Jari Koistinaho

Ahmad, Farizan; Hyvärinen, Anna; Pirinen, Agnieszka; Olsson, Venla; Rummukainen, Jaana; Immonen, Arto; Närväinen, Johanna; Tuunanen, Pasi; Liimatainen, Timo; Kärkkäinen, Virve; Koistinaho, Jari; Ylä-Herttuala, Seppo. 2021. Lentivirus vector-mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain Molecular medicine reports 23 6: 422. 2021

Studying non-cell-autonomous neurodegeneration in Parkinson's disease with induced pluripotent stem cells. Sonninen, Tuuli-Maria; Plotnikova, Lidiia; Laham-Karam, Nihay; Goldsteins, Gundars; Koistinaho, Jari; Lehtonen, Šárka / iPSCs for Modeling Central Nervous System Disorders. 2021. 2021

Wu, Ying-Chieh; Sonninen, Tuuli-Maria; Peltonen, Sanni; Koistinaho, Jari; Lehtonen, Sarka. 2021. Blood-Brain Barrier and Neurodegenerative Diseases-Modeling with iPSC-Derived Brain Cells International journal of molecular sciences 22 14: 7710. 2021

Wojciechowski, Sara; Virenque, Anaïs; Vihma, Maria; Galbardi, Barbara; Rooney, Erin Jane; Keuters, Meike Hedwig; Antila, Salli; Koistinaho, Jari; Noe, Francesco M. 2021. Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury Frontiers in immunology 11: 559810. 2021

Tiihonen, Jari; Koskuvi, Marja; Lähteenvuo, Markku; Trontti, Kalevi; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Cheng, Lesley; Tanskanen, Antti; Taipale, Heidi; Lehtonen, Šárka; Koistinaho, Jari. 2021. Molecular signaling pathways underlying schizophrenia Schizophrenia research 232: 33-41. 2021

Talvio, Karo; Kanninen, Katja M; White, Anthony R; Koistinaho, Jari; Castrén, Maija L. 2021. Increased iron content in the heart of the Fmr1 knockout mouse Biometals 34 4: 947-954. 2021

Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2021. Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids Cells 2022; 11 1: 124. 2021

Räsänen, Noora; Tiihonen, Jari; Koskuvi, Marja; Lehtonen, Šárka; Koistinaho, Jari. 2021. The iPSC perspective on schizophrenia Trends in neurosciences 2022; 41 1: 8-26. 2021

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model Journal of pharmaceutical sciences 110 12: 3953-3962. 2021

Koskuvi, Marja; Lehtonen, Šárka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Toh. 2021. Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia Glia 2022; 70 4: 650-660. 2021

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, Šárka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo Scientific reports 11 1: 3518. 2021

Garcia, Gonçalo; Pinto, Sara; Cunha, Mar; Fernandes, Adelaide; Koistinaho, Jari; Brites, Dora. 2021. Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor Cells 10 9: 2424. 2021

Puris, Elena; Kouril, Štepán; Najdekr, Lukáš; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice Scientific reports 11 1: 13076. 2021

Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka. 2020. Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease Stem cell research 48: 101968. 2020

Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, Šárka. 2020. Metabolic alterations in Parkinson's disease astrocytes Scientific reports 10 1: 14474. 2020

Sonninen, Tuuli-Maria; Goldsteins, Gundars; Laham-Karam, Nihay; Koistinaho, Jari; Lehtonen, Sarka. 2020. Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases Cells 9 10: 2183. 2020

Oikari, Lotta; Pandit, Rucha; Stewart, Romal; Cuní-López, Carla; Quek, Hazel; Sutharsan, Ratneswary; Rantanen, Laura; Oksanen, Minna; Lehtonen, Sarka; de Boer, Carmela Maria; Polo, Jose; Götz, Jürgen; Koistinaho, Jari; White, Anthony. 2020. Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery Stem cell reports 14: 1-16. 2020

Rolova, Taisia; Lehtonen, Sárka; Goldsteins, Gundars; Kettunen, Pinja; Koistinaho, Jari. 2020. Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models Stem cells 2021; 39 3: 256-265. 2020

Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals Aging cell 2021; 20 1: e13287. 2020

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020

Grubman, Alexandra; Vandekolk, Teresa H; Schröder, Jan; Sun, Guizhi; Hatwell-Humble, Jessica; Chan, Jonathan; Oksanen, Minna; Lehtonen, Sarka; Hunt, Cameron; Koistinaho, Jari; Nilsson, Susan; Haynes, John; Pouton, Colin; Polo, Jose. 2020. A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture Stem cell reports 14: 1-15. 2020

Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, Š; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes Glia 2020; 68 3: 589-599. 2019

Tiihonen, J; Koskuvi, M; Lähteenvuo, M; Virtanen, PLJ; Ojansuu, I; Vaurio, O; Gao, Y; Hyötyläinen, I; Puttonen, KA; Repo-Tiihonen, E; Paunio, T; Rautiainen, MR; Tyni, S; Koistinaho, J; Lehtonen, S. 2019. Neurobiological roots of psychopathy Molecular psychiatry [Epub ahead of print 27 Aug 2019]: 1-10. 2019

Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice Human molecular genetics 28 11: 3309-3322. 2019

Oksanen, M; Lehtonen, S; Jaronen, M; Goldsteins, G; Hämäläinen, RH; Koistinaho, J. 2019. Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms Cellular and molecular life sciences 76 14: 2739-2760. 2019

Tiihonen, J; Koskuvi, M; Storvik, M; Hyötyläinen, I; Gao, Y; Puttonen, KA; Giniatullina, R; Poguzhelskaya, E; Ojansuu, I; Vaurio, O; Cannon, TD; Lönnqvist, J; Therman, S; Suvisaari, J; Kaprio, J; Cheng, L; Hill, AF; Lähteenvuo, M; Tohka, J; Giniatullin, R; et al.. 2019. Sex-specific transcriptional and proteomic signatures in schizophrenia Nature communications 10 1: 3933. 2019

Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid. 2019. Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges Frontiers in cellular neuroscience 13: 45. 2019

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis IBRO Reports 6: 74-86. 2019

Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Stem cell reports 13 4: 669-683. 2019

Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke Neurotherapeutics 16: 1304-1319. 2019

Lehtonen, Š; Sonninen, TM; Wojciechowski, S; Goldsteins, G; Koistinaho, J. 2019. Dysfunction of Cellular Proteostasis in Parkinson's Disease Frontiers in neuroscience 13: 457. 2019

Lehtonen, S; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J. 2018. Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease Stem cell research 30: 96-99. 2018

Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A; Hämäläinen, Riikka H; Graff, Caroline; Lehtonen, Šarka; Koistinaho, Jari. 2018. Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene Stem Cell Research 31: 181-185. 2018

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage Brain, behavior, and immunity 73: 670-681. 2018

Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling. Frontiers in Physiology 9: 80. 2018

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes GLIA 2019; 67 1: 146-159. 2018

Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes PHARMACEUTICAL RESEARCH 2019; 36: 17. 2018

Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. CuII(atsm) Attenuates Neuroinflammation Frontiers in neuroscience 12: 668. 2018

Belt, H; Koponen, JK; Kekarainen, T; Puttonen, KA; Mäkinen, PI; Niskanen, H;, Oja, J; Wirth, G; Koistinaho, J; Kaikkonen, MU; Ylä-Herttuala, S. 2018. Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules. Frontiers in cardiovascular medicine 5: 16. 2018

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017

Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder. Disease models & mechanisms 10 9: 1089-1100. 2017

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017

Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Lack of collagen XV is protective after ischemic stroke in mice. Cell Death and Disease 8 January: 1-8. 2017

Lemarchant Sighild, Wojciechowski Sara, Vivien Denis, Koistinaho Jari. 2017. ADAMTS-4 in central nervous system pathologies. JOURNAL OF NEUROSCIENCE RESEARCH 95 9: 1703-1711. 2017

Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Scientific Reports 7: 1597. 2017

Härönen H, Zainul Z, Tu H, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Oikarainen T, Abdullin A, Martin P, Santoleri S, Koistinaho J, Silman I, Giniatullin R, Fox MA, Heikkinen A, Pihlajaniemi T. 2017. Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse. HUMAN MOLECULAR GENETICS 26 11: 2076-2090. 2017

Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu NEUROTHERAPEUTICS 14 2: 519-532. 2017

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14 11: 237. 2017

Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2016. Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment. Frontiers in Cellular Neuroscience 10: 279. 2016

Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016

Lemarchant Sighild, Wojciechowski Sara, Koistinaho Jari. 2016. Perineuronal nets in neurodegeneration. Oncotarget 7 48: 78224-78225. 2016

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 10. 2016

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 15. 2016

Lehtonen Šárka, Jaronen Merja, Vehviläinen Piia, Lakso Merja, Rudgalvyte Martina, Keksa-Goldsteine Velta, Wong Garry, Courtney Michael J, Koistinaho Jari, Goldsteins Gundars. 2016. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models. ANTIOXIDANTS AND REDOX SIGNALING 25 8: 485-497. 2016

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke Glia 64 9: 1492-507. 2016

Lehtonen Šárka, Lehtonen Marko, Koistinaho Jari. 2016. Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases. In: Tomizava Minoru (ed.) Pluripotent Stem Cells - From the Bench to the Clinic. Intech. s. 209-226. 2016

Achuta VS, Grym H, Putkonen N, Louhivuori V, Kärkkäinen V, Koistinaho J, Roybon L, Castrén ML. 2016. Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome. Developmental neurobiology [Epub ahead of print 28 July 2016]: 1-16. 2016

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy Scientific Reports 6: 33176. 2016

Holmqvist S, Lehtonen S, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Djelloul M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L. 2016. Creation of a library of induced pluripotent stem cells from Parkinsonian patients. npj Parkinson's Disease 2: 16009. 2016

Heneka Michael T, Carson Monica J, El Khoury Joseph, Landreth Gary E, Brosseron Frederic, Feinstein Douglas L, Jacobs Andreas H, Wyss-Coray Tony, Vitorica Javier, Ransohoff Richard M, Herrup Karl, Frautschy Sally A, Finsen Bente, Brown Guy C, Verkhratsky Alexei, Yamanaka Koji, Koistinaho Jari, Latz Eicke, Halle Annett, Petzold Gabor C et al. 2015. Neuroinflammation in Alzheimer's disease. LANCET NEUROLOGY 14 4: 388-405. 2015

Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Exosomes as new diagnostic tools in CNS diseases. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE 2016; 1862 3: 403-410. 2015

Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Applications of the Keap1-Nrf2 system for gene and cell therapy. FREE RADICAL BIOLOGY & MEDICINE 88 Part B: 350-361. 2015

Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation Brain, behavior, and immunity 49: 322-336. 2015

Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M. 2015. A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow & Metabolism [epub ahead of print Sep 30, 2015]: -. 2015

Puttonen Katja A, Ruponen Marika, Naumenko Nikolay, Hovatta Outi H, Tavi Pasi, Koistinaho Jari. 2015. Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines. Frontiers in Cellular Neuroscience 9:473: -. 2015

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging and disease [epub ahead of print 3 Dec 2015]: -. 2015

Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity. STEM CELLS 32 7: 1904-1916. 2014

Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. 2014. Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury. Cell Transplantation 2014 Sep 8. [Epub ahead of print]: - -. 2014

Pollari Eveliina, Goldsteins Gundars, Bart Genevieve, Koistinaho Jari, Giniatullin Rashid. 2014. The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience 2014 May 13;8:131.: --. 2014

Lemarchant S, Pruvost M, Hébert M, Gauberti M, Hommet Y, Briens A, Maubert E, Gueye Y, Féron F, Petite D, Mersel M, do Rego JC, Vaudry H, Koistinaho J, Ali C, Agin V, Emery E, Vivien D. 2014. tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2014 Jun;66: 28-42. 2014

Vehviläinen P, Koistinaho J, Goldsteins, G. 2014. Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience 126 8: -. 2014

Koistinaho Jari, Koistinaho Milla. 2014. Minocycline, A Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke: Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang, Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer Series in Translational Stroke Research. 275-285. 2014

Grubman Alexandra, Lidgerwood Grace E, Duncan Clare, Bica Laura, Tan Jiang-Li, Parker Sarah J, Caragounis Aphrodite, Meyerowitz Jodi, Volitakis Irene, Moujalled Diane, Liddell Jeffrey R, Hickey James L, Horne Malcolm, Longmuir Shoshanah, Koistinaho Jari, Donnelly Paul S, Crouch Peter J, Tammen Imke, White Anthony R, Kanninen Katja M. 2014. Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. Acta neuropathologica communications 2014 Feb 28:2:25: --. 2014

Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H. 2014. Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice. BEHAVIOURAL BRAIN RESEARCH Volume 275, 15 December 2014: 15-26. 2014

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. Brain, behavior, and immunity 2014 Aug 18 ePub ahead of print: --. 2014

Grubman Alexandra, Pollari Eveliina, Duncan Clare, Caragounis Aphrodite, Blom Tea, Volitakis Irene, Wong Andrew, Cooper Jonathan, Crouch Peter J, Koistinaho Jari, Jalanko Anu, White Anthony R, Kanninen Katja M. 2014. Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?. Metallomics 2014 Apr;6(4): 932-943. 2014

Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin. Aging and disease 2014 Apr 1;5(2): 76-87. 2014

Jaronen M, Goldsteins G, Koistinaho J. 2014. ER stress and unfolded protein response in amyotrophic lateral sclerosis - a controversial role of protein disulphide isomerase. Frontiers in Cellular Neuroscience 2014 Dec 2;8:402.: --. 2014

Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A. 2013. Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase. AMINO ACIDS 2013 Jul 9. [Epub ahead of print]: -. 2013

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) [Epub ahead of print] 64C: 16-29. 2013

Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013

Rosell A, Agin V, Rahman M, Morancho A, Ali C, Koistinaho J, Wang X, Vivien D, Schwaninger M, Montaner J. 2013. Distal occlusion of the middle cerebral artery in mice: are we ready to assess long-term functional outcome?. Translational stroke research 2013 Jun;4(3):: 297-307. 2013

Parker SJ, Koistinaho J, White AR, Kanninen KM. 2013. Biometals in rare neurodegenerative disorders of childhood. Frontiers in aging neuroscience 5 14: x-x. 2013

Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J. 2013. ADAMTS proteoglycanases in the physiological and pathological central nervous system. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2013 Oct 31;10(1): 133. 2013

Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. 2013. Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2013 Aug 20;10(1):102: --. 2013

Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J. 2013. Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection. Aging cell 2013 Jun 3. (Epub ahead of print): --. 2013

Qu C, Puttonen KA, Lindeberg H, Ruponen M, Hovatta O, Koistinaho J, Lammi MJ. 2013. Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 2013 Jun 2;45(8): 1802-1812. 2013

Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production. HUMAN MOLECULAR GENETICS 2012 Nov 1. [Epub ahead of print]: - -. 2012

Koistinaho J, Goldsteins G.. 2012. Mutant Cu/Zn-Superoxide Dismutase Induced Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis: Maurer, Martin H., Amyotrophic Lateral Sclerosis. 249-264. 2012

Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J. 2012. Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo. World Journal of Neuroscience 2/2012: 57-67. 2012

Kärkkäinen V, Magga J, Koistinaho J, Malm T. 2012. Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells. CURRENT ALZHEIMER RESEARCH 2012 Aug 30. [Epub ahead of print]: --. 2012

Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. 2012. Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2012 May;16(5): 1060-73. 2012

Malm T, Magga J, Koistinaho J. 2012. Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance. Current Translational Geriatrics and Gerontology Reports - -: - -. 2012

Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2012 May 29;9:105: - -. 2012

Puttonen Katja A, Ruponen Marika, Kauppinen Riitta, Wojciechowski Sara, Hovatta Outi, Koistinaho Jari. 2012. Improved method of producing human neural progenitor cells of high purity and in large quantities from pluripotent stem cells for transplantation studies. Cell Transplantation 2013:22: 1753-1766. 2012

Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M. 2011. Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes. GLIA Nov;59(11): 1643-57. 2011

Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 84: 1-14. 2011

Koistinaho J, Malm T, Goldsteins G. 2011. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International Journal of Alzheimer's Disease 2011;2011:129753. Epub 2011 May 4: --. 2011

Naumenko N, Pollari E, Kurronen A, Giniatullina R, Shakirzyanova A, Magga J, Koistinaho J, Giniatullin R.. 2011. Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS Frontiers in Cellular Neuroscience 2011; 5: 26: --. 2011

Malm T, Koistinaho J, Kanninen K. 2011. Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications International Journal of Alzheimer's Disease 2011;2011:517160. Epub 2011 Oct 30: --. 2011

Kanninen K, White AR, Koistinaho J, Malm T. 2011. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway International Journal of Alzheimer's Disease 2011;2011:985085. Epub 2011 May 2: --. 2011

Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J. 2010. The role and therapeutic potential of monocytic cells in Alzheimer's disease GLIA 58 8: 889-900. 2010

Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 7: 90. 2010

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008

Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. 2008. Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS LETTERS 582: 2397-2401. 2008

Malm TM, Magga J, Ful Kuh G, Vatanen T, Koistinaho M, Koistinaho J. 2008. Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of alzheimer¿s disease GLIA 56: 1767-1779. 2008

Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M. 2008. Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease GLIA 56: 154-163. 2008

Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. 2008. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 103: e1-e9. 2008

Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Jaronen M, Arens E, Åkerman K, Chan PH, Koistinaho J. 2008. Deleterious role of superoxide dismutase in the mitochondrial intermembrane space. JOURNAL OF BIOLOGICAL CHEMISTRY 283 13: 8446-8452. 2008

Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U. 2008. Improving outcome after stroke: Overcoming the translational roadblock. CEREBROVASCULAR DISEASES 25: 268-278. 2008

Ahtoniemi T, Jaronen M, Keksa-Goldsteine V, Goldsteins G, Koistinaho J. 2008. Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 32: 479-485. 2008

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. JOURNAL OF NEUROCHEMISTRY 105: 584-594. 2008

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis MOLECULAR PHARMACOLOGY 71: 30-37. 2007

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007

Jacobo-Herrera NJ, Vartiainen N, Bremner P, Gibbons S, Koistinaho J, Heinrich M. 2006. F-kappaB modulators from Valeriana officinalis. PHYTOTHERAPY RESEARCH 20 10: 917-919. 2006

Korolainen MA, Goldsteins G, Nyman TA, Alafuzoff I, Koistinaho J, Pirttilä T, Korolainen MA, Pirttilä T. 2006. Oxidative modification of proteins in the frontal cortex of Alzheimer¿s disease brain NEUROBIOLOGY OF AGING 27: 42-53. 2006

Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103 23: 8852-8857. 2006

Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron J-C, Hossmann K, Engelhardt B, Ferro J, McCulloch J, Kaste M, Endres M, Koistinaho J, Planas A, Vivien D, Dijkhuizen R, Czlonkowska A, Hagen A, Evan A, De Libero G, Nagy Z, Rastenyte D. 2006. Stroke research priorities for the next decade - A representative view of the European scientific community CEREBROVASCULAR DISEASES 22: 765-782. 2006

Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006

Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia. FREE RADICAL BIOLOGY & MEDICINE 40 10: 1776-1784. 2006

Yrjänheikki J, Koistinaho J, Kettunen M, Kauppinen RA, Appel K, Hüll M, Fiebich BL. 2005. Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. BRAIN RESEARCH 1052 2: 174-179. 2005

Koistinaho M, Koistinaho J. 2005. Interactions between Alzheimer's disease and cerebral ischemia - focus on inflammation. BRAIN RESEARCH REVIEWS 48: 240-250. 2005

Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J. 2005. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 18 1: 134-142. 2005

Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25: 460-467. 2005

Bhowmik A, Oksala N, Roivainen R, Koistinaho J, Paavonen T, Halme T, Mustonen H, Paimela H. 2004. Regulation of restitution after superficial injury in isolated guinea pig gastric mucosa APMIS: ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA 112 4-5: 225-232. 2004

Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. The microglia-activating potential of thrombin. JOURNAL OF BIOLOGICAL CHEMISTRY 279 50: 51880-51887. 2004

Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach. NEUROSCIENCE LETTERS 367 2: 235-240. 2004

Koistinaho J, Yrjänheikki J, Kauppinen T, Koistinaho M. 2004. Tetracycline derivates as anti-inflammatory agents and potential agents in stroke treatment: Dirnagl U, Elger B, Neuroinflammation in Stroke. Workshop 47.Springer. 101-115. 2004

Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, Karjalainen-Lindsberg M-L, Weih F, Frank N, Schwaninger M, Koistinaho J. 2004. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. STROKE 35 4: 987-991. 2004

Nurmi A, Vartiainen N, Pihlaja R, Goldsteins G, Yrjänheikki J, Koistinaho J. 2004. Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window. JOURNAL OF NEUROCHEMISTRY 91 3: 755-765. 2004

Koponen S, Kurkinen K, Åkerman KEO, Mochly-Rosen D, Chan PH, Koistinaho J. 2003. Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta. JOURNAL OF NEUROCHEMISTRY 86: 442-450. 2003

Vartiainen N, Goldsteins G, Keksa-Goldsteine V, Chan PH, Koistinaho J. 2003. Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage. STROKE 34 3: 752-757. 2003

Korolainen MA, Goldsteins G, Alafuzoff I, Koistinaho J, Pirttilä T. 2002. Proteomic analysis of protein in Alzheimer's disease brain. ELECTROPHORESIS 23 19: 3428-3433. 2002

Vartiainen N, Keksa-Goldsteine V, Goldsteins G, Koistinaho J. 2002. Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. JOURNAL OF NEUROCHEMISTRY 82: 329-335. 2002

Tikka TM, Vartiainen NE, Goldsteins G, Oja SS, Andersen PM, Marklund SL, Koistinaho J. 2002. Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease. BRAIN 125: 722-731. 2002

Koistinaho J. 2002. Neuroprotection with tetracyclines in brain ischemia models: Chan PH, Cerebrovascular Disease. 22nd Princeton Conference.Cambridge University Press. 135-141. 2002

Koistinaho M, Koistinaho J. 2002. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. GLIA 40: 175-183. 2002

Koistinaho M, Kettunen MI, Holtzman DM, Kauppinen RA, Higgins LS, Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility STROKE 33: 1905-1910. 2002

Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J. 2002. Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99 3: 1610-1615. 2002

Kaasinen SK, Goldsteins G, Alhonen L, Jänne J, Koistinaho J. 2002. Induction and activation of protein kinase Cdelta in hippocampus and cortex after kainic acid treatment EXPERIMENTAL NEUROLOGY 176: 203-212. 2002

Vartiainen N, Huang C-Y, Salminen A, Goldsteins G, Chan PH, Koistinaho J. 2001. Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition JOURNAL OF NEUROCHEMISTRY 76 2: 480-489. 2001

Tikka TM, Koistinaho JE. 2001. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. JOURNAL OF IMMUNOLOGY (BALTIMORE) 166: 7527-7533. 2001

Tikka T, Usenius T, Tenhunen M, Keinänen R, Koistinaho J. 2001. Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation. JOURNAL OF NEUROCHEMISTRY 78: 1409-1414. 2001

Tikka T, Fiebich BL, Goldsteins G, Keinänen R, Koistinaho J. 2001. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia JOURNAL OF NEUROSCIENCE 21 8: 2580-2588. 2001

Kurkinen K, Keinänen R, Li W, Koistinaho J. 2001. Preconditioning with spreading depression activates specifically protein kinase Cdelta. NEUROREPORT 12 2: 269-273. 2001

Puurunen K, Koistinaho J, Sirviö J, Jolkkonen J, Sivenius J. 2001. Enriched-environment housing increases neuronal Fos-staining in the dentate gyrus after a water maze spatial learning task. NEUROPHARMACOLOGY 40 3: 440-447. 2001

Koistinaho M, Ort M, Cimadevilla JM, Vondrous R, Cordell B, Koistinaho J, Bures J, Higgins LS. 2001. Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98 25: 14675-14680. 2001

Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, Swanson RA. 2001. Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. JOURNAL OF NEUROCHEMISTRY 77: 1601 - 1610. 2001

11th Nordic Meeting on Cerebrovascular Diseases and 2nd Biennial Symposium on Ischaemic Stroke. Jolkkonen J, Kauppinen R, Koistinaho J. 2001 2001

Kurkinen K, Busto R, Goldsteins G, Koistinaho J, Perez-Pinzon MA. 2001. Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning. NEUROCHEMICAL RESEARCH 26 10: 1139-1144. 2001

Kurkinen KMA, Keinänen RA, Karhu R, Koistinaho J. 2000. Genomic structure and chromosomal localization of the rat protein kinase Cdelta-gene. GENE 242: 115-123. 2000

Yrjänheikki J, Tikka T, Goldsteins G, Koistinaho M, Keinänen R, Chan PH, Koistinaho J. 2000. Inhibition of inflammation and neuroprotection by tetracyclines. In: Krieglstein J, Klumpp S (ed.) , Pharmacology of Cerebral Ischemia 2000.Medpharm Scientific Publishers. ss. 267-274. 2000

Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 16: 87-96. 2000

Yrjänheikki J, Koistinaho J, Copin J-C, de Crespigny A, Moseley ME, Chan PH. 2000. Spreading depression-induced expression of c-fos and cyclooxygenase-2 in transgenic mice that overexpress human copper/zinc-superoxide dismutase. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 17 8: 713-718. 2000

Koponen S, Goldsteins G, Keinänen R, Koistinaho J. 2000. Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 93-102. 2000

Koistinaho J, Chan PH. 2000. Spreading depression-induced cyclooxygenase-2 expression in the cortex NEUROCHEMICAL RESEARCH 25 5: 645-651. 2000

Kaasinen K, Koistinaho J, Alhonen L, Jänne J. 2000. Overexpression of spermidine/spermine N1-acetyltranferase in transgenic mice protects the animals from kainate-induced toxicity. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 12: 540-548. 2000

Diez M, Koistinaho J, Kahn K, Games D, Hökfelt T. 2000. Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein - initial observations. NEUROSCIENCE 100 2: 259-286. 2000

Hökfelt T, Broberger C, Diez M, Xu Z-Q, Shi T, Kopp J, Zhang X, Holmberg K, Landry M, Koistinaho J. 1999. Galanin and NPY, two peptides with multiple putative roles in the nervous system HORMONE AND METABOLIC RESEARCH 31: 330-334. 1999

Jolkkonen J, Puurunen K, Koistinaho J, Kauppinen R, Haapalinna A, Nieminen L, Sivenius J. 1999. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. EUROPEAN JOURNAL OF PHARMACOLOGY 372: 31-36. 1999

Keinänen R, Vartiainen N, Koistinaho J. 1999. Molecular cloning and characterization of the rat inducible nitric oxide synthase (iNOS) gene. GENE 234: 297-305. 1999

Koistinaho J, Koponen S, Chan PH. 1999. Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids. STROKE 30: 1900-1906. 1999

Koistinaho J, Pasonen S, Yrjänheikki J, Chan PH. 1999. Spreading depression-induced gene expression is regulated by plasma glucose. STROKE 30: 114-119. 1999

Koponen S, Keinänen R, Roivainen R, Hirvonen T, Närhi M, Chan PH, Koistinaho J. 1999. Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids. NEUROSCIENCE 93 3: 985-993. 1999

Rodriguez-Puertas R, Herrera-Marschitz M, Koistinaho J, Hökfelt T. 1999. Dopamine D1 receptor modulation of glutamate receptor messenger RNA levels in the neocortex and neostriatum of unilaterally 6-hydroxydopamine-lesioned rats. NEUROSCIENCE 89 3: 781-797. 1999

Vartiainen N, Tikka T, Keinänen R, Chan PH, Koistinaho J. 1999. Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons. NEUROSCIENCE 93 3: 1123-1133. 1999

Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH, Koistinaho J. 1999. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96 23: 13496-13500. 1999

Yrjänheikki J, Keinänen R, Pellikka M, Hökfelt T, Koistinaho J. 1998. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95: 15769-15774. 1998

Hökfelt T, Broberger C, Zhang X, Diez M, Kopp J, Xu Z-Q, Landry M, Bao L, Schalling M, Koistinaho J, DeArmond SJ, Prusiner S, Gong J, Walsh JH. 1998. Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. BRAIN RESEARCH REVIEWS 26: 154-166. 1998

Miettinen S, Fusco FR, Yrjänheikki J, Keinänen R, Hirvonen T, Roivainen R, Närhi M, Hökfelt T, Koistinaho J. 1997. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94: 6500-6505. 1997

Wittner M, Sivenius J, Koistinaho J. 1997. Alfa2-Adrenoreceptor agonist, dexmedetomidine, alters acute gene expression after global ischemia in gerbils NEUROSCIENCE LETTERS 232: 75-78. 1997

Diez M, Koistinaho J, Dearmond SJ, Groth D, Prusiner SB, Hökfelt T. 1997. Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94: 13267-13272. 1997

Toropainen M, Näkki R, Honkanen A, Rosenberg PH, Laurie DJ, Pelto-Huikko M, Koistinaho J, Eriksson CJP, Korpi ER. 1997. Behavioral sensitivity and ethanol potentiation of the N-methyl-D-aspartate receptor antagonist MK-801 in a rat line selected for high ethanol sensitivity. ALCOHOLISM, CLINICAL AND EXPERIMENTAL RESEARCH 21 4: 666-671. 1997

Saransaari P, Oja SS, Borkowska HD, Koistinaho J, Hilgier W, Albrecht J. 1997. Effects of thioacetamide-induced hepatic failure on the N-methyl-D-aspartate receptor complex in the rat cerebral cortex, striatum, and hippocampus. MOLECULAR AND CHEMICAL NEUROPATHOLOGY 32: 179-193. 1997

Puurunen K, Sirviö J, Koistinaho J, Miettinen R, Haapalinna A, Riekkinen P Sr, Sivenius J. 1997. Studies on the influence of enriched-environment housing combined with systemic administration of an alpha2-adrenergic antagonist on spatial learning and hyperactivity after global ischemia in rats STROKE 28 3: 623-631. 1997

Wittner M, Sivenius J, Koistinaho J. 1997. Alfa2-adrenoreceptor agonist, dexmedetomidine, alters acute gene expression after global ischemia in gebrils. NEUROSCIENCE LETTERS 232: 75-78. 1997

Lahtinen H, Koistinaho J, Kauppinen R, Haapalinna A, Keinänen R, Sivenius J. 1997. Selegiline treatment after transient global ischemia in gerbils enhances the survival of Ca1 pyramidal cells in the hippocampus. BRAIN RESEARCH 757: 260-267. 1997

Kurkinen KMA, Koistinaho J, Laitinen JT. 1997. [gamma-35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum. BRAIN RESEARCH 769: 21-28. 1997

Koistinaho J, Hökfelt T. 1997. Altered gene expression in brain ischemia. NEUROREPORT 8 2: i-viii. 1997

Keinänen R, Miettinen S, Yrjänheikki J, Koistinaho J. 1997. Induction of ornithine decarboxylase mRNA in transient focal cerebral ischemia in the rat. NEUROSCIENCE LETTERS 239: 69-72. 1997

Hiltunen MO, Koistinaho J, Alhonen L, Myöhänen S, Marin S, Kosma V-M, Pääkkönen M, Jänne J. 1997. Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer BRITISH JOURNAL OF CANCER 76 9: 1124-1130. 1997

Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen S, Pääkkönen M, Marin S, Kosma V-M, Jänne J. 1997. Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. INTERNATIONAL JOURNAL OF CANCER 70: 644-648. 1997

Diez M, Koistinaho J, DeArmond SJ, Camerino AP, Groth D, Caytano JC, Prusiner SB, Hökfelt T. 1996. Aberrant induction of neuropeptide Y mRNA in hippocampal CA3 pyramidal neurones in scrapie-infected mice. NEUROREPORT 7: 1887-1892. 1996

Koistinaho J, Miettinen S, Keinänen R, Vartiainen N, Roivainen R, Laitinen JT. 1996. Long-term induction of haem oxygenase-1 (HSP-32) in astrocytes and microglia following transient focal brain ischaemia in the rat EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 8: 2265-2272. 1996

Koistinaho J, Pyykönen I, Keinänen R, Hökfelt T. 1996. Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. NEUROREPORT 7: 2727-2731. 1996

Miettinen S, Roivainen R, Keinänen R, Hökfelt T, Koistinaho J. 1996. Specific induction of protein kinase Cdelta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801 JOURNAL OF NEUROSCIENCE 16 19: 6236-6245. 1996

Roivainen R, Koistinaho J. 1996. Histochemical detection of age- and injury-related changes in signal transduction in the superior cervical ganglion. MICROSCOPY RESEARCH AND TECHNIQUE 35: 20-31. 1996

The First Annual A.I.Virtanen Institute Post-Graduate Mini-Symposium 1996. 1st March, 1996, Kuopio, Finland. Abstracts. Alhonen L, Koistinaho J, Kauppinen R. 1996 1996

Usenius T, Tenhunen M, Koistinaho J. 1996. Ionizing radiation induces expression of immediate early genes in the rat brain. NEUROREPORT 7: 2559-2563. 1996

Vartiainen N, Pyykönen I, Hökfelt T, Koistinaho J. 1996. Induction of thymosin beta4 mRNA following focal brain ischemia. NEUROREPORT 7: 1613-1616. 1996

Koistinaho J, Sagar SM. 1995. NADPH-diaphorase-reactive neurones in the retina. PROGRESS IN RETINAL AND EYE RESEARCH 15 1: 69-87. 1995

Lukkarinen J, Kauppinen RA, Koistinaho J, Halmekytö M, Alhonen L, Jänne J. 1995. Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 7: 1840-1849. 1995

Contact info

Organization

Email

Phone

Publications