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Rauno Harvima

Rauno Harvima

Clinical Lecturer

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

rauno.harvima@uef.fi

Information Publications

Research groups

North-Savo Skin Cancer Program (NoSCaP)

Publications

60/60 items

FoxP3-Positive Cells and Their Contacts with Mast Cells Are Highly Increased in Basal Cell Carcinoma
Kaukinen, Antti P; Harvima, Rauno J; Harvima, Ilkka T. 2023. International archives of allergy and immunology. 2024; 185: 167-169
Gynecomastia in a Young Male Caused by lsotretinoin : A Case Report
Harvima, Rauno J.; Laaksonen, David E.; Lonka, Minna; Harvima, Ilkka T.. 2023. Journal of clinical case reports. 13:
Patients with a history of atopy have fewer cutaneous melanomas than those without atopy: a cross-sectional study in 496 patients at risk of skin cancers
Komulainen, Jenni; Siiskonen, Hanna; Haimakainen, Salla; Kanasuo, Emilia; Harvima, Rauno J.; Harvima, Ilkka T.. 2023. Melanoma research. 33: 218-229
Real-world registry-based study on apremilast use in psoriasis and psoriatic arthritis in Finland
Koskivirta, I; Ruotsalainen, J; Kurki, S; Lakkakorpi, P; Salminen-Mankonen, H; Pirilä, L; Harvima, R; Palomäki, A. 2023. Scandinavian journal of rheumatology. 52: 549-555
Vaikean penisilliiniallergian epätavallinen kehittyminen
Harvima, Rauno; Harvima, Ilkka. 2023. Lääkärilehti. 78: 721-724
Case: Unexpected development of severe penicillin allergy and review of literature
Harvima, Rauno J; Harvima, Ilkka T. 2022. Clinical case reports. 10: . e05248
Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report
Harvima, Rauno; Harvima, Ilkka. 2022. Journal of clinical case reports. 12: 1-3
Guselkumab Treatment Outcomes and Persistence in a Nationwide Real-world Cohort of Patients with Plaque Psoriasis
Mälkönen, Tarja; Nuutinen, Pauliina; Hallinen, Taru; Soini, Erkki; Nissinen, Riikka; Wennerstöm, Christina; Rantanen, Tapio; Hagman, Johanna H.; Harvima, Rauno; Höök-Nikanne, Johanna; Ilves, Tiina; Lintu, Päivi; Malanin, Ken; Soramäki, Iina; Tasanen, Kaisa; Teho, Arja; Vähävihu, Katja; Itälinna, Sari; Leinonen, Pekka; Sarajärvi, Piia; Huilaja, Laura; Pasternack, Rafael. 2022. Acta dermato-venereologica. 102:
Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals
Vandamme, C; Rytkönen-Nissinen, M; Lönnberg, T; Randell, J; Harvima RJ; Kinnunen, T; Virtanen, T. 2022. Journal of allergy and clinical immunology. 149: 1732-1743.e15
Survival from cutaneous malignant melanoma is improving, but is it because of a trend in decreasing melanoma thickness or the advent of new ‘revolutionary’ therapeutics?
Harvima, Ilkka T.; Harvima, Rauno J.. 2022. British journal of dermatology. 187: 6-7
The Use of Lymphocyte Stimulation Test in Severe Nabumetone-Induced Stevens-Johnson Syndrome: A Case Report
Harvima, Rauno J; Harvima, Ilkka T; Poso, Antti; Rysä , Jaana; Ojala, Raimo . 2022. Journal of clinical case reports. 12:
Clinical, patient and estimated cost benefits of proactive management versus reactive management with calcipotriol/betamethasone dipropionate foam for the treatment of plaque psoriasis in Finland
Harvima, Rauno J.; Gooderham, Melinda; Tyring, Stephen; Thoning, Henrik; Nyholm, Nanna; Stein Gold, Linda. 2021. Journal of dermatological treatment. [Epub ahead of print 7 July 2021]: 1-7
Erythrasma Capitis and Diffuse Hair Loss with Patches and Eczema-a Rare but Underdiagnozed Entity?
Harvima, Rauno; Harvima, Ilkka. 2021. Annals of case reports. 6:
Occupational allergic rhinitis and asthma caused by guar gum
Ruoppi, Pirkko; Koistinen, Tiina; Purokivi, Minna; Harvima, Rauno. 2021. Annals of case reports. 6: 1-4
Patients with Hidradenitis Suppurativa Suffer from Low Health-Related Quality of Life as Measured by the Generic 15D Instrument
Hirvonen, Mirkka J; Pasternack, Rafael; Lipitsä, Tiina; Vihervaara, Armi; Harvima, Rauno; Ranta, Martta; Sintonen, Harri; Huilaja, Laura. 2021. Skin appendage disorders. 8: 221-227
Sisters with Generalized Pustular Psoriasis Successful Treatment with Biologics
Harvima, Rauno; Harvima, Ilkka. 2021. Journal of case reports in medicine. 10: 21-23
Unusual Clinical Picture of a Comedo Mimicking Keratoacanthoma
Harvima, Rauno J.; Saksela, Olli; Kariniemi, Arja-Leena. 2021. Annals of case reports. 6: 647
Patients with hidradenitis suppurativa may suffer from neuropathic pain: A Finnish multicenter study
Huilaja, L; Hirvonen, MJ; Lipitsä, T; Vihervaara, A; Harvima, R; Sintonen, H; Kouri, JP; Ranta, M; Pasternack, R. 2020. Journal of the american academy of dermatology. 82: 1232-1234
Successful treatment of iatrogenically developed cutaneous calcification by tetracycline in Labrador retriever
Harvima, RJ; Halonen, P; Pirinen, E; Kolehmainen-Harvima, KS; Harvima, IT. 2020. Animal husbandry, dairy and veterinary science. 4: 1-4
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
Diaconu Nicolae-Costin, Rummukainen Jaana, Naukkarinen Anita, Mättö Mikko, Harvima Rauno J, Pelkonen Jukka, Harvima Ilkka T.. 2011. Archives of dermatological research. 303: 499-512
Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
Diaconu N-C, Rummukainen J, Mättö M, Naukkarinen A, Harvima RJ, Pelkonen J, Harvima IT. 2008. Bmc cancer. 8: [15, art. 46]
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer
Ahvenainen T, Lehtonen HJ, Lehtonen R, Vahteristo P, Aittomäki K, Baynam G, Dommering C, Eng C, Gruber SB, Grönberg H, Harvima R, Herva R, Hietala M, Kujala M, Kääriäinen H, Sunde L, Vierimaa O, Pollard PJ .... 2008. Cancer genetics and cytogenetics. 183: 83-88
Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma
Diaconu NC, Kaminska R, Naukkarinen A, Harvima RJ, Nilsson G, Harvima IT. 2007. Cancer immunology immunotherapy. 56: 1407-1415
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma
Diacony NC, Kaminska R, Naukkarinen A, Harvima R, Harvima I. 2007. Journal of the european academy of dermatology and venereology. 21: 908-915
Evaluation of exposure to 1-alkoxy-2propanols and 1-(2-methoxy-1-methylethoxy)-2-propanol by the analysis of the parent compounds in urine
Laitinen J, Liesvuori J, Harvima R. 2006. Toxicology letters. 162: 186-194
Microdialysis for detection of dynamic changes in tissue histamine levels in experimental thermal injury
Papp A, Härmä M, Harvima R, Lahtinen T, Uusaro A, Alhava E. 2005. Burns. 31: 476-481
Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland -a multicentre study
Hasan T, Rantanen T, Alanko K, Harvima RJ, Jolanki R, Kalimo K, Lahti A, Lammintausta K, Lauerma AI, Laukkanen A, Luukkala T, Riekki R, Turjanmaa K, Varjonen E, Vuorela A-M. 2005. Contact dermatitis. 53: 40-45
Ärsytysihottuma ammattitautina
Kalimo K, Estlander T, Alanko K, Hannuksela M, Suomen kontaktidermatiittiryhmä, Harvima R. 2005. Duodecim. 121: 773-777
Psoriaasin uudet hoidot - yhdistelmävoidetta ja biologisia lääkkeitä
Rantanen T, Harvima R, Karvnen S-L. 2004. Lääkärilehti. 59: 2485-2489
Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis
Papp KA, Guenther L, Boyden B, Larsen FG, Harvima RJ, Guilhou JJ, Kaufmann R, Rogers S, Van De Kerkhof PC, Hanssen LI, Tegner E, Burg G, Talbot D, Chu A. 2003. Journal of the american academy of dermatology. 48: 48-54
Psoriasis ja sen hoidoista
Harvima R. 2003. TIETOA TERVEYDESTÄ. : 18-20
Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis
Palosuo K, Varjonen E, Nurkkala J, Kalkkinen N, Harvima R, Reunala T, Alenius H. 2003. Journal of allergy and clinical immunology. 111: 1386-1392
A multicenter study of patch test reactions with dental screening series
Kanerva L, Rantanen T, Aalto-Korte K, Estlander T, Hannuksela M, Harvima RJ, Hasan T, Horsmanheimo M, Jolanki R, Kalimo K, Lahti A, Lammintausta K, Lauerma A, Niinimäki A, Turjanmaa K, Vuorela A-M. 2001. AMERICAN JOURNAL OF CONTACT DERMATITIS. 12: 83-87
Interleukin-4-posituve mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT, Naukkarinen A. 2001. Allergy. 56: 58-64
Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects on leukotriene C4 and prostaglandin D2
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. European journal of clinical pharmacology. 57: 1-4
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells
Kivinen PK, Kaminska R, Naukkarinen A, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. Experimental dermatology. 10: 246-255
The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2001. Clinical and experimental allergy. 31: 593-601
Alterations in mast cells showing tryptase and chymase activity in epithelializatingand chronic wounds
Huttunen M, Aalto M-L, Harvima RJ, Horsmanheimo M, Harvima IT. 2000. Experimental dermatology. 9: 258-265
Histamine and LTC4 in stinging nettle-induced urticaria
Taskila K, Saarinen JV, Harvima IT, Harvima RJ. 2000. Allergy. 55: 679-680
Kun tutkija yrittää julkaista tutkimuksensa... Kokeneiden tutkijoiden näkökulmia käsikirjoituksen tarjoamisesta tieteelliseen lehteen
Harvima R, Harvima I. 2000. LÄÄKÄRISANOMAT. : 31
Lääkkeiden käytön ja ihoreaktioiden kuvauksen sekä kirjaamisen tärkeys myöhemmälle diagnostiikalle
Harvima R, Laukkanen A, Harvima I, Mattila R, Hollmén A. 2000. Lääkärilehti. 55: 2195-2196
Release of histamine and leukotriene C4 in immendiate allergic wheal reaction as measured with microdialysis techinique
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2000. Archives of dermatological research. 292: 333-340
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
Harvima IT, Haapanen L, Ackermann L, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. Acta dermato-venereologica. 79: 98-104
Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase
Kaminska R, Helisalmi P, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Journal of investigative dermatology. 113: 567-573
Histone-Hydrolyzing Proteinases in the Skin with Special Reference to the Mast Cell Tryptase Upregulated in Psoriasis
Harvima R. 1999. Kuopio University Publications D. Medical Sciences
Identification and characterization of multiple forms of tryptase from human mast cells
Harvima RJ, Harvima IT, Dull D, Dunder UK, Schwartz LB. 1999. Archives of dermatological research. 291: 73-80
Käsien työperäisen urtikarian syy
Harvima RJ, Tuomisto L, Husman T. 1999. Duodecim. 115: 1038-1040
Mast cells in psoriatic skin are strongly positive for interferon-gamma
Ackermann L, Harvima IT, Pelkonen J, Ritamäki-Salo V, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. British journal of dermatology. 140: 624-633
Pyoderma gangraenosumin paikallishoito kromoglikaattiliuoksella
Harvima RJ, Hollmén A, Mattila R, Kaipiainen-Seppänen O, Harvima IT, Kaminska R, Laukkanen A, Räsänen L, Horsmanheimo M. 1999. Duodecim. 115: 2085-2090
Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin
Kivinen PK, Hyttinen M, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Archives of dermatological research. 291: 217-223
Repeated hand urticaria due to contact with fishfood
Harvima RJ, Tuomisto L, Husman T. 1999. Scandinavian journal of work environment and health. 25: 151-152
Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study
Molin L, Cutler TP, Helander I, Nyfors B, Downes N, The Calsipotriol Study Group, Förström L, Kariniemi A-L, Tuomi M-L, Vaalasti A, Sysilampi M-L, Horsmanheimo M, Harvima R. 1997. British journal of dermatology. 136: 89-93
Association of psychic stress with clinical severity and symptoms of psoriatic patients
Harvima RJ, Viinamäki H, Harvima IT, Naukkarinen A, Savolainen L, Aalto M-L, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 467-471
Histamine release in skin monitored with the mikrodialysis technique does not correlate with the weal size induced by cow allergen
Horsmanheimo L, Harvima IT, Harvima RJ, Ylönen J, Naukkarinen A, Horsmanheimo M. 1996. British journal of dermatology. 134: 94-100
Kun nuori nainen valittaa tukan lähtöä
Harvima R, Harvima I. 1996. Lääkärilehti. 51: 1799-1801
Neuropeptide- and capsaicin-induced histamine release in skin monitored with the microdialysis technique
Huttunen M, Harvima IT, Ackermann L, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 205-209
Quantitative histochemical analysis of mast cells and sensory nerves in psoriatic skin
Naukkarinen A, Järvikallio A, Lakkakorpi J, Harvima IT, Harvima RJ, Horsmanheimo M. 1996. Journal of pathology. 180: 200-205
Skin tryptase: Features and expression in human dermatological disorders
Harvima IT, Harvima RJ, Naukkarinen A, Horsmanheimo M. Teoksessa: Caughey GH(toim.) , 1995. Mast Cell Proteases in Immunology and Biology. s. 25-46. Marcel Dekker
Analysis of the protein pattern of Gremmeniella abietina with special reference to protease activity
Petäistö R-L, Rissanen TE, Harvima RJ, Kajander EO. 1994. Mycologia. 86: 242-249
Mast cells are one major source of interleukin-4 in atopic dermatitis
Horsmanheimo L, Harvima IT, Järvikallio A, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1994. British journal of dermatology. 131: 348-353

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Rauno Harvima

Research groups

FoxP3-Positive Cells and Their Contacts with Mast Cells Are Highly Increased in Basal Cell Carcinoma

Gynecomastia in a Young Male Caused by lsotretinoin : A Case Report

Patients with a history of atopy have fewer cutaneous melanomas than those without atopy: a cross-sectional study in 496 patients at risk of skin cancers

Real-world registry-based study on apremilast use in psoriasis and psoriatic arthritis in Finland

Vaikean penisilliiniallergian epätavallinen kehittyminen

Case: Unexpected development of severe penicillin allergy and review of literature

Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report

Guselkumab Treatment Outcomes and Persistence in a Nationwide Real-world Cohort of Patients with Plaque Psoriasis

Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals

Survival from cutaneous malignant melanoma is improving, but is it because of a trend in decreasing melanoma thickness or the advent of new ‘revolutionary’ therapeutics?

The Use of Lymphocyte Stimulation Test in Severe Nabumetone-Induced Stevens-Johnson Syndrome: A Case Report

Clinical, patient and estimated cost benefits of proactive management versus reactive management with calcipotriol/betamethasone dipropionate foam for the treatment of plaque psoriasis in Finland

Erythrasma Capitis and Diffuse Hair Loss with Patches and Eczema-a Rare but Underdiagnozed Entity?

Occupational allergic rhinitis and asthma caused by guar gum

Patients with Hidradenitis Suppurativa Suffer from Low Health-Related Quality of Life as Measured by the Generic 15D Instrument

Sisters with Generalized Pustular Psoriasis Successful Treatment with Biologics

Unusual Clinical Picture of a Comedo Mimicking Keratoacanthoma

Patients with hidradenitis suppurativa may suffer from neuropathic pain: A Finnish multicenter study

Successful treatment of iatrogenically developed cutaneous calcification by tetracycline in Labrador retriever

Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro

Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma

The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma

Evaluation of exposure to 1-alkoxy-2propanols and 1-(2-methoxy-1-methylethoxy)-2-propanol by the analysis of the parent compounds in urine

Microdialysis for detection of dynamic changes in tissue histamine levels in experimental thermal injury

Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland -a multicentre study

Ärsytysihottuma ammattitautina

Psoriaasin uudet hoidot - yhdistelmävoidetta ja biologisia lääkkeitä

Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis

Psoriasis ja sen hoidoista

Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis

A multicenter study of patch test reactions with dental screening series

Interleukin-4-posituve mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin

Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects on leukotriene C4 and prostaglandin D2

Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells

The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin

Alterations in mast cells showing tryptase and chymase activity in epithelializatingand chronic wounds

Histamine and LTC4 in stinging nettle-induced urticaria

Kun tutkija yrittää julkaista tutkimuksensa... Kokeneiden tutkijoiden näkökulmia käsikirjoituksen tarjoamisesta tieteelliseen lehteen

Lääkkeiden käytön ja ihoreaktioiden kuvauksen sekä kirjaamisen tärkeys myöhemmälle diagnostiikalle

Release of histamine and leukotriene C4 in immendiate allergic wheal reaction as measured with microdialysis techinique

Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions

Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase

Histone-Hydrolyzing Proteinases in the Skin with Special Reference to the Mast Cell Tryptase Upregulated in Psoriasis

Identification and characterization of multiple forms of tryptase from human mast cells

Käsien työperäisen urtikarian syy

Mast cells in psoriatic skin are strongly positive for interferon-gamma

Pyoderma gangraenosumin paikallishoito kromoglikaattiliuoksella

Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin

Repeated hand urticaria due to contact with fishfood

Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study

Association of psychic stress with clinical severity and symptoms of psoriatic patients

Histamine release in skin monitored with the mikrodialysis technique does not correlate with the weal size induced by cow allergen

Kun nuori nainen valittaa tukan lähtöä

Neuropeptide- and capsaicin-induced histamine release in skin monitored with the microdialysis technique

Quantitative histochemical analysis of mast cells and sensory nerves in psoriatic skin

Skin tryptase: Features and expression in human dermatological disorders

Analysis of the protein pattern of Gremmeniella abietina with special reference to protease activity

Mast cells are one major source of interleukin-4 in atopic dermatitis