Jukka Mönkkönen
Rector
PhD (Pharm.)
Professor in Biopharmaceutics
University of Eastern Finland, leadership
jukka.monkkonen@uef.fi | +358 40 728 8057
0407288057
040 7288057
040 728 8057
+358 40 728 8057
+35840 728 8057
040 7288 057
+358 40 7288 057
+35840 7288 057
+358 40 7288057
+35840 7288057
+358407288057
040 7288057
040 728 8057
+358 40 728 8057
+35840 728 8057
040 7288 057
+358 40 7288 057
+35840 7288 057
+358 40 7288057
+35840 7288057
+358407288057
Contact via:
Excecutive Coordinator Henriikka Hätinen,
henriikka.hatinen@uef.fi, tel. +358 50 345 9689 .
Publications
140 items-
Liposome-encapsulated zoledronate increases inflammatory macrophage population in TNBC tumours
Petruk, Nataliia; Sousa, Sofia; Croset, Martine; Polari, Lauri; Zlatev, Hristo; Selander, Katri; Mönkkönen, Jukka; Clézardin, Philippe; Määttä, Jorma. 2023. European journal of pharmaceutical sciences. 190: -
Molecular Mechanisms of Actions of Bisphosphonates and New Insights Into Their Effects Outside the Skeleton
Rogers, Michael J; Mönkkönen, Jukka; Munoz, Marcia A. 2020. Bone. 139: 115493 -
Keuhkot lääkeaineen antoreittinä
Ruponen, Marika; Pajula, Katja; Mönkkönen, Jukka; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 121-134. Farmasian opiskelijayhdidtys Fortis ry -
Lääkemuodot ja antoreitit
Mönkkönen, Jukka; Ruponen, Marika. Teoksessa: Koulu, Markku; Mervaala, Eero(toim.) , 2018. Farmakologia ja toksikologia. s. 127-135. Kustannusosakeyhtiö Medicina -
Nenä lääkeaineen antoreittinä
Ruponen, Marika; Mönkkönen, Jukka; Pajula, Katja. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 113-120. Farmasian opiskelijayhdidtys Fortis ry -
Peräsuoli lääkeaineen antoreittinä
Ruponen, Marika; Mönkkönen, Jukka; Pajula, Katja. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 107-112. Farmasian opiskelijayhdidtys Fortis ry -
Avoin tiede tulee
Mönkkönen Jukka. 2017. Dosis. 33: 90-91 -
Avoin tiede vaikuttaa laajemmin yhteiskuntaan
Mönkkönen Jukka, Saarti Jarmo. 2017. Savon Sanomat. : B4 -
Avoin, vaikuttava tiede
Mönkkönen Jukka, Saarti Jarmo. 2017. Karjalainen. : B7 -
Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI
Ishchenko Y, Shakirzyanova A, Giniatullina R, Skorinkin A, Bart G, Turhanen P, Määttä JA, Mönkkönen J, Giniatullin R. 2017. Journal of pharmacology and experimental therapeutics. 361: 472-481 -
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells
Zlatev Hristo P, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma A. 2016. European journal of pharmaceutical sciences. 86: 58-66 -
Human breast cancer cells educate macrophages toward the M2 activation status
Sousa Sofia, Brion Régis, Lintunen Minnamaija, Kronqvist Pauliina, Sandholm Jouko, Mönkkönen Jukka, Kellokumpu-Lehtinen Pirkko-Liisa, Lauttia Susanna, Tynninen Olli, Joensuu Heikki, Heymann Dominique, Määttä Jorma A. 2015. Breast cancer research. 17:101: 1-14 -
Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells
Sousa Sofia, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma. 2015. Bmc cancer. 15: 1-11 -
Bisphosphonate research
Määttä Jorma, Mönkkönen Jukka, Auriola Seppo, Sousa Sofia, Zlatev Hristo, Arkko Satu. 2014. Dosis. 30: 199 -
International Evaluation of Research Activities at the University of Eastern Finland 2010-2012
Liikanen, Anu; Tirronen, Jarkko; Keinänen, Riitta; Sagulin, Merja; Simonaho, Simo-Pekka; Taskinen Helena; Mönkkönen, Jukka. 2014. Publications of the University of Eastern Finland. General series. . -
Oxidative stress plays an important role in zoledronic acid-induced autophagy
Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. 2014. Physiological research. 63: S601-S612 -
Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vgamma9Vdelta2 T cell cytotoxicity in PC-3 prostate cancer cells
Arkko Satu, Zlatev Hristo P, Mönkkönen Hannu, Räikkönen Johanna, Benzaïd I, Clézardin P, Mönkkönen Jukka, Määttä Jorma A. 2014. Cancer letters. 357 (2015): 279-285 -
Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ 2Vδ 2 T cells
Wang Hong, Henry Olivier, Distefano Mark D, Wang Yyen-Chih, Räikkönen Johanna, Mönkkönen Jukka, Tanaka Yoshimasa, Morita Craig T. 2013. Journal of immunology. 191: 1029-1042 -
ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells
Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. International journal of pharmaceutics. 437: 29-41 -
Apoptosis-induced anticancer effect of transferrinconjugated solid lipid nanoparticles of curcumin
Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. Cancer nanotechnology. 3: 65-81 -
Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel
Chaudhari Kiran R, Kumar Abhinesh, Khandelwal Vinoth KM, Ukawala Mukesh, Manjappa Arehalli S, Mishra Anil K, Monkkonen Jukka, Murthy Rayasa SR. 2012. Journal of controlled release. 158: 470-478 -
Effect of Free and Liposome Encapsulated Bisphosphonates on J774 Macrophages
Sousa Sofia, Mönkkönen Jukka, Määttä Jorma. 2012. Dosis -
Farmasian tieteen tila
Mönkkönen Jukka. 2012. Dosis. 28: 275 -
In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ 9Vδ 2 T-cell antitumor cytotoxicity through ICAM-1 engagement
Benzaïd Ismahéne, Mönkkönen Hannu, Bonnelye Edith, Mönkkönen Jukka, Clézardin Philippe. 2012. Clinical cancer research. 18: 6249-6259 -
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γ δ T-cell subset
Harly Christelle, Guillaume Yves, Nedellec Steven, Peigné Cassie-Marie, Mönkkönen Hannu, Mönkkönen Jukka, Li Jianqiang, Kuball Jürgen, Adams Erin J, Netzer Sonia, Déchanet-Merville Julie, Léger Alexandra, Herrmann Thomas, Breathnach Richard, Olive Daniel, Bonneville Marc, Scotet Emmanuel. 2012. Blood. 120: 2269-2279 -
Lääkemuodot ja antoreitit
Mönkkönen Jukka. Teoksessa: Koulu Markku, Mervaala Eero, Tuomisto Jouko (toim.)(toim.) , 2012. Farmakologia ja toksikologia, 8. uudistettu painos. s. 107-114. Medicina -
Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier
Chaudhari Kiran R, Ukawala Mukesh, Manjappa Arehalli S, Kumar Abhinesh, Mundada Piyush K, Mishra Anil K, Mathur Rashi, Mönkkönen Jukka, Murthy Rayasa SR. 2012. Pharmaceutical research. 29: 53-68 -
Studying Intracellular Kinetics of Free and Liposome Encapsulated Doxorubicin by Quantitative HPLC-MS/MC
Soininen Suvi K, Mönkkönen Jukka, Ruponen Marika. 2012. Dosis -
Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes
Soininen Suvi K, Lehtolainen-Dalkilic Pauliina, Karppinen Tanja, Puustinen Tiina, Dragneva Galina, Kaikkonen Minna U, Jauhiainen Marjo, Allart Brigitte, Selwood David L, Wirth Thomas, Lesch Hanna P, Määttä Ann-Marie, Mönkkönen Jukka, Ylä-Herttuala Seppo, Ruponen Marika. 2012. European journal of pharmaceutical sciences. 47: 848-856 -
Targeting efficiency and biodistribution of zoledronate conjugated docetaxel loaded pegylated PBCA nanoparticles for bone metastasis
Chaudhari Kiran R, Kumar Abhinesh, Khandelwal Vinoth KM, Mishra Anil K, Monkkonen Jukka, Murthy Rayasa S. 2012. Advanced functional materials. 22: 4101-4114 -
siRNA transfection with calcium phosphate nanoparticles stabilized with PEGylated chelators
Giger Elisabeth V, Castagner Bastien, Räikkönen Johanna, Mönkkönen Jukka, Leroux Jean-Christophe. 2012. Advanced healthcare materials. 2013:2: 134-144 -
Biochemical and molecular mechanisms of action of bisphosphonates
Rogers Michael J, Crockett Julie C, Coxon Fraser P, Mönkkönen Jukka. 2011. Bone. 49: 34-41 -
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Räikkönen Johanna, Taskinen Markku, Dunford James E, Mönkkönen Hannu, Auriola Seppo, Mönkkönen Jukka. 2011. Biochemical and biophysical research communications. 407: 663-667 -
High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity In Vivo
Benzaïd Ismahène, Mönkkönen Hannu, Stresing Verena, Bonnelye Edith, Green Jonathan, Mönkkönen Jukka, Touraine Jean-Lois, Clézardin Philippe. 2011. Cancer research. 71: 4562-4572 -
Indirect stimulation of human Vγ 2Vδ 2 T cells through alterations in isoprenoid metabolism
Wang Hong, Sarikonda Ghanashyam, Puan Kia-Joo, Tanaka Yoshimasa, Feng Ju, Giner José-Luis, Cao Rong, Mönkkönen Jukka, Oldfield Eric, Morita Craig T. 2011. Journal of immunology. 187: 5099-5113 -
Targeting of Biotinylated Doxorubicin Derivative and Lipo¬somes to Avidin Fusion Protein Expressing Tumor Cells and Tissue
Soininen Karoliina, Lehtolainen-Dalkilic Pauliina, Karppinen Tanja, Dragneva Galina, Kaikkonen Minna-Unelma, Jauhiainen Marjo, Wirth Thomas, Lesch Hanna, Määttä Ann-Marie, Mönkkönen Jukka, Ruponen Marika. 2011. - -
Activation of γ δ T cells by bisphosphonates
Thompson K, Roelofs AJ, Jauhiainen M, Mönkkönen H, Mönkkönen J & Rogers MJ. 2010. Advances in experimental medicine and biology. 658: 11-20 -
Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients
Cabillic F, Toutirais O, Lavoué V, de La Pintiére CT, Daniel P, Rioux-Leclere N, Turlin B, Mönkkönen H, Mönkkönen J, Boudjema K et al. 2010. Cancer immunology immunotherapy. 59: 1611-1619 -
ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxity using in vitro cell culture model
Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. Molecular pharmaceutics. 7: 815-825 -
Assessment of bisphosphonate activity in vitro
Mitrofan LM, Auriola S, Mönkkönen H & Mönkkönen J. 2010. Current pharmaceutical design. 16: 2970-2980 -
Comparison of in vitro cell models in predicting in vivo brain entry of drugs
Hakkarainen JJ, Jalkanen AJ, Kääriäinen TM, Keski-Rahkonen P, Venäläinen T, Hokkanen J, Mönkkönen J, Suhonen M & Forsberg MM. 2010. International journal of pharmaceutics. 402: 27-36 -
Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments
Heikkinen AT, Mönkkönen J & Korjamo T. 2010. European journal of pharmaceutical sciences. 40: 132 - 142 -
Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments
Heikkinen AT, Korjamo T, Lepikkö V & Mönkkönen J. 2010. Molecular pharmaceutics. 7: 605 - 617 -
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells
Mitrofan LM, Castells FB, Pelkonen J & Mönkkönen J. 2010. Journal of biological chemistry. 285: 1967 - 1979 -
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells
Räikkönen J, Mönkkönen H, Auriola S & Mönkkönen J. 2010. Biochemical pharmacology. 79: 777 - 783 -
Modelling of drug disposition kinetics in in vitro intestinal absorption cell models
Heikkinen AT, Korjamo T & Mönkkönen J. 2010. Basic and clinical pharmacology and toxicology. 106: 180 - 188 -
Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis
Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. International journal of pharmaceutics. 398: 190-203 -
Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process
Moriceau Gatien, Ory Benjamin, Mitrofan Laura, Riganti Chiara, Blanchard Frédéric, Brion Régis, Charrier Céline, Battaglia Séverine, Pilet Paul, Denis Marc G, Shultz Leonard D, Mönkkönen Jukka, Rédini Francoise, Heymann Dominique. 2010. Cancer research. 70: 10329-10339 -
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry
Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. 2009. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 877: 2967-2975 -
Analysis of unstirred water layer in in vitro permeability experiments
Korjamo T, Heikkinen AT, Mönkkönen J. 2009. Journal of pharmaceutical sciences. 98: 4469-4479 -
Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats
Miettinen SSA, Jaatinen J, Pelttari A, Lappalainen R, Mönkkönen J, Venesmaa PK, Kröger HPJ. 2009. Journal of orthopaedic science. 14: 431-436 -
In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption
del Amo EM, Heikkinen AT, Mönkkönen J. 2009. European journal of pharmaceutical sciences. 36: 200-211 -
Kinetics of cellular retention during Caco-2 permeation experiments: Role of lysosomal sequestration and impact on permeability estimates
Heikkinen A, Mönkkönen J, Korjamo T. 2009. Journal of pharmacology and experimental therapeutics. 328: 882-892 -
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP
Roelofs AJ, Jauhiainen M, Mönkkönen H, Rogers MJ, Mönkkönen J, Thompson K. 2009. British journal of haematology. 144: 245-250 -
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro
Mitrofan LM, Pelkonen J, Mönkkönen J. 2009. Bone. 45: 1153-1160 -
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J. 2009. British journal of pharmacology. 157: 427-435 -
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth
Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J. 2008. Anti-cancer drugs. 19: 391-399 -
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols F, Müllertz A, Mönkkönen J, O¿Driscoll C, Oppers-Tiemissen HM, Ragnarsson EGE, Rooseboom M, Ungell AL. 2008. European journal of pharmaceutical sciences. 35: 383-396 -
Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells
Korjamo T, Holappa J, Taimisto S, Savolainen J, Järvinen T, Mönkkönen J. 2008. European journal of pharmaceutical sciences. 35: 226-234 -
Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics
Heikkinen AT, Mönkkönen J. 2008. International journal of pharmaceutics. 346: 169-172 -
The asymmetry of the unstirred water layer in permeability experiments
Korjamo T, Heikkinen AT, Waltari P, Mönkkönen J. 2008. Pharmaceutical research. 25: 1714-1722 -
Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates
Korjamo T, Kemiläinen H, Heikkinen AT, Mönkkönen J. 2007. Drug metabolism and disposition. 35: 1574-1579 -
Lääkemuodot ja antoreitit
Mönkkönen J. Teoksessa: Koulu M, Tuomisto J(toim.) , 2007. Farmakologia ja toksikologia, 7. uudistettu painos. s. 105-112. Gummerus Kirjapaino Oy, Jyväskylä -
Zoledronic acid-induced IPP/ApppI production in vivo
Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. 2007. Life sciences. 81: 1066-1070 -
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. British journal of pharmacology. 147: 437-445 -
Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis
Gomez-Barrena E, Lindroos L, Ceponis A, López-Franco M, Sanchez-Pernaute O, Mönkkönen J, Salo J, Herrero-Beaumont G, Konttinen Y. 2006. Clinical and experimental rheumatology. 24: 622-628 -
Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
Palmgrén JJ, Mönkkönen J, Korjamo T, Hassinen A, Auriola S. 2006. European journal of pharmaceutics and biopharmaceutics. 64: 369-378 -
Measurement of oedema in irritant-exposed skin by a dielectric technique
Miettinen M, Mönkkönen J, Lahtinen M-R, Nuutinen J, Lahtinen T. 2006. Skin research and technology. 12: 235-240 -
Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors
Korjamo T, Mönkkönen J, Uusitalo J, Turpeinen M, Pelkonen O, Honkakoski P. 2006. Pharmaceutical research. 23: 1991-2001 -
Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines
Korjamo T, Honkakoski P, Toppinen M-R, Niva S, Reinisalo M, Palmgrén JJ, Mönkkönen J. 2005. European journal of pharmaceutical sciences. 26: 266-279 -
In vitro comparison os clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblats
Kellinsalmi M, Mönkkönen H, Mönkkönen J, Leskelä H-V, Parikka V, Hämäläinen M, Lehenkari P. 2005. Basic and clinical pharmacology and toxicology. 97: 382-391 -
Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
Palmgrén JJ, Töyräs A, Mauriala T, Mönkkönen J, Auriola S. 2005. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 821: 144-152 -
Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC
Palmgrén J, Mönkkönen J, Jukkola E, Niva S, Auriola S. 2004. European journal of pharmaceutics and biopharmaceutics. 57: 319-328 -
Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer
Alanen E, Nuutinen J, Nicklén K, Lahtinen T, Mönkkönen J. 2004. Skin research and technology. 10: 32-37 -
Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects
Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. European journal of pharmaceutical sciences. 19: 23-29 -
Effects of various absorption enhancers on transport of clodronate through Caco-2 cells
Raiman J, Törmälehto S, Yritys K, Junginger HE, Mönkkönen J. 2003. International journal of pharmaceutics. 261: 129-136 -
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro
Töyräs A, Ollikainen J, Taskinen M, Mönkkönen J. 2003. European journal of pharmaceutical sciences. 19: 223-230 -
Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates
Valleala H, Hanemaaijer R, Mandelin J, Salminen A, Teronen O, Mönkkönen J, Konttinen YT. 2003. Life sciences. 73: 2413-2420 -
Systemic depletion of macrophages by liposomal bisphosphonates reduces neointimal formation following balloon-injury in the rat carotid artery
Danenberg HD, Fishbein I, Epstein H, Waltenberger J, Moerman E, Mönkkönen J, Gao J, Gathi I, Golomb G. 2003. Journal of cardiovascular pharmacology. 42: 671-679 -
Alendronate disturbs vesicular trafficking in osteoclasts
Alakangas A, Selander K, Mulari M, Halleen J, Lehenkari P, Mönkkönen J, Salo J, Väänänen K. 2002. Calcified tissue international. 70: 40-47 -
Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
Lehenkari PP, Kellinsalmi M, Näpänkangas JP, Ylitalo KV, Mönkkönen J, Rogers MJ, Azhayev A, Väänänen HK, Hassinen IE. 2002. Molecular pharmacology. 62: 1255-1262 -
Liposomes - an invaluable tool in bisphoshonate research
Mönkkönen J. 2002. Cellular and molecular biology letters. 7: 241-242 -
Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits
Danenberg HD, Fishbein I, Gao J, Mönkkönen J, Reich R, Gati I, Moerman E, Golomb G. 2002. Circulation. 106: 599-605 -
Muutoshaasteita farmasiassa
Mönkkönen J. 2002. Dosis -
Suppression of viability and acetyl-LDL metabolism in Raw 264 macrophage-like and smooth muscle cells by bisphosphonates in vitro
Tuominen O-M, Hollmén M, Jaakkola O, Mönkkönen J, Ylitalo R. 2002. Methods and findings in experimental and clinical pharmacology. 24: 487-492 -
Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells
Raiman J, Niemi R, Vepsäläinen J, Yritys K, Järvinen T, Mönkkönen J. 2001. International journal of pharmaceutics. 213: 135-142 -
Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits
Ceponis A, Waris E, Mönkkönen J, Laasonen L, Hyttinen M, Solovieva SA, Hanemaaijer R, Bitsch A, Konttinen YT. 2001. Arthritis and rheumatism. 44: 1908-1916 -
Nitrogen-containing bisphosphonates induce apoptosis of caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity
Suri S, Mönkkönen J, Taskinen M, Pesonen J, Blank MA, Phipps RJ, Rogers MJ. 2001. Bone. 29: 336-343 -
The cellular uptake and metabolism of clodronate in RAW 264 macrophages
Mönkkönen H, Rogers MJ, Makkonen N, Niva S, Auriola S, Mönkkönen J. 2001. Pharmaceutical research. 18: 1550-1555 -
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate
Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. 2001. Arthritis and rheumatism. 44: 2201-2210 -
A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides
Jääskeläinen I, Peltola S, Honkakoski P, Mönkkönen J, Urtti A. 2000. European journal of pharmaceutical sciences. 10: 187-193 -
A peptide prodrug approach for improving bisphosphonate oral absorption
Ezra A, Hoffman A, Breuer E, Alferiev IS, Mönkkönen J, El Hanany-Rozen N, Weiss G, Stepensky D, Gati I, Cohen H, Törmälehto S, Amidon GL, Golomb G. 2000. Journal of medicinal chemistry. 43: 3641-3652 -
Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry
Mönkkönen H, Moilanen P, Mönkkönen J, Frith JC, Rogers MJ, Auriola S. 2000. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 738: 395-403 -
Cellular and molecular mechanisms of action of bisphosphonates
Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J, Frith JC. 2000. CANCER. SUPPLEMENT. 88: 2961-2978 -
Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro
Kirjavainen M, Urtti A, Mönkkönen J, Hirvonen J. 2000. European journal of pharmaceutical sciences. 10: 97-102 -
Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium
Alatalo SL, Halleen JM, Hentunen TA, Mönkkönen J, Väänänen HK. 2000. Clinical chemistry. 46: 1751-1754 -
The 11th International Social Pharmacy Workshop "Past and Future of Social Pharmacy. June 13 - 17, 2000 Kuopio, Finland
Mönkkönen J. 2000. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. . - -
Transdermal delivery of levosimendan
Valjakka-Koskela R, Hirvonen J, Mönkkönen J, Kiesvaara J, Antila S, Lehtonen L, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 343-350 -
Analysis of adenine nucleotide containing metabolite of clodronate using ion pair HPLC-ESI-MS
Auriola S, Monkkonen H, Frith J, Rogers M, Monkkonen J. Teoksessa: (toim.) , 1999. The 47th ASMS Conference on Mass Spectrometry And Allied Topics. Proceedings. [CD-ROM]. s. . -
Comparison of pharmacokinetics of clodronate after single and repeated doses
Ylitalo P, Holli K, Mönkkönen J, Elo HA, Juhakoski A, Liukko-Sipi S, Ylitalo R. 1999. International journal of clinical pharmacology and therapeutics. 37: 294-300 -
Conditioned medium of estrogen-treated osteoblasts inhibits osteoclast maturation and function in vitro
Qu Q, Härkönen PL, Mönkkönen J, Väänänen HK. 1999. Bone. 25: 211-215 -
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite
Makkonen N, Salminen A, Rogers MJ, Frith JC, Urtti A, Azhayeva E, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 8: 109-118 -
Effects of bisphosphonates on the inflammatory processes of activated macrophages
Mönkkönen J, Makkonen N, Rogers MJ, Frith JC, Auriola S. 1999. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS. 144-146: 321-324 -
Farmaseuttista kielenhuoltoa
Mönkkönen J. 1999. Dosis -
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
Benford HL, Frith JC, Auriola S, Mönkkönen J, Rogers MJ. 1999. Molecular pharmacology. 56: 131-140 -
Liposome-skin interactions and their effects on the skin permeation of drugs
Kirjavainen M, Urtti A, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 7: 279-286 -
Liposomit iholääkinnässä ja kosmetiikassa
Kirjavainen M, Mönkkönen J. 1999. Dosis. 15: 79-87 -
Molecular mechanisms of action of bisphosphonates
Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RGG. 1999. Bone. 24: 73S-79S -
Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers
Kirjavainen M, Mönkkönen J, Saukkosaari M, Valjakka-Koskela R, Kiesvaara J, Urtti A. 1999. Journal of controlled release. 58: 207-214 -
Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate
Cohen H, Alferiev IS, Mönkkönen J, Seibel MJ, Pinto T, Ezra A, Solomon V, Stepensky D, Sagi H, Ornoy A, Patlas N, Hägele G, Hoffman A, Breuer E, Golomb G. 1999. Pharmaceutical research. 16: 1399-1406 -
Toxicity of gamma irradiated liposomes. 1. In vitro interactions with blood components
Stensrud G, Passi S, Larsen T, Sandset PM, Smistad G, Mönkkönen J, Karlsen J. 1999. International journal of pharmaceutics. 178: 33-46 -
Toxicity of gamma irradiated liposomes. 2. In vitro effects on cells in culture
Stensrud G, Mönkkönen J, Karlsen J. 1999. International journal of pharmaceutics. 178: 47-53 -
Dosista tarvitaan
Mönkkönen J. 1998. Dosis -
Effects of liposome-encapsulated bisphosphonates on acetylated LDL metabolism, lipid accumulation and viability of phagocyting cells
Ylitalo R, Mönkkönen J, Ylä-Herttuala S. 1998. Life sciences. 62: 413-422 -
Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro
Mönkkönen J, Similä J, Rogers MJ. 1998. Life sciences. 62: 95-102 -
Enhancement of percutaneous absorption of naproxen by phospholipids
Valjakka-Koskela R, Kirjavainen M, Mönkkönen J, Urtti A, Kiesvaara J. 1998. International journal of pharmaceutics. 175: 225-230 -
Farmasia monitieteistyy
Mönkkönen J. 1998. Dosis -
Geenitekniikkaa tulee - oletko valmis
Mönkkönen J. 1998. Dosis -
Lipid fusion in oligonucleotide and gene delivery with cationic lipids
Mönkkönen J, Urtti A. 1998. Advanced drug delivery reviews. 34: 37-49 -
Physicochemical and morphological properties of complexes made of cationic liposomes and oligonucleotides
Jääskeläinen I, Sternberg B, Mönkkönen J, Urtti A. 1998. International journal of pharmaceutics. 167: 191-203 -
Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta,gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
Frith JC, Mönkkönen J, Blackburn GM, Russell RGG, Rogers MJ. 1997. Journal of bone and mineral research. 12: 1358-1367 -
Effects of phospholipids on the percutaneous penetration of sotalol and propranolol
Kirjavainen M, Urtti A, Mönkkönen J. Teoksessa: Couvreur P, Duchêne D, Green P, Junginger HE(toim.) , 1997. Transdermal Administration, a Case Study, Iontophoresis. European Symposium. s. 221-225. Éditions de Santé -
Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry
Auriola S, Frith J, Rogers MJ, Koivuniemi A, Mönkkönen J. 1997. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 704: 187-195 -
In vitro and in vivo effects of tetrakisphosphonates on bone resorption tumor osteolysis, ectopic calcification, and macrophages
Van Gelder JM, Breuer E, Schlossman A, Ornoy A, Mönkkönen J, Similä J, Klenner T, Stadler H, Krempien B, Patlas N, Golomb G. 1997. Journal of pharmaceutical sciences. 86: 283-289 -
Induced production of nitric oxide, tumor necrosis factor, and interleukin-6 in RAW 264.7 macrophages by streptomycetes from indoor air of moldy houses
Hirvonen M-R, Nevalainen A, Makkonen N, Mönkkönen J, Savolainen K. 1997. ARCHIVES OF ENVIRONMENTAL HEALTH. 52: 426-432 -
Inhibition of growth of dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake
Rogers MJ, Xiong X, Ji X, Mönkkönen J, Russell RGG, Williamson MP, Ebetino FH, Watts DJ. 1997. Pharmaceutical research. 14: 625-630 -
Streptomyces spores from mouldy houses induce nitric oxide, TNFAlfa and IL-6 secretion from RAW264.7 macrophage cell line without causing subsequent cell death
Hirvonen M-R, Nevalainen A, Makkonen N, Mönkkönen J, Savolainen K. 1997. Environmental toxicology and pharmacology. 3: 57-63 -
The pharmacology of bisphosphonates
Ylitalo P, Mönkkönen J. 1997. VOX. 18: 3-11 -
Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits
Ylitalo R, Mönkkönen J, Urtti A, Ylitalo P. 1996. Translational research. 127: 200-206 -
Calcitonin promotes osteoclast survival in vitro
Selander KS, Härkönen PL, Valve E, Mönkkönen J, Hannuniemi R, Väänänen HK. 1996. Molecular and cellular endocrinology. 122: 119-129 -
Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages
Selander KS, Mönkkönen J, Karhukorpi E-K, Härkönen P, Hannuniemi R, Väänänen HK. 1996. Molecular pharmacology. 50: 1127-1138 -
Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro
Makkonen N, Hirvonen M-R, Teräväinen T, Savolainen K, Mönkkönen J. 1996. Journal of pharmacology and experimental therapeutics. 277: 1097-1102 -
Interaction of liposomes with human skin in vitro - the influence of lipid composition and structure
Kirjavainen M, Urtti A, Jääskeläinen I, Suhonen TM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1996. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1304: 179-189 -
Liposomit ja niiden lääkeellinen käyttö
Mönkkönen J. 1996. Dosis. 12: 5-16 -
Streptomyces bacteria isolated from moldy houses induce the expression of inducible nitric oxide synthase and cause production of no, tumor necrosis factor and interleukin-6 in macrophage cell line
Hirvonen M-R, Nevalainen A, Makkonen N, Mönkkönen J, Savolainen K. Teoksessa: (toim.) , 1996. INDOOR AIR '96. Proceedings of the 7th International Conference on Indoor Air Quality and Climate. s. 669-674. The Organizing Committee of the 7th International Confere... -
Streptomyces-induced production of nitric oxide, tumor necrosis factor and interleukin-6 is not cytotoxic in raw264.7 macrophage cell line
Hirvonen M-R, Nevalainen A, Makkonen N, Mönkkönen J, Savolainen K. Teoksessa: (toim.) , 1996. INDOOR AIR '96. Proceedings of the 7th International Conference on Indoor Air Quality and Climate. s. 699-704. The Organizing Committee of the 7th International Confere... -
Effect of liposomal and free bisphosphonates on the IL-1ß, IL-6 and TNFAlfa secretion from RAW 264 cells in vitro
Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J. 1995. Pharmaceutical research. 12: 916-922 -
Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretion
Pennanen N, Lapinjoki S, Palander A, Urtti A, Mönkkönen J. 1995. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. 17: 475-480 -
Studies on liposome formulations for intra-articular delivery of clodronate
Mönkkönen J, Liukkonen J, Taskinen M, Heath TD, Urtti A. 1995. Journal of controlled release. 35: 145-154 -
The effect of free gallium and gallium in liposomes on cytokine and nitric oxide secretion from macrophage-like cells in vitro
Makkonen N, Hirvonen M-R, Savolainen K, Lapinjoki S, Mönkkönen J. 1995. Inflammation research. 44: 523-528