A.B.M. Manjur

The projects I am working on are important research in the field of gene regulation. Furthermore, the TFs that we study, glucocorticoid receptor (GR) and androgen receptor (AR) are important therapeutic targets in inflammation and prostate cancer respectively. On the chromatin environment, GR and AR exert their functions by interacting with other assisting proteins, coregulators. Thus, coregulators can affect the outcome of GR and AR activation through different processes, such as chromatin remodeling, histone-binding and post-translational modification. Despite the importance of coregulatory interactions in GR and AR function, the protein interactomes of these important drug targets have remained poorly defined. The results from these projects will enable us to increase our understanding about the regulatory mechanisms of these two physiologically important TFs.