MIKKO TURUNEN

Visiting Researcher

Adjunct professor

My research focuses on the role of non-coding RNAs for transcriptional gene activation (TGA) and transcriptional gene silencing (TGS). When applied to gene therapy, it is called "Epigenetherapy". I am also exploring extracellular vesicles for efficient and targeted delivery of therapeutic non-coding RNAs.

Contact info

Organization

Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences

Email

mikko.turunen@uef.fi

Phone

Keywords

epigenetics exosome extracellular vesicles microRNA non-coding RNA transcriptional gene activation VEGF

Research groups

Neuroinflammation research group

Publications

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals Aging cell 2021; 20 1: e13287. 2020
Saari, H; Turunen, T; Lõhmus, A; Turunen, M; Jalasvuori, M; Butcher, SJ; Ylä-Herttuala, S; Viitala, T; Cerullo, V; Siljander, PRM; Yliperttula, M. 2020. Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery Journal of extracellular vesicles 9 1: 1747206. 2020
Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress Scientific reports 9: 10332. 2019
Merentie, Mari; Rissanen, Riina; Lottonen-Raikaslehto, Line; Huusko, Jenni; Gurzeler, Erika; Turunen, Mikko P; Holappa, Lari; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2018. Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice. PLOS ONE 13 1: e0190981. 2018
Turunen Tiia A, Ylä-Herttuala Seppo, Turunen Mikko P. 2017. Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs. In: Long-Cheng Li (ed.) RNA Activation. Springer. Advances in Experimental Medicine and Biology 983. s. 195-205. 2017
Coenen-Stass Anna ML, Betts Corinne A, Lee Yi F, Mäger Imre, Turunen Mikko P, Andaloussi Samir EL, Morgan Jennifer E, Wood Matthew JA, Roberts Thomas C. 2016. Selective release of muscle-specific, extracellular microRNAs during myogenic differentiation. HUMAN MOLECULAR GENETICS [Epub ahead of print 27 Jul 2016]: 1-15. 2016
Husso Tiia, Turunen Mikko P, Ylä-Herttuala Seppo. 2015. Regulation of VEGF-A Expression in Endothelial Cells by Transcriptional Gene Activation or Transcriptional Gene Silencing: Analysis of Genome Wide Transcriptional Response. Gene Technology 4 2: 122. 2015
Kolari Ida-Liisa, Laitinen Pia, Turunen Mikko P, Ylä-Herttuala Seppo. 2015. Novel Nuclear Biology of Small Non-Coding RNAs. Gene Technology 4: 120. 2015
Turunen Mikko P, Husso Tiia, Musthafa Haja, Laidinen Svetlana, Dragneva Galina, Laham-Karam Nihay, Honkanen Sanna, Paakinaho Anne, Laakkonen Johanna P, Gao Erhe, Vihinen-Ranta Maija, Liimatainen Timo, Ylä-Herttuala Seppo. 2014. Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice. PLOS ONE [ONLINE] 2014 Feb 26;9(2):e89979: e89979. 2014
Husso Tiia, Ylä-Herttuala Seppo, Turunen Mikko P. 2014. A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus. Molecular Therapy - Nucleic Acids (2014) 3, e197: --. 2014
Gomes RS, das Neves RP, Cochlin L, Lima A, Carvalho R, Korpisalo P, Dragneva G, Turunen M, Liimatainen T, Clarke K, Ylä-Herttuala S, Carr C, Ferreira L. 2013. Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial. ACS NANO 2013 Apr 23;7(4): 3362-72. 2013
Turunen MP, Aavik E, Ylä-Herttuala S. 2013. Epigenetic regulation in vascular cells. CURRENT OPINION IN LIPIDOLOGY 2013 Jul 18. [Epub ahead of print] 24: x-x. 2013
Aavik Einari, Turunen Mikko P, Ylä-Herttuala Seppo. 2012. Epigenetics and Atherosclerosis. In: Minarovits Janos, Niller Hans Helmut (ed.) Patho-Epigenetics of Disease. Springer science+business media. s. 397-418. 2012
Husso T, Turunen M, Parker N, Ylä-Herttuala S. 2011. Epigenetherapy, a new concept. BioMolecular Concepts Volume 2, Issue 3: 127-134. 2011
Kärkkäinen A-M, Kotimaa A, Huusko J, Kholova I, Heinonen SE, Stefanska A, Dijkstra MH, Purhonen H, Hämäläinen E, Mäkinen PI, Turunen MP, Ylä-Herttuala S. 2009. Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation. BLOOD 113: 4468-4475. 2009
Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. 2008. Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS LETTERS 582: 2397-2401. 2008
Tuomisto TT, Lumivuori H, Kansanen E, Häkkinen S-K, Turunen MP, van Thienen JV, Horrevoets AJ, Levonen A-L, Ylä-Herttuala S. 2008. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2. CARDIOVASCULAR RESEARCH 78 1: 175-184. 2008
Hedman M, Turunen MP, Ylä-Herttuala S. 2006. New technologies in cardiovascular research gene therapy. In: Pasterkamp G, de Kleijn DPV (ed.) Cardiovascular Research. New Technologies, Methods, and Applications. Ei jufo-kustantaja/not jufo publisher. s. 85-101. 2006
Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006
Puhakka HL, Turunen P, Rutanen J, Hiltunen MO, Turunen MP, Ylä-Herttuala S. 2005. Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model. JOURNAL OF VASCULAR RESEARCH 42 5: 361-367. 2005
Rutanen J, Turunen A-M, Teittinen M, Rissanen TT, Heikura T, Koponen JK, Gruchala M, Inkala M, Jauhiainen S, Hiltunen MO, Turunen MP, Stacker SA, Achen MG, Ylä-Herttuala S. 2005. Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism. GENE THERAPY 12: 980-987. 2005
Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin C-H, Östman A, Ylä-Herttuala S. 2004. Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits. CIRCULATION 109: 1140-1146. 2004
Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppänen P, Turunen A-M, Ylä-Herttuala S. 2004. Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vasvular smooth muscle cells. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36 3: 333-341. 2004
Turunen MP, Hiltunen MO, Ylä-Herttuala S. 2003. Cardiovascular gene therapy. In: Rolland A, Sullivan SM (ed.) Pharmaceutical Gene Delivery Systems. Ei jufo-kustantaja/not jufo publisher. s. 345-362. 2003
Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. 2002. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. VASCULAR MEDICINE (LONDON) 7: 5-11. 2002
Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M, Leppänen P, Turunen MP, Markkanen JE, Arve K, Alhava E, Kauppinen RA, Ylä-Herttuala S. 2002. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. AMERICAN JOURNAL OF PATHOLOGY 160 4: 1393-1403. 2002
Turunen MP, Puhakka HL, Koponen JK, Hiltunen MO, Rutanen J, Leppänen O, Turunen A-M, Närvänen A, Newby AC, Baker AH, Ylä-Herttuala S. 2002. Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. MOLECULAR THERAPY 6: 306-312. 2002
Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes. GENE THERAPY 8: 784-788. 2001
Leppänen PM, Koponen J, Turunen MP, Pakkanen T, Ylä-Herttuala S. 2001. Optimized in situ PCR method for the detection of gene transfer vector in histological sections. JOURNAL OF GENE MEDICINE 3: 173-178. 2001
Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods. FASEB JOURNAL 14: 2230-2236. 2000
Turunen MP. 2000. Arterial Gene Transfer - New Methods and Safety Aspects. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2000
Airenne KJ, Hiltunen MO, Turunen MP, Turunen A-M, Laitinen OH, Kulomaa MS, Ylä-Herttuala S. 2000. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery. GENE THERAPY 7: 1499-1504. 2000
Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. 2000. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer. VASCULAR MEDICINE (LONDON) 5: 41-48. 2000
Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. 2000. Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta. CIRCULATION 102: 2262-2268. 2000
Gough PJ, Greaves DR, Suzuki H, Hakkinen T, Hiltunen MO, Turunen M, Ylä-Herttuala S, Kodama T, Gordon S. 1999. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 461-471. 1999
Turunen M, Hiltunen M, Ylä-Herttuala S. 1999. Geeniterapia ja sen mahdollisuudet verisuonitautien hoidossa. KEMIA-KEMI 26: 186-188. 1999
Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. 1999. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes. GENE THERAPY 6: 6-11. 1999
Turunen MP, Hiltunen MO, Ylä-Herttuala S. 1999. Gene therapy for angiogenesis, restenosis and related diseases. EXPERIMENTAL GERONTOLOGY 34: 567-574. 1999
Hiltunen MO, Turunen MP, Ylä-Herttuala S. 1998. Geeniterapia verisuonitautien hoidossa. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 14 4: 202-206. 1998