Sirtuin Research Group
Research group
01.01.2012 -
School of Pharmacy, Faculty of Health Sciences
Leaders
Group description
Sirtuin research group
Our Reserch Group applies computer-aided drug design tools to develop epigenetic regulators. Designed compounds are synthetized by ourselves or by collaborators. We have wide selection of in vitro assays to study the regulator’s effect on sirtuins and bromodomains, also in cells. Our research results in dozens of peer-reviewed articles and several Ph.D Thesis.
Cooperation
Keywords
Leaders
Senior Researchers
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Minna Rahnasto-Rilla
Information SpecialistLibrary, Kuopio Campus Library, Snellmania -
Jenni Küblbeck
Senior ResearcherFaculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences
Doctoral Researchers
Technicians
Other group members
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Carita Sallomy
Publications
4 items-
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Tenhunen, Jonna; Kucera, Tomá¨; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Dole¸al, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. 2021. Biomedicine and pharmacotherapy. 138: 111452 -
Impact of Structurally Diverse BET Inhibitors on SIRT1
Tenhunen, Jonna; Kokkola, Tarja; Huovinen, Marjo; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija. 2020. Gene. 741: 144558 -
Natural polyphenols as sirtuin 6 modulators
Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R. 2018. Scientific reports. 8: 4163 -
New Insights into the Epigenetic Activities of Natural Compounds
Vidakovic, Melita; Marinello, Jessica; Kakkonen, Maija L; Matulis, Daumantas; Linkuviene, Vaida; Michel, Benoît Y; Navakauskiene, Ruta; Christodoulou, Michael S; Passarella, Danielle; Klimasauskas, Saulius; Blanquart, Christophe; Cuendet, Muriel; Ovadi, Judit; Poulain, Stéphane; Fontaine-Vive, Fabien; Burger, Alain; Martinet, Nadine. 2018. OBM genetics. 2: 29