Emilia Kansanen

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa. 2024. Redox biology. 69:

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Adinolfi, Simone; Patinen, Tommi; Jawahar Deen, Ashik; Pitkänen, Sini; Härkönen, Jouni; Kansanen, Emilia; Küblbeck, Jenni; Levonen, Anna-Liisa. 2023. Redox biology. 63:

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. 2021. Cardiovascular research. 117: 1339-1357

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. International journal of molecular sciences. 20: 5395

International evaluation of research activities at the University of Eastern Finland 2015-2018

Liikanen, Anu; Kansanen, Emilia; Kettunen, Marjo. 2019. Publications of the University of Eastern Finland. General series. .

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

Jobbagy, Soma; Vitturi, Dario A; Salvatore, Sonia R; Turell, Lucía; Pires, Maria F; Kansanen, Emilia; Batthyany, Carlos; Lancaster, Jack R Jr; Freeman, Bruce A; Schopfer, Francisco. 2018. Redox biology. 2019; 21: 101050

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

Kuosmanen, SM; Sihvola, V; Kansanen, E; Kaikkonen, MU; Levonen, AL. 2018. Redox biology. 18: 77-83

MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells

Kuosmanen Suvi M, Kansanen Emilia, Sihvola Virve, Levonen Anna-Liisa. 2017. Scientific reports. 7: 10943

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. Nucleic acids research. 2018; 46: 1124-1138

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells

Kansanen Emilia, Kuosmanen Suvi M, Ruotsalainen Anna-Kaisa, Hynynen Heidi, Levonen Anna-Liisa. 2017. Molecular pharmacology. 92: 481-490

The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs

Kuosmanen Suvi M, Viitala Sari, Laitinen Tuomo, Peräkylä Mikael, Pölönen Petri, Kansanen Emilia, Leinonen Hanna, Raju Suresh, Wienecke-Baldacchino Anke, Närvänen Ale, Poso Antti, Heinäniemi Merja, Heikkinen Sami, Levonen Anna-Liisa. 2016. Nucleic acids research. 44: 1760-1775

Dysregulation of the Keap1-Nrf2 pathway in cancer

Leinonen Hanna M, Kansanen Emilia, Polonen Petri, Heinaniemi Merja, Levonen Anna-Liisa. 2015. Biochemical society transactions. 43: 645-649

Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway

Kansanen Emilia, Levonen Anna-Liisa. Teoksessa: Corinne M. Spickett, Henry Jay Forman(toim.) , 2015. Lipid Oxidation in Health and Disease. s. 255-277. CRC press

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S. 2014. Nucleic acids research. 42: 12570-84

HIF-1 alpha and HIF-2 alpha induce angiogenesis and improve muscle energy recovery

Niemi Henna, Honkonen Krista, Korpisalo Petra, Huusko Jenni, Kansanen Emilia, Merentie Mari, Rissanen Tuomas T, André Helder, Pereira Teresa, Poellinger Lorenz, Alitalo Kari, Ylä-Herttuala Seppo. 2014. European journal of clinical investigation. 44: 989-999

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM. 2014. Free radical biology and medicine. 71: 196-207

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)

Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Molecular pharmacology. Epub ahead of print: -

Lipid Oxidation and Nitration Products as Activators of Cytoprotective Nrf2 Signaling in the Endothelium

Kansanen, Emilia. 2012. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Novel keto-phospholipids are generated by monocytes and macrophages, detected in Cystic Fibrosis, and activate peroxisome proliferator-activated receptor-&#947

Hammond VJ, Morgan AH, Lauder SN, Thomas CP, Brown S, Freeman BA, Lloyd C, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia Diaz YM, Schopfer F, O'Donnell VB. 2012. Journal of biological chemistry. 2012 Oct 11. [Epub ahead of print]: --

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment

Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. 2012. Cancer research. 2012 Oct 9. [Epub ahead of print]: - -

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

Kansanen E, Jyrkkänen HK, Levonen AL. 2011. Free radical biology and medicine. 2012 Mar 15;52(6: 973-82

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism

Kansanen Emilia, Bonacci Gustavo, Schopfer Francisco J, Kuosmanen Suvi M, Tong Kit I, Leinonen Hanna, Woodcock Steven R, Yamamoto Masayuk, Carlberg Carsten, Ylä-Herttuala Seppo, Freeman Bruce A, Levonen Anna-Liisa. 2011. Journal of biological chemistry. 286: 14019-14027

Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Jyrkkänen HK, Kuosmanen S, Heinäniemi M, Laitinen H, Kansanen E, Mella-Aho E, Leinonen H, Ylä-Herttuala S, Levonen AL. 2011. Biochemical journal. : 167-74

Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects

Jauhiainen Suvi, Häkkinen Sanna-Kaisa, Toivanen Pyry I, Heinonen Suvi E, Jyrkkänen Henna-Kaisa, Kansanen Emilia, Leinonen Hanna, Levonen Anna-Liisa, Ylä-Herttuala Seppo. 2011. Arteriosclerosis, thrombosis, and vascular biology. 31: 1617-1624

Sulforaphane inhibits endothelial lipase expression through NF-&#954 B in endothelial cells

Kivelä AM, Mäkinen PI, Jyrkkänen HK, Mella-Aho E, Xia Y, Kansanen E, Leinonen H, Verma IM, Ylä-Herttuala S & Levonen AL. 2010. Atherosclerosis. 213: 122-128

Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid

Kansanen E, Jyrkkänen H-K, Volger OL, Leinonen H, Kivelä AM, Häkkinen S-K, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen A-L. 2009. Journal of biological chemistry. 284: 33233-33241

Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2

Kansanen E, Kivelä AM, Levonen A-L. 2009. Free radical biology and medicine. 47: 1310-1317

Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells

Kivelä AM, Kansanen E, Jyrkkänen HK, Nurmi T, Ylä-Herttuala S, Levonen AL. 2008. Journal of nutrition. 138: 1263-1268

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo

Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. 2008. Circulation research. 103: e1-e9

Oxidative stress-inducible lentiviral vectors for gene therapy

Hurttila H, Koponen JK, Kansanen E, Jyrkkänen H-K, Kivelä A, Kylätie R, Ylä-Herttuala S, Levonen A-L. 2008. Gene therapy. 15: 1271-1279

Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

Tuomisto TT, Lumivuori H, Kansanen E, Häkkinen S-K, Turunen MP, van Thienen JV, Horrevoets AJ, Levonen A-L, Ylä-Herttuala S. 2008. Cardiovascular research. 78: 175-184

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Molecular and cellular biology. 27: 4953-4967

Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo

Levonen A-L, Inkala M, Heikura T, Jauhiainen S, Jyrkkänen H-K, Kansanen E, Määttä K, Romppanen E, Turunen P, Rutanen J, Ylä-Herttuala S. 2007. Arteriosclerosis, thrombosis, and vascular biology. 27: 741-747

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Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

International evaluation of research activities at the University of Eastern Finland 2015-2018

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells

The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs

Dysregulation of the Keap1-Nrf2 pathway in cancer

Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

HIF-1 alpha and HIF-2 alpha induce angiogenesis and improve muscle energy recovery

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)

Role of the Keap1-Nrf2 pathway in cancer

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

The absence of macrophage Nrf2 promotes early atherogenesis

Lipid Oxidation and Nitration Products as Activators of Cytoprotective Nrf2 Signaling in the Endothelium

Novel keto-phospholipids are generated by monocytes and macrophages, detected in Cystic Fibrosis, and activate peroxisome proliferator-activated receptor-&#947

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism

Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects

Sulforaphane inhibits endothelial lipase expression through NF-&#954 B in endothelial cells

Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid

Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2

Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo

Oxidative stress-inducible lentiviral vectors for gene therapy

Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo