Metagenomic and metabolomics analysis of microbiota intervention therapies of non-alcoholic fatty liver disease in vivo models in the BestTreat program
Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences
Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Non-alcoholic Fatty Liver Disease (BestTreat) is a program funded by the European Commission which aims to develop novel diagnostic and therapeutic methods for NAFLD based on gut microbiota.
Aim of my study is to investigate the association between the NAFLD progression and alterations in gut microbiota and metabolites. Correlations between metagenomics, metabolomics, imaging data and other prognostic biomarkers for NAFLD are investigated to elucidate the mechanisms behind metabolic benefits conveyed by specific functional strains of the gut microbiota to the pathophysiology and pathogenesis of NAFLD. Metagenomic and metabolomic signatures of specific gut microbiota and metabolites will be used to develop novel microbiome-based disease prognostic biomarkers and therapeutic interventions for NAFLD.
Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progressionIannone, V; Lok, J; Babu, AF; Gómez-Gallego, C; Willman, RM; Koistinen, VM; Klåvus, A; Kettunen, MI; Kårlund, A; Schwab, U; Hanhineva, K; Kolehmainen, M; Nezami, H El. 2023. Journal of nutritional biochemistry. 115:
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse modelIannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka. 2023. Molecular metabolism. 78:
Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-AnalysisBabu, Ambrin Farizah; Csader, Susanne; Lok, Johnson; Gómez-Gallego, Carlos; Hanhineva, Kati; El-Nezami, Hani; Schwab, Ursula. 2021. Nutrients. 13: 3135
The Food Environments of Fruit and Vegetable Consumption in East and Southeast Asia: A Systematic ReviewCheung, Jason Tsz Him; Lok, Johnson; Gietel-Basten, Stuart; Koh, Keumseok. 2021. Nutrients. 13: 148