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Nadine Huber

Nadine Huber

Postdoctoral Researcher

PhD Student

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

[email protected]

Information Publications

Hi, I´m Nadine and my project focuses on the potential synaptic dysfunction in C9orf72 hexanucleotide repeat expansion-associated frontotemporal dementia (FTD)

Research groups

Annakaisa Haapasalo Group (Molecular Neurodegeneration) 01.06.2015 -

Projects

Synapsing Mental Disorders and Neurodegenerative Diseases: Towards more effective diagnosis and management of psychiatric symptoms 01.01.2025 - 31.12.2029

Keywords

C9orf72 dendritic spines frontotemporal dementia neurodegeneration synaptic dysfunction

Publications

26/26 items

Combining a computerized cognitive test with serum biomarkers improves detection of early-onset neurodegenerative disorders
Tikkanen, Veera; Paajanen, Teemu I; Heikkinen, Anna-Leena; Solje, Eino; Katisko, Kasper; Kokkola, Tarja; Kärkkäinen, Sari; Herukka, Sanna-Kaisa; Huber, Nadine; Haapasalo, Annakaisa; Hänninen, Tuomo; Hublin, Christer; Koivisto, Anne M; Virkkala, Jussi; Saari, Toni T; Portaankorva, Anne M; Krüger, Johanna, 2025, Journal of Alzheimer's disease, 108, 4, 1647-1658. A1 Journal article (refereed), original research
Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism
Harjuhaahto, Sandra; Jokela, Manu; Rajendran, Jayasimman; Rokka, Minea; Hu, Bowen; Kvist, Jouni; Zhang, Fuping; Zárybnický, Tomáš; Haimilahti, Kimmo; Euro, Liliya; Pirinen, Eija; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Kuuluvainen, Emilia; Gopalakrishnan, Swetha; Katajisto, Pekka; Hietakangas, Ville; Burg, Thibaut; Van Den Bosch, Ludo; Huang, Xiaoping; Narendra, Derek P.; Kuure, Satu; Ylikallio, Emil; Tyynismaa, Henna, 2025, Acta neuropathologica communications, 13, 1, 111. A1 Journal article (refereed), original research
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, [Published: 26 September 2025], 1-17. A1 Journal article (refereed), original research
Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease
Cantoni, Valentina; Casula, Elias Paolo; Tarantino, Barbara; Cupidi, Chiara; Huber, Nadine; Altomare, Daniele; Premi, Enrico; Zummo, Elisa; Esposito, Romina; Leonardi, Carla; Herukka, Sanna-Kaisa; Solje, Eino; Ferrari, Asia; Cotelli, Maria Sofia; Gasparotti, Roberto; Martorana, Alessandro; Fracassi, Claudia; Santarnecchi, Emiliano; Koch, Giacomo; Haapasalo, Annakaisa; Grassi, Mario; Benussi, Alberto; Borroni, Barbara, 2025, JAMA network open, 8, 12, e2546556. A1 Journal article (refereed), original research
Low-molecular weight protamine enhances neuroprotection and remyelination by mitigating chondroitin sulfate proteoglycan inhibition in models of demyelination
Koppinen, Tapani K.; Reyes, Carolina R.; Beckett, Liam; Nam, Jinhan; Kallionpää, Tuomas A.E.; Leskinen, Saila Medina; Huber, Nadine; Haapasalo, Annakaisa; Rivera, Francisco J.; Voutilainen, Merja H.; Rauvala, Heikki, 2025, Neuropharmacology, 279, 110618. A1 Journal article (refereed), original research
Mechanisms of neurodegeneration in frontotemporal dementia: focus on synaptic dysfunction
Huber, Nadine, 2024, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)
Cortico-spinal tDCS in amyotrophic lateral sclerosis: A randomized, double-blind, sham-controlled trial followed by an open-label phase
Benussi, Alberto; Cantoni, Valentina; Grassi, Mario; Libri, Ilenia; Cotelli, Maria Sofia; Tarantino, Barbara; Datta, Abhishek; Thomas, Chris; Huber, Nadine; Kärkkäinen, Sari; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Filosto, Massimiliano; Padovani, Alessandro; Borroni, Barbara, 2023, Brain stimulation, 16, 6, 1666-1676. A1 Journal article (refereed), original research
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko, 2023, Cells, 12, 10, 1422. A1 Journal article (refereed), original research
Rare PMP22 variants in mild to severe neuropathy uncorrelated to plasma GDF15 or neurofilament light
Palu, Edouard; Järvilehto, Julius; Pennonen, Jana; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Isohanni, Pirjo; Tyynismaa, Henna; Auranen, Mari; Ylikallio, Emil, 2023, Neurogenetics, 24, 4, 291-301. A1 Journal article (refereed), original research
Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa, 2023, Journal of Alzheimer's disease, 93, 2, 395-401. A1 Journal article (refereed), original research
Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons
Sainio, Markus T.; Rasila, Tiina; Molchanova, Svetlana M.; Järvilehto, Julius; Torregrosa-Muñumer, Rubén; Harjuhaahto, Sandra; Pennonen, Jana; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Zetterberg, Henrik; Taira, Tomi; Palmio, Johanna; Ylikallio, Emil; Tyynismaa, Henna, 2022, Frontiers in cell and developmental biology, 9, 820105. A1 Journal article (refereed), original research
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino, 2022, Alzheimer's research and therapy, 14, 1, 151. A1 Journal article (refereed), original research
Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism
Kenvin, Sebastian; Torregrosa-Muñumer, Ruben; Reidelbach, Marco; Pennonen, Jana; Turkia, Jeremi J; Rannila, Erika; Kvist, Jouni; Sainio, Markus T; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Auranen, Mari; Trokovic, Ras; Sharma, Vivek; Ylikallio, Emil; Tyynismaa, Henna, 2022, Human molecular genetics, 31, 6, 958-974. A1 Journal article (refereed), original research
C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction
Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa, 2021, Neurobiology of disease, 2022; 162, 105584. A1 Journal article (refereed), original research
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches
Huber, Nadine; Korhonen, Sonja; Hoffmann, Dorit; Leskelä, Stina; Rostalski, Hannah; Remes, Anne M.; Honkakoski, Paavo; Solje, Eino; Haapasalo, Annakaisa, 2021, Molecular psychiatry, Published online: 19 November 2021, 1 - 10. A2 Review article, Literature review, Systematic review
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells
Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa, 2021, Biochimica et biophysica acta: molecular cell research, 1868, 7, 119021. A1 Journal article (refereed), original research
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62
Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A, 2021, Molecular neurobiology, 58, 11, 5438-5458. A1 Journal article (refereed), original research
GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance
Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2021, Journal of neurology neurosurgery and psychiatry, 92, 12, 1305-1312. A1 Journal article (refereed), original research
Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis
Niiranen, Marja; Kontkanen, Aleksi; Jääskeläinen, Olli; Tertsunen, Hanna-Mari; Selander, Tuomas; Hartikainen, Päivi; Huber, Nadine; Solje, Eino; Haapasalo, Annakaisa; Kokkola, Tarja; Lohioja, Tarja; Herukka, Sanna-Kaisa; Simula, Sakari; Remes, Anne M., 2021, Multiple sclerosis and related disorders, 56, 103280. A1 Journal article (refereed), original research
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci
Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa, 2020, Frontiers in neurology, 11, 550140. A1 Journal article (refereed), original research
Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium
Hoffmann, Dorit; Huber, Nadine; Leskelä, Stina; Rostalski, Hannah; Solje, Eino; Remes, Anne M; Haapasalo, Annakaisa, 2020, Neurodegenerative disease management, 10, 3, 1758-2024. B1 Non-refereed journal articles
Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS
Rostalski, Hannah; Leskelä, Stina; Huber, Nadine; Katisko, Kasper; Cajanus, Antti; Solje, Eino; Marttinen, Mikael; Natunen, Teemu; Remes, Anne M; Hiltunen, Mikko; Haapasalo, Annakaisa, 2019, Frontiers in neuroscience, 13, 486. A2 Review article, Literature review, Systematic review
C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner
Leskelä, S; Huber, N; Rostalski, H; Natunen, T; Remes, AM; Takalo, M; Hiltunen, M; Haapasalo, A, 2019, Cells, 8, 10, 1233. A1 Journal article (refereed), original research
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al., 2019, Stem cell reports, 13, 4, 669-683. A1 Journal article (refereed), original research
Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples
Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A, 2018, Journal of Alzheimer's disease, 62, 1, 269-278. A1 Journal article (refereed), original research
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M, 2017, Journal of neuroinflammation, 14, 215. A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Nadine Huber

Research groups

Projects

Keywords

Combining a computerized cognitive test with serum biomarkers improves detection of early-onset neurodegenerative disorders

Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease

Low-molecular weight protamine enhances neuroprotection and remyelination by mitigating chondroitin sulfate proteoglycan inhibition in models of demyelination

Mechanisms of neurodegeneration in frontotemporal dementia: focus on synaptic dysfunction

Cortico-spinal tDCS in amyotrophic lateral sclerosis: A randomized, double-blind, sham-controlled trial followed by an open-label phase

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates

Rare PMP22 variants in mild to severe neuropathy uncorrelated to plasma GDF15 or neurofilament light

Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism

C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction

Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches

Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells

FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance

Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci

Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS

C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death