäki-maunus teemmaki@student.uef.fi

Collaboration with UEF research groups

Cooperation partners

Files