MERVI HYVöNEN

Contact info

Keywords

Research groups - UEF

• 
  Applied chemistry

Publications

• Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation Biomolecules 11 5: 707. 2021
• Li, Qian; Hagberg, Carolina E.; Silva Cascales, Helena; Lang, Shuai; Hyvönen, Mervi T.; Salehzadeh, Firoozeh; Chen, Ping; Alexandersson, Ida; Terezaki, Eleni; Harms, Matthew J.; Kutschke, Maria; Arifen, Nahida; Krämer, Niels; Aouadi, Myriam; Knibbe, Carole; Boucher, Jeremie; Thorell, Anders; Spalding, Kirsty L.. 2021. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce Nature medicine 27 11: 1941-1953. 2021
• Khandazhinskaya, Anastasia; Eletskaya, Barbara; Fateev, Ilja; Kharitonova, Maria; Konstantinova, Irina; Barai, Vladimir; Azhayev, Alex; Hyvonen, Mervi T.; Keinanen, Tuomo A.; Kochetkov, Sergey; Seley-Radtke, Katherine; Khomutov, Alex; Matyugina, Elena. 2021. Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis Organic and biomolecular chemistry 19 34: 7379-7389. 2021
• Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans et al. [incl. Keinänen, Tuomo]. 2020. Chemical activation of SAT1 corrects diet-induced metabolic syndrome Cell death and differentiation 27 10: 2904-2920. 2020
• Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules 10 3: 406. 2020
• Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR. 2020. Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine Russian journal of bioorganic chemistry 46 6: 686-692. 2020
• Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives Journal of medicinal chemistry 62 24: 11335-11347. 2019
• Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators Bioscience reports 38 4: BSR20180527. 2018
• Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase MENDELEEV COMMUNICATIONS 28 5: 479-481. 2018
• Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration BIOCHEMICAL JOURNAL 475 3: 663-676. 2018
• Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV. 2017. Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 2: 904-909. 2017
• Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation. BIOCHEMICAL JOURNAL 473 10: 1433-1441. 2016
• Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo. ACS Applied Materials & Interfaces 8 48: 32723-32731. 2016
• Thomas TJ, Thomas Thresia, John Shali, Hsu Hui-Chen, Yang PingAr, Keinänen Tuomo A, Hyvönen Mervi T. 2016. Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer. AMINO ACIDS 48 10: 2293-2302. 2016
• Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R.. 2015. Synthesis of biologically active analogues of spermine and spermidine.Springer. 1667. 2015
• Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR. 2015. Enantioselective synthesis of (R)- and (S)-3-methylspermidines. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 41 5: 548-553. 2015
• Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A. 2015. Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport. ACS Chemical Biology 10 6: 1417-1424. 2015
• Hyvönen Mervi T, Spalding Kirsty L. 2014. Maintenance of white adipose tissue in man. INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 56: 123-132. 2014
• Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. 2014. Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. BIOCHEMISTRY (MOSCOW) 2013; 78 13: 1431-1446. 2014
• Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A. BIOCHEMICAL JOURNAL 453: 467-474. 2013
• Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R. 2013. Selective regulation of polyamine metabolism with methylated polyamine analogues. AMINO ACIDS 2014:46: 605-620. 2013
• Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R. 2013. Charge deficient analogues of the natural polyamines. CURRENT PHARMACEUTICAL DESIGN 2014:20 2: 262-277. 2013
• Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H. 2012. Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. AMINO ACIDS 42: 685-695. 2012
• Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena. 2012. Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase AMINO ACIDS 42: 485-493. 2012
• Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A. 2012. Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase. DRUG METABOLISM AND DISPOSITION 2013:41: 30-32. 2012
• Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ. 2012. A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells AMINO ACIDS 2012 Feb;42(2-3): 899-911. 2012
• Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V. 2012. Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells BIOCHIMIE 94 9: 1876-1883. 2012
• Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen. 2011. Complex N-Acetylation of Triethylentetramine. DRUG METABOLISM AND DISPOSITION 39 12: 2242-2249. 2011
• Uimari Anne, Hyvönen Mervi T, Pirinen Eija, Alhonen Leena. 2011. Transgenic rodents with altered SSAT expression as models of pancreatitis and altered glucose and lipid metabolism: Pegg, A.E. ja Casero, R.A. Jr., Polyamines. Methods and Protocols. Methods in Molecular Biology. 143-158. 2011
• Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov. 2011. The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism JOURNAL OF MEDICINAL CHEMISTRY 54 13: 4611-4618. 2011
• Jin Hai-Tao, Lämsä Teemu, Nordbak Panu H, Hyvönen Mervi T, Räty Sari, Nordback Isto, Herzig Karl-Heinz, Alhonen Leena, Sand Juhani. 2011. Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. PANCREATOLOGY 11: 83-91. 2011
• Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA. 2011. Novel metabolically stable functionally active mimetic of spermidine RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 37 2: 253-258. 2011
• Khomutov Alex R, Weisell Janne, Khomutov Maxim A, Grigorenko Nikolay A, Simonian Alina R, Häkkinen Merja R, Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Kochetkov Sergey N, Vepsäinen Jouko. 2011. Methylated polyamines as research tools: Pegg, A.E. ja Casero, R.A. Jr., Polyamines. Methods and Protocols. Methods in Molecular Biology 720. 449-461. 2011
• Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Grigorenko N, Khomutov AR, Nordback I, Räty S, Pörsti I, Alhonen L, Sand J. 2011. Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with polyamine analogue bismethylspermine Pharmacological Reports 63: 999-1008. 2011
• Cerrada-Gimenez M, Pietilä Marko, Loimas Suvikki, Pirinen Eija , Hyvönen Mervi T, Keinänen Tuomo A, Jänne Juhani, Alhonen Leena. 2011. Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults TRANSGENIC RESEARCH 20: 387-396. 2011
• Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L. 2010. alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. AMINO ACIDS 38: 575-581. 2010
• Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L. 2010. Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis PANCREATOLOGY 10: 208-221. 2010
• Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases. AMINO ACIDS 38: 369-381. 2010
• Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ. 2010. DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage. BIOMACROMOLECULES 11: 97-105. 2010
• Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues. JOURNAL OF MEDICINAL CHEMISTRY 53 15: 5738-5748. 2010
• Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P. 2010. Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity. AMINO ACIDS 38 2: 501-507. 2010
• Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism. MOLEKULIARNAIA BIOLOGIIA [MOSKVA] 43 2: 274-285. 2009
• Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA. 2009. Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues BIOCHEMICAL JOURNAL 422: 321-328. 2009
• Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA. 2009. Transgenic animals modelling polyamine metabolism-related diseases. ESSAYS IN BIOCHEMISTRY 46: 125-144. 2009
• Jin H-T, Lämsä T, Hyvönen MT, Sand J, Räty S, Grigorenko N, Khomutov AR, Herzig K-H, Alhonen L, Nordback I. 2008. A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. SURGERY (ST. LOUIS MO) 144: 49-56. 2008
• Jin HT, Lämsa T, Merentie M, Hyvönen MT, Sand J, Räty S, Herzig K-H, Alhonen L, Nordback I. 2008. Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis PANCREATOLOGY 8 1: 15-24. 2008
• Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. 2007. Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 282 48: 34700-34706. 2007
• Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L. 2007. Mechanisms of polyamine catabolism-induced acute pancreatitis. BIOCHEMICAL SOCIETY TRANSACTIONS 35: 326-330. 2007
• Hyvönen MT. 2007. Regulation of Spermidine/Spermine N1-Acetyltransferase and its Involvement in Cellular Proliferation and Development of Acute Pancreatitis. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. 2007
• Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. 2007. Alpha-methylated polyamines as potential drugs and experimental tools in enzymology. MINI REVIEWS IN MEDICINAL CHEMISTRY 7 8: 813-820. 2007
• Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. 2006. Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. AMERICAN JOURNAL OF PATHOLOGY 168: 115-122. 2006
• Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J. 2006. Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase RNA (NEW YORK, N.Y.) 12 8: 1569-1582. 2006
• Jänne J, Alhonen L, Pietilä M, Keinänen TA, Suppola S, Pirinen E, Hyvönen MT, Järvinen A, Laakso M. 2006. Genetic engineering of polyamine catabolism in transgenic mice and rats: Wang J-Y, Casero RA Jr, Polyamine Cell Signaling. Physiology, Pharmacology, and Cancer Research.Humana Press. 465-477. 2006
• Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E. 2006. Genetic manipulation of polyamine catabolism in rodents. JOURNAL OF BIOCHEMISTRY 139 2: 155-160. 2006
• Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A. 2005. Animal disease models generated by genetic engineering of polyamine metabolism. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 9 4: 865-882. 2005
• Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J. 2005. Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines. JOURNAL OF BIOLOGICAL CHEMISTRY 280 8: 6595-6601. 2005