I am a Researcher in Precision Medicine at the Internal Medicine Department at the University of Eastern Finland and a fellow at the David Geffen School of Medicine, UCLA. My research focuses on identifying and characterizing metabolites involved in metabolic diseases, particularly on understanding metabolic pathways across different physiological states, including normal glucose tolerance, pre-diabetes, and type 2 diabetes, by leveraging advanced metabolomics and clinical data, aiming to develop personalized approaches for the early detection and treatment of metabolic disorders, contributing to the advancement of precision medicine in metabolic diseases. With a strong background in pharmacy, I combine biochemical expertise with clinical insights to translate findings into potential therapeutic interventions.
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Publications
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Genome-wide characterization of circulating metabolic biomarkers
Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartson. 2024. Nature. 628: 130-138 -
Gut microbe-derived metabolites and the risk of cardiovascular disease in the METSIM cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M.; Cupido, Arjen; Fernandes Silva, Lilian; Laakso, Markku; Lusis, Aldons J. 2024. Frontiers in microbiology. 15: . 1411328 -
Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2024. International journal of molecular sciences. 25: -
Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M; Cupido, Arjen J; Pan, Calvin; Ha, Sung Min; Silva, Lilian Fernandes; Hilser, James R; Hartiala, Jaana; Allayee, Hooman; Rey, Federico E; Laakso, Markku; Lusis, Aldons J. 2024. Metabolites. 14: -
A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin
Sarsani, Vishal; Brotman, Sarah M; Xianyong, Yin; Fernandes Silva, Lillian; Laakso, Markku; Spracklen, Cassandra N. 2023. HGG advances. 2024; 5: -
Cell-type composition affects adipose gene expression associations with cardiometabolic traits
Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718 -
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Hawkes, Gareth; Beaumont, Robin N; Tyrrell, Jessica; Power, Grace M; Wood, Andrew; Laakso, Markku; Silva, Lilian Fernandes; Boehnke, Michael; Yin, Xianyong; Richardson, Tom G; Smith, George Davey; Frayling, Timothy M. 2023. Diabetologia. 66: 1472-1480 -
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983 -
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Broadaway, K. Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A.; Wilson, Emma P.; Moxley, Anne H.; Vadlamudi, Swarooparani; Varshney, Arushi; Jackson, Anne U.; Ahuja, Vasudha; Bornstein, Stefan R.; Corbin, Laura J.; Delgado, Graciela E.; Dwivedi, Om P.; Fernandes Silva, Lilian; Frayling, Timothy M.; Grallert, Harald; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Herder, Christian; Herrmann, Sandra; Højlund, Kurt; Hughes, David A.; Kleber, Marcus E.; Lindgren, Cecilia M.; Liu, Chi. 2023. American journal of human genetics. 110: 284-299 -
Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study
Fernandes Silva, Lilian; Hokkanen, Jenna; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2023. Journal of clinical endocrinology and metabolism. 2024; 109: 100–106