Markku Laakso
Professor
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 50 412 8793
Research groups
Publications
963/963 items-
Dissecting genetic regulation of metabolic coordination
Hector, Emily C; Zhang, Daiwei; Tian, Leqi; Feng, Junning; Yin, Xianyong; Xu, Tianyi; Laakso, Markku; Bai, Yun; Xiao, Jiashun; Kang, Jian; Yu, Tianwei. 2025. Briefings in bioinformatics. 26: . bbaf095 A1 Journal article (refereed), original research -
Metabolomics, Genetics, and Environmental Factors: Intersecting Paths in Abdominal Aortic Aneurysm
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Lusis, Aldons Jake; Laakso, Markku. 2025. International journal of molecular sciences. 26: A1 Journal article (refereed), original research -
Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits
Okamoto, Jeffrey; Yin, Xianyong; Ryan, Brady; Chiou, Joshua; Luca, Francesca; Pique-Regi, Roger; Im, Hae Kyung; Morrison, Jean; Burant, Charles; Fauman, Eric B.; Laakso, Markku; Boehnke, Michael; Wen, Xiaoquan. 2025. Genome biology. 26: . 19 A1 Journal article (refereed), original research -
A novel long non-coding RNA connects obesity to impaired adipocyte function
Lluch, Aina; Latorre, Jèssica; Oliveras-Cañellas, Núria; Fernández-Sánchez, Ana; Moreno-Navarrete, José M; Castells-Nobau, Anna; Comas, Ferran; Buxò, Maria; Rodríguez-Hermosa, José I; Ballester, María; Espadas, Isabel; Martin-Montalvo, Alejandro; Zhang, Birong; Zhou, You; Burkhardt, Ralph; Höring, Marcus; Liebisch, Gerhard; Castellanos-Rubio, Ainara; Santin, Izortze; Kar, Asha; Laakso, Markku; Pajukanta, Päivi; Olkkonen, Vesa M; Fernández-Real, José M.; Ortega, Francisco J. 2024. Molecular metabolism. 90: A1 Journal article (refereed), original research -
Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions
Kar, Asha; Alvarez, Marcus; Garske, Kristina M; Huang, Huiling; Lee, Seung Hyuk T; Deal, Milena; Das, Sankha Subhra; Koka, Amogha; Jamal, Zoeb; Mohlke, Karen L; Laakso, Markku; Heinonen, Sini; Pietiläinen, Kirsi H; Pajukanta, Päivi. 2024. Genome medicine. 16: . 19 A1 Journal article (refereed), original research -
Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial
Nuotio, Petrus; Lankinen, Maria A; Meuronen, Topi; de Mello, Vanessa D; Sallinen, Taisa; Virtanen, Kirsi A; Pihlajamäki, Jussi; Laakso, Markku; Schwab, Ursula. 2024. Atherosclerosis. 395: A1 Journal article (refereed), original research -
Effects of genetic risk on incident type 2 diabetes and glycemia: the T2D-GENE lifestyle intervention trial
Lankinen, Maria Anneli; Nuotio, Petrus; Kauppinen, Susanna; Koivu, Noora; Tolonen, Ulla; Malkki-Keinänen, Katriina; Oravilahti, Anniina; Kuulasmaa, Teemu; Uusitupa, Matti; Schwab, Ursula; Laakso, Markku. 2024. Journal of clinical endocrinology and metabolism. 2025; 110: 130-138 A1 Journal article (refereed), original research -
Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology
Madsen, AL.; Bonàs-Guarch, S; Gheibi, S; Prasad, R; Vangipurapu, J; Ahuja, V.; Cataldo, LR; Dwivedi, O; Hatem, G; Atla, G; Guindo-Martínez, M; Jørgensen, AM; Jonsson, AE; Miguel-Escalada, I; Hassan, S; Linneberg, A; Ahluwalia, Tarunveer S; Drivsholm, T; Pedersen, O; Sørensen, T A.; Astrup, A; Witte, D; Damm, P; Clausen, TD; Mathiesen, E; Pers, TH; Loos, RJF; Hakaste, L; Fex, M; Grarup, N; Tuomi, T; Laakso, M; Mulder, H; Ferrer, J; Hansen, T. 2024. Nature metabolism. 6: 1897-1912 A1 Journal article (refereed), original research -
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Suzuki, Ken; Hatzikotoulas, Konstantinos; Southam, Lorraine; Taylor, Henry J.; Yin, Xianyong; Lorenz, Kim M.; Mandla, Ravi; Huerta-Chagoya, Alicia; Melloni, Giorgio E.M.; Kanoni, Stavroula; Rayner, Nigel W.; Bocher, Ozvan; Arruda, Ana Luiza; Sonehara, Kyuto; Namba, Shinichi; Lee, Simon S.K.; Preuss, Michael H.; Petty, Lauren E.; Schroeder, Philip; Vanderwerff, Brett; Kals, Mart; Bragg, Fiona; Lin, Kuang; Guo, Xiuqing; Zhang, Weihua; Yao, Jie; Kim, Young Jin; Graff, Mariaelisa; Takeuchi, Fumihiko. 2024. Nature. 627: 347-357 A1 Journal article (refereed), original research -
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Keaton, Jacob M.; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; Goleva, Slavina B.; Ani, Alireza; Evangelou, Evangelos; Hellwege, Jacklyn N.; Yengo, Loic; Young, William J.; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; Chasman, Daniel I.; Morris, Andrew P.; Caulfield, Mark J.; Hwang, Shih Jen; Kooner, Jaspal S.; et al.. 2024. Nature genetics. 56: 778-791 A1 Journal article (refereed), original research -
Genome-wide characterization of circulating metabolic biomarkers
Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartson. 2024. Nature. 628: 130-138 A1 Journal article (refereed), original research -
Gut microbe-derived metabolites and the risk of cardiovascular disease in the METSIM cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M.; Cupido, Arjen; Fernandes Silva, Lilian; Laakso, Markku; Lusis, Aldons J. 2024. Frontiers in microbiology. 15: . 1411328 A1 Journal article (refereed), original research -
Healthy dietary pattern is associated with lower glycemia independently of the genetic risk of type 2 diabetes: a cross-sectional study in Finnish men
Tolonen, Ulla; Lankinen, Maria; Laakso, Markku; Schwab, Ursula. 2024. European journal of nutrition. 63: 2521-2531 A1 Journal article (refereed), original research -
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Wu, Ying-Chieh; Lehtonen, Šárka; Trontti, Kalevi; Kauppinen, Riitta; Kettunen, Pinja; Leinonen, Ville; Laakso, Markku; Kuusisto, Johanna; Hiltunen, Mikko; Hovatta, Iiris; Freude, Kristine; Dhungana, Hiramani; Koistinaho, Jari; Rolova, Taisia. 2024. Fluids and barriers of the cns. 21: . 78 A1 Journal article (refereed), original research -
Mechanisms of thyrotropin receptor–mediated phenotype variability deciphered by gene mutations and M453T-knockin model
Makkonen, Kristiina; Jännäri, Meeri; Crisóstomo, Luís; Kuusi, Matilda; Patyra, Konrad; Melnyk, Vladyslav; Linnossuo, Veli; Ojala, Johanna; Ravi, Rowmika; Löf, Christoffer; Mäkelä, Juho-Antti; Miettinen, Päivi; Laakso, Saila; Ojaniemi, Marja; Jääskeläinen, Jarmo; Laakso, Markku; Bossowski, Filip; Sawicka, Beata; Stożek, Karolina; Bossowski, Artur; Kleinau, Gunnar; Scheerer, Patrick; FinnGen; Reeve, Mary Pat; Kero, Jukka. 2024. JCI insight. 9: . e167092 A1 Journal article (refereed), original research -
Metabolomics-Based Machine Learning for Predicting Mortality: Unveiling Multisystem Impacts on Health
Oravilahti, Anniina; Vangipurapu, Jagadish; Laakso, Markku; Fernandes Silva, Lilian. 2024. International journal of molecular sciences. 25: A1 Journal article (refereed), original research -
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet - an exploratory study
Vaittinen, Maija; Ilha, Mariana; Sehgal, Ratika; Lankinen, Maria A; Ågren, Jyrki; Käkelä, Pirjo; Virtanen, Kirsi A; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi. 2024. Journal of lipid research. 65: A1 Journal article (refereed), original research -
Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2024. International journal of molecular sciences. 25: A1 Journal article (refereed), original research -
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
O’Keefe, James H.; Tintle, Nathan L.; Harris, William S.; O’Keefe, Evan L.; Sala-Vila, Aleix; Attia, John; Garg, G. Manohar; Hure, Alexis; Bork, Christian Sørensen; Schmidt, Erik Berg; Venø, Stine Krogh; Chien, Kuo-Liong; Chen, Yun-Yu (Amelia); Egert, Sarah; Feldreich, Tobias Rudholm; Ärnlöv, Johan; Lind, Lars; Forouhi, Nita G.; Geleijnse, Johanna M.; Pertiwi, Kamalita; Imamura, Fumiaki; de Mello Laaksonen, Vanessa; Uusitupa, W. Matti; Tuomilehto, Jaakko; Laakso, Markku; Lankinen, Maria Anneli; . 2024. Stroke. 55: 50-58 A1 Journal article (refereed), original research -
PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids
Tauriainen, Milla-Maria; Csader, Susanne; Lankinen, Maria; Lo, Kwun Kwan; Chen, Congjia; Lahtinen, Olli; El-Nezamy, Hani; Laakso, Markku; Schwab, Ursula. 2024. Nutrients. 16: A1 Journal article (refereed), original research -
Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M; Cupido, Arjen J; Pan, Calvin; Ha, Sung Min; Silva, Lilian Fernandes; Hilser, James R; Hartiala, Jaana; Allayee, Hooman; Rey, Federico E; Laakso, Markku; Lusis, Aldons J. 2024. Metabolites. 14: A1 Journal article (refereed), original research -
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies
Laguzzi, F.; Åkesson, A.; Marklund, M.; Qian, F.; Gigante, B.; Bartz, T.M.; Bassett, J.K.; Birukov, A.; Campos, H.; Hirakawa, Y.; Imamura, F.; Jäger, S.; Lankinen, M.; Murphy, R.A.; Senn, M.; Tanaka, T.; Tintle, N.; Virtanen, J.K.; Yamagishi, K.; Allison, M.; Brouwer, I.A.; De Faire, U.; Eiriksdottir, G.; Ferrucci, L.; Forouhi, N.G.; Geleijnse, J.M.; Hodge, A.M; Kimura, H.; Laakso, M.; Risérus, U.; van Westing, A.C.; Bandinelli, S.; Baylin, A.; Giles, G.G.; Gudnason, V.; Iso, H.; Lemaitre, R.N.;. 2024. Circulation. 149: 305-316 A1 Journal article (refereed), original research -
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232 A1 Journal article (refereed), original research -
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 203: A1 Journal article (refereed), original research -
A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin
Sarsani, Vishal; Brotman, Sarah M; Xianyong, Yin; Fernandes Silva, Lillian; Laakso, Markku; Spracklen, Cassandra N. 2023. HGG advances. 2024; 5: A1 Journal article (refereed), original research -
Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts
Ong, Kwok Leung; Marklund, Matti; Huang, Liping; Rye, Kerry-Anne; Hui, Nicholas; Pan, Xiong-Fei; Rebholz, Casey M; Kim, Hyunju; Steffen, Lyn M; van Westing, Anniek C; Geleijnse, Johanna M; Hoogeveen, Ellen K; Chen, Yun-Yu; Chien, Kuo-Liong; Fretts, Amanda M; Lemaitre, Rozenn N; Imamura, Fumiaki; Forouhi, Nita G; Wareham, Nicholas J; Birukov, Anna; Jäger, Susanne; Kuxhaus, Olga; Schulze, Matthias B; de Mello, Vanessa Derenji; Tuomilehto, Jaakko; Uusitupa, Matti; Lindström, Jaana; Tintle, Nathan; . 2023. BMJ. 380: A1 Journal article (refereed), original research -
Cell-type composition affects adipose gene expression associations with cardiometabolic traits
Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718 A1 Journal article (refereed), original research -
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92: A1 Journal article (refereed), original research -
Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes
Mäkinen, Selina; Datta, Neeta; Rangarajan, Savithri; Nguyen, Yen; Olkkonen, Vesa; Latva-Rasku, Aino; Nuutila, Pirjo; Laakso, Markku; Koistinen, Heikki A. 2023. Journal of molecular endocrinology. 70: A1 Journal article (refereed), original research -
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Brown, Andrew A.; Fernandez-Tajes, Juan J.; Hong, Mun-gwan; Brorsson, Caroline A.; Koivula, Robert W.; Davtian, David; Dupuis, Théo; Sartori, Ambra; Michalettou, Theodora-Dafni; Forgie, Ian M.; Adam, Jonathan; Allin, Kristine H.; Caiazzo, Robert; Cederberg, Henna; De Masi, Federico; Elders, Petra J. M.; Giordano, Giuseppe N.; Haid, Mark; Hansen, Torben; Hansen, Tue H.; Hattersley, Andrew T.; Heggie, Alison J.; Howald, Cédric; Jones, Angus G.; Kokkola, Tarja; Laakso, Markku; Mahajan, Anubha; Mar. 2023. Nature communications. 14: . 5062 A1 Journal article (refereed), original research -
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Hawkes, Gareth; Beaumont, Robin N; Tyrrell, Jessica; Power, Grace M; Wood, Andrew; Laakso, Markku; Silva, Lilian Fernandes; Boehnke, Michael; Yin, Xianyong; Richardson, Tom G; Smith, George Davey; Frayling, Timothy M. 2023. Diabetologia. 66: 1472-1480 A1 Journal article (refereed), original research -
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983 A1 Journal article (refereed), original research -
Lifestyle Intervention Guided by Group and Internet-Based Counseling in the T2D-GENE Trial Supports Its Applicability and Feasibility
Schwab, Ursula; Lankinen, Maria; Uusitupa, Matti; Laakso, Markku. 2023. Nutrients. 15: A1 Journal article (refereed), original research -
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Broadaway, K. Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A.; Wilson, Emma P.; Moxley, Anne H.; Vadlamudi, Swarooparani; Varshney, Arushi; Jackson, Anne U.; Ahuja, Vasudha; Bornstein, Stefan R.; Corbin, Laura J.; Delgado, Graciela E.; Dwivedi, Om P.; Fernandes Silva, Lilian; Frayling, Timothy M.; Grallert, Harald; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Herder, Christian; Herrmann, Sandra; Højlund, Kurt; Hughes, David A.; Kleber, Marcus E.; Lindgren, Cecilia M.; Liu, Chi. 2023. American journal of human genetics. 110: 284-299 A1 Journal article (refereed), original research -
Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study
Fernandes Silva, Lilian; Hokkanen, Jenna; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2023. Journal of clinical endocrinology and metabolism. 2024; 109: 100–106 A1 Journal article (refereed), original research -
Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Männistö, Ville; Laakso, Markku. 2023. Metabolites. 13: A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research -
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
Kettunen, Pinja; Lesnikova, Angelina; Räsänen, Noora; Ojha, Ravi; Palmunen, Leena; Laakso, Markku; Lehtonen, Šárka; Kuusisto, Johanna; Pietiläinen, Olli; Saber, Saber H; Joensuu, Merja; Vapalahti, Olli P; Koistinaho, Jari; Rolova, Taisia; Balistreri, Giuseppe. 2023. Journal of virology. 97: . e00144-23 A1 Journal article (refereed), original research -
Statins and risk of type 2 diabetes: mechanism and clinical implications
Laakso, Markku; Fernandes Silva, Lilian. 2023. Frontiers in endocrinology. 14: . 1239335 A2 Review article, Literature review, Systematic review -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; Surakka, Ida; Wenz, Brandon; Clarke, Shoa L.; Chesi, Alessandra; Wells, Andrew; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han,. 2022. American journal of human genetics. 109: 1366-1387 A1 Journal article (refereed), original research -
A saturated map of common genetic variants associated with human height
Yengo, Loïc; Vedantam, Sailaja; Marouli, Eirini; Sidorenko, Julia; Bartell, Eric; Sakaue, Saori; Graff, Marielisa; Eliasen, Anders U.; Jiang, Yunxuan; Raghavan, Sridharan; Miao, Jenkai; Arias, Joshua D.; Graham, Sarah E.; Mukamel, Ronen E.; Spracklen, Cassandra N.; Yin, Xianyong; Chen, Shyh-Huei; Ferreira, Teresa; Highland, Heather H.; Ji, Yingjie; Karaderi, Tugce; Lin, Kuang; Lüll, Kreete; Malden, Deborah E.; Medina-Gomez, Carolina; Machado, Moara; Moore, Amy; Rüeger, Sina; Sim, Xueling; Vrieze. 2022. Nature. 610: 704–712 A1 Journal article (refereed), original research -
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19
El-Sayed Moustafa, Julia S.; Jackson, Anne U.; Brotman, Sarah M.; Guan, Li; Villicaña, Sergio; Roberts, Amy L.; Zito, Antonino; Bonnycastle, Lori; Erdos, Michael R.; Narisu, Narisu; Stringham, Heather M.; Welch, Ryan; Yan, Tingfen; Lakka, Timo; Parker, Stephen; Tuomilehto, Jaakko; Seow, Jeffrey; Graham, Carl; Huettner, Isabella; Acors, Sam; Kouphou, Neophytos; Wadge, Samuel; Duncan, Emma L.; Steves, Claire J.; Doores, Katie J.; Malim, Michael H.; Collins, Francis S.; Pajukanta, Päivi; Boehnke, M. 2022. International journal of obesity. 46: 1478-1486 A1 Journal article (refereed), original research -
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Winkler, Thomas W.; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X.; Stanzick, Kira J.; Thomas, Laurent F.; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y.; Tayo, Bamidele; Thio, Chris H. L.; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B.; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter J.; Yang, Qiong; Ghasemi, Sahar; Nutile, Teresa; Li, Yong; Pontali, Giulia; Günther, Felix; Dehghan, Abbas; Correa, Adolfo; Parsa, Afshin. 2022. Communications biology. 5: A1 Journal article (refereed), original research -
Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment
Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2022. Metabolites. 12: A1 Journal article (refereed), original research -
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition
Wesenhagen, Kirsten E. J.; Gobom, Johan; Bos, Isabelle; Vos, Stephanie J. B.; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magda; Vandenberghe, Rik; Freund-Levi, Yvonne; Verhey, Frans; Lovestone, Simon; Streffer, Johannes; Dobricic, Valerija; Bertram, Lars; Blennow, Kaj; Pikkarainen, Maria; Hallikainen, Merja; Kuusisto, Johanna; Laakso, Markku; Soininen, Hilkka; Scheltens, Philip; Zetterberg, Henrik; Teunissen, Charlotte E.; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer’s Disease Neur. 2022. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 14: A1 Journal article (refereed), original research -
Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing
Hanks, Sarah C.; Forer, Lukas; Schönherr, Sebastian; LeFaive, Jonathon; Martins, Taylor; Welch, Ryan; Gagliano Taliun, Sarah A.; Braff, David; Johnsen, Jill M.; Kenny, Eimear E.; Konkle, Barbara A.; Laakso, Markku; Loos, Ruth F.J.; McCarroll, Steven; Pato, Carlos; Pato, Michele T.; Smith, Albert V.; Boehnke, Michael; Scott, Laura J.; Fuchsberger, Christian. 2022. American journal of human genetics. 109: 1653-1666 A1 Journal article (refereed), original research -
Genetic diversity fuels gene discovery for tobacco and alcohol use
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Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
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A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression
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A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
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Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
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Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
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Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia
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Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
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Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations
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Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
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Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
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Correction: The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
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Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers
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Diabetes secondary to treatment with statins
Laakso Markku, Kuusisto Johanna. 2017. Current diabetes reports. 17: 1-9 A2 Review article, Literature review, Systematic review -
Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study
Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Laakso M, Stancáková A. 2017. Journal of clinical endocrinology and metabolism. 102: 3600-3609 A1 Journal article (refereed), original research -
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes
Mardinoglu A, Gogg S, Lotta LA, Stancáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U. 2017. EBioMedicine. 2018; 27: 151-155 A1 Journal article (refereed), original research -
Exome-wide association study of plasma lipids in >300,000 individuals
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. 2017. Nature genetics. 49: 1758-1766 A1 Journal article (refereed), original research -
Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family
Nikkola Elina, Ko Arthur, Alvarez Marcus, Cantor Rita M, Garske Kristina, Kim Elliot, Gee Stephanie, Rodriguez Alejandra, Muxel Reinhard, Matikainen Niina, Söderlund Sanni, Motazacker Mahdi M, Borén Jan, Lamina Claudia, Kronenberg Florian, Schneider Wolfgang J, Palotie Aarno, Laakso Markku, Taskinen Marja-Riitta, Pajukanta Päivi. 2017. Atherosclerosis. 264: 58-66 A1 Journal article (refereed), original research -
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits
Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T et al. 2017. American journal of human genetics. 100: 428-443 A1 Journal article (refereed), original research -
Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study
Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku. 2017. Diabetologia. 60: 1722-1730 A1 Journal article (refereed), original research -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. 2017. Nature communications. 8: 14977 A1 Journal article (refereed), original research -
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
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Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk
Braenne Ingrid, Zeng Lingyao, Willenborg Christina, Tragante Vinicius, Kessler Thorsten, Willer Cristen J, Laakso Markku, Wallentin Lars, Franks Paul W, Salomaa Veikko, Dehghan Abbas, Meitinger Thomas, Samani Nilesh J, Asselbergs Folkert W, Erdmann Jeanette, Schunkert Heribert, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium. 2017. PLoS ONE. 12: e0182999 A1 Journal article (refereed), original research -
Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
Patel KA, Kettunen J, Laakso M, Stancáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, Shepherd MH, Flanagan SE, Ellard S, Inagaki N1, Hattersley AT, Tuomi T, Cnop M, Weedon MN. 2017. Nature communications. 8: 888 A1 Journal article (refereed), original research -
Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells
López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. 2017. Genome medicine. 9: 63 A1 Journal article (refereed), original research -
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC et al. (incl. Kuusisto J, Laakso M). 2017. PLoS ONE. 14: 1002383 A1 Journal article (refereed), original research -
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku, Alena Stancáková). 2017. Nature communications. 8: 80 A1 Journal article (refereed), original research -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
Kraja Aldi T, Cook James P, Warren Helen R, Surendran Praveen, Liu Chunyu, Evangelou Evangelos, Mannig Alisa K, Grarup Niels, Drenos Fotios, Sim Xueling, Smith Albert Vernon, Amin Najaf, Blakemore Alexandra I F, Bork-Jensen Jette, Brandslund Ivan, Farmaki Aliki-Eleni, Fava Cristiano, Ferreira Teresa, Herzig Karl-Heinz, Giri Ayush et al.. 2017. Circulation: cardiovascular genetics. 10: e001778 A1 Journal article (refereed), original research -
Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns
Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. 2017. Journal of lipid research. 58: 1471-1481 A1 Journal article (refereed), original research -
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Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells
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Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease
Mardinoglu Adil, Stancáková Alena, Lotta Luca A, Kuusisto Johanna, Boren Jan, Blüher Matthias, Wareham Nicholas J, Ferrannini Ele, Groop Per Henrik, Laakso Markku, Langenberg Claudia, Smith Ulf. 2017. Cell metabolism. 26: 281-283 B1 Non-refereed journal articles -
Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT - DETECT prediction model - a DIRECT study
Rauh Simone P, Heymans Martijn W, Koopman Anitra DM, Nijpels Giel, Stehouwer Coen D, Thorand Barbara, Rathmann Wolfgang, Meisinger Christa, Peters Annette, de las Heras Gala Tonia, Glümer Charlotte, Pedersen Olut, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Pearson Ewan R, Franks Paul W, Rutters Femke, Dekker Jacqueline M. 2017. PLoS ONE. 12: e0171816 A1 Journal article (refereed), original research -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Rare and low-frequency coding variants alter human adult height
Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). 2017. Nature. 542: 186-190 A1 Journal article (refereed), original research -
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang ZN, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. 2017. Genome biology. 18: 70 A1 Journal article (refereed), original research -
Role of osteopontin and its regulation in pancreatic islet
Cai M, Bompada P, Salehi A, Acosta JR, Prasad RB, Atac D, Laakso M, Groop L, De Marinis Y. 2017. Biochemical and biophysical research communications. 2018; 495: 1426-1431 A1 Journal article (refereed), original research -
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
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The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael. 2017. Journal of lipid research. 58: 481-493 A1 Journal article (refereed), original research -
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
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The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31 A2 Review article, Literature review, Systematic review -
Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus
Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke K. 2017. G3: genes, genomes, genetics. 7: 3217-3227 A1 Journal article (refereed), original research -
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Scott Robert A, Freitag Daniel F, Li Li, Chu Audrey Y, Surendran Praveen, Young Robin, Grarup Niels, Stancáková Alena, Chen Yuning, Varga Tibor V, Yaghootkar Hanieh, Luan Jian'an, Zhao Jing Hua, Willems Sara M, Wessel Jennifer, Wang Shuai, Maruthur Nisa, Michailidou Kyriaki, Pirie Ailith, van der Lee Sven J et al. 2016. Science translational medicine. 8: pp. 341ra76 A1 Journal article (refereed), original research -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
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Analysis of protein-coding genetic variation in 60,706 humans
Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN et al. 2016. Nature. 536: 285-291 A1 Journal article (refereed), original research -
Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population
Huopio Hanna, Miettinen Päivi J, Ilonen Jorma, Nykänen Päivi, Veijola Riitta, Keskinen Päivi, Näntö-Salonen Kirsti, Vangipurapu Jagadish, Raivo Joose, Stancáková Alena, Männistö Jonna, Kuulasmaa Teemu, Knip Mikael, Otonkoski Timo, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 101: 3018-3026 A1 Journal article (refereed), original research -
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2016. PLoS genetics. 12: e1006166 A1 Journal article (refereed), original research -
Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort
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Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney
De Marinis Yang, Cai Mengyin, Bompada Pradeep, Atac David, Kotova Olga, Johansson Martin E, Garcia-Vaz Eliana, Gomez Maria F, Laakso Markku, Groop Leif. 2016. Kidney international. 89: 342-353 A1 Journal article (refereed), original research -
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity
Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666 A1 Journal article (refereed), original research -
Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort
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Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
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Integrated network analysis reveals an association between plasma mannose levels and insulin resistance
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Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy
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Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al. 2016. Nature communications. 7: 10495 A1 Journal article (refereed), original research -
Quantifying prion disease penetrance using large population control cohorts
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SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
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Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men
Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 2017: 102: 443-450 A1 Journal article (refereed), original research -
The genetic architecture of type 2 diabetes
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. 2016. Nature genetics. 48: 1171-1184 A1 Journal article (refereed), original research -
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Nature genetics. 48: 1151-1161 A1 Journal article (refereed), original research -
A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data
Kim Young Jin, Lee Juyoung, Kim Bong-Jo, Park Taesung, T2D-Genes Consortium (incl. Laakso Markku). 2015. Bmc genomics. 16: 1109 A1 Journal article (refereed), original research -
Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion
Yaghootkar Hanieh, Stancáková Alena, Freathy Rachel M, Vangipurapu Jagadish, Weedon Michael N, Xie Weijia, Wood Andrew R, Ferrannini Ele, Mari Andrea, Ring Susan M, Lawlor Debbie A, Smith George Davey, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Steinthorsdottir Valgerdur, Guðbjartsson Daniel F, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari et al. 2015. Diabetes. 64: 2279-2285 A1 Journal article (refereed), original research -
Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men
Fizelova Maria, Miilunpohja Manna, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku, Stancáková Alena. 2015. Atherosclerosis. 240: 272-277 A1 Journal article (refereed), original research -
Biological interpretation of genome-wide association studies using predicted gene functions
Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel N, Franke Lude. 2015. Nature communications. 6: 5890 A1 Journal article (refereed), original research -
Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men
Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. 2015. PLoS ONE. 10: e0124028 A1 Journal article (refereed), original research -
Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial
Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Genes and nutrition. 10: 43 A1 Journal article (refereed), original research -
Directional dominance on stature and cognition in diverse human populations
Joshi Peter K, Esko Tonu, Mattsson Hannele, Eklund Niina, Gandin Ilaria, Nutile Teresa, Jackson Anne U, Schurmann Claudia, Smith Albert V, Zhang Weihua, Okada Yukinori, Stancáková Alena, Faul Jessica D, Zhao Wei, Bartz Traci M, Pina Concas Maria, Franceschini Nora, Enroth Stefan, Vitart Veronique, Trompet Stella et al (incl. Kuusisto Johanna, Laakso Markku). 2015. Nature. 523: 459-462 A1 Journal article (refereed), original research -
Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney
Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y. 2015. Biochemical and biophysical research communications. 2016; 469: 108-113 A1 Journal article (refereed), original research -
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men
Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Molecular nutrition and food research. 2016; 60: 381-389 A1 Journal article (refereed), original research -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. 2015. Nature genetics. 47: 1415-1425 A1 Journal article (refereed), original research -
Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study
Mäkelä J, Lagström H, Pitkänen N, Kuulasmaa T, Kaljonen A, Laakso M, Niinikoski H. 2015. Pediatric obesity. [epub ahead of print 11 Dec 2015]: - A1 Journal article (refereed), original research -
Genetic studies of body mass index yield new insights for obesity biology
Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. 2015. Nature. 518: 197-206 A1 Journal article (refereed), original research -
Genetically determined height and coronary artery disease
Christopher P. Nelson, Stephen E. Hamby, Danish Saleheen, Jenna C. Hopewell, Lingyao Zeng, Themistocles L. Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O. Boehm, Robert J. Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W. Franks, Leif Groop, Alistair S. Hall et al. for the CARDIoGRAM+C4D Consortium (inicl. Kuusisto, Laakso). 2015. The new england journal of medicine. 372: 1608-1618 A1 Journal article (refereed), original research -
Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB
Berglund Lisa M, Lyssenko Valeriya, Ladenvall Claes, Kotova Olga, Edsfeldt Andreas, Pilgaard Kasper, Alkayyali Sami, Brøns Charlotte, Forsblom Carol, Jonsson Anna, Zetterqvist Anna V, Nitulescu Mihaela, McDavitt Christian Ruiz, Dunér Pontus, Stancáková Alena, Kuusisto Johanna, Ahlqvist Emma, Lajer Maria, Tarnow Lise, Madsbad Sten et al. 2015. Diabetes. (2016) 65: 239-254 A1 Journal article (refereed), original research -
Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes
Fizelova Maria, Stancáková Alena, Lorenzo Carlos, Haffner Steven M, Cederberg Henna, Kuusisto Johanna, Laakso Markku. 2015. Journal of clinical endocrinology and metabolism. 100: 1989-1996 A1 Journal article (refereed), original research -
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus
Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium. 2015. PLoS genetics. 11: e1004876 A1 Journal article (refereed), original research -
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Knowles Joshua W, Xie Weijia, Zhang Zhongyang, Chennemsetty Indumathi, Assimes Themistocles L, Paananen Jussi, Hansson Ola, Pankow James, Goodarzi Mark O, Carcamo-Orive Ivan, Morris Andrew P, Chen Yii-Der I, Mäkinen Ville-Petteri, Ganna Andrea, Mahajan Anubha, Guo Xiuqing, Abbasi Fahim, Greenawalt Danielle M, Lum Pek, Molony Cliona et al. 2015. Journal of clinical investigation. 125: 1739-1751 A1 Journal article (refereed), original research -
Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort
Cederberg Henna, Stancáková Alena, Yaluri Nagendra, Modi Shalem, Kuusisto Johanna, Laakso Markku. 2015. Diabetologia. 58: 1109-1117 A1 Journal article (refereed), original research -
Influence of endogenous NEFA on beta cell function in humans
Rebelos Eleni, Seghieri Marta, Natali Andrea, Balkau Beverly, Golay Alain, Piatti Pier Marco, Lalic Nebojsa M, Laakso Markku, Mari Andrea, Ferrannini Ele. 2015. Diabetologia. 58: 2344-2351 A1 Journal article (refereed), original research -
Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?
Laakso Markku. 2015. Current diabetes reports. 15: 1-9 A1 Journal article (refereed), original research -
LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging
Alastalo Tero-Pekka, West Gun, Li Song-Ping, Keinänen Anni, Helenius Mikko, Tyni Tiina, Lapatto Risto, Turanlahti Maila, Heikkilä Päivi, Kääriäinen Helena, Laakso Markku, Mauermann Monika, Herrmann Harald, Pihkala Jaana, Taimen Pekka. 2015. Human mutation. 36: 694-703 A1 Journal article (refereed), original research -
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Wessel Jennifer, Chu Audrey Y, Willems Sara M, Wang Shuai, Yaghootkar Hanieh, Brody Jennifer A, Dauriz Marco, Hivert Marie-France, Raghavan Sridharan, Lipovich Leonard, Hidalgo Bertha, Fox Keolu, Huffman Jennifer E, An Ping, Lu Yingchang, Rasmussen-Torvik Laura J, Grarup Niels, Ehm Margaret G, Li Li, Baldridge Abigail S et al. 2015. Nature communications. 6: 5897 A1 Journal article (refereed), original research -
Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol
Roman Tamara S, Marvelle Amanda F, Fogarty Marie P, Vadlamudi Swarooparani, Gonzalez Arlene J, Buchkovich Martin L, Huyghe Jeroen R, Fuchsberger Christian, Jackson Anne U, Wu Ying, Civelek Mete, Lusis Aldons J, Gaulton Kyle J, Sethupathy Praveen, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L.. 2015. American journal of human genetics. 97: 801-815 A1 Journal article (refereed), original research -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. 2015. Nature. 518: 187-196 A1 Journal article (refereed), original research -
Plasma fatty acids as predictors of glycaemia and type 2 diabetes
Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Diabetologia. 58: 2533-2544 A1 Journal article (refereed), original research -
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells
Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. 2015. PLoS ONE. 10: e0142902 A1 Journal article (refereed), original research -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2015. PLoS genetics. 11: e1005378 A1 Journal article (refereed), original research -
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy
Jorgenrud Benedicte, Jalanko Mikko, Heliö Tiina, Jääskeläinen Pertti, Laine Mika, Hilvo Mika, Nieminen Markku S., Laakso Markku, Hyötyläinen Tuulia, Oresic Matej, Kuusisto Johanna. 2015. PLoS ONE. 10: e0134184 A1 Journal article (refereed), original research -
Treatment with the dipeptidyl peptidase-4 inhibitor linagliptin or placebo followed by glimepiride in patients with type 2 diabetes with moderate to severe renal impairment: a 52-week, randomized, double-blind clinical trial
Laakso Markku, Rosenstock Julio, Groop Per-Henrik, Barnett Anthony H, Gallwitz Baptist, Hehnke Uwe, Tamminen Ilkka, Patel Sanjay, Von Eynatten Maximilian, Woerle Hans-Juergen. 2015. Diabetes care. 38: e15-e17 A1 Journal article (refereed), original research -
Type 2 diabetes mellitus and dyslipidemia
Cederberg Henna, Laakso Markku. Teoksessa: Abhimanyu Garg(toim.) , 2015. Dyslipidemias : Pathophysiology, Evaluation and Management. s. 99-113. Humana press A3 Book section, Chapters in research books -
Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy
Panduru Nicolae M, Saraheimo Markku, Forsblom Carol, Thorn Lena M, Gordin Daniel, Wadén Johan, Tolonen Nina, Bierhaus Angelika, Humpert Per M, Groop Per-Henrik on behalf of the FinnDiane Study Group (incl. Markku Laakso). 2015. Diabetes care. 38: 883-90 A1 Journal article (refereed), original research -
Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter
Cederberg Henna, Laakso Markku. 2015. Diabetologia. 58: 1962-3 A1 Journal article (refereed), original research -
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). 2014. PLoS genetics. 10: e1004235 A1 Journal article (refereed), original research -
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell
Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. 2014. American journal of human genetics. 94: 186-197 A1 Journal article (refereed), original research -
A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy
Jääskeläinen Pertti, Heliö Tiina, Aalto-Setälä Katriina, Kaartinen Maija, Ilveskoski Erkki, Hämäläinen Liisa, Melin John, Kärkkäinen Satu, Peuhkurinen Keijo, Nieminen Markku S, Laakso Markku, the FinHCM MStudy Group, Kuusisto Johanna. 2014. Annals of medicine. 46: 424-429 A1 Journal article (refereed), original research -
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. 2014. Nature genetics. 46: 1173-86 A1 Journal article (refereed), original research -
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium
Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstråle M, Rutters F, Vestergaard H, Gupta R, Herrgård S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJ, Thorand B, Bell J, Brunak S, Frost G, et al. (including Laakso M). 2014. Diabetologia. 57: 1132-1142 A1 Journal article (refereed), original research -
Distribution and medical impact of loss-of-function variants in the Finnish founder population
Lim Elaine T, Würtz Peter, Havulinna Aki S, Palta Priit, Tukiainen Taru, Rehnström Karola, Esko Tõnu, Mägi Reedik, Inouye Michael, Lappalainen Tuuli, Chan Yingleong, Salem Ranu M, Lek Monkol, Flannick Jason, Sim Xueling, Manning Alisa, Ladenvall Claes, Bumpstead Suzannah, Hämäläinen Eija, Aalto Kristiina et al., (including Laakso Markku). 2014. PLoS genetics. 10: e1004494 A1 Journal article (refereed), original research -
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations
Ganesh SK, Chasman D, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS (including Kuusisto J, Laakso M). 2014. American journal of human genetics. 95: 49-65 A1 Journal article (refereed), original research -
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?
Cederberg Henna, Stancakova Alena, Kuusisto Johanna, Laakso Markku, Smith Ulf. 2014. Journal of internal medicine. 277: 540-551 A1 Journal article (refereed), original research -
Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in non-diabetic Finnish offspring of type 2 diabetic individuals
Lorenzo Carlos, Haffner Steven M, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2014. Journal of clinical endocrinology and metabolism. 2015; 100: 544-550 A1 Journal article (refereed), original research -
Genetics of metabolic syndrome
Stancakova A, Laakso M. 2014. Reviews in endocrine and metabolic disorders. 15: 243-252 A2 Review article, Literature review, Systematic review -
Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci
Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. 2014. Human molecular genetics. Epub ahead of print: - A1 Journal article (refereed), original research -
Genome-wide association study identifies three novel loci for type 2 diabetes
Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald CW, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui et al. (including Kuusisto Johanna, Laakso Markku). 2014. Human molecular genetics. 23: 239-246 A1 Journal article (refereed), original research -
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abec. 2014. Nature genetics. 46: 234-244 A1 Journal article (refereed), original research -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 A1 Journal article (refereed), original research -
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Wellöw, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês et al (including Kuusisto Johanna, Laakso Markku). 2014. Diabetes. 63: 2158-2171 A1 Journal article (refereed), original research -
Insulin resistance and hyperglycaemia in cardiovascular disease development
Laakso Markku, Kuusisto Johanna. 2014. Nature reviews endocrinology. 10: 293-302 A2 Review article, Literature review, Systematic review -
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861 A1 Journal article (refereed), original research -
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms
Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard et al. (including Kuusisto Johanna, Laakso Markku). 2014. Cell. 156: 343-358 A1 Journal article (refereed), original research -
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Flannick Jason, Thorleifsson Gudmar, Beer Nicola L, Jacobs Suzanne BR, Grarup Niels, Burtt Noël P, Mahajan Anubha, Fuchsberger Christian, Atzmon Gil, Benediktsson Rafn, Blangero John, Bowden Don W, Brandslund Ivan, Brosnan Julia, Burslem Frank, Chambers John, Cho Yoon Shin, Christensen Cramer, Douglas Desirée A, Duggirala Ravindranath et al. (including Laakso Markku). 2014. Nature genetics. 46: 357-363 A1 Journal article (refereed), original research -
Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease
Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. 2014. PLoS ONE. 9: e109772 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL et al. (including Kuusisto J, Laakso M). 2014. PLoS genetics. 10: e1004517 A1 Journal article (refereed), original research -
Multi-ethnic fine-mapping of 14 central adiposity loci
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM et al. (including Kuusisto J, Laakso M). 2014. Human molecular genetics. 23: 4738-4744 A1 Journal article (refereed), original research -
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, T¨ernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, Laakso Markku, Uusitupa Matti). 2014. PLoS genetics. 10: e1004508 A1 Journal article (refereed), original research -
Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease
Vepsäläinen Teemu, Laakso Markku, Lehto Seppo, Juutilainen Auni, Airaksinen Juhani, Rönnemaa Tapani. 2014. Bmc cardiovascular disorders. 14: 168 A1 Journal article (refereed), original research -
Quality control and conduct of genome-wide association meta-analyses
Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Mägi Reedik, Ferreira Teresa, Fall Tove, Graff Mariaelisa, Justice Anne E, Luan Jian'an, Gustafsson Stefan, Randall Joshua C, Vedantam Sailaja, Workalemahu Tsegaselassie, Kilpeläinen Tuomas O, Scherag André, Esko Tonu, Kutalik Zoltán, Heid Iris M, The Genetic Investigation of Anthropometric Traits (GIANT) Consortium et al. (including Atalay Mustafa, Kuusisto Johanna, Laakso Markku, Yaluri Alena). 2014. Nature physics. 9: 1192-1212 A1 Journal article (refereed), original research -
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
Majithia Amit R, Flannick Jason, Shahinian Peter, Guo Michael, Bray Mark-Anthony, Fontanillas Pierre, Gabriel Stacey B, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen Evan D, Altshuler David (including Laakso Markku). 2014. Proceedings of the National Academy of Sciences of the United States of America. 111: 13127-13132 A1 Journal article (refereed), original research -
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D (including Laakso M). 2014. Nature. 506: 97-101 A2 Review article, Literature review, Systematic review -
Serum 25-Hydroxyvitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes
Herrmann Markus, Sullivan David R, Veillard Anne-Sophie, McCorquodale Thomas, Straub Isabella R, Scott Russell, Laakso Markku, Topliss Duncan, Jenkins Alicia J, Blankenberg Stefan, Burton Anthony, Keech Anthony C for the FIELD study investigators. 2014. Diabetes care. 38: 521-528 A1 Journal article (refereed), original research -
The DEXLIFE study methods: Identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals
Andersen GS, Thybo T, Cederberg H, Oresic M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ, on behalf of the DEXLIFE Consortium (including Laakso M). 2014. Diabetes research and clinical practice. 106: 383-389 A1 Journal article (refereed), original research -
A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
Shimomura K, Tusa M, Iberl M, Brereton MF, Kaizik S, Proks P, Lahmann C, Yaluri N, Modi S, Huopio H, Ustinov J, Otonkoski T, Laakso M, Ashcroft FM. 2013. Diabetes. 62: 3797-3806 A1 Journal article (refereed), original research -
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, et al. (including Kuusisto J, Laakso M). 2013. Diabetes. 62: 291-298 A1 Journal article (refereed), original research -
Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss
Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Diabetologia. Epub 2013 Nov 7.: 1-5 A1 Journal article (refereed), original research -
Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes
Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. 2013. American journal of clinical nutrition. -: - A1 Journal article (refereed), original research -
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626 A1 Journal article (refereed), original research -
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes
Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M. 2013. European journal of endocrinology. 169: 291-297 A1 Journal article (refereed), original research -
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu S, Boehnke M, Urano F, Collins FS, Laakso M. 2013. Diabetes. 62: 3943-3950 A1 Journal article (refereed), original research -
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, et al. (including Laakso M, Kuusisto J). 2013. PLoS medicine. 10: e1001383 A1 Journal article (refereed), original research -
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. 2013. Nature genetics. 45: 1345-52 A1 Journal article (refereed), original research -
Desmosterol in human nonalcoholic steatohepatitis
Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982 A1 Journal article (refereed), original research -
Dietary fat in relation to erythrocyte fatty acid composition in men
Takkunen M, Ågren J, Kuusisto J, Laakso M, Uusitupa M, Schwab U. 2013. Lipids. 48: 1093-1102 A1 Journal article (refereed), original research -
Discovery and refinement of loci associated with lipid levels
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. 2013. Nature genetics. 45: 1274-1283 A1 Journal article (refereed), original research -
Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models
Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A. 2013. American journal of physiology : endocrinology and metabolism. vol. 305 no. 5: E573-E584 A1 Journal article (refereed), original research -
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stancáková A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, et al (including J Kuusisto, M Laakso). 2013. Nature genetics. 45: 197-201 A2 Review article, Literature review, Systematic review -
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, et al. (including Stancakova A, Kuusisto J, Laakso M). 2013. Diabetologia. 56: 298-310 A1 Journal article (refereed), original research -
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stančáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T et al. (including Laakso M). 2013. PLoS genetics. 9: e1003607 A1 Journal article (refereed), original research -
Genetic Loci for Retinal Arteriolar Microcirculation
Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG et al (including M Laakso, J Kuusisto). 2013. PLoS ONE. 8: e65804 A1 Journal article (refereed), original research -
Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M; MAGIC Investigators; DIAGRAM Consortium; GENESIS Consortium; RISC Consortium, Dekker JM. 2013. Diabetes. 62: 2141-2150 A1 Journal article (refereed), original research -
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits
Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ.. 2013. Human molecular genetics. 22: 3023-3037 A1 Journal article (refereed), original research -
Genetic screening for the risk of type 2 diabetes
Lyssenko V, Laakso M. 2013. Diabetes care. 36: S120-S126 A1 Journal article (refereed), original research -
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, et al (including M Laakso, J Kuusisto). 2013. Diabetes. 62: 977-986 A1 Journal article (refereed), original research -
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, et al. (including J Kuusisto, M Laakso). 2013. Diabetes. 62: 1746-1755 A1 Journal article (refereed), original research -
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). 2013. Nature genetics. 45: 501-512 A1 Journal article (refereed), original research -
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men
Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Diabetes care. 36: 3732-3738 A1 Journal article (refereed), original research -
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB, Hay N. 2013. Cancer cell. 24: 213-228 A1 Journal article (refereed), original research -
Influence of apolipoproteins on the association between lipids and insulin sensitivity: a cross-sectional analysis of the RISC Study.
Baldi S, Bonnet F, Laville M, Morgantini C, Monti L, Hojlund K, Ferrannini E, Natali A; RISC Investigators (including Laakso, M).. 2013. Diabetes care. 36: 4125-4131 A1 Journal article (refereed), original research -
Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study
Kozakova M, Natali A, Dekker J, Beck-Nielsen H, Laakso M, Nilsson P, Balkau B, Ferrannini E; RISC Investigators. 2013. Arteriosclerosis, thrombosis, and vascular biology. 33: 1409-1417 A1 Journal article (refereed), original research -
Link between GIP and osteopontin in adipose tissue and insulin resistance
Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Diabetes. 62: 2088-2094 A1 Journal article (refereed), original research -
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen L-P, Henneman P, Wu Y, Cheung CYY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M et al. (including J Kuusisto, M Laakso, J Paananen). 2013. Diabetes. 62: 3589-3598 A1 Journal article (refereed), original research -
Meta-analysis of gene-level associations for rare variants based on single-variant statistics
Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. 2013. American journal of human genetics. 93: 236-248 A1 Journal article (refereed), original research -
Mining the human phenome using allelic scores that index biological intermediates
Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G et al. (including M Laakso ja J Kuusisto). 2013. PLoS genetics. 9: e1003919 A1 Journal article (refereed), original research -
Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men
Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. PLoS ONE. 8: e67406 A1 Journal article (refereed), original research -
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators (including M Laakso). 2013. The new england journal of medicine. 369: 1317-1326 A1 Journal article (refereed), original research -
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). 2013. PLoS genetics. 9: e1003500 A1 Journal article (refereed), original research -
The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis
Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, Asia-Pacific Cohort Studies Collaboration (APCSC), Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE), (incl) Pekkanen J, (incl) Laakso M, et al.. 2013. PLoS ONE. 8: 1-10 A1 Journal article (refereed), original research -
The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes
Ezzat S, Zheng L, Florez JC, Stefan N, Mayr T, Hliang MM, Jablonski K, Harden M, Stančáková A, Laakso M, Haring HU, Ullrich A, Asa SL. 2013. Cell metabolism. 17: 929-940 A1 Journal article (refereed), original research -
The Genetic and Metabolic Determinants of Cardiovascular Complications in Type 2 Diabetes: Recent Insights from Animal Models and Clinical Investigations
Avramoglu RK, Laplante M-A, Quang KL, Deshaies Y, Despres J-P, Larose E, Mathieu P, Poirier P, Perusse L, Vohl M-C, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A. 2013. Canadian journal of diabetes. 37: 351-358 A2 Review article, Literature review, Systematic review -
The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry
Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R; DIAGRAM consortium (including Kuusisto J, Laakso M), Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, Doria A, Trischitta V. 2013. Nutrition metabolism and cardiovascular diseases. 23: 1043-1049 A1 Journal article (refereed), original research -
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). 2013. PLoS genetics. 9: e1003379 A1 Journal article (refereed), original research -
Tunnistatko diabetestyypin?
Laakso M. 2013. Yleislääkäri. 28: 9-12 D1 Article in a trade journal -
Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population
Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.. 2013. Annals of medicine. 45: 85-90 A1 Journal article (refereed), original research -
Update on type 2 diabetes as a cardiovascular disease risk equivalent
Kuusisto J, Laakso M. 2013. Current cardiology reports. 15: 331 A1 Journal article (refereed), original research -
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4
Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M, Smith U.. 2013. Proceedings of the National Academy of Sciences of the United States of America. 110: 2563-2568 A1 Journal article (refereed), original research -
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. 2012. Nature genetics. 44: 659-669 A1 Journal article (refereed), original research -
A genome-wide association search for type 2 diabetes genes in African Americans
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D et.al.. 2012. PLoS ONE. 7: e29202 A1 Journal article (refereed), original research -
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (including M Laakso, J Kuusisto). 2012. Human molecular genetics. 21: 3042-3049 A1 Journal article (refereed), original research -
Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso , Aguilar-Salinas CA, Pajukanta P. 2012. Bmc medical genomics. 5: 61 A1 Journal article (refereed), original research -
Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism
Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Diabetes. 61: 2807-2813 A1 Journal article (refereed), original research -
Association between liver insulin resistance and cardiovascular risk factors
Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Journal of internal medicine. 272: 402-408 A1 Journal article (refereed), original research -
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA; Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. 2012. Nature genetics. 44: 483-489 A1 Journal article (refereed), original research -
Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study
Ting RD, Keech AC, Drury PL, Donoghoe MW, Hedley J, Jenkins AJ, Davis TM, Lehto S, Celermajer D, Simes RJ, Rajamani K, Stanton K; FIELD Study Investigators. 2012. Diabetes care. 35: 218-225 A1 Journal article (refereed), original research -
Circadian gene variants and susceptibility to type 2 diabetes: a pilot study
Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O¿Hare JP, Kumar S, Taheri S, Basit A, Barnett AH, DIAGRAM consortium, SAT2D consortium. 2012. PLoS ONE. 7: e32670 A1 Journal article (refereed), original research -
Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women
Würtz Peter, Tiainen Mika, Mäkinen Ville-Petteri, Kangas Antti, Soininen Pasi, Saltevo Juha, Keinänen-Kiukaanniemi Sirkka, Mäntyselkä Pekka, Lehtimäki Terho, Laakso Markku, Jula Antti, Kähönen Mika, Vanhala Mauno, Ala-Korpela Mika. 2012. Diabetes care. 35: 1749-1756 A1 Journal article (refereed), original research -
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Obesity surgery. 22: 1473-1480 A1 Journal article (refereed), original research -
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine. 16: 1206-1222 A1 Journal article (refereed), original research -
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
Kozakova M, Palombo C, Eng MP, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E; RISC Investigators.. 2012. Hepatology. 55: 1406-1415 A1 Journal article (refereed), original research -
From metabolic normality to cardiometabolic risk factors in subjects with obesity.
Heine RJ, Dekker J, Nijpels G, Boorsma W, Mitrakou A, Tournis S, Kyriakopoulou K, Thomakos P, Lalic N, Lalic K, Jotic A, Lukic L, Civcic M, Nolan J, Yeow TP, Murphy M, DeLong C, Neary G, Colgan MP, Hatunic M, et al. (inclunding Laakso). 2012. Obesity. 20: 2063-2069 A1 Journal article (refereed), original research -
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L et.al.. 2012. PLoS genetics. 8: e1002695 A1 Journal article (refereed), original research -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV et.al.. 2012. PLoS genetics. 8: e1002490 A1 Journal article (refereed), original research -
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. 2012. Circulation: cardiovascular genetics. 5: 242-249 A1 Journal article (refereed), original research -
Glucose control in diabetes: which target level to aim for?
Laakso M, Cederberg H. 2012. Journal of internal medicine. 272: 1-12 A1 Journal article (refereed), original research -
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
Wu R, Wyatt E, Chawla K, Tran M, Ghanefar M, Laakso M, Epting CL, Ardehali H. 2012. Embo molecular medicine. 4: 633-646 A1 Journal article (refereed), original research -
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Diabetes. 61: 1895-1902 A1 Journal article (refereed), original research -
Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the finnish diabetes prevention study
de Mello Laaksonen VD, Lindström J, Eriksson J, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Sundvall J, Laakso M, Tuomilehto J, Uusitupa M. 2012. Diabetes care. 35: 211-217 A1 Journal article (refereed), original research -
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjaerg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD et.al.. 2012. The Lancet. 379: 1205-1213 A1 Journal article (refereed), original research -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. 2012. Nature genetics. 44: 991-1005 A1 Journal article (refereed), original research -
Large-scale association analysis identifies new risk loci for coronary artery disease
The CARDIoGRAMplusC4D Consortium (including M Laakso, J Kuusisto), Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T et al. 2012. Nature genetics. 45: 25-33 A1 Journal article (refereed), original research -
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. 2012. Nature genetics. 44: 981-990 A1 Journal article (refereed), original research -
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men
Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen J, Kuusisto J, Ala-Korpela M, Laakso M. 2012. Journal of internal medicine. 272: 562-572 A1 Journal article (refereed), original research -
Long-term effects of placental growth on overweight and body composition
Eriksson JG, Gelow J, Thornburg KL, Osmond C, Laakso M, Uusitupa M, Lindi V, Kajatie E, Barker DJP. 2012. International journal of pediatrics. 2012: 6 pages A1 Journal article (refereed), original research -
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk
Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium. 2012. Diabetes. 61: 524-530 A1 Journal article (refereed), original research -
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy
Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. 2012. Heart. 98: 1007-1013 A1 Journal article (refereed), original research -
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Scott RA, Chu AY, Grarup N, ManningAK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadah M, Arking DE et.al.. 2012. Diabetes. 61: 1291-1296 A2 Review article, Literature review, Systematic review -
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S et.al.. 2012. PLoS genetics. 8: e1002607 A1 Journal article (refereed), original research -
Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population
Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck-Nielsen H; RISC Investigators. 2012. Journal of internal medicine. 271: 294-304 A1 Journal article (refereed), original research -
Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes.
Vepsäläinen T, Laakso M, Kantola I, Lehto S, Juutilainen A, Rönnemaa T. 2012. Journal of internal medicine. 272: 611-619 A1 Journal article (refereed), original research -
Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men
Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH; FinnDiane Study Group.. 2012. Diabetologia. 55: 73-79 A1 Journal article (refereed), original research -
Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis
Smeele KM, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ. 2012. Journal of applied physiology. 113: 608-618 A1 Journal article (refereed), original research -
Response to Brosch et al.
Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. 2012. Cell metabolism. 15: 267-269 A1 Journal article (refereed), original research -
Serine/threonine protein kinase 25(STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle
Nerstedt A, Cansby E, Andersson CX, Laakso M, Stancakova A, Blüher M, Smith U, Mahlapuu M. 2012. Diabetologia. 55: 1797-1807 A1 Journal article (refereed), original research -
Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans
Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Journal of hepatology. 56: 663-670 A1 Journal article (refereed), original research -
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis
Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.. 2012. Amino acids. 42: 427-440 A1 Journal article (refereed), original research -
A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes
Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A. 2011. Cell metabolism. 13: 80-91 A1 Journal article (refereed), original research -
A novel surrogate index for hepatic insulin resistance
Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 540-543 A1 Journal article (refereed), original research -
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility
Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CNA, Frayling TM, DIAGRAM Consortium, Gloyn AL, McCarthy MI. 2011. Diabetologia. 54: 111-119 A1 Journal article (refereed), original research -
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; International Consortium for Blood Pressure Genome-wide Assoc. 2011. Human molecular genetics. 20: 2273-2284 A1 Journal article (refereed), original research -
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 563-571 A1 Journal article (refereed), original research -
Blood pressure loci identified with a gene-centric array
Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ,...BPgen Consortium (including M Laakso). 2011. American journal of human genetics. 89: 688-700 A1 Journal article (refereed), original research -
Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis
Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. 2011. Circulation research. 108: 1165-1169 A1 Journal article (refereed), original research -
Effects of 34 Risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
Stancáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA, Collins FS, Jackson AU, Boehnke ML, Kuusisto J, Ala-Korpela M, Laakso M. 2011. Diabetes. 60: 1608-1616 A1 Journal article (refereed), original research -
Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles
Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I, Riba L, Stancakova A, Kuusisto J, Soininen P, Kangas AJ, Ala-Korpela M, Tusie-Luna T, Laakso M, Pajukanta P. 2011. Arteriosclerosis, thrombosis, and vascular biology. 31: 1201-1207 A1 Journal article (refereed), original research -
Exercise during military training improves cardiovascular risk factors in young men
Cederberg H, Mikkola I, Jokelainen J, Laakso M, Härkönen P, Ikäheimo T, Laakso M, Keinänen-Kiukaanniemi S. 2011. Atherosclerosis. 216: 489-495 A1 Journal article (refereed), original research -
Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis
Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. 2011. Cell metabolism. 14: 208-218 A1 Journal article (refereed), original research -
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability
Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Grazia Piras M, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood III WH, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M,et al.. 2011. PLoS genetics. 7: e1002198 A1 Journal article (refereed), original research -
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH et. al.. 2011. Nature. 478: 103-109 A1 Journal article (refereed), original research -
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen TO, Zillikens MC, Stančáková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M et al.. 2011. Nature genetics. 43: 753-760 A1 Journal article (refereed), original research -
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators (including M. Laakso), Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB; GOLD Consortium:. 2011. PLoS genetics. 7: e1001324 A1 Journal article (refereed), original research -
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, et al. 2011. Diabetes. 60: 2624-2534 A1 Journal article (refereed), original research -
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an et.al.. 2011. Nature genetics. 43: 1131-1138 A1 Journal article (refereed), original research -
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium. 2011. Diabetologia. 54: 795-802 A1 Journal article (refereed), original research -
Heart in diabetes: a microvascular disease
Laakso M. 2011. Diabetes care. 34: S145-S149 A1 Journal article (refereed), original research -
High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive
Ferrannini E, Betteridge DJ, Dormandy JA, Charbonnel B, Wilcox RG, Spanheimer R, Erdmann E, DeFronzo RA, Laakso M. 2011. Diabetes obesity and metabolism. 13: 759-764 A1 Journal article (refereed), original research -
Impact of positive family history and genetic risk variants on the incidence of diabetes - the Finnish Diabetes Prevention Study
Uusitupa MI, Stancáková A, Peltonen M, Eriksson JG, Lindström J, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M. 2011. Diabetes care. Online: 1-6 A1 Journal article (refereed), original research -
Influence of hyperinsulinemia and insulin resistance on in vivo β -cell function: their role in human β -cell dysfunction.
Mari A, Tura A, Natali A, Anderwald C, Balkau B, Lalic N, Walker M, Ferrannini E, for the RISC Investigators (including Laakso M). 2011. Diabetes. 60: 3141-3147 A1 Journal article (refereed), original research -
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. 2011. Cardiovascular diabetology. 10: 1-12 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT,... Kuusisto J, Laakso M. 2011. Nature genetics. 44: 67-72 A1 Journal article (refereed), original research -
Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A; on behalf of the RISC Investigators. 2011. Diabetologia. 54: 1507-1516 A1 Journal article (refereed), original research -
Novel Susceptibility Locus at 22q11 for Diabetic Nephropathy in Type 1 Diabetes
Wessman M, Forsblom C, Kaunisto M, Söderlund J, Ilonen J, Sallinen R, Hiekkalinna T, Parkkonen M, Maxwell A, Tarnow L et.al.. 2011. PLoS ONE. 6: 1-9 A1 Journal article (refereed), original research -
Onko diabeteksen geenidiagnostiikasta hyötyä potilastyössä?
Laakso M. 2011. Lääkärilehti. 66: 37-42 A2 Review article, Literature review, Systematic review -
Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children
Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. 2011. PLoS medicine. 8: e1001116 A1 Journal article (refereed), original research -
Physical activity, high-sensitivity C-reactive protein, and total and cardiovascular disease mortality in type 2 diabetes
Vepsäläinen T, Soinio M, Marniemi J, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. 2011. Diabetes care. 34: 1492-1496 A1 Journal article (refereed), original research -
Plant stanol esters lower LDL cholesterol level in statin-treated subjects with type 1 diabetes by interfering the absorption and synthesis of cholesterol
Hallikainen Maarit, Kurl Sudhir, Laakso Markku, Miettinen Tatu A, Gylling Helena. 2011. Atherosclerosis. 217: 473-478 A1 Journal article (refereed), original research -
Pleiotropic Effects of GIP on Islet Function Involves Osteopontin
Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, et al.. 2011. Diabetes. 60: 2424-2433 A1 Journal article (refereed), original research -
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, et al.. 2011. Molecular cell. 44: 177-190 A1 Journal article (refereed), original research -
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Journal of hepatology. 56: 663-670 A1 Journal article (refereed), original research -
The Adipocyte-expressed forkhead transcription factor foxc2 regulates metabolism through altered mitochondrial function
Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, et al.. 2011. Diabetes. 60: 427-435 A1 Journal article (refereed), original research -
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T. 2011. PLoS ONE. 6: e27096 A1 Journal article (refereed), original research -
The Lin28/let-7 axis regulates glucose metabolism
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. 2011. Cell. 147: 81-94 A1 Journal article (refereed), original research -
The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury
Smeele KM, Ter Horst LH, Koeman A, Heikkinen S, Laakso M, Weber NC, Hollmann MW, Zuurbier CJ. 2011. Laboratory animals. 45: 160-166 A1 Journal article (refereed), original research -
Unacylated ghrelin is associated with changes in body composition and body fat distribution during a long-term exercise intervention
Cederberg H, Rajala U, Koivisto VM, Jokelainen J, Surcel HM, Keinänen-Kiukaanniemi S, Laakso M. 2011. European journal of endocrinology. 165: 243-248 A1 Journal article (refereed), original research -
Äidin ja vastasyntyneen diabetes - pistoksista pillereihin
Kaunisto K, Ojaniemi M, Juuti A-K, Huopio H, Laakso M, Veijola R. 2011. Duodecim. 127: 61-64 A2 Review article, Literature review, Systematic review -
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Amino acids. 38: 549-560 A1 Journal article (refereed), original research -
Age at onset and the risk of proliferative retinopathy in type 1 diabetes
Hietala K, Harjutsalo V, Forsblom C, Summanen P, Groop PH, FinnDiane Study Group. 2010. Diabetes care. 33: 1315-1319 A1 Journal article (refereed), original research -
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, ..., Kuusisto J, ..., Laakso M, et al.. 2010. Nature genetics. 42: 937-948 A1 Journal article (refereed), original research -
Cardiovascular disease in type 2 diabetes. From population to man to mechanisms: Kelly West Lecture 2008
Laakso M. 2010. Diabetes care. 33: 442-449 A2 Review article, Literature review, Systematic review -
Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects
Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. 2010. Atherosclerosis. 210: 536-541 A1 Journal article (refereed), original research -
Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, et al. on behalf of Procardis Consortium. 2010. Diabetes. 59: 3229-3239 A1 Journal article (refereed), original research -
Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millenium Genome Project
Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, et al.. 2010. Hypertension. 56: 973-980 A1 Journal article (refereed), original research -
Depression is associated with the metabolic syndrome among patients with type 1 diabetes
Ahola AJ, Thorn LM, Saraheimo M, Forsblom C, Groop P-H, & on behalf of the Finndiane Study Group. 2010. Annals of medicine. 42: 495-501 A1 Journal article (refereed), original research -
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Ingelsson E, Langenberg C, Hivert MF, ProkopenkoI, Lyssenko V, Dupuis J, Mägi R, Sharp S, ..., Kuusisto J, Laakso M, et al. 2010. Diabetes. 59: 1266-1275 A1 Journal article (refereed), original research -
Effect of nateglinide on the incidence of diabetes and cardiovascular events
Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, ..., Laakso M, et al.. 2010. The new england journal of medicine. 362: 1463-1476 A1 Journal article (refereed), original research -
Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population
Kozakova M, Palombo C, Morizzo C, Nolan JJ, Konrad T, Balkau B, the RISC Investigtors. 2010. European heart journal. 31: 1511-1519 A1 Journal article (refereed), original research -
Effect of valsartan on the incidence of diabetes and cardiovascular events
McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang F-T, Charbonnel B, Chow C-C, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, et al. for The NAVIGAT. 2010. The new england journal of medicine. 362: 1477-1490 A1 Journal article (refereed), original research -
Four Novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MMB, et al.. 2010. PLoS ONE. 6: e1001184 A1 Journal article (refereed), original research -
Genetic Variation of DKK3 May Modify Renal Disease Severity in ADPKD.
Liu M, Shi S, Senthilnathan S, Yu J, Wu E, Bergmann C, Zerres K, Bogdanova N, Coto E, ..., Laakso M, et al.. 2010. Journal of the american society of nephrology. 21: 1510-1520 A1 Journal article (refereed), original research -
Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes
Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, ..., Kuusisto J, ..., Laakso M, et al. 2010. Human molecular genetics. 19: 535-544 A1 Journal article (refereed), original research -
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW et al.. 2010. Nature genetics. 42: 142-148 A1 Journal article (refereed), original research -
Genetic variation in gastric inhibitory polypeptide receptor (GIPR): Impacts the glucose and insulin responses to an oral glucose challenge
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, .., Kuusisto J, Laakso M, et al.. 2010. Nature genetics. 42: 142-148 A1 Journal article (refereed), original research -
Identification of undiagnosed type 2 diabetic individuals by the Finnish diabetes risk score, biochemical and genetic markers: A population-based study of 7232 Finnish men
Wang J, Stancakova A, Kuusisto J, Laakso M. 2010. Journal of clinical endocrinology and metabolism. 95: 3858-3862 A1 Journal article (refereed), original research -
Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults
Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A on behalf of the RISC Investigators. 2010. Heart. 96: 1191-1200 A1 Journal article (refereed), original research -
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance
Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck-Nielsen H, Ferrannini E, RISC Investigators. 2010. Diabetologia. 53: 749-756 A1 Journal article (refereed), original research -
Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Burgess DC, Hunt D, Li L, Zannino D, Williamson E, Davis TM, Laakso M, Kesäniemi YA, Zhang J, Sy RW, et al.. 2010. European heart journal. : 92-99 A1 Journal article (refereed), original research -
Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
Natali A, Muscelli E, Mari A, Balkau B, Walker M, Tura A, Anderwald C, Golay A, & Ferrannini E, the Relationship between Insulin Sensitivity and Cardiovascular disease investigators. 2010. Journal of clinical endocrinology and metabolism. 95: 4703-4711 A1 Journal article (refereed), original research -
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.
Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Journal of lipid research. 51: 2422-2427 A1 Journal article (refereed), original research -
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, van Rooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S (including M Laakso). 2010. Diabetes care. 33: 2684-2691 A1 Journal article (refereed), original research -
Lipid disorders in type 2 diabetes
Laakso M. 2010. Endocrinologia y nutricion. 56: 43-45 A1 Journal article (refereed), original research -
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, ..., Kuusisto J, ... , Laakso M, et al.. 2010. Nature genetics. 42: 949-960 A1 Journal article (refereed), original research -
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Kuusisto J, Laakso M, et al.. 2010. Nature genetics. 42: 105-116 A1 Journal article (refereed), original research -
Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice
Smeele KM, Eerbeek O, Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, et al. 2010. Pflugers archiv: european journal of physiology. 459: 705-712 A1 Journal article (refereed), original research -
Polymorphism Pro12Ala of PPARG in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children
Laakso S, Utriainen P, Laakso M, Voutilainen R & Jääskeläinen J. 2010. Hormone research in paediatrics. 74: 365-371 A1 Journal article (refereed), original research -
Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes
Vepsäläinen T, Soinio M, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. 2010. Diabetologia. 53: 1886-1889 A1 Journal article (refereed), original research -
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia-reperfusion injury
Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, MS, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H. 2010. Circulation research. 108: 60-69 A1 Journal article (refereed), original research -
Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals
Lorenzo C, Haffner SM, Stancakova A, Laakso M. 2010. Journal of clinical endocrinology and metabolism. 95: 5082-5090 A1 Journal article (refereed), original research -
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. 2010. Diabetes. 59: 829-835 A1 Journal article (refereed), original research -
The D299G/T3991 toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM studies
Weyrich P, Staiger H, Stancakova A, Machicao F, Machann J, Schick F, Stefan N, Kuusisto J, Laakso M, Schäfer S, Fritsche A, Häring H-U. 2010. PLoS ONE. 5: e13980 A1 Journal article (refereed), original research -
The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns
Wang J, Sarnola K, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M & Kuusisto J. 2010. Atherosclerosis. 210: 237-242 A1 Journal article (refereed), original research -
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish diabetes prevention study
Kilpeläinen TO, Laaksonen DE, Lakka TA, Herder C, Koenig W, Lindström J, Eriksson JG, Uusitupa M, Kolb H, Laakso M, Tuomilehto J, for the Finnish Diabetes Prevention Study Group. 2010. Experimental and clinical endocrinology and diabetes. 118: 757-759 A2 Review article, Literature review, Systematic review -
Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects. A 18-year follow-up study
Juutilainen A, Lehto S, Suhonen M, Rönnemaa T, Laakso M. 2010. Diabetes care. 33: 583-585 A1 Journal article (refereed), original research -
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Voight BF,Scott LJ,Steinthorsdottir V,Morris AP,Dina C,Welch RP,Zeggini E,Huth C,..., ,Kuusisto J,..., Laakso M,et al.. 2010. Nature genetics. 42: 579-589 A1 Journal article (refereed), original research -
A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes
Wadén J, Forsblom C, Thorn LM, Gordin D, Saraheimo M, Groop PH, on behalf of the Finnish Diabetic Nephropathy Study Group, Karhapää P, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Moilanen L. 2009. Diabetes. 58: 2649-2655 A1 Journal article (refereed), original research -
Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose
Li X, Shu Y-H, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. 2009. Diabetes. 58: 2946-2953 A1 Journal article (refereed), original research -
Adult stature and diabetes complications in patients with type 1 diabetes: the FinnDiane Study and the diabetes control and complications trial
Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Hietala K, Ong K, Wareham N, Groop PH, on behalf of the FinnDiane Study Group, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2009. Diabetes. 58: 1914-1920 A1 Journal article (refereed), original research -
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M. 2009. Diabetes. 58: 2129-2136 A1 Journal article (refereed), original research -
Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring H-U. 2009. Journal of clinical endocrinology and metabolism. 94: 1353-1360 A1 Journal article (refereed), original research -
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. 2009. Diabetes. 58: 1212-1221 A1 Journal article (refereed), original research -
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF, Wareham NJ, Walker M, the RISC Consortium. 2009. Diabetologia. 52: 1537-1542 A1 Journal article (refereed), original research -
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring H-U. 2009. Bmc medical genetics. 10: 77 A1 Journal article (refereed), original research -
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko V, Nagorny CLF, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M..., Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. 2009. Nature genetics -
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T..., Kuusisto J, Bergman RN..., Laakso M, Ferrucci L, Scheet P..., Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS. 2009. Nature genetics. 41: 56-65 A1 Journal article (refereed), original research -
Early autonomic dysfunction in type 1 diabetes: a reversible disorder?
Rosengård-Bärlund M, Bernardi L, Fagerudd J, Mäntysaari M, Af Björkesten CG, Lindholm H, Forsblom C, Wadén J, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. Diabetologia. 52: 1164-1172 A1 Journal article (refereed), original research -
Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial
Rajamani K, Colman PG, Li LP, Best JD, Voysey M, D'Emden MC, Laakso M, Baker JR, Keech AC, on behalf of the FIELD Study Investigators. 2009. The Lancet. 373: 1780-1788 A1 Journal article (refereed), original research -
Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy
Kaunisto MA, Sjölind L, Sallinen R, Pettersson-Fernholm K, Saraheimo M, Fröjdö S, Forsblom C, Fagerudd J, Hansen TK, Flyvbjerg A, Wessman M, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. Diabetes. 57: 1710-1714 A1 Journal article (refereed), original research -
Endokriinisten sairauksien geenidiagnostiikka
Laakso M. Teoksessa: Välimäki M, Sane T, Dunkel L(toim.) , 2009. Endokrinologia. s. 50-62. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study
de Rooij SR, Dekker JM, Kozakova M, Mitrakou A, Melander O, Gabriel R, Guidone C, Højlund K, Murphy MS, Nijpels G, and the RISC Group Investigators, Laakso M. 2009. European journal of endocrinology. 161: 223-230 A1 Journal article (refereed), original research -
Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B, the RISC Investigators, Laakso M. 2009. Hepatology. 49: 1537-1544 A1 Journal article (refereed), original research -
Galanin preproprotein is associated with elevated plasma triglycerides
Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A..., Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 147-152 A1 Journal article (refereed), original research -
Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure
Ahonen T, Saltevo J, Laakso M, Kautiainen H, Kumpusalo E, Vanhala M. 2009. Mediators of inflammation. : [6 p.] A1 Journal article (refereed), original research -
Genetic variation of FTO and TCF7L2 in premature adrenarche
Lappalainen S, Voutilainen R, Utriainen P, Laakso M, Jääskeläinen J. 2009. Metabolism: clinical and experimental. 58: 1263-1269 A1 Journal article (refereed), original research -
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM..., Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney..., Laakso M, Kuusisto J. 2009. PLoS genetics. 5: e1000508 A1 Journal article (refereed), original research -
Genome-wide association study identifies eight loci associated with blood pressure
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS..., Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome TRUST Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ..., Laakso M. 2009. Nature genetics. 41: 666-676 A1 Journal article (refereed), original research -
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J. 2009. PLoS genetics. 5: e100591 A1 Journal article (refereed), original research -
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women
Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. 2009. Atherosclerosis. 205: 590-594 A1 Journal article (refereed), original research -
Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, Barker DJ, Groop LC, Eriksson JG. 2009. Diabetologia. 52: 825-829 A1 Journal article (refereed), original research -
Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile
de Rooij SR, Nijpels G, Nilsson PM, Nolan JJ, Gabriel R, Bobbioni-Harsch E, Mingrone G, Dekker JM, for the Relationship Between Insulin Sensitivity And Cardiovascular, Disease (risc) Investigators, Laakso M. 2009. Diabetes care. 32: 1295-1301 A1 Journal article (refereed), original research -
Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes
Thorn LM, Forsblom C, Wadén J, Saraheimo M, Tolonen N, Hietala K, Groop P-H, for the Finnish Diabetic Nephropathy (FinnDiane) Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I. 2009. Diabetes care. 32: 950-952 A1 Journal article (refereed), original research -
Natural history of type 2 diabetes and macrovascular disease
Laakso M. Teoksessa: Serrano-Riós M, Gutiérrez-Fuentes JA(toim.) , 2009. Type 2 Diabetes Mellitus. s. 151-166. Elsevier A3 Book section, Chapters in research books -
Not for the eyes only: PAX6 and glucose metabolism
Laakso M. 2009. Diabetologia. 52: 381-384 A2 Review article, Literature review, Systematic review -
Parental origin of sequence variants associated with complex diseases
Kong A, Steinthorsdottir V, Masson G, Thorleifsson G..., ...Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Laakso M, Kuusisto J. 2009. Nature. 462: 868-874 A1 Journal article (refereed), original research -
Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes
Nymark M, Pussinen PJ, Tuomainen AM, Forsblom C, Groop PH, Lehto M, on behalf of the FinnDiane Study Group, Karhapää P, Laakso M, Lumiaho A, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2009. Diabetes care. 32: 1689-1693 A1 Journal article (refereed), original research -
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N..., Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Kuusisto J, Laakso M. 2009. Nature genetics. 41: 25-34 A1 Journal article (refereed), original research -
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels
Meex SJR, Weissglas-Volkov D, van der Kallen CJH, Thuerauf DJ, van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CDA, Feskens EJM, Heldens L, Ayoubi TA, Hofker MH, Wouters BG..., Taskinen M-R, Kuusisto J, Laakso M, de Bruin TWA.... 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 1322-1327 A1 Journal article (refereed), original research -
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface
Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy M-F, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J. 2009. . 9: 88-98 A1 Journal article (refereed), original research -
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus
Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. 2009. Metabolism: clinical and experimental. 58: 541-546 A1 Journal article (refereed), original research -
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease
Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. 2009. Metabolism: clinical and experimental. 58: 401-407 A1 Journal article (refereed), original research -
The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes
Groop PH, Thomas MC, Moran JL, Wadèn J, Thorn LM, Mäkinen V-P, Rosengård-Bärlund M, Saraheimo M, Hietala K, Heikkilä O, Forsblom C, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. Diabetes. 58: 1651-1658 A1 Journal article (refereed), original research -
Underlying genetic models of inheritance in established type 2 diabetes associations
Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C.... 2009. American journal of epidemiology. 170: 537-545 A1 Journal article (refereed), original research -
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients-EUGENE2 study
Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson P-A, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T, for the EUGENE2 Consortium. 2009. PLoS ONE. 4: e7236 A1 Journal article (refereed), original research -
Variants in MTNR1B influence fasting glucose levels
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K..., Kuusisto J, Laakso M. 2009. Nature genetics. 41: 77-81 A1 Journal article (refereed), original research -
Variation in the UCP2 and UCP3 genes associated with abdominal obesity and serum lipids: The Finnish diabetes prevention study
Salopuro T, Pulkkinen L, Lindström J, Kolehmainen M, Tolppanen A-M, Eriksson JG, Valle TT, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Salopuro T, Pulkkinen L, Kolehmainen M, Tolppanen A-M, Uusitupa M. 2009. Bmc medical genetics. 10: [13 p.] A1 Journal article (refereed), original research -
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson P-A, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring H-U. 2008. Diabetes. 57: 514-517 A1 Journal article (refereed), original research -
Body composition and common carotid artery remodeling in a healthy population
Kozakova M, Palombo C, Paterni M, Anderwald CH, Konrad T, Colgan MP, Flyvbjerg A, Dekker J, Relationship between Insulin Sensitivity Cardiovascular Risk Investigators, Laakso M. 2008. Journal of clinical endocrinology and metabolism. 93: 3325-3332 A1 Journal article (refereed), original research -
Cardiovascular protection for all individuals at high risk: evidence-based best practice
Bakris G, Böhm M, Dagenais G, Diener H-C, Fujita T, Gorelick P, Kjeldsen SE, Laakso M, Mancia G, Pitt B, Sharma A, Sleight P, Teo K, Unger T, Weber M, Williams B, Zannad F. 2008. Clinical research in cardiology. 97: 713-725 A2 Review article, Literature review, Systematic review -
Diabetes as a 'cardiovascular disease equivalent': implications for treatment
Laakso M. 2008. NATURE CLINICAL PRACTICE. CARDIOVASCULAR MEDICINE. 5: 682-683 A2 Review article, Literature review, Systematic review -
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. 2008. Cell. 132: 375-386 A1 Journal article (refereed), original research -
Early familial dilated cardiomyopathy: Identification with determination of disease state parameter from cine MR image data
Koikkalainen JR, Antila M, Lötjönen JMP, Heliö T, Lauerma K, Kivistö SM, Sipola P, Kaartinen MA, Kärkkäinen STJ, Reissell E, Kuusisto J, Laakso M, Oresic M, Nieminen MS, Peuhkurinen KJ. 2008. Radiology. 249: 88-96 A1 Journal article (refereed), original research -
Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose. Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
The DREAM Trial Investigators, Laakso M. 2008. Diabetes care. 31: 1007-1014 A1 Journal article (refereed), original research -
Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects
Laitinen T, Lyyra-Laitinen T, Huopio H, Vauhkonen I, Halonen T, Hartikainen J, Niskanen L, Laakso M. 2008. Annals of noninvasive electrocardiology. 13: 97-105 A1 Journal article (refereed), original research -
Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study
Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. 2008. Diabetic medicine. 25: 747-750 A1 Journal article (refereed), original research -
Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease
Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Journal of neurology. 255: 668-673 A1 Journal article (refereed), original research -
High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects
Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. 2008. Journal of internal medicine. 263: 440-449 A1 Journal article (refereed), original research -
IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy
Liu X-Q, Paterson AD, He N, St George-Hyslop P, Rauta V, Gronhagen-Riska C, Laakso M, Thibaudin L, Berthoux F, Cattran D, Pei Y. 2008. Journal of the american society of nephrology. 19: 1025-1033 A1 Journal article (refereed), original research -
Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N, Walker M, European GROUP For the Study of Insulin Resistance Relationship Between Insulin Sensitivity And Cardiovascular Disease Risk Study Group., Laakso M. 2008. Diabetes care. 31: 789-794 A1 Journal article (refereed), original research -
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson P-A, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U, for the EUGENE2 Consortium. 2008. Diabetologia. 51: 502-511 A1 Journal article (refereed), original research -
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study
Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2008. Metabolism: clinical and experimental. 57: 428-436 A1 Journal article (refereed), original research -
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study
Saltevo J, Laakso M, Jokelainen J, Keinänen-Kiukaanniemi S, Kumpusalo E, Vanhala M. 2008. Diabetes/metabolism research and reviews. 24: 378-383 A1 Journal article (refereed), original research -
Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. 2008. Atherosclerosis. 197: 271-277 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Laakso M, Kuusisto J. 2008. Nature genetics. 40: 638-645 A1 Journal article (refereed), original research -
Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes
Mäkinen V-P, Forsblom C, Thorn LM, Wadén J, Gordin D, Heikkilä O, Hietala K, Kyllönen L, Kytö J, Rosengård-Bärlund M, Saraheimo M, Tolonen N, Parkkonen M, Kaski K, Ala-Korpela M, Groop P-H, on behalf of the FinnDiane Study Group, Huttunen E. 2008. Diabetes. 57: 2480-2487 A1 Journal article (refereed), original research -
Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II
Ungaro P, Teperino R, Mirra P, Cassese A, Fiory F, Perruolo G, Miele C, Laakso M, Formisano P, Beguinot F. 2008. Journal of biological chemistry. 283: 30970-30979 A1 Journal article (refereed), original research -
Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study
Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Diabetes care. 31: 230-232 A2 Review article, Literature review, Systematic review -
Physical activity and insulin sensitivity: the RISC Study
Balkau B, Mhamdi L, Oppert J-M, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E, on behalf of the EGIR-RISC Study Group. 2008. Diabetes. 57: 2613-2618 A1 Journal article (refereed), original research -
Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial
Califf RM, Boolell M, Haffner SM, Bethel MA, McMurray J, Duggal A, Holman RR, for the NAVIGATOR Study Group, Laakso M. 2008. American heart journal. 156: 623-632 A1 Journal article (refereed), original research -
Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure
Miettinen KH, Lassus J, Harjola VP, Siirilä-Waris K, Melin J, Punnonen KR, Nieminen MS, Laakso M, Peuhkurinen KJ. 2008. European journal of heart failure. 10: 396-403 A1 Journal article (refereed), original research -
Relationship between lipid profiles and kidney function in patients with type 1 diabetes
Tolonen N, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Saraheimo M, Heikkilä O, Pettersson-Fernholm K, Taskinen MR, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Mykkänen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Diabetologia. 51: 12-20 A1 Journal article (refereed), original research -
SNPs in PPARG associte with type 2 diabetes and intract with physival activity
Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. 2008. Medicine and science in sports and exercise. 40: 25-33 A1 Journal article (refereed), original research -
Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes
Saraheimo M, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Heikkilä O, Hietala K, Gordin D, Frystyk J, Flyvbjerg A, Groop PH, on behalf of the FINNDIANE Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2008. Diabetes care. 31: 1165-1169 A1 Journal article (refereed), original research -
Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects
Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2008. Diabetes care. 31: 714-719 A1 Journal article (refereed), original research -
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Journal of clinical endocrinology and metabolism. 93: 1924-1930 A1 Journal article (refereed), original research -
Sleep-disordered breathing and type 2 diabetes. A report from the International Diabetes Federation Taskforce on Epidemiology and Prevention
Shaw JE, Punjabi NM, Wilding JP, Alberti KGMM, Zimmet PZ, Laakso M. 2008. Diabetes research and clinical practice. 81: 2-12 A2 Review article, Literature review, Systematic review -
The G-250A polymorphism in the hepatic lipase gene promotor is associated with changes in hepatic lipase activity and LDL cholesterol:The KANWU study
Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, Tapsell L, Riccardi G, Rivellese AA, Laakso M, Uusitupa MIJ, KANWU Study Group. 2008. Nutrition metabolism and cardiovascular diseases. 18: 88-95 A1 Journal article (refereed), original research -
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients - the EUGENE2 study
Boesgaard TW, Zilinskaite J, Vänttinen M, Laakso M, Jansson P-A, Hammarstedt A, Smith U, Stefan N, Fritsche A, Häring H, Hribal M, Sesti G, Zobel DP, Pedersen O, Hansen T, for the EUGENE 2 Consortium. 2008. Diabetologia. 51: 816-820 A1 Journal article (refereed), original research -
The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2008. Stroke. 39: 1078-1083 A1 Journal article (refereed), original research -
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, AND METSIM studies
Friedrich B, Weyrich P, Stancakova A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring H-U. 2008. PLoS ONE. 3: e3506 A1 Journal article (refereed), original research -
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects
Patel S, Flyvbjerg A, Kozàkovà M, Frystyk J, Ibrahim IM, Petrie JR, Avery PJ, Ferrannini E, Walker M, RISC Investigators, Laakso M. 2008. European heart journal. 29: 386-393 A1 Journal article (refereed), original research -
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Chen W-M, Erdos MR, Jackson AU..., Kuusisto J, Ebrahim S..., Laakso M. 2008. Journal of clinical investigation. 118: 2620-2628 A1 Journal article (refereed), original research -
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
Lee JC, Weissglas-Volkov D, Kyttäjä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greenvenbroek MMJ, Kane JP, Malloy MJ..., Kuusisto J, Laakso M, Taskinen M-R, Genest J, Pajukanta P. 2008. American journal of human genetics. 83: 180-192 A1 Journal article (refereed), original research -
A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis
Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jörgensen T, Hansen T, Pedersen O, Laakso M, Arner P, Laakso M. 2007. American journal of human genetics. 80: 1115-1124 A1 Journal article (refereed), original research -
Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome
Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. 2007. Mediators of inflammation. : Article ID 93573 A1 Journal article (refereed), original research -
Association of fasting glucagon and proinsulin concentrations with insulin resistance
Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, the Relationship between Insulin Sensitivity, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Diabetologia. 50: 2342-2347 A1 Journal article (refereed), original research -
Atherosclerosis and cardiovascular risk reduction with PPAR agonists
Kuusisto J, Andrulionyte L, Laakso M, Laakso M. 2007. Current atherosclerosis reports. 9: 274-280 A2 Review article, Literature review, Systematic review -
Cerebrovascular disease in type 2 diabetes
Laakso M, Kuusisto J. Teoksessa: Grepaldi G, Tiengo A, Avogaro A(toim.) , 2007. The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease. Proceedings ot the 9th European Symposium on Metabolism. s. 65-69. A4 Conference proceedings -
Challenges in studies of the genetic basis of type 2 diabetes
Laakso M. 2007. Expert review of endocrinology & metabolism. 2: 451-459 A2 Review article, Literature review, Systematic review -
Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control
Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. 2007. Atherosclerosis. 194: 465-472 A1 Journal article (refereed), original research -
Cholesterol synthesis prevails over absorption in metabolic syndrome
Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. 2007. Translational research. 149: 310-316 A1 Journal article (refereed), original research -
Clustering of risk factors in parents of patients with type 1 diabetes and nephropathy
Thorn LM, Forsblom C, Fagerudd J, Pettersson-Fernholm K, Kilpikari R, Groop PH, on behalf of the FinnDiane Study Group, Huttunen E, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2007. Diabetes care. 30: 1162-1167 A1 Journal article (refereed), original research -
Diabeteksen Käypä hoito -suositus
Suomalaisen Lääkäriseuran Duodecimin, Diabetesliiton Lääkärineuvoston, ja Suomen Sisätautilääkärien Yhdistyksen Asettama Työryhmä, Laakso M, Louheranta A. 2007. Duodecim. 123: 1490-1520 A1 Journal article (refereed), original research -
Diabetes - glukoosiaineenvaihdunnan säätelyn perinnöllinen häiriö
Laakso M, Laakso M. 2007. Duodecim. 123: 2195-2204 A2 Review article, Literature review, Systematic review -
Effect of fenofibrate on the need for treatment for diabetic retinopathy (FIELD study): a randomised controlled trial
Keech AC, Mitchell P, Summanen PA, O¿Day J, Davis TME, Moffitt MS, Taskinen M-R, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d¿Emden MC, Crimert DC, O¿Connell RL, Colman PG, for the Field study investigators, Laakso M. 2007. The Lancet. 370: 1687-1697 A1 Journal article (refereed), original research -
Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes
Weyrich P, Stefan N, Häring H-U, Laakso M, Fritsche A. 2007. Journal of molecular medicine: jmm. 85: 107-117 A1 Journal article (refereed), original research -
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Molecular and cellular biology. 27: 4953-4967 A1 Journal article (refereed), original research -
Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population
Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring H-U, Laakso M. 2007. Diabetic medicine. 24: 817-822 A1 Journal article (refereed), original research -
Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic pysical fitness and insulin sensitivity during lifestyle intervention
Stefan N, Thamer C, Staiger H, Machicao F, Machann J, Shick F, Venter C, Niess A, Laakso M, Fritsche A, Häring H-U, Laakso M. 2007. Journal of clinical endocrinology and metabolism. 92: 1827-1833 A1 Journal article (refereed), original research -
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
Rydén L, Standl E, Bartnik M, Van den Berghe G, Betteridge J, de Boer MJ, Cosentino F, Jönsson B, Laakso M, Malmberg K, Priori S, Östergren J, Tuomilehto J, Thrainsdottir I, Vanhorebeek I, Stramba-Badiale M, Lindgren P, Qiao Q, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, Mcgregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Deckers JW, Bertrand M, Charbonnel B, Erdmann E, Ferrannini E, Flyvbjerg A, Gohlke H, Juanatey JR, Graham I, Monteiro PF, P. 2007. European heart journal. 28: 88-136 A2 Review article, Literature review, Systematic review -
Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk
Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, Paterni M, Balkau B, on behalf of the RISC Investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Stroke. 38: 2549-2555 A1 Journal article (refereed), original research -
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia
Heinonen SE, Leppänen P, Kholová I, Lumivuori H, Häkkinen S-K, Bosch F, Laakso M, Ylä-Herttuala S, Kholova I, Laakso M. 2007. Circulation research. 101: 1058-1067 A1 Journal article (refereed), original research -
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study
Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. 2007. Diabetologia. 50: 1409-1417 A1 Journal article (refereed), original research -
Insulin resistance, insulin response, and obesity as indicators of metabolic risk
Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck-Nielsen H, and the RISC investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Journal of clinical endocrinology and metabolism. 92: 2885-2892 A1 Journal article (refereed), original research -
Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study
Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. 2007. Diabetes care. 30: 1618-1620 A2 Review article, Literature review, Systematic review -
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood
Saltevo J, Vanhala M, Kautiainen H, Laakso M. 2007. Diabetes and vascular disease research. 4: 328-331 A1 Journal article (refereed), original research -
Metabolic syndrome and incident end-stage peripheral vascular disease. A 14-year follow-up study in elderly Finns
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. Diabetes care. 30: 3099-3104 A1 Journal article (refereed), original research -
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study
Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J, Laakso M. 2007. Journal of nuclear cardiology. 14: 354-365 A1 Journal article (refereed), original research -
Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II
Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2007. Diabetes. 56: 2476-2484 A1 Journal article (refereed), original research -
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2007. Physiological genomics. 31: 264-272 A1 Journal article (refereed), original research -
Pioglitazone use and heart failure in patients with type 2 diabetes and preexisting cardiovascular disease. Data from the PROactive Study (PROactive 08)
Erdmann E, Charbonnel B, Wilcox RG, Skene AM, Massi-Benedetti M, Yates J, Tan M, Spanheimer R, Standl E, Dormandy JA, on behalf of the PROactive Investigators, Laakso M, Laakso M. 2007. Diabetes care. 30: 2773-2778 A1 Journal article (refereed), original research -
Prevention of cardiovascular events in diabetic patients
Laakso M. Teoksessa: Fisher M, McMurray JJ(toim.) , 2007. Diabetic Cardiology. s. 221-239. John Wiley & Sons A3 Book section, Chapters in research books -
Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women
Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2007. Diabetes care. 30: 292-299 A1 Journal article (refereed), original research -
Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women
Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2007. Diabetes care -
Serum zinc level and coronary heart disease events in patients with type 2 diabetes
Soinio M, Marniemi J, Laakso M, Pyörälä K, Lehto S, Rönnemaa T. 2007. Diabetes care. 30: 523-528 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Obesity. 15: 2902-2907 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2007. Journal of clinical endocrinology and metabolism. 92: 1112-1117 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes. The STOP-NIDDM Trial
Andrulionyté L, Kuulasmaa T, Chiasson J-L, Laakso M, for the STOPP-NIDDM Study Group, Laakso M. 2007. Diabetes. 56: 1181-1186 A1 Journal article (refereed), original research -
Sirtuiinit - energiatasapainon ja glukoosimetabolian uudet molekyylit
Laakso M, Laakso M. 2007. Duodecim -
The effect of pioglitazone on recurrent myocardial infaraction in 2,445 patients with type 2 diabetes and previous myocardial infarction
Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM, on behalf of the PROactive Investigators, Laakso M. 2007. Journal of the american college of cardiology. 49: 1772-80 A1 Journal article (refereed), original research -
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. European heart journal. 28: 857-864 A1 Journal article (refereed), original research -
Tyypin 2 diabeteksen ehkäisy
Laakso M, Uusitupa M. 2007. Duodecim. 123: 1439-1447 A1 Journal article (refereed), original research -
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2007. Diabetologia. 50: 1192-1200 A1 Journal article (refereed), original research -
Yksi, kaksi vai monta diabetesta?
Laakso M, Groop L. 2007. Duodecim. 123: 1427-1429 A2 Review article, Literature review, Systematic review -
Adiponectin gene haplotype is associated with preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. GENETIC TESTING. 10: 35-39 A1 Journal article (refereed), original research -
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population
Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453 A1 Journal article (refereed), original research -
Association of metabolic syndrome with Alzheimer disease: a population-based study
Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Neurology. 67: 843-847 A1 Journal article (refereed), original research -
Association of sequence variations in the gene encoding adoponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish diabetes prevention study
Siitonen N, Pulkkinen L, Mager U, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish diabetes prevention study group, Siitonen N, Pulkkinen L, Mager U. 2006. Diabetologia. 49: 1795-1805 A1 Journal article (refereed), original research -
Association of the Leu72Met polymorphism of the ghrelin gene with the risk of type 2 diabetes in subjects with impaired glucose tolerance in the Finnish diabetes prevention study
Mager U, Lindi V, Lindström J, Eriksson JG, Vallet TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Pulkkinen L, Uusitupa M, for the Finnish diabetes prevention study group, Mager U, Lindi V, Pulkkinen L. 2006. Diabetic medicine. 23: 685-689 A1 Journal article (refereed), original research -
Autosomissa vallitsevasti periytyvä munuaisten monirakkulatauti
Lumiaho A, Laakso M. 2006. Duodecim. 122: 200-207 A2 Review article, Literature review, Systematic review -
Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects
Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. 2006. Diabetes care. 29: 2714-2720 A1 Journal article (refereed), original research -
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2006. Molecular genetics and metabolism. 87: 147-151 A1 Journal article (refereed), original research -
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Diabetologia. 49: 1560-1566 A1 Journal article (refereed), original research -
Correction to the FIELD study report
Keech A, Simes J, Barter P, Best J, Scott R, Taskinen M-R, on behalf of the FIELD Management Committee, Laakso M. 2006. The Lancet -
Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beeta-myosin heavy chain, alfa-tropomyosin, and myosin-binding protein C genes
Poutanen T, Tikanoja T, Jääskeläinen P, Jokinen E, Silvast A, Laakso M, Kuusisto J, Laakso M. 2006. American heart journal. 151: 725.e1-725.e9 A1 Journal article (refereed), original research -
Effect of ramipril on the incidence of diabetes
The DREAM Trial Investigators, Laakso M. 2006. The new england journal of medicine. 355: 1551-1562 A1 Journal article (refereed), original research -
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
The DREAM Trial Investigators, Laakso M, Rutanen J, Jantunen A. 2006. The Lancet. 368: 1096-1105 A1 Journal article (refereed), original research -
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 191-199 A1 Journal article (refereed), original research -
HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 1299-1304 A1 Journal article (refereed), original research -
High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study
Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T. 2006. Diabetes care. 29: 329-333 A1 Journal article (refereed), original research -
Interaction of the - 308G/A promoter polymorphism of the tumor necrosis factor-alfa gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population
González-Sánchez JL, Martínez-Calatrava MJ, Martínez-Larrad MT, Zabena C, Fernández-Pérez C, Laakso M, Serrano-Ríos M, Laakso M. 2006. Clinical chemistry. 52: 97-103 A1 Journal article (refereed), original research -
Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients
Fagerudd J, Forsblom C, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Thorn L, Wessman M, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Karhapää P, Mykkänen L, Niskanen L, Vauhkonen I. 2006. Nephrology dialysis transplantation. 21: 2159-2165 A1 Journal article (refereed), original research -
Metabolic syndrome: To be or not to be?
Laakso M, Kovanen PT. 2006. Annals of medicine. 38: 32-33 A2 Review article, Literature review, Systematic review -
Metformiini: vanha lääke, uusi vaikutusmekanismi
Laakso M. 2006. Duodecim -
Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging
Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Journal of cellular and molecular medicine. 10: 933-945 A1 Journal article (refereed), original research -
Mutations in the PPARgamma gene relevant for diabetes and the metabolic syndrome
Laakso M. Teoksessa: Brigelius-Flohé R, Joost H-G(toim.) , 2006. Nutritional Genomics. Impact on Health and Disease. s. 195-207. Wiley A3 Book section, Chapters in research books -
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene:
Sipola P, Peuhkurinen K, Lauerma K, Husso M, Jääskeläinen P, Laakso M, Aronen HJ, Risteli J, Kuusisto J, Laakso M. 2006. Heart -
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography
Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y, Rahier J, Laakso M, Rintala R, Nuutila P, Minn H. 2006. Diabetes. 55: 13-18 A1 Journal article (refereed), original research -
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy
Kärkkäinen S, Reissell E, Heliö T, Kaartinen M, Tuomainen P, Toivonen L, Kuusisto J, Kupari M, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2006. Heart. 92: 524-526 A1 Journal article (refereed), original research -
Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases
Smith U, Laakso M, Eliasson B, Wesslau C, Borén J, Wiklund O, Attvall S. 2006. Journal of internal medicine. 260: 409-420 A2 Review article, Literature review, Systematic review -
Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Gynecologic and obstetric investigation. 61: 124-127 A1 Journal article (refereed), original research -
Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. European journal of obstetrics and gynecology and reproductive biology. 128: 175-179 A1 Journal article (refereed), original research -
Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women
Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2006. Diabetologia. 49: 56-65 A1 Journal article (refereed), original research -
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliot P, Geny B, Laakso M, Puigserver P, Auwerx J, Laakso M. 2006. Cell. 127: 1109-1122 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM Trial
Andrulionyté L, Peltola P, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group. 2006. Diabetes. 55: 2148-2152 A2 Review article, Literature review, Systematic review -
Single nucleotide polymorphisms of the HNF4alfa gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial
Andrulionyté L, Laukkanen O, Chiasson J-L, Laakso M, STOP-NIDDM Study Group, Laakso M. 2006. Journal of molecular medicine: jmm. 84: 701-708 A1 Journal article (refereed), original research -
The pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Laakso M, Keinänen-Kiukaanniemi S. 2006. ENDOCRINE. 30: 185-190 A1 Journal article (refereed), original research -
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits
Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumäki J, Laakso M, Herzig K-H, Ylä-Herttuala S. 2006. Faseb journal. 20: 2159-2161 A1 Journal article (refereed), original research -
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits [FJ Express Full-Length Article]
Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig K-H, Ylä-Herttuala S. 2006. Faseb journal. 20: E1550-E1559 A1 Journal article (refereed), original research -
Visceral obesity is associated with high levels of serum squalene
Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. 2006. Obesity. 14: 1155-1163 A1 Journal article (refereed), original research -
Visfatin is an adipokine, but it is not regulated by Thiazolidinediones
Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. 2006. Journal of clinical endocrinology and metabolism. 91: 1181-1184 A2 Review article, Literature review, Systematic review -
A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients
Pätäri A, Karhapää P, Taipale H, Salmenniemi U, Ruotsalainen E, Vanninen P, Holthöfer H, Laakso M. 2005. Diabetologia. 48: 1844-1850 A1 Journal article (refereed), original research -
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance
González-Sánchez JL, Zabena CA, Martínez-Larrad MT, Fernández-Pérez C, Pérez-Barba M, Laakso M, Serrano-Ríos M, Laakso M. 2005. Obesity. 13: 807-812 A1 Journal article (refereed), original research -
Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients
Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. 2005. Journal of clinical endocrinology and metabolism. 90: 4216-4223 A1 Journal article (refereed), original research -
Associations between two single nucleotide polymorphism in the adiponectin gene and polycystic ovary syndrome
Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen J, Hippeläinen M, Laakso M. 2005. Gynecological endocrinology. 21: 165-169 A1 Journal article (refereed), original research -
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease
Luoma JS, Kareinen A, Närvänen O, Viitanen L, Laakso M, Ylä-Herttuala S. 2005. Free radical biology and medicine. 39: 1660-1665 A1 Journal article (refereed), original research -
Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene
Sipola P, Lauerma K, Jääskeläinen P, Laakso M, Peuhkurinen K, Manninen H, Aronen HJ, Kuusisto J, Laakso M. 2005. Radiology. 236: 815- 824 A1 Journal article (refereed), original research -
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2005. Molecular genetics and metabolism. 84: 344-348 A1 Journal article (refereed), original research -
Effect of the Pro12Ala polymorphism of the PPARgamma2 gene on serum adiponectin changes
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2005. ENDOCRINE. 27: 307-309 A1 Journal article (refereed), original research -
Effect of the interleukin-6 (-174) G/C promoter polymorphism on adiponectin and insulin sensitivity
Yang X, Jansson P-A, Pellmé F, Laakso M, Smith U, Laakso M. 2005. Obesity. 13: 813-817 A1 Journal article (refereed), original research -
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
The Field study investigators, Laakso M, Jantunen A, Kähkönen H, Kortelainen S, Koukkunen H, Laitinen M, Lehto S, Lehto R, Lumiaho A. 2005. The Lancet. 366: 1849-1861 A1 Journal article (refereed), original research -
Fenofibrate intervention and event lowering in diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
The FIELD Study Investigators, Laakso M, Kortelainen S, Koukkunen H, Lehto S, Lehto R, Lumiaho A, Ruotsalainen S. 2005. Cardiovascular diabetology. 4: article 13 [9 p.] A1 Journal article (refereed), original research -
Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish diabetes prevention study
Salopuro T, Pulkkinen L, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish Diabetes Prevention Study Group, Salopuro T, Pulkkinen L, Uusitupa M, Laakso M. 2005. International journal of obesity. 29: 1245-1251 A1 Journal article (refereed), original research -
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns
Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. 2005. Journal of molecular medicine: jmm. 83: 638-646 A1 Journal article (refereed), original research -
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes
Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2005. Diabetologia. 48: 1331-1334 A1 Journal article (refereed), original research -
Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse
Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2005. Journal of physiology: london. 566: 533-541 A1 Journal article (refereed), original research -
High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients
Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. 2005. International journal of obesity. 29: 1464-1470 A1 Journal article (refereed), original research -
High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men. A population-based 18-year follow-up study
Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Birkeland KI, Berg TJ, Hanssen KF, Laakso M. 2005. Arteriosclerosis, thrombosis, and vascular biology. 25: 815-820 A1 Journal article (refereed), original research -
High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction. The IDEAL study: A randomized controlled trial
Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Lytken Larsen M, Bendiksen FS, Lindahl C, Szarek M, Tsai J, for the IDEAL Study Group, Laakso M, Lehto S, Gylling H. 2005. JAMA : Journal of the American Medical Association. 294: 2437-2445 A1 Journal article (refereed), original research -
Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy
Saraheimo M, Forsblom C, Hansen TK, Teppo A-M, Fagerudd J, Pettersson-Fernholm K, Thiel S, Tarnow L, Ebeling P, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2005. Diabetologia. 48: 198-202 A1 Journal article (refereed), original research -
Insulin resistance and coronary heart disease
Laakso M, Kuusisto J. Teoksessa: Serrano Ríos M, Caro JF, Carraro R, Gutiérrez Fuentes JA(toim.) , 2005. The Metabolic Syndrome at the Beginning of the XXIst Century. s. 369-382. Elsevier A3 Book section, Chapters in research books -
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI ): effects on mortality and morbidity
Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A, for the DIGAMI 2 Investigators. 2005. European heart journal. 26: 650-661 A1 Journal article (refereed), original research -
Islet amyloid polypeptide gene promoter polymorphisms are not associated with type 2 diabetes or with the severity of islet amyloidosis
Esapa C, Moffitt JH, Novials A, McNamara CM, Levy JC, Laakso M, Gomis R, Clark A. 2005. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1740: 74-78 A1 Journal article (refereed), original research -
Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance
Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. Obesity. 13: 501-506 A1 Journal article (refereed), original research -
Lipids and glucose in type 2 diabetes: what about the beta-cell and the mitochondria? Response to Eldor and Raz
Boden G, Laakso M. 2005. Diabetes care -
Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with type 2 diabetes mellitus
Roden M, Laakso M, Johns D, Widel M, Urquhart R, Richardson C, Mariz S, Tan MH. 2005. Diabetic medicine. 22: 1101-1106 A1 Journal article (refereed), original research -
Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)
Thron LM, Forsblom C, Fagerudd J, Thomas MC, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Taskinen M-R, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Mykkänen L. 2005. Diabetes care. 28: 2019-2024 A1 Journal article (refereed), original research -
Metabolisen oireyhtymän uudet kriteerit ja hoito
Laakso M. 2005. Duodecim. 121: 1521-1530 A2 Review article, Literature review, Systematic review -
Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversation from impaired glucose tolerance to type 2 diabetes.The Finnish diabetes prevention study
Laukkanen O, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2005. Diabetes. 54: 2256-2260 A1 Journal article (refereed), original research -
Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy
Fröjdö S, Sjölind L, Parkkonen M, Mäkinen V-P, Kilpikari R, Pettersson-Fernholm K, Forsblom C, Fagerudd J, Tikellis C, Cooper ME, Wessman M, Groop P-H, FinnDiane Study Group. 2005. Diabetologia. 48: 2278-2281 A1 Journal article (refereed), original research -
Prevention of type 2 diabetes
Laakso M. 2005. Current molecular medicine. 5: 365-374 A1 Journal article (refereed), original research -
Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by left ventricular dysfunction: the OPTIMAAL experience
Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen M, on behalf of the OPTIMAAL investigators, Laakso M, Lehto S. 2005. European heart journal. 26: 350-356 A1 Journal article (refereed), original research -
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy JA, Charbonnel B, Eckland DJA, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J, on behalf of the PROactive investigators. 2005. The Lancet. 366: 1279-1289 A1 Journal article (refereed), original research -
Serum adiponectin in increased in type 1 diabetic patients with nephropathy
Saraheimo M, Forsblom C, Fagerudd J, Teppo A-M, Pettersson-Fernholm K, Frystyk J, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P, Huttunen E. 2005. Diabetes care. 28: 1410-1414 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Diabetes. 54: 3587-3591 A1 Journal article (refereed), original research -
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults
Vauhkonen I, Niskanen L, Knip M, Moilanen Mykkänen L, Uusitupa M, Laakso M. 2005. European journal of endocrinology. 153: 265-273 A1 Journal article (refereed), original research -
Synnynnäinen hyperinsulinismi
Huopio H, Laakso M, Otonkoski T. 2005. Duodecim. 121: 1166-1175 A2 Review article, Literature review, Systematic review -
The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects
Dahlman I, Kaaman M, Jiao H, Kere J, Laakso M, Arner P, Laakso M. 2005. Diabetes. 54: 3032-3034 A1 Journal article (refereed), original research -
The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
Zacharova J, Todorova BR, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. Journal of internal medicine. 257: 185-193 A1 Journal article (refereed), original research -
The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: The STOPP-NIDDM trial
Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. Diabetes. 54: 893-899 A1 Journal article (refereed), original research -
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Journal of clinical endocrinology and metabolism. 90: 4249-4254 A1 Journal article (refereed), original research -
Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. 2005. Molecular human reproduction. 11: 437-440 A1 Journal article (refereed), original research -
Type 2 diabetes as a "coronary heart diasease equivalent". An 18-year prospective population-based study in Finnish subjects
Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2005. Diabetes care. 28: 2901-2907 A1 Journal article (refereed), original research -
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy
Kärkkäinen S, Heliö T, Miettinen R, Tuomainen P, Peltola P, Rummukainen J, Ylitalo K, Kaartinen M, Kuusisto J, Toivonen L, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2004. European heart journal. 25: 885-893 A1 Journal article (refereed), original research -
Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data
Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, and the STOP-NIDDM Trial Research Group. 2004. Diabetologia. 47: 969-975 A1 Journal article (refereed), original research -
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis
Temelkova-Kurktschiev T, Hanefeld M, Chinetti G, Zawadzki C, Haulon S, Kubaszek A, Koehler C, Leonhardt W, Staels B, Laakso M, Laakso M. 2004. Journal of clinical endocrinology and metabolism. 89: 4238-4242 A1 Journal article (refereed), original research -
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes
Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. 2004. Diabetes care. 27: 2021-2026 A1 Journal article (refereed), original research -
Aldose reductase gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes
Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M. 2004. Diabetic medicine. 21: 1325-1333 A1 Journal article (refereed), original research -
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb
Pirinen E, Heikkinen S, Malkki M, Deep SS, Jänne J, Laakso M. 2004. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION. 1676: 149-154 A1 Journal article (refereed), original research -
Association between a deletion/insertion polymorphism in the alfa2B-adrenergic receptor gene and insulin secretion and type 2 diabetes. The Finnish diabetes prevention study
Siitonen N, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2004. Diabetologia. 47: 1416-1424 A1 Journal article (refereed), original research -
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes
Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämaläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2004. Diabetologia. 47: 871-877 A1 Journal article (refereed), original research -
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
Andrulionyte L, Zacharova J, Chiasson JL, Laakso M, for the STOP-NIDDM Study Group. 2004. Diabetologia. 47: 2176-2184 A1 Journal article (refereed), original research -
Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish diabetes prevention study
Salopuro T, Lindström J, Eriksson JG, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Finnish Diabetes Preventio Study Group. 2004. Clinical genetics -
Dyslipidemiat
Suomen Sisätautilääkärien Yhdistys ry:n asettama työryhmä, Gylling H, Uusitupa M, Laakso M. 2004. Duodecim. 120: 1794-1816 A1 Journal article (refereed), original research -
Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus
Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T. 2004. Annals of internal medicine. 140: 94-100 A1 Journal article (refereed), original research -
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis AJ, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, Laakso M, Ehnholm C, Taskinen M-R, Peltonen L. 2004. Nature genetics -
Gender difference in the impact of type 2 diabetes on coronary heart disease risk
Juutilainen A, Kortelainen S, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2004. Diabetes care. 27: 2898-2904 A1 Journal article (refereed), original research -
Gene variants, insulin resistance, and dyslipidaemia
Laakso M. 2004. Current opinion in lipidology. 15: 115-120 A1 Journal article (refereed), original research -
Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes
Jääskeläinen P, Miettinen R, Kärkkäinen P, Toivonen L, Laakso M, Kuusisto J. 2004. Annals of medicine. 36: 23-32 A2 Review article, Literature review, Systematic review -
Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci
Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. American journal of medical genetics. Part A. 130: 345-350 A1 Journal article (refereed), original research -
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attridutable to the Asp175Asn mutation in the Alfa-tropomyo
Hedman A, Hartikainen J, Vanninen E, Laitinen T, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Laakso M. 2004. Journal of molecular and cellular cardiology. 36: 91-99 A1 Journal article (refereed), original research -
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. 2004. Journal of lipid research. 45: 507-512 A1 Journal article (refereed), original research -
Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication
Yliharsila H, Eriksson JG, Forsen T, Laakso M, Uusitupa M, Osmond C, Barker DJ, Laakso M. 2004. Journal of hypertension. 22: 1283-1287 A1 Journal article (refereed), original research -
Lipids and glucose in type 2 diabetes: what is the cause and effect?
Boden G, Laakso M. 2004. Diabetes care. 27: 2253-2259 A1 Journal article (refereed), original research -
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. 2004. Circulation. 110: 3842-3848 A1 Journal article (refereed), original research -
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorbtion and insulin sensitivity
Gylling H, Hallikainen M, Pihlajamäki J, Ågren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA, Laakso M. 2004. Journal of lipid research. 45: 1660-1665 A1 Journal article (refereed), original research -
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish diabetes prevention study
Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish diabetes prevention study group. 2004. Journal of clinical endocrinology and metabolism. 89: 6286-6290 A1 Journal article (refereed), original research -
Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
The DREAM Trial Investigators, Laakso M, Sivenius K. 2004. Diabetologia. 47: 1519-1527 A1 Journal article (refereed), original research -
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation
Cuesta-Munoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, Lopez-Enriquez S, Garcia-Gimeno MA, Sanz P, Soriguer FC, Laakso M, Laakso M. 2004. Diabetes. 53: 2164-2168 A1 Journal article (refereed), original research -
The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome
Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen JS, Laakso M, Laakso M. 2004. Fertility and sterility -
The EGIR-RISC Study (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E, Report prepared on behalf of the EGIR-RISC Study Group, Laakso M, Aura A, Raisanen R, Ruotsalainen U, Sistonen T, Laitinen M. 2004. Diabetologia. 47: 566-570 A1 Journal article (refereed), original research -
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2004. Journal of clinical endocrinology and metabolism. 89: 2019-2023 A1 Journal article (refereed), original research -
The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood
Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. 2004. Obesity. 12: 187-190 A1 Journal article (refereed), original research -
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. Obesity. 12: 1060-1066 A1 Journal article (refereed), original research -
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth
Kubaszek A, Markkanen A, Eriksson JG, Forsen T, Osmond C, Barker DJ, Laakso M, Laakso M. 2004. Journal of clinical endocrinology and metabolism. 89: 2044-2047 A1 Journal article (refereed), original research -
The need for a large-scale trial of fibrate therapy in diabetes: the rationale and design of the Fenofibrate Intervention and Event Lowering in Diabets (FIELD) study. [ISRCTN64783481]
The FIELD Study Investigators, Laakso M. 2004. Cardiovascular diabetology. 3: [11 p.] A1 Journal article (refereed), original research -
The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients
Charbonnel B, Dormandy J, Erdmann E, Massi-Benedetti M, Skene A, on behalf of the PROactive Study Group, Laakso M. 2004. Diabetes care. 27: 1647-1653 A1 Journal article (refereed), original research -
The relative importance of cardiovascular risk factors in type 2 diabetic
Laakso M. 2004. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. SUPPLEMENT. 58: 20-24 A1 Journal article (refereed), original research -
Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy
Kärkkäinen S, Heliö T, Jääskeläinen P, Miettinen R, Tuomainen P, Ylitalo K, Kaartinen M, Reissell E, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K. 2004. European journal of heart failure. 6: 861-868 A1 Journal article (refereed), original research -
A deletion in the alfa2B-adrenergic receptor gene and autonomic nervous function in central obesity
Sivenius K, Niskanen L, Laakso M, Uusitupa M, Laakso M. 2003. Obesity. 11: 962-970 A1 Journal article (refereed), original research -
A new subtype of autosomal dominant diabetes attributabe to a mutation in the gene for sulfonylurea receptor 1
Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M, Laakso M. 2003. The Lancet. 361: 301-07 A1 Journal article (refereed), original research -
A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy
Kärkkäinen S, Miettinen R, Tuomainen P, Kärkkäinen P, Heliö T, Reissell E, Kaartinen M, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K, Laakso M. 2003. Journal of molecular medicine: jmm. 81: 795-800 A1 Journal article (refereed), original research -
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The STOPP-NIDDM Trial
Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, for the STOP-NIDDM Trial Research Group, Laakso M. 2003. JAMA : Journal of the American Medical Association. 290: 486-494 A1 Journal article (refereed), original research -
Akarboosi - tehokas lääke tyypin 2 diabeteksen ja sydänsairauksien estoon?
Laakso M. 2003. Duodecim -
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects
Niskanen L, Lindi V, Erkkilä A, Sivenius K, Luoma J, Ylä-Herttuala S, Laakso M, Uusitupa MIJ, Laakso M. 2003. Metabolism: clinical and experimental. 52: 213-217 A1 Journal article (refereed), original research -
Candidate genes for insulin resistance: what's new?
Laakso M, Kubaszek A. Teoksessa: Crepaldi G, Tiengo A, Avogaro A(toim.) , 2003. The Metabolic Syndrome: Diabetes, Obesity, Hyperlipidemia and Hypertension. Proceedings of the 8th European Symposium on Metabolism. s. 55-61. Elsevier A4 Conference proceedings -
Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogenous subjects with hypertrophic cardiomyopathy
Sipola P, Vanninen E, Aronen HJ, Lauerma K, Simula S, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Kuikka JT, Laakso M. 2003. Journal of nuclear medicine. 44: 487-493 A1 Journal article (refereed), original research -
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population
Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM, Laakso M. 2003. Diabetologia. 46: 241-249 A1 Journal article (refereed), original research -
Combined analysis of genome scans of Dutch and Finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
Pajukanta P, Allayee H, Krass KL, Kuraishy A, Soro A, Lilja HE, Mar R, Taskinen M-R, Nuotio I, Laakso M, Rotter JI, de Bruin TWA, Cantor RM, Lusis AJ, Peltonen L, Laakso M. 2003. American journal of human genetics. 72: 903-917 A1 Journal article (refereed), original research -
Coronary artery disease in type 2 diabetes
Laakso M, Kubaszek A. 2003. INTERNATIONAL DIABETES MONITOR. 15: 1-7 A2 Review article, Literature review, Systematic review -
Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients
Saraheimo M, Teppo A-M, Forsblom C, Fagerudd J, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Voutilainen E, Niskanen L, Vauhkonen I, Ikäheimo R, Karhapää P, Mykkänen L. 2003. Diabetologia. 46: 1402-1407 A1 Journal article (refereed), original research -
Dietary fat predicts coronary heart disease events in subjects with type 2 diabets
Soinio M, Laakso M, Lehto S, Hakala P, Rönnemaa T. 2003. Diabetes care. 26: 619-624 A1 Journal article (refereed), original research -
Effect of the pro12ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects
Kolehmainen M, Uusitupa MIJ, Alhava E, Laakso M, Vidal H, Laakso M. 2003. Journal of clinical endocrinology and metabolism. 88: 1717-1722 A1 Journal article (refereed), original research -
Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects
Laitinen T, Huopio H, Vauhkonen I, Camaro C, Hartikainen J, Laakso M, Niskanen L. 2003. Clinical science. 105: 315-322 A1 Journal article (refereed), original research -
Epidemiology and diagnosis of type 2 diabetes
Laakso M. Teoksessa: Goldstein BJ, Mûller-Wieland D(toim.) , 2003. Textbook of Type 2 Diabetes. s. 1-12. Martin Dunitz A3 Book section, Chapters in research books -
First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the asp 175asn mutation of the alfa-tropomyosin gene
Sipola P, Lauerma K, Husso-Saastamoinen M, Kuikka JT, Vanninen E, Laitinen T, Manninen H, Niemi P, Peuhkurinen K, Jääskeläinen P, Laakso M, Kuusisto J, Aronen HJ, Laakso M. 2003. Radiology. 226: 129-137 A1 Journal article (refereed), original research -
From hyperinsulinemia in childhood to diabetes in adulthood
Laakso M, Huopio H. Teoksessa: Betteridge DJ(toim.) , 2003. Case Studies in Diabetes. s. 63-66. Martin Dunitz A3 Book section, Chapters in research books -
Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice
Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, Wasserman DH. 2003. American journal of physiology : endocrinology and metabolism. 285: E958-E963 A1 Journal article (refereed), original research -
Impact of the pro12ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n - 3 fatty acid supplementation. For the KANWU study group
Lindi V, Schwab U, Louheranta A, Laakso M, Vessby B, Hermansen K, Storlien L, Riccardi G, Rivellese AA, Uusitupa MIJ, for the KANWU Study Group, Laakso M. 2003. Molecular genetics and metabolism. 79: 52-60 A1 Journal article (refereed), original research -
Insulin resistance is related to left ventricular hyperthrophy in patients with polycystic kidney disease type 1
Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M. 2003. American journal of kidney diseases. 41: 1219-1224 A1 Journal article (refereed), original research -
Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes
Eriksson JG, Osmond C, Lindi V, Uusitupa M, Forsen T, Laakso M, Barker D, Laakso M. 2003. Diabetes care -
K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population
González-Sánchez JL, Martínez-Larrad MT, Fernández-Pérez C, Kubaszek A, Laakso M, Serrano-Ríos M, Laakso M. 2003. Obesity. 11: 603-605 A1 Journal article (refereed), original research -
Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome
Korhonen S, Heinonen S, Hiltunen M, Helisalmi S, Hippeläinen M, Koivunen R, Tapanainen JS, Laakso M, Laakso M. 2003. Human reproduction. 18: 540-543 A1 Journal article (refereed), original research -
Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland
Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M. 2003. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 37: 352-358 A1 Journal article (refereed), original research -
Prolonged corrected QT interval is associated with acute and chronic hyperinsulinemia in nondiabetic subjects
Laitinen T, Vauhkonen I, Niskanen L, Hartikainen J, Uusitupa M, Laakso M. 2003. Diabetes care -
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects
Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. 2003. Diabetes care. 26: 179-182 A1 Journal article (refereed), original research -
Promoter polymorphisms of the TNF-alfa (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2003. Diabetes. 52: 1872-1876 A1 Journal article (refereed), original research -
Reply (to the editor)
Niskanen L, Luoma J, Laakso M. 2003. Metabolism: clinical and experimental -
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]
Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S. 2003. Circulation. 107: 2677-2683 A1 Journal article (refereed), original research -
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. Diabetes. 52: 558-561 A1 Journal article (refereed), original research -
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. Diabetes care. 26: 464-467 A1 Journal article (refereed), original research -
The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M. 2003. Metabolism: clinical and experimental. 52: 643-646 A1 Journal article (refereed), original research -
The effect of the -308A allele of the TNF-alfa gene on insulin action is dependent on obesity
Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M. 2003. Obesity. 11: 912-917 A1 Journal article (refereed), original research -
The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth
Eriksson J, Lindi V, Uusitupa M, Forsén T, Laakso M, Osmond C, Barker D, Laakso M. 2003. Clinical genetics. 64: 366-370 A2 Review article, Literature review, Systematic review -
Understanding patient needs. Diabetology for cardiologists
Laakso M, Kuusisto J. 2003. European heart journal supplements. 5 (Suppl B): B5-B13 A1 Journal article (refereed), original research -
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index an waist circumference
Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MIJ, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sorensen TIA, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E, Allison DB. 2002. International journal of obesity. 26: 640-646 A1 Journal article (refereed), original research -
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
Chiasson J-L, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, for The STOP-NIDDM Trial Research Group. 2002. The Lancet. 359: 2072-2077 A1 Journal article (refereed), original research -
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism
Huopio H, Jääskeläinen J, Komulainen J, Miettinen R, Kärkkäinen P, Laakso M, Tapanainen P, Voutilainen R, Otonkoski T. 2002. Journal of clinical endocrinology and metabolism. 87: 4502-4507 A1 Journal article (refereed), original research -
Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients
Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Saikku P, Laakso M. 2002. Archives of internal medicine. 162: 594-599 A1 Journal article (refereed), original research -
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease
Erkkilä AT, Lindi V, Lehto S, Laakso M, Uusitupa MIJ. 2002. Molecular genetics and metabolism. 75: 260-264 A1 Journal article (refereed), original research -
Association of the Pro12Ala polymorphism in the PPAR-gamma2 with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
Lindi VI, Uusitupa MIJ, Lindström J, Louheranta A, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Tuomilehto J, for the Finnish Diabetes Prevention Study Group. 2002. Diabetes. 51: 2581-2586 A1 Journal article (refereed), original research -
Baroreflex sensitivity in essential and secondary hypertension
Mussalo H, Vanninen E, Ikäheimo R, Laitinen T, Laakso M, Länsimies E, Hartikainen J. 2002. Clinical autonomic research. 12: 465-471 A1 Journal article (refereed), original research -
Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease
Simula S, Vanninen E, Viitanen L, Kareinen A, Lehto S, Pajunen P, Syvänne M, Kuikka J, Laakso M, Hartikainen J. 2002. Journal of nuclear medicine. 43: 1-7 A1 Journal article (refereed), original research -
Carriers of an inactivating beta-cell ATP-sensitive K+ channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion
Huopio H, Vauhkonen I, Komulainen J, Niskanen L, Otonkoski T, Laakso M. 2002. Diabetes care. 25: 101-106 A1 Journal article (refereed), original research -
Diabetic macrovascular complications
Laakso M. Teoksessa: Mogensen CA(toim.) , 2002. Hypertension and Diabetes. s. 69-79. Lippincott Williams & Wilkins A3 Book section, Chapters in research books -
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
González Sánchez JL, Serrano Rios M, Fernandez Perez C, Laakso M, Martinez Larrad MT. 2002. European journal of endocrinology. 147: 495-501 A1 Journal article (refereed), original research -
Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial
Dickstein K, Kjekshus J, and the OPTIMAAL Steering Committee, for the OPTIMAAL Study Group, Laakso M, Lehto S, Luoma J. 2002. The Lancet. 360: 752-760 A1 Journal article (refereed), original research -
Genetic influences contributing to LDL particle siz in familial combined hyperlipidaemia
Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JSA, Peltonen L, Taskinen M-R. 2002. European journal of human genetics. 10: 547-552 A1 Journal article (refereed), original research -
Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease
Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Dementia and geriatric cognitive disorders. 14: 123-127 A1 Journal article (refereed), original research -
Lipids in type 2 diabetes
Laakso M. 2002. SEMINARS IN VASCULAR MEDICINE. 2: 59-66 A2 Review article, Literature review, Systematic review -
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland
Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Journal of molecular medicine: jmm. 80: 412-422 A1 Journal article (refereed), original research -
No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy
Kärkkäinen S, Peuhkurinen K, Jääskeläinen P, Miettinen R, Kärkkäinen P, Kuusisto J, Laakso M. 2002. American heart journal. 143: 11-14 A1 Journal article (refereed), original research -
Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia
Laasanen J, Heinonen S, Hiltunen M, Mannermaa A, Laakso M. 2002. Early human development. 69: 77-82 A1 Journal article (refereed), original research -
Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families
Pajunen P, Syvänne M, Nieminen MS, Kareinen A, Viitanen L, Lehto S, Laakso M. 2002. European journal of clinical investigation. 32: 472-478 A1 Journal article (refereed), original research -
The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
Eriksson JG, Lindi V, Uusitupa M, Forsén TJ, Laakso M, Osmond C, Barker DJP. 2002. Diabetes. 51: 2321-2324 A1 Journal article (refereed), original research -
The heavy burden of cardiovascular disease in type 2 diabetes
Laakso M. Teoksessa: Hâncu N(toim.) , 2002. Cardiovascular Risk in Type 2 Diabetes Mellitus: Assessment and Control. s. 2-10. Springer A3 Book section, Chapters in research books -
Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease
Erkkilä AT, Lindi V, Lehto S, Pyörälä K, Laakso M, Uusitupa MIJ. 2002. Nutrition metabolism and cardiovascular diseases. 12: 53-59 A1 Journal article (refereed), original research -
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia
Pihlajamäki J, Austin M, Edwards K, Laakso M. 2001. Diabetes. 50: 2396-2401 A1 Journal article (refereed), original research -
APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose 1-3
Erkkilä AT, Sarkkinen ES, Lindi V, Lehto S, Laakso M, Uusitupa MIJ. 2001. American journal of clinical nutrition. 73: 746-752 A1 Journal article (refereed), original research -
APOE-epsilon4 is associated with weight loss in women with AD. A population-based study
Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. 2001. Neurology. 56: 655-659 A1 Journal article (refereed), original research -
An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin
Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. Neurogenetics -
Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease
Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M. 2001. Journal of molecular medicine: jmm. 79: 732-737 A1 Journal article (refereed), original research -
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease
Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M. 2001. Atherosclerosis. 157: 57-64 A1 Journal article (refereed), original research -
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention
Laakso M. 2001. Journal of internal medicine. 249: 225-235 A1 Journal article (refereed), original research -
Cardiovascular risk factors associated with insulin resistence cluster in families with early-onset coronary heart disease
Kareinen A, Viitanen L, Halonen P, Lehto S, Laakso M. 2001. Arteriosclerosis, thrombosis, and vascular biology. 21: 1346-1352 A1 Journal article (refereed), original research -
Comparison of baseline data, initial course, and management: Losartan versus Captopril following acute myocardial infarction (The OPTIMAAL Trial)
Dickstein K, Kjekshus J, for the OPTIMAAL Trial Steering Committee and Investigators, Laakso M. 2001. American journal of cardiology. 87: 766-771 A1 Journal article (refereed), original research -
Diabetes and cardiovascular disease
Laakso M. Teoksessa: Stalenhoef AFH, Kastelein JJP(toim.) , 2001. Diabetes, Lipids and Cardiovascular Disease. s. 111-125. Benecke N.I. A3 Book section, Chapters in research books -
Diabetic macroangiopathy
Laakso M. Teoksessa: Pinchera A(toim.) , 2001. Endocrinology and Metabolism. s. 639-643. McGraw-Hill A3 Book section, Chapters in research books -
Effect of a three-amino acid deletion in the alfa2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects
Sivenius K, Lindi V, Niskanen L, Laakso M, Uusitupa M. 2001. International journal of obesity. 25: 1609-1614 A1 Journal article (refereed), original research -
Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomized study
Diabetes Atherosclerosis Intervention Study Investigators, Laakso M, Lehto S, Räisänen R, Jantunen A, Toivanen A. 2001. The Lancet. 357: 905-910 A1 Journal article (refereed), original research -
Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on lon-term weight change in Finnish non-diabetic subjects
Lindi V, Sivenius K, Niskanen L, Laakso M, Uusitupa MIJ. 2001. Diabetologia -
Heart rate variability and its determinants in patients with severe or mild essential hypertension
Mussalo H, Vanninen E, Ikäheimo R, Laitinen T, Laakso M, Länsimies E, Hartikainen J. 2001. Clinical physiology and functional imaging. 5: 594-604 A1 Journal article (refereed), original research -
Insulin resistance and its impact on the approach to therapy of type 2 diabetes
Laakso M. 2001. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. SUPPLEMENT. 121: 8-12 A2 Review article, Literature review, Systematic review -
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men
Kuusisto J, Lempiäinen P, Mykkänen L, Laakso M. 2001. Diabetes care. 24: 1629-1633 A1 Journal article (refereed), original research -
Metabolic impact of a family history of type 2 diabetes. Results from a European multicentre study (EGIR)
Vaag A, Lehtovirta M, Thye-Rönn P, Groop L, for the European group of Insulin Resistance, Laakso M. 2001. Diabetic medicine. 18: 533-540 A1 Journal article (refereed), original research -
Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1
Lumiaho A, Ikäheimo R, Miettinen R, Niemitukia L, Laitinen T, Rantala A, Lampainen E, Laakso M, Hartikainen J. 2001. American journal of kidney diseases. 38: 1208-1216 A1 Journal article (refereed), original research -
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes
Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M. 2001. Diabetes. 50: 1949-1951 A1 Journal article (refereed), original research -
Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene 1,2
Ågren JJ, Vidgren HM, Valve RS, Laakso M, Uusitupa MI. 2001. American journal of clinical nutrition. 73: 31-35 A1 Journal article (refereed), original research -
The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance
Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2001. European journal of clinical investigation. 31: 302-308 A1 Journal article (refereed), original research -
alpha-Synuclein pathology is highly dependent on the case selection
Parkkinen L, Soininen H, Laakso M, Alafuzoff I. 2001. Neuropathology and applied neurobiology. 27: 314-325 A1 Journal article (refereed), original research -
Aikuistyypin diabetes ja sydänsairaudet - ehkäisyn ja hoidon haasteet
Laakso M. 2000. Erikoislääkäri. 10: 131-139 D1 Article in a trade journal -
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study
Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Neuroepidemiology. 19: 327-332 A1 Journal article (refereed), original research -
Cardiovascular disease and diabetes mellitus
Laakso M. 2000. European heart journal supplements. 2: D26-D28 A2 Review article, Literature review, Systematic review -
Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type II diabetes
Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2000. Diabetologia. 43: 148-155 A1 Journal article (refereed), original research -
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. 2000. Human gene therapy. 11: 263-270 A1 Journal article (refereed), original research -
Depression after coronary heart disease events
Lehto S, Koukkunen H, Hintikka J, Viinamäki H, Laakso M, Pyörälä K. 2000. Scandinavian cardiovascular journal. 34: 580-583 A1 Journal article (refereed), original research -
Determinants of postabsorptive endogenous glucose output in non-diabetic subjects
Natali A, Toschi E, Camastra S, Gastaldelli A, Groop L, Ferrannini E, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. 2000. Diabetologia. 43: 1266-1272 A1 Journal article (refereed), original research -
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1
Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko H-L, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. 2000. Journal of clinical investigation. 106: 897-906 A1 Journal article (refereed), original research -
Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow
Mather K, Laakso M, Edelman S, Hook G, Baron A. 2000. American journal of physiology : endocrinology and metabolism. 279: E1264-E1270 A1 Journal article (refereed), original research -
G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia
Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen M-R, Deeb SS, Laakso M. 2000. Arteriosclerosis, thrombosis, and vascular biology. 20: 1789-95 A1 Journal article (refereed), original research -
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes
Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen MO, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M. 2000. Diabetes. 49: 1740-1743 A1 Journal article (refereed), original research -
Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes
Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Laakso M. 2000. Diabetes care -
Hyperglycaemia as a cardiovascular risk factor
Laakso M. 2000. INTERNATIONAL DIABETES MONITOR -
Hyperglycemia and cardiovascular disease in patients with type 2 diabetes
Laakso M. 2000. CURRENT OPINION IN ENDOCRINOLOGY AND DIABETES. 7: 197-202 A1 Journal article (refereed), original research -
Hyperproinsulinemia is not a charascteristic feature in the offspring of patients with different phenotypes of type II diabetes
Vauhkonen IKJ, Niskanen LK, Mykkänen L, Haffner SM, Uusitupa MIJ, Laakso M. 2000. European journal of endocrinology. 143: 251-260 A1 Journal article (refereed), original research -
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic paitients
Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2000. Arteriosclerosis, thrombosis, and vascular biology. 20: 164-170 A1 Journal article (refereed), original research -
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
Vauhkonen I, Niskanen L, Knip M, Ilonen J, Vanninen E, Kainulainen S, Uusitupa M, Laakso M. 2000. Diabetologia. 43: 69-78 A1 Journal article (refereed), original research -
Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policeman Study
Pyörälä M, Miettinen H, Halonen P, Laakso M, Pyörälä K. 2000. Arteriosclerosis, thrombosis, and vascular biology. 20: 538-544 A1 Journal article (refereed), original research -
Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease
Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Vauhkonen I, Laakso M. 2000. Journal of molecular medicine: jmm. 78: 372-379 A1 Journal article (refereed), original research -
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects
Niskanen L, Karvonen MK, Valve R, Koulu M, Pesonen UM, Mercuri M, Rauramaa R, Töyry J, Laakso M, Uusitupa MIJ. 2000. Journal of clinical endocrinology and metabolism. 85: 2266-2269 A1 Journal article (refereed), original research -
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in Type 2 diabetes
Niskanen L, Voutilainen-Kaunisto R, Teräsvirta M, Karvonen M K, Valve R, Pesonen U, Laakso M, Uusitupa MIJ, Koulu M. 2000. Experimental and clinical endocrinology and diabetes. 108: 235-236 A1 Journal article (refereed), original research -
Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance
Kekäläinen P, Sarlund H, Laakso M. 2000. Metabolism: clinical and experimental. 49: 1247-1254 A1 Journal article (refereed), original research -
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern
Heikkinen S, Suppola S, Malkki M, Deeb SS, Jänne J, Laakso M. 2000. Mammalian genome. 11: 91-96 A1 Journal article (refereed), original research -
Mspl polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of hdl cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic patients with coronary
Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Laakso M. 2000. Diabetes care. 23: 791-795 A1 Journal article (refereed), original research -
Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality
Pyörälä M, Miettinen H, Laakso M, Pyörälä K. 2000. Diabetes care. 23: 1097-1102 A1 Journal article (refereed), original research -
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. 2000. Diabetes care. 23: 70-73 A1 Journal article (refereed), original research -
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight chance in Finnish type 2 diabetic and non-diabetic control subjects
Sivenius K, Valve R, Lindi V, Niskanen L, Laakso M, Uusitupa M. 2000. International journal of obesity. 24: 514-519 A1 Journal article (refereed), original research -
The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d
Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. 2000. Atherosclerosis. 151: 567-574 A1 Journal article (refereed), original research -
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland
Pajukanta P, Cargill M, Viitanen L, Nuotio I, Kareinen A, Perola M, Terwilliger JD, Kempas E, Daly M, Lilja H, Rioux JD, Brettin T, Viikari JSA, Rönnemaa T, Laakso M, Lander ES, Peltonen L. 2000. American journal of human genetics. 67: 1481-1493 A1 Journal article (refereed), original research -
Variants in the hepatocyte nuclear factor-1alfa and -4alfa genes in Finnish and Chinese subjects with late-onset type 2 diabetes
Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M. 2000. Diabetes care. 23: 1533-1538 A1 Journal article (refereed), original research -
Antiplatelet treatment does not reduce the severity of subsequent stroke
Sivenius J, Cunha L, Diener H-C, Forbes C, Laakso M, Lowenthal A, Smets P, Riekkinen P Sr, for the European Stroke Prevention Study 2 Working Group. 1999. Neurology. 53: 825-829 A1 Journal article (refereed), original research -
Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Dementia and geriatric cognitive disorders. 10: 252-257 A1 Journal article (refereed), original research -
Baseline characteristics of the study population in the Diabetes Atherosclerosis Intervention Study (DAIS)
Steiner G, Stewart D, Hosking JD, And THE Dais Project Group And the World Health Organization Collaborating Centre For the Study of Atherosclerosis in Diabetes, Laakso M. 1999. American journal of cardiology. 84: 1004-1010 A1 Journal article (refereed), original research -
Benefits of strict glucose and blood pressure control in type 2 diabetes: lessons from the UK Prospective Diabetes Study
Laakso M. 1999. Circulation. 99: 461-462 A2 Review article, Literature review, Systematic review -
Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man
Camastra S, Bonora E, Del Prato S, Rett K, Weck M, Ferrannini E, on behalf of EGIR (European Group for the Study of Insulin Resistance), Laakso M. 1999. International journal of obesity. 23: 1307-1313 A1 Journal article (refereed), original research -
Evidence of a state of increased insulin resistance in preeclampsia
Kaaja R, Laivuori H, Laakso M, Tikkanen MJ, Ylikorkala O. 1999. Metabolism: clinical and experimental. 48: 892-896 A1 Journal article (refereed), original research -
Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels
Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen M-R, Peltonen L. 1999. American journal of human genetics. 64: 1453-1463 A1 Journal article (refereed), original research -
Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes
Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb SS, Jänne J, Laakso M. 1999. Journal of biological chemistry. 274: 22517-22523 A1 Journal article (refereed), original research -
Hyperglycaemia as a risk factor for cardiovascular disease
Laakso M. Teoksessa: Marshall SM, Home PD, Rizza RA(toim.) , 1999. The Diabetes Annual/12. s. 317-328. Elsevier A3 Book section, Chapters in research books -
Hyperglycemia and cardiovascular disease in type 2 diabetes
Laakso M. 1999. Diabetes. 48: 937-942 A2 Review article, Literature review, Systematic review -
Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes
Laakso M. 1999. Primary care. 26: 829-839 A1 Journal article (refereed), original research -
Hyperglykemian lääkehoito ja aikuistyypin diabeteksen ennuste
Niskanen L, Uusitupa M, Laakso M. 1999. Duodecim. 115: 1122-1124 A1 Journal article (refereed), original research -
Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes
Kekäläinen P, Sarlund H, Pyörälä K, Laakso M. 1999. Diabetes care. 22: 86-92 A1 Journal article (refereed), original research -
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men
Hosszúfalusi N, Pánczél P, Jánoskuti L, Pyörälä M, Miettinen H, Laakso M, Pyörälä K. 1999. Circulation -
Identification of a three-amino acid deletion in the alfa2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects
Heinonen P, Koulu M, Pesonen U, Karvonen MK, Rissanen A, Laakso M, Valve R, Uusitupa M, Scheinin M. 1999. Journal of clinical endocrinology and metabolism. 84: 2429-2433 A1 Journal article (refereed), original research -
Independent influence of age on basal insulin secretion in nondiabetic humans
Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Järvinen H, Ferrannini E, on behalf of the European Group for the Study of Insulin Resistance. 1999. Journal of clinical endocrinology and metabolism. 84: 863-868 A1 Journal article (refereed), original research -
Insulin resistance syndrome and Alzheimer's disease: the summary of Finnish studies
Kuusisto J, Koivisto K, Mykkänen L, Helkala E, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen P, Laakso M. Teoksessa: Vellas B, Fitten LJ(toim.) , 1999. Research and Practice in Alzheimer's Disease. s. 135-139. Serdi Publisher A3 Book section, Chapters in research books -
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
Lempiäinen P, Mykkänen L, Pyörälä K, Laakso M, Kuusisto J. 1999. Circulation. 100: 123-128 A1 Journal article (refereed), original research -
Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?
Haffner SM, Mykkänen L, Rainwater DL, Karhapää P, Laakso M. 1999. Obesity. 7: 164-169 A1 Journal article (refereed), original research -
LDL size and risk of coronary heart disease in elderly men and women
Mykkänen L, Kuusisto J, Haffner SM, Laakso M, Austin MA. 1999. Arteriosclerosis, thrombosis, and vascular biology. 19: 2742-2748 A1 Journal article (refereed), original research -
Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy
Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 1999. Arteriosclerosis, thrombosis, and vascular biology. 19: 1014-1019 A1 Journal article (refereed), original research -
Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects
Laitinen T, Vauhkonen IKJ, Niskanen LK, Hartikainen JEK, Länsimies EA, Uusitupa MIJ, Laakso M. 1999. Diabetes. 48: 1295-1299 A1 Journal article (refereed), original research -
Prandial glucose regulation and cardiovascular disease in Type 2 diabetes
Kuusisto J, Laakso M. 1999. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. SUPPLEMENT. 29: 7-11 A1 Journal article (refereed), original research -
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Acta neuropathologica. 97: 383-392 A1 Journal article (refereed), original research -
Reducing the burden of diabetes: managing cardiovascular disease
Keen H, Clark C, Laakso M. 1999. Diabetes/metabolism research and reviews. 15: 186-196 A2 Review article, Literature review, Systematic review -
Sarkomeerin geenimutaatiot - hypertrofisen kardiomyopatian syy
Kuusisto J, Jääskeläinen P, Laakso M. 1999. Duodecim -
Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age
Sivenius J, Cunha L, Diener H-C, Forbes C, Laakso M, Lowenthal A, Smets P, Riekkinen P Sr, for the ESPS2 Working Group. 1999. Acta neurologica scandinavica. 99: 54-60 A1 Journal article (refereed), original research -
Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia
Laivuori HM, Laakso M, Tikkanen MJ, Cacciatore B, Ylikorkala RO, Kaaja RJ. 1999. Journal of hypertension. 17: 1189-1194 A1 Journal article (refereed), original research -
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children
Tikanoja T, Jääskeläinen P, Laakso M, Kuusisto J. 1999. American journal of cardiology. 84: 485-486 A1 Journal article (refereed), original research -
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from Eastern Finland
Jääskeläinen P, Miettinen R, Silvennoinen K, Vauhkonen I, Laakso M, Kuusisto J. 1999. Journal of molecular and cellular cardiology. 31: 2031-2036 A1 Journal article (refereed), original research -
The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients
Pulkkinen A, Kareinen A, Saarinen L, Heikkinen S, Lehto S, Laakso M. 1999. Metabolism: clinical and experimental. 48: 853-856 A1 Journal article (refereed), original research -
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb SS, Auwerx J, Uusitupa M, Laakso M. 1999. Journal of clinical endocrinology and metabolism. 84: 3708-3712 A1 Journal article (refereed), original research -
Type-2 diabetes and cognitive function in a non-demented population
Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1999. Acta neurologica scandinavica. 100: 97-101 A1 Journal article (refereed), original research -
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. 1998. Nature genetics -
Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women
Fogelholm M, Valve R, Kukkonen-Harjula K, Nenonen A, Hakkarainen V, Laakso M, Uusitupa M. 1998. Journal of clinical endocrinology and metabolism. 83: 4246-4250 A1 Journal article (refereed), original research -
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S. 1998. Human gene therapy. 9: 1481-1486 A1 Journal article (refereed), original research -
Akuutin alkoholipankreatiitin jälkeiset glukoosiaineenvaihdunnan häiriöt
Saltevo J, Valtola K, Mecklin J-P, Palmu A, Niskanen L, Laakso M. 1998. Duodecim. 114: 1111-1115 A1 Journal article (refereed), original research -
An international study on the efficacy of an alfa-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data
Chiasson J-L, Gomis R, Hanefeld M, Josse RG, Karasik A, Laakso M, The STOPP-NIDDM Trial Research Group. 1998. Diabetes care. 21: 1720-1725 A1 Journal article (refereed), original research -
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
Karvonen MK, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, Dekker JM, ¿T Hart LM, Valve R, Uusitupa MIJ. 1998. Nature medicine. 4: 1434-1437 A1 Journal article (refereed), original research -
Cognitive function in an elderly population with persistent impaired glucose tolerance
Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1998. Diabetes care. 21: 398-402 A1 Journal article (refereed), original research -
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited: metabolic studies on offspring of diabetic probands
Vauhkonen I, Niskanen L, Vanninen E, Kainulainen S, Uusitupa M, Laakso M. 1998. Journal of clinical investigation. 101: 86-96 A1 Journal article (refereed), original research -
Diabetes Atherosclerosis Intervention Study (DAIS): quantitative coronary angiographic analysis of coronary artery atherosclerosis
McLaughlin PR, Gladstone P, for the DAIS Project Group, Laakso M, Kettunen R, Eränen J. 1998. CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS. 44: 249-256 A1 Journal article (refereed), original research -
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. 1998. Metabolism: clinical and experimental. 47: 1397-1402 A1 Journal article (refereed), original research -
Efficacy of antiplatelet treatment in hypertensive patients with TIA or stroke
Puranen J, Laakso M, Riekkinen PJ Sr, Sivenius J. 1998. Journal of cardiovascular pharmacology. 32: 291-294 A1 Journal article (refereed), original research -
Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance
Laakso M, Lehto S. 1998. ATHEROSCLEROSIS. SUPPLEMENT. 137: S65-S73 A2 Review article, Literature review, Systematic review -
Epidemiología de la enfermedad macrovascular en la diabetes
Laakso M, Lehto S. 1998. CARDIOLOGIA AL DIA. : 202-223 A2 Review article, Literature review, Systematic review -
Functional consequences of naturally occurring variants of human hexokinase II
Malkki M, Laakso M, Deeb SS. 1998. Diabetologia. 41: 1205-1209 A1 Journal article (refereed), original research -
Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns
Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. 1998. Diabetes care. 21: 1194-1197 A1 Journal article (refereed), original research -
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: 22-year follw-up results of the Helsinki Policemen Study
Pyörälä M, Miettinen H, Laakso M, Pyörälä K. 1998. Stroke. 29: 1860-1866 A1 Journal article (refereed), original research -
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study
Pyörälä M, Miettinen H, Laakso M, Pyörälä K. 1998. Circulation. 98: 398-404 A1 Journal article (refereed), original research -
Hypertension and macrovascular disease - the killing fields of NIDDM
Laakso M. 1998. DIABETES RESEARCH AND CLINICAL PRACTICE. SUPPLEMENT. 39: 27-33 A2 Review article, Literature review, Systematic review -
Identification of new sequence variants in the leptin gene
Karvonen MK, Pesonen U, Heinonen P, Laakso M, Rissanen A, Naukkarinen H, Valve R, Uusitupa MIJ, Koulu M. 1998. Journal of clinical endocrinology and metabolism. 83: 3239-3242 A1 Journal article (refereed), original research -
Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?
Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M. 1998. Arteriosclerosis, thrombosis, and vascular biology. 18: 1548-1553 A1 Journal article (refereed), original research -
Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus
Vauhkonen I, Niskanen L, Haffner S, Kainulainen S, Uusitupa M, Laakso M. 1998. European journal of endocrinology. 139: 598-604 A1 Journal article (refereed), original research -
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen A-C, Lehtimäki T, Viikari JSA, Laakso M, Taskinen M-R, Ehnholm C, Peltonen L. 1998. Nature genetics. 18: 369-373 A1 Journal article (refereed), original research -
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 1998. The new england journal of medicine. 339: 229-234 A1 Journal article (refereed), original research -
Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene
Ågren JJ, Valve R, Vidgren H, Laakso M, Uusitupa M. 1998. Arteriosclerosis, thrombosis, and vascular biology. 18: 1606-1610 A1 Journal article (refereed), original research -
Risk factors and antiplatelet therapy in TIA and stroke patients
Puranen J, Laakso M, Riekkinen P Sr, Sivenius J. 1998. Journal of the neurological sciences. 154: 200-204 A1 Journal article (refereed), original research -
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus
Lehto S, Niskanen L, Rönnemaa T, Laakso M. 1998. Stroke. 29: 635-639 A1 Journal article (refereed), original research -
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns
Valve R, Heikkinen S, Rissanen A, Laakso M, Uusitupa M. 1998. Diabetologia. 41: 357-361 A1 Journal article (refereed), original research -
The authors reply to the editor (to Diabetes and coronary heart disease)
Haffner SM, Lehto S, Laakso M. 1998. The new england journal of medicine -
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population
Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. 1998. Journal of the american college of cardiology. 32: 1709-1716 A1 Journal article (refereed), original research -
The plate model: A visual method of teaching meal planning
Camelon KM, Hådell K, Jämsén PT, Ketonen KJ, Kohtamäki HM, Mäkimatilla S, Törmälä M-L, Valve RH, for the DAIS Project Group, Laakso M, Kettunen R, Eränen J, Lehto S. 1998. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION. 98: 1155-1158 A1 Journal article (refereed), original research -
Treatment of hypercholesterolemia and combined hyperlipidemia with simvastatin and gemfibrozil in patients with NIDDM: a multicenter comparison study
Tikkanen MJ, Laakso M, Ilmonen M, Helve E, Kaarsalo E, Kilkki E, Saltevo J, for the Study Group. 1998. Diabetes care. 21: 477-481 A1 Journal article (refereed), original research -
Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM
Saarinen L, Pulkkinen A, Kareinen A, Heikkinen S, Lehto S, Laakso M. 1998. Diabetes care. 21: 849-850 A1 Journal article (refereed), original research -
Akarboosi diabeteksen hoidossa
Eriksson J, Forsén B, Laakso M, Tuomilehto J. 1997. Lääkärilehti. 52: 309-311 A2 Review article, Literature review, Systematic review -
Association between features of the insulin resistance syndrome and Alzheimer`s disease independently of apolipoprotein E4 phenotype:cross sectional population based study
Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen PJ, Laakso M. 1997. BMJ international edition. 315: 1045-1049 A1 Journal article (refereed), original research -
Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease
Mustonen J, Uusitupa M, Mäntysaari M, Länsimies E, Pyörälä K, Laakso M. 1997. Journal of internal medicine. 241: 227-235 A1 Journal article (refereed), original research -
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. 1997. Arteriosclerosis, thrombosis, and vascular biology. 17: 1039-1044 A1 Journal article (refereed), original research -
Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM
Lehto S, Rönnemaa T, Haffner SM, Pyörälä K, Kallio V, Laakso M. 1997. Diabetes. 46: 1354-1359 A1 Journal article (refereed), original research -
Dyslipidemia, morbidity, and mortality in non-insulin-dependent diabetes mellitus: lipoproteins and coronary heart disease in non-insulin-dependent diabetes mellitus
Laakso M. 1997. Journal of diabetes and its complications. 11: 137-141 A1 Journal article (refereed), original research -
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. 1997. JAMA : Journal of the American Medical Association. 278: 1349-1356 A1 Journal article (refereed), original research -
Epidemiology of macrovascular disease in diabetes
Laakso M, Lehto S. 1997. DIABETES REVIEWS. 5: 294-315 A2 Review article, Literature review, Systematic review -
Insulin action and non-esterified fatty acids
Ferrannini E, Camastra S, Coppack SW, Fliser D, Golay A, Mitrakou A, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. 1997. Proceedings of the Nutrition Society. 56: 753-761 A1 Journal article (refereed), original research -
Insulin resistance and hypersecretion in obesity
Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G, on behalf of the European Group for the Study of Insulin Resistance (EGIR), Laakso M. 1997. Journal of clinical investigation. 100: 1166-1173 A1 Journal article (refereed), original research -
Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity
Ferrannini E, Natali A, Capaldo B, Lehtovirta M, Jacob S, Yki-Järvinen H, for European Group for the Study of Insulin Resistance (EGIR), Laakso M. 1997. Hypertension. 30: 1144-1149 A1 Journal article (refereed), original research -
Leptin concentrations and insulin sensitivity in normoglycemic men
Haffner SM, Miettinen H, Mykkänen L, Karhapää P, Rainwater DL, Laakso M. 1997. International journal of obesity. 21: 393-399 A1 Journal article (refereed), original research -
Leptin concentrations, sex hormones and cortisol in non-diabetic men
Haffner SM, Miettinen H, Karhapää P, Mykkänen L, Laakso M. 1997. Journal of clinical endocrinology and metabolism. 82: 1807-1809 A1 Journal article (refereed), original research -
Low insulin sensitivity is associated with clustering of cardiocascular risk factors
Mykkänen L, Haffner SM, Rönnemaa T, Bergman RN, Laakso M. 1997. American journal of epidemiology. 146: 315-321 A1 Journal article (refereed), original research -
Metabolic effects of diets rich in saturated and omega-6 polyunsatured fatty acids in healthy young females
Schwab US, Karhapää P, Sarkkinen ES, Salminen I, Laakso M, Uusitupa MIJ. 1997. DIABETES, NUTRITION & METABOLISM. 10: 35-38 A2 Review article, Literature review, Systematic review -
New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. Diabetologia. 40: 1313-1319 A1 Journal article (refereed), original research -
Polymorphism of the Beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns
Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Diabetes. 46: 77-80 A1 Journal article (refereed), original research -
Relationship of LDL size to insulin sensitivity in normoglycemic men
Mykkänen L, Haffner SM, Rainwater DL, Karhapää P, Miettinen H, Laakso M. 1997. Arteriosclerosis, thrombosis, and vascular biology. 17: 1447-1453 A1 Journal article (refereed), original research -
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function
Vanhanen M, Koivisto K, Karjalainen L, Helkala E-L, Laakso M, Soininen H, Riekkinen P Sr. 1997. Neuroreport. 8: 1527-1530 A1 Journal article (refereed), original research -
Stability of age-associated memory impairment during a longitudinal population-based study
Helkala E-L, Koivisto K, Hanninen T, Vanhanen M, Kuusisto J, Mykkanen L, Laakso M, Riekkinen P Sr. 1997. Journal of the american geriatrics society -
The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes. 46: 711-712 A2 Review article, Literature review, Systematic review -
The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM
Malkki M, Laakso M, Deeb SS. 1997. Diabetologia. 40: 1461-1469 A1 Journal article (refereed), original research -
The relation of proinsulin, insulin and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects
Mykkänen L, Haffner SM, Hales CN, Rönnemaa T, Laakso M. 1997. Diabetes. 46: 1990-1995 A1 Journal article (refereed), original research -
The trp64arg polymorphism of the beta3-adrenergic receptor gene
Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes care. 20: 1319-1323 A1 Journal article (refereed), original research -
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects
Vidgren HM, Sipiläinen RH, Heikkinen S, Laakso M, Uusitupa MIJ. 1997. European journal of clinical investigation. 27: 405-408 A1 Journal article (refereed), original research -
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S. 1997. Human gene therapy. 8: 1737-1744 A1 Journal article (refereed), original research -
Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects
Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Journal of clinical endocrinology and metabolism. 82: 2629-2632 A1 Journal article (refereed), original research -
Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland
Miettinen H, Lehto S, Saikku P, Haffner SM, Rönnemaa T, Pyörälä K, Laakso M. 1996. European heart journal. 17: 682-688 A1 Journal article (refereed), original research -
Bisphosphonate therapy in multiple myeloma
Laakso M, Jantunen E. 1996. Acta oncologica. 35: 55-56 A1 Journal article (refereed), original research -
Bisphosphonates in multiple myeloma: current status: future perspectives
Jantunen E, Laakso M. 1996. British journal of haematology. 93: 501-506 A2 Review article, Literature review, Systematic review -
ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM
Vanhanen M, Karhu J, Koivisto K, Pääkkönen A, Partanen J, Laakso M, Riekkinen P Sr. 1996. Neuroreport. 7: 2767-2771 A1 Journal article (refereed), original research -
Effects of Losartan on insulin sensitivity in hypertensive subjects
Laakso M, Karjalainen L, Lempiäinen-Kuosa P. 1996. Hypertension. 28: 392-396 A1 Journal article (refereed), original research -
Epidemiological evidence for the association of hyperglycaemia and atheroslecrotic vascular disease in non-insulin-dependent diabetes mellitus
Laakso M, Kuusisto J. 1996. Annals of medicine. 28: 415-418 A2 Review article, Literature review, Systematic review -
Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus
Kekäläinen P, Sarlund H, Pyörälä K, Laakso M. 1996. Atherosclerosis. 123: 203-213 A1 Journal article (refereed), original research -
Femoral atherosclerosis in middle-aged subjects:association with cardiovascular risk factors and insulin resistance
Kekäläinen P, Sarlund H, Farin P, Kaukanen E, Yang X, Laakso M. 1996. American journal of epidemiology. 144: 742-748 A1 Journal article (refereed), original research -
Glycaemic control and macrovascular disease in NIDDM
Laakso M. 1996. DIAMET: DIABETES METABOLISM. 44: 1-3 A2 Review article, Literature review, Systematic review -
Glycemic Control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus: the Finnish studies
Laakso M. 1996. Annals of internal medicine. 124: 127-130 A1 Journal article (refereed), original research -
Hyperglykemia lisää sydän- ja verisuonitauteihin sairastuvuutta aikuistyypin diabeteksessa
Kuusisto J, Lehto S, Laakso M. 1996. Duodecim. 112: 1965-1966 A2 Review article, Literature review, Systematic review -
Incidence of rheumatoid arthritis in Finland during 1980-1990
Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M. 1996. Annals of the rheumatic diseases. 55: 608-611 A1 Journal article (refereed), original research -
Insulin action and age
Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U, European Group for the Study of Insulin Resistance (EGIR). 1996. Diabetes. 45: 947-953 A1 Journal article (refereed), original research -
Insulin resistance and coronary heart disease
Laakso M. 1996. Current opinion in lipidology. 7: 217-226 A2 Review article, Literature review, Systematic review -
Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus
Laakso M. 1996. Annals of medicine. 28: 341-345 A2 Review article, Literature review, Systematic review -
Long-term influence of glycaemic control on cardiovascular risk in NIDDM
Laakso M. 1996. DIABETES RESEARCH AND CLINICAL PRACTICE. SUPPLEMENT. 31: S61-S65 A2 Review article, Literature review, Systematic review -
Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men
Haffner SM, Laakso M, Miettinen H, Mykkänen L, Karhapää P, Rainwater DL. 1996. Journal of clinical endocrinology and metabolism. 81: 3697-3701 A1 Journal article (refereed), original research -
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus
Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Laakso M. 1996. Arteriosclerosis, thrombosis, and vascular biology. 16: 978-983 A1 Journal article (refereed), original research -
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study
Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1996. Neuroscience letters. 204: 177-180 A1 Journal article (refereed), original research -
Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma
Elomaa I, Risteli L, Laakso M, Lahtinen R, Virkkunen P, Risteli J. 1996. European journal of cancer. 32A: 1166-1170 A1 Journal article (refereed), original research -
Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes
Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 1996. Stroke. 27: 63-68 A1 Journal article (refereed), original research -
Prevalence of ageing-associated cognitive decline in an elderly population
Hänninen T, Koivisto K, Reinikainen KJ, Helkala E-L, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ. 1996. Age and ageing. 25: 201-205 A1 Journal article (refereed), original research -
Proteinuria predicts stroke and other atherosclerotic vascular disease events in non-insulin-dependent diabetic subjects
Miettinen H, Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 1996. Stroke. 27: 2033-2039 A1 Journal article (refereed), original research -
Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity?
Mykkanen L, Haffner SM, Ronnemaa T, Watanable RW, Laakso M. 1996. Journal of hypertension. 14: 399-405 A1 Journal article (refereed), original research -
Retinopathy predicts coronary heart disease events in NIDDM patients
Miettinen H, Rönnemaa T, Haffner SM, Pyörälä K, Lehto S, Laakso M. 1996. Diabetes care. 19: 1445-1448 A1 Journal article (refereed), original research -
Risk factors predicting lower extremity amputations in patients with NIDDM
Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 1996. Diabetes care. 19: 607-612 A1 Journal article (refereed), original research -
Shift in the incidence of rheumatoid arthritis towards wlderly patients in Finland during 1975-1990
Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M. 1996. Clinical and experimental rheumatology. 14: 537-542 A1 Journal article (refereed), original research -
Smoking is independently associated with high plasma insulin levels in nondiabetic men
Rönnemaa T, Pyörälä K, Rönnemaa EM, Laakso M, Puukka P. 1996. Diabetes care. 19: 1229-1232 A1 Journal article (refereed), original research -
Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma
Pulkki K, Pelliniemi T-T, Rajamäki A, Tienhaara A, Laakso M, Lahtinen R. 1996. British journal of haematology. 92: 370-374 A1 Journal article (refereed), original research -
Structure and costs of health care of diabetic patients in Finland
Kangas T, Aro S, Koivisto VA, Salinto M, Laakso M, Reunanen A. 1996. Diabetes care. 19: 494-497 A1 Journal article (refereed), original research -
The diabetes atherosclerosis intervention study (DAIS): a study conducted in cooperation with the World Health Organization
Steiner G for the DAIS Project Group, Laakso M, Kettunen R, Eränen J, Lehto S, Räisänen R. 1996. Diabetologia. 39: 1655-1661 A1 Journal article (refereed), original research -
The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects
Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Paljärvi L, Laakso M. 1996. International journal of obesity. 20: 154-160 A1 Journal article (refereed), original research -
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia
Hänninen T, Hallikainen M, Koivisto K, Helkala E-L, Reinikainen KJ, Soininen H, Mykkänen L, Laakso M, Pyörälä K, Riekkinen PJ Sr. 1995. Journal of the american geriatrics society. 43: 1007-1015 A1 Journal article (refereed), original research -
Aikuistyypin diabetes
Laakso M. 1995. Duodecim. 111: 2331-2333 A2 Review article, Literature review, Systematic review -
Aikuistyypin diabetes ja perintötekijät
Laakso M. 1995. DIABETES JA LÄÄKÄRI. : 6-7 D1 Article in a trade journal -
Amino acid substitutions in hexokinase II among patients with NIDDM
Laakso M, Malkki M, Deeb SS. 1995. Diabetes. 44: 330-334 A1 Journal article (refereed), original research -
Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes
Sivenius J, Riekkinen PJ Sr, Laakso M. 1995. BMJ international edition. 310: 25-26 A1 Journal article (refereed), original research -
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects
Kuusisto J, Mykkänen L, Kervinen K, Kesäniemi YA, Laakso M. 1995. Arteriosclerosis, thrombosis, and vascular biology. 15: 1280-1286 A1 Journal article (refereed), original research -
Does NIDDM increase the risk for coronary heart disease similarly in both low- and high-risk populations?
Laakso M, Rönnemaa T, Lehto S, Puukka P, Kallio V, Pyörälä K. 1995. Diabetologia. 38: 487-493 A1 Journal article (refereed), original research -
Epidemiology of diabetic dyslipidemia
Laakso M. 1995. DIABETES REVIEWS. 3: 408-422 A1 Journal article (refereed), original research -
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance
Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Mykkänen L, Deeb SS. 1995. Diabetes care. 18: 398-400 A1 Journal article (refereed), original research -
Hyperinsulinemic microalbuminuria: A new risk indicator for coronary heart disease
Kuusisto J, Mykkänen L, Pyörälä K, Laakso M. 1995. Circulation. 91: 831-837 A1 Journal article (refereed), original research -
Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma
Pelliniemi T-T, Irjala K, Mattila K, Pulkki K, Rajamäki A, Tienhaara A, Laakso M, Lahtinen R. 1995. Blood. 85: 765-771 A1 Journal article (refereed), original research -
Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus
Virtaniemi J, Kuusisto J, Karjalainen L, Karjalainen S, Laakso M. 1995. American journal of otolaryngology. 16: 172-176 A1 Journal article (refereed), original research -
Insuliiniresistenssi - epidemiologiasta molekyylibiologiaan
Laakso M. 1995. Lääkärilehti. 50: 203-208 A2 Review article, Literature review, Systematic review -
Insulin sensitivity and Lp(a) concentrations in normoglycemic men
Haffner SM, Karhapää P, Rainwater DL, Mykkänen L, Aldrete G, Laakso M. 1995. Diabetes care. 18: 193-199 A1 Journal article (refereed), original research -
Klodronaatti ja myelooma
Jantunen E, Lahtinen R, Laakso M. 1995. Duodecim. 111: 1085-1087 A2 Review article, Literature review, Systematic review -
Metabolic defects in persistent impaired glucose tolerance are related to the family history of non-insulin-dependent diabetes mellitus
Niskanen L, Sarlund H, Laakso M. 1995. Metabolism: clinical and experimental. 44: 1099-1104 A1 Journal article (refereed), original research -
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance
Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb SS. 1995. Diabetologia. 38: 617-622 A1 Journal article (refereed), original research -
Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland
Koivisto K, Reinikainen KJ, Hänninen T, Vanhanen M, Helkala E-L, Mykkänen L, Laakso M, Pyörälä K, Riekkinen PJ Sr. 1995. Neurology. 45: 741-747 A1 Journal article (refereed), original research -
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women
Austin MA, Mykkänen L, Kuusisto J, Edwards KL, Nelson C, Haffner SM, Pyörälä K, Laakso M. 1995. Circulation. 92: 1770-1778 A1 Journal article (refereed), original research -
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
Mykkänen L, Haffner SM, Kuusisto J, Pyörälä K, Hales CN, Laakso M. 1995. Diabetologia. 38: 1176-1182 A1 Journal article (refereed), original research -
The association of apolipoprotein E polymorphism with memory: a population based study
Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1995. Neuroscience letters. 191: 141-144 A1 Journal article (refereed), original research -
Use of clodronate in multiple myeloma
Jantunen E, Lahtinen R, Laakso M. 1995. Leukemia & lymphoma. 19: 207-211 A1 Journal article (refereed), original research