The projects I am working on are important research in the field of gene regulation. Furthermore, the TFs that we study, glucocorticoid receptor (GR) and androgen receptor (AR) are important therapeutic targets in inflammation and prostate cancer respectively. On the chromatin environment, GR and AR exert their functions by interacting with other assisting proteins, coregulators. Thus, coregulators can affect the outcome of GR and AR activation through different processes, such as chromatin remodeling, histone-binding and post-translational modification. Despite the importance of coregulatory interactions in GR and AR function, the protein interactomes of these important drug targets have remained poorly defined. The results from these projects will enable us to increase our understanding about the regulatory mechanisms of these two physiologically important TFs.
School of Medicine, Biomedicine
Research groups and research projects
Research groups - UEF
Manjur, ABM Kaiser (ed.) . 2021. Characterization of IRF2BP2 and BCOR as coregulators of the glucocorticoid and androgen receptors. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Health Sciences 638. 2021
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility Journal of steroid biochemistry and molecular biology 210: 105873. 2021
Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation Oncogene 39: 2391-2407. 2020
Kaiser Manjur, ABM; Lempiäinen, Joanna K; Malinen, Marjo; Palvimo, Jorma J; Niskanen, Einari A. 2019. IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling Journal of steroid biochemistry and molecular biology 192: 105382. 2019