PASI TAVI

Contact info

Research groups - UEF

• 
  In vitro and ex vivo electrophysiology core facility
• 
  Molecular Physiology

PROJECTS - UEF

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  Exercise mimetic drug molecules (EXMI)

Publications

• Naumenko, Nikolay; Mutikainen, Maija; Holappa, Lari; Ruas, Jorge L; Tuomainen, Tomi; Tavi, Pasi. 2022. PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice Cardiovascular research [corrected proof]: 32 s.. 2022
• Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. 2021. Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response Expert opinion on therapeutic targets 25 9: 773-785. 2021
• Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. 2021. NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli Cardiovascular research 117 5: 1339-1357. 2021
• Liu, Zhengye; Chaillou, Thomas; Santos Alves, Estela; Mader, Theresa; Jude, Baptiste; Ferreira, Duarte MS; Hynynen, Heidi; Cheng, Arthur J; Jonsson, William O; Pironti, Gianluigi; Andersson, Daniel C; Kenne, Ellinor; Ruas, Jorge L; Tavi, Pasi; Lanner, Johanna T. 2021. Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force Faseb journal 35 12: e22010. 2021
• Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death Biomolecules 11 3: 452. 2021
• Elkhwanky, Mahmoud-Sobhy; Kummu, Outi; Piltonen, Terhi T; Laru, Johanna; Morin-Papunen, Laure; Mutikainen, Maija; Tavi, Pasi; Hakkola, Jukka. 2020. Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues JBMR plus 4 11: 1-14. 2020
• Hynynen, H; Mutikainen, M; Naumenko, N; Shakirzyanova, A; Tuomainen, T; Tavi, P. 2020. Short High-Fat Diet Interferes With the Physiological Maturation of the Late Adolescent Mouse Heart Physiological reports 8 13: e14474. 2020
• Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, Šárka. 2020. Metabolic alterations in Parkinson's disease astrocytes Scientific reports 10 1: 14474. 2020
• Aatsinki, SM; Elkhwanky, MS; Kummu, O; Karpale, M; Buler, M; Viitala, P; Rinne, V; Mutikainen, M; Tavi, P; Franko, A; Wiesner, RJ; Chambers, KT; Finck, BN; Hakkola, J. 2019. Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes Diabetes 68 5: 918-931. 2019
• Pölönen, P; Jawahar Deen, A; Leinonen, HM; Jyrkkänen, HK; Kuosmanen, S; Mononen, M; Jain, A; Tuomainen, T; Pasonen-Seppänen, S; Hartikainen, JM; Mannermaa, A; Nykter, M; Tavi, P; Johansen, T; Heinäniemi, M; Levonen, AL. 2019. Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma Oncogene 38: 7473-7490. 2019
• Steinz, Maarten M; Persson, Malin; Aresh, Bejan; Olsson, Karl; Cheng, Arthur J; Ahlstrand, Emma; Lilja, Mats; Lundberg, Tommy R; Rullman, Eric; Moller, Kristina Angeby; Sandor, Katalin; Ajeganova, Sofia; Yamada, Takashi; Beard, Nicole; Karlsson, Bjorn C G; Tavi, Pasi; Kenne, Ellinor; Svensson, Camilla, I; Rassier, Dilson E; Karlsson, Roger et al.. 2019. Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis JCI insight 4: 9. 2019
• Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure CARDIOVASCULAR RESEARCH 2019; 115 1: 107-118. 2018
• Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes Scientific reports 8: 13036. 2018
• Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling. Frontiers in Physiology 9: 80. 2018
• Karppinen, Sari; Hänninen, Sandra L; Rapila, Risto; Tavi, Pasi. 2018. Sarcoplasmic reticulum Ca2+ -induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes Physiological reports 6 2: e13522. 2018
• Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018
• Durga Devi T, Babu M, Mäkinen P, Kaikkonen M, Heinaniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N,Tavi P, Ylä-Herttuala S. 2017. Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation. AMERICAN JOURNAL OF PATHOLOGY 187 12: 2659-2673. 2017
• Kaikkonen Minna U, Halonen Paavo, Liu Oscar Hsin-Fu, Turunen Tiia A, Pajula Juho, Moreau Pierre, Selvarajan Ilakya, Tuomainen Tomi, Aavik Einari, Tavi Pasi, Ylä-Herttuala Seppo. 2017. Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction Circulation: Cardiovascular Genetics 10 3: e001702. 2017
• Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation. NUCLEIC ACIDS RESEARCH 2018; 46 3: 1124-1138. 2017
• Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P. 2017. Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart. Frontiers in Physiology 8: 373. 2017
• Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017
• Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder. Disease models & mechanisms 10 9: 1089-1100. 2017
• Tuomainen Tomi, Tavi Pasi. 2017. The role of cardiac energy metabolism in cardiac hypertrophy and failure. EXPERIMENTAL CELL RESEARCH 360 1: 12-18. 2017
• Winther SV, Tuomainen T, Borup R, Tavi P, Antoons G, Thomsen MB. 2016. Potassium channel interacting protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling. Scientific Reports 6: 28760. 2016
• Skibsbye Lasse, Jespersen Thomas, Christ Torsten, Maleckar Mary M, van den Brink Jonas, Tavi Pasi, Koivumäki Jussi T. 2016. Refractoriness in human atria: Time and voltage dependence of sodium channel availability. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 101: 26-34. 2016
• Mutikainen Maija, Tuomainen Tomi, Naumenko Nikolay, Huusko Jenni, Smirin Boris, Laidinen S, Kokki K, Hynynen H, Ylä-Herttuala S, Heinäniemi M, Ruas JL, Tavi P. 2016. Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 594 23: 7049-7071. 2016
• Laine M, Tavi P, Lommi J. 2016. Sydänlihaksen vaurioitumisesta sydämen systoliseen vajaatoimintaan. In: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste (ed.) Kardiologia. Duodecim. s. 679-680. 2016
• Laine M, Tavi P, Lommi J. 2016. Sydämen vajaatoiminnan hemodynaamiset häiriömekanismit. In: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste (ed.) Kardiologia. Duodecim. s. 678-679. 2016
• Laine M, Tavi P, Lommi J. 2016. Sydämen rakennemuutokset (remodeling) vajaatoiminnassa. In: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste (ed.) Kardiologia. s. 680-682. 2016
• Laine M, Tavi P, Lommi J. 2016. Neuraaliset ja endokriiniset mekanismit sydämen vajaatoiminnassa. In: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen ja Antti Saraste (ed.) Kardiologia. Duodecim. s. 683-688. 2016
• Laine M, Tavi P, Lommi J. 2016. Myosyyttien toimintahäiriöt, kuolema ja uusiutuminen sydämen vajaatoiminnassa. In: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen ja Antti Saraste (ed.) Kardiologia. s. 682-683. 2016
• Giniatullin Rashid, Bart Geneviève, Tavi Pasi. 2015. Complex role of peroxisome proliferator activator receptors (PPARs) in nociception. SCANDINAVIAN JOURNAL OF PAIN 9: 70-71. 2015
• Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. 2015. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. PNAS (ONLINE: HTTP://WWW.PNAS.ORG/] 112 42: 13036-13068. 2015
• Karppinen S, Rapila R, Naumenko N, Tuomainen T, Koivumäki JT, Hänninen SL, Korhonen T, Tavi P. 2015. Ca2+-activated K+ current is essential for maintaining excitability and gene transcription in early embryonic cardiomyocytes. ACTA PHYSIOLOGICA (OXFORD) [epub 28 JUN 2015]: -. 2015
• Kuosmanen Suvi M, Hartikainen Juha, Hippeläinen Mikko, Kokki Hannu, Levonen Anna-Liisa, Tavi Pasi. 2015. MicroRNA profiling of pericardial fluid samples from patients with heart failure. PLOS ONE [ONLINE] 10 3: e0119646. 2015
• Louch William E, Koivumäki Jussi T, Tavi Pasi. 2015. Calcium signalling in developing cardiomyocytes: implications for model systems and disease. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 593 5: 1047-1063. 2015
• Moilanen Anne-Mari, Rysä Jaana, Kaikkonen Leena, Karvonen Teemu, Mustonen Erja, Serpi Raisa, Szabó Zoltán, Tenhunen Olli, Bagyura Zsolt, Näpänkangas Juha, Ohukainen Pauli, Tavi Pasi, Kerkelä Risto, Leósdóttir Margrét, Wahlstrand Björn, Hedner Thomas, Melander Olle, Ruskoaho Heikki. 2015. WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function. PLOS ONE [ONLINE] 10 4: e0124907. 2015
• Puttonen Katja A, Ruponen Marika, Naumenko Nikolay, Hovatta Outi H, Tavi Pasi, Koistinaho Jari. 2015. Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines. Frontiers in Cellular Neuroscience 9:473: -. 2015
• Vlasova Maria A, Tarasova Olga S, Riikonen Joakim, Raula Janne, Lobach Anatoly S, Borzykh Anna A, Smirin Boris V, Kauppinen Esko I, Eletskii Alexander V, Herzig Karl-Heinz, Salonen Jarno, Tavi Pasi, Lehto Vesa-Pekka, Järvinen Kristiina. 2014. Injected nanoparticles: The combination of experimental systems to assess cardiovascular adverse effects. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 87: 64-72. 2014
• Ronkainen Veli-Pekka, Tuomainen Tomi, Huusko Jenni, Laidinen Svetlana, Malinen Marjo, Palvimo Jorma J, Ylä-Herttuala Seppo, Vuolteenaho Olli, Tavi Pasi. 2014. Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling. CARDIOVASCULAR RESEARCH 2014 Jan 1;101(1): 69-77. 2014
• Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity. STEM CELLS 32 7: 1904-1916. 2014
• Koivumäki Jussi T, Seemann Gunnar, Maleckar Mary M, Tavi Pasi. 2014. In silico screening of the key cellular remodeling targets in chronic atrial fibrillation. PLOS COMPUTATIONAL BIOLOGY 2014 May 22;10(5):e1003620.: e1003620. 2014
• Karppinen S, Rapila R, Mäkikallio K, Hänninen SL, Rysä J, Vuolteenaho O, Tavi P. 2014. Endothelin-1 signalling controls early embryonic heart rate in vitro and in vivo. ACTA PHYSIOLOGICA (OXFORD) Volume 210, Issue 2: 369-380. 2014
• Huusko J, Lottonen L, Merentie M, Gurzeler E, Anisimov A, Miyanohara A, Alitalo K, Tavi P, Ylä-Herttuala S. 2012. AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy. MOLECULAR THERAPY 20 (2012): 2212 - 2221. 2012
• Koivumäki Jussi T, Korhonen Topi, Tavi Pasi. 2011. Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: A computational study. PLOS COMPUTATIONAL BIOLOGY 7: e1001067. 2011
• Kubin Anna-Maria, Skoumal Réka, Tavi Pasi, Kónyi Attila, Perjés Ábel , Leskinen Hanna, Ruskoaho Heikki, Szokodi István. 2011. Role of reactive oxygen species in the regulation of cardiac contractility. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 50: 884-893. 2011
• Ronkainen Jarkko J, Hänninen Sandra L, Korhonen Topi, Koivumäki Jussi T, Skoumal Reka, Rautio Sini, Ronkainen Veli-Pekka, Tavi Pasi. 2011. Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel α1C-subunit gene (Cacna1c) by DREAM translocation. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 589: 2669-2686. 2011
• Ronkainen Veli-Pekka, Skoumal Reka, Tavi Pasi. 2011. Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 50: 1008-1016. 2011
• Tavi P, Westerblad H. 2011. The role of in vivo Ca²⁺ signals acting on Ca²⁺-calmodulin-dependent proteins for skeletal muscle plasticity JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 2011 Nov 1;589(Pt 21): 5021-31. 2011
• Bruton JD, Aydin J, Yamada T, Shabalina IG, Ivarsson N, Zhang SJ, Wada M, Tavi P, Nedergaard J, Katz A et al. 2010. Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 588: 4275-4288. 2010
• Hänninen SL, Ronkainen JJ, Leskinen H & Tavi P. 2010. Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes CARDIOVASCULAR RESEARCH 88: 75-82. 2010
• Korhonen T, Rapila R, Ronkainen V-P, Koivumäki JT & Tavi P. 2010. Local Ca2+ releases enable rapid heart rates in developing cardiomyocytes. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 588: 1407-1417. 2010
• Tavi P, Korhonen T, Hänninen SL, Bruton JD, Lööf S, Simon A & Westerblad H. 2010. Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes. JOURNAL OF CELLULAR PHYSIOLOGY 223 2: 376-383. 2010
• Koivumäki JT, Korhonen T, Takalo J, Weckström M, Tavi P. 2009. Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling. BMC PHYSIOLOGY [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCPHYSIOL/] 9: 16. 2009
• Korhonen T, Hänninen SL, Tavi P. 2009. Model of excitation-contraction coupling of rat neonatal ventricular myocytes. BIOPHYSICAL JOURNAL 96: 1189-1209. 2009