
MIKKO TURUNEN
Visiting Researcher
Adjunct professor
My research focuses on the role of non-coding RNAs for transcriptional gene activation (TGA) and transcriptional gene silencing (TGS). When applied to gene therapy, it is called "Epigenetherapy". I am also exploring extracellular vesicles for efficient and targeted delivery of therapeutic non-coding RNAs.
Contact info
Organization
Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences
mikko.turunen@uef.fi
Phone
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Keywords
epigenetics
exosome
extracellular vesicles
microRNA
non-coding RNA
transcriptional gene activation
VEGF
Research groups - UEF
Publications
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Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020
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Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals Aging cell 2021; 20 1: e13287. 2020
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Saari, H; Turunen, T; Lõhmus, A; Turunen, M; Jalasvuori, M; Butcher, SJ; Ylä-Herttuala, S; Viitala, T; Cerullo, V; Siljander, PRM; Yliperttula, M. 2020. Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery Journal of extracellular vesicles 9 1: 1747206. 2020
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Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress Scientific reports 9: 10332. 2019
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Merentie, Mari; Rissanen, Riina; Lottonen-Raikaslehto, Line; Huusko, Jenni; Gurzeler, Erika; Turunen, Mikko P; Holappa, Lari; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2018. Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice. PLOS ONE 13 1: e0190981. 2018
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Turunen Tiia A, Ylä-Herttuala Seppo, Turunen Mikko P. 2017. Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs. In: Long-Cheng Li (ed.) RNA Activation. Springer. Advances in Experimental Medicine and Biology 983. s. 195-205. 2017
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Coenen-Stass Anna ML, Betts Corinne A, Lee Yi F, Mäger Imre, Turunen Mikko P, Andaloussi Samir EL, Morgan Jennifer E, Wood Matthew JA, Roberts Thomas C. 2016. Selective release of muscle-specific, extracellular microRNAs during myogenic differentiation. HUMAN MOLECULAR GENETICS [Epub ahead of print 27 Jul 2016]: 1-15. 2016
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Husso Tiia, Turunen Mikko P, Ylä-Herttuala Seppo. 2015. Regulation of VEGF-A Expression in Endothelial Cells by Transcriptional Gene Activation or Transcriptional Gene Silencing: Analysis of Genome Wide Transcriptional Response. Gene Technology 4 2: 122. 2015
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Kolari Ida-Liisa, Laitinen Pia, Turunen Mikko P, Ylä-Herttuala Seppo. 2015. Novel Nuclear Biology of Small Non-Coding RNAs. Gene Technology 4: 120. 2015
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Turunen Mikko P, Husso Tiia, Musthafa Haja, Laidinen Svetlana, Dragneva Galina, Laham-Karam Nihay, Honkanen Sanna, Paakinaho Anne, Laakkonen Johanna P, Gao Erhe, Vihinen-Ranta Maija, Liimatainen Timo, Ylä-Herttuala Seppo. 2014. Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice. PLOS ONE [ONLINE] 2014 Feb 26;9(2):e89979: e89979. 2014