Genetics of gene regulation in disease

Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic...

Sirtuin Research Group- UEF Pharmacy

Sirtuin Research Group at School of Pharmacy develops novel modulators involved in histone acetylation. We have hundreds of in-house epigenetic regulators. We explore the regulation of sirtuins and BRD bromodomains in cancer.

Epigenomics of vitamin D

01.10.2000 -
The scientific interest of our team is on mechanisms of gene regulation and its impact on major common diseases, such as type 2 diabetes, atherosclerosis and cancer. Our investigations use methods of molecular biology, bioinformatics and systems biology.