Seppo Helisalmi
Senior Researcher
School of Medicine, Faculty of Health Sciences
seppo.helisalmi@uef.fi | +358 44 716 2202
0447162202
044 7162202
044 716 2202
+358 44 716 2202
+35844 716 2202
044 7162 202
+358 44 7162 202
+35844 7162 202
+358 44 7162202
+35844 7162202
+358447162202
044 7162202
044 716 2202
+358 44 716 2202
+35844 716 2202
044 7162 202
+358 44 7162 202
+35844 7162 202
+358 44 7162202
+35844 7162202
+358447162202
Research groups
Projects
Publications
151 items-
Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation
Valtola, Kati; Hedman, Marja; Kantola, Ilkka; Walls, Susanne; Helisalmi, Seppo; Maria, Maleeha; Raivo, Joose; Auray-Blais, Christiane; Kuusisto, Johanna. 2023. Open heart. 10: -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 -
Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study
Ravi, Rowmika; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Maria, Maleeha; Raivo, Joose; Helisalmi, Seppo; Laakso, Markku. 2022. Metabolites. 12: -
NDUFA1 p.Gly32Arg variant in early-onset dementia
Huttula, Samuli; Väyrynen, Henri; Helisalmi, Seppo; Kytövuori, Laura; Luukkainen, Laura; Hiltunen, Mikko; Remes, Anne M; Krüger, Johanna. 2022. Neurobiology of aging. 114: 113-116 -
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em. 2022. Nature genetics. 54: 412-436 -
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino. 2022. Alzheimer's research and therapy. 14: . 151 -
GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance
Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. Journal of neurology neurosurgery and psychiatry. 92: 1305-1312 -
Molecular epidemiology of hereditary ataxia in Finland
Lipponen, Joonas; Helisalmi, Seppo; Raivo, Joose; Siitonen, Ari; Doi, Hiroshi; Rusanen, Harri; Lehtilahti, Maria; Ryytty, Mervi; Laakso, Markku; Tanaka, Fumiaki; Majamaa, Kari; Kytövuori, Laura. 2021. Bmc neurology. 21: 382 -
Novel Rare SORL1 Variants in Early-Onset Dementia
Korpioja, Anita; Krüger, Johanna; Koivuluoma, Susanna; Pylkäs, Katri; Moilanen, Virpi; Helisalmi, Seppo; Hiltunen, Mikko; Remes, Anne M; Zhu, Ling-Qiang. 2021. Journal of Alzheimer's disease. 82: 761-770 -
Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial
Rosenberg, Anna; Solomon, Alina; Soininen, Hilkka; Visser, Pieter Jelle; Blennow, Kaj; Hartmann, Tobias; Kivipelto, Miia; on behalf of the LipiDiDiet clinical study group [incl. Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu]. 2021. Alzheimer's research and therapy. 13: 64 -
36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease
Soininen, Hilkka; Solomon, Alina; Visser, Pieter Jelle; Hendrix, Suzanne B; Blennow, Kaj; Kivipelto, Miia; Hartmann, Tobias; Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu; Wahlund, Lars-Olof; Freund-Levi, Yvonne; Hagman, Göran; Hartmann, Tobias; Fassbender, Klaus; Riemenschneider, Matthias; Grimm, Marcus OW et al.. 2020. Alzheimer's & dementia. 2021; 17: 29-40 -
Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline
Pekkala, Timo; Hall, Anette; Ngandu, Tiia; Gils, Mark van; Helisalmi, Seppo; Hänninen, Tuomo; Kemppainen, Nina; Liu, Yawu; Lötjönen, Jyrki; Paajanen, Teemu; Rinne, Juha O; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2020. Frontiers in aging neuroscience. 12: 228 -
Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members
Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Fluids and barriers of the cns. 17: 57 -
Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.
Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Journal of Alzheimer's disease. 74: 277-286 -
Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia
Luukkainen, L; Huttula, S; Väyrynen, H; Helisalmi, S; Kytövuori, L; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2020. Journal of Alzheimer's disease. 76: 955-965 -
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing
Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Nature genetics. 51: 414-430 -
Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients
Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137 -
Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration
Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2019. Journal of Alzheimer's disease. 69: 775-782 -
Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion
Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology. 2020; 267: 76-86 -
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243 -
Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus
Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103 -
Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders
Katisko, K; Cajanus, A; Jääskeläinen, O; Kontkanen, A; Hartikainen, P; Korhonen, VE; Helisalmi, S; Haapasalo, A; Koivumaa-Honkanen, H; Herukka, SK; Remes, AM; Solje, E. 2019. Journal of neurology. 2020; 267: 162-167 -
Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis
Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM. 2018. Dementia and geriatric cognitive disorders extra. 8: 51-59 -
Brain ß-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
Martikainen, IK; Kemppainen, N; Johansson, J; Teuho, J; Helin, S; Liu, Y; Helisalmi, S; Soininen, H; Parkkola, R; Ngandu, T; Kivipelto, M; Rinne, JO. 2018. American journal of neuroradiology. 2019; 40: 80-85 -
Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH
Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291 -
Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial
Solomon, A; Turunen, H; Ngandu, T; Peltonen, M; Levälahti, E; Helisalmi, S; Antikainen, R; Bäckman, L; Hänninen, T; Jula, A; Laatikainen, T; Lehtisalo, J; Lindström, J; Paajanen, T; Pajala, S; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Soininen, H; Kivipelto, M. 2018. JAMA neurology. 75: 462-470 -
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Peloso, GM; van der Lee, SJ; International Genomics of Alzheimer's Project (IGAP); Destefano, AL; Seshardi, S; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Helisalmi, Seppo; Koivisto, Anne). 2018. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 10: 595-598 -
Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration
Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Journal of Alzheimer's disease. 62: 789-794 -
Melatonin receptor type 1A gene linked to Alzheimer's disease in old age
Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T. 2018. Sleep. 41: 1-10 -
Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers
Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Journal of neuroimmunology. 321: 29-35 -
Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject
Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Journal of Alzheimer's disease. 62: 165-174 -
The association between frontotemporal lobar degeneration and bullous pemphigoid
Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. Journal of Alzheimer's disease. 66: 743-750 -
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; et al [ Incl Helisalmi, Seppo; HIltunen, Mikko; Remes, Anne; Soininen, Hilkka]. 2018. Molecular psychiatry. [Published: 14 August 2018]: 1-17 -
Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus
Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085 -
Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition
Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, Laatikainen T, Paajanen T, Hänninen T, Strandberg T, Antikainen R, Tuomilehto J, Keinänen Kiukaanniemi S, Vanninen R, Helisalmi S, Levälahti E, Kivipelto M, Soininen H, Solomon A. 2017. Journal of Alzheimer's disease. 59: 695-705 -
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants
Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD et al.. 2017. PLoS ONE. 12: e0185777 -
Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study
Marttila Maria, Kytövuori Laura, Helisalmi Seppo, Kallio Mika, Laitinen Marjo, Hiltunen Mikko, Kärppä Mikko, Majamaa Kari. 2017. Neuroepidemiology. 49: 34-39 -
Neuropsychological Profile in the C9ORF72 Associated Behavioral Variant Frontotemporal Dementia
Suhonen N-M, Haanpää RM, Korhonen V, Jokelainen J, Pitkäniemi A, Heikkinen A-L, Krüger J, Hartikainen P, Helisalmi S, Hiltunen M, Hänninen T, Remes AM. 2017. Journal of Alzheimer's disease. 58: 479-489 -
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADGC, EADI. 2017. Nature genetics. 49: 1373-1384 -
Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion
Junttila A, Kuvaja M, Hartikainen P, Siloaho M, Helisalmi S, Moilanen V, Kiviharju A, Jansson L, Tienari PJ, Remes AM, Herukka SK. 2016. Dementia and geriatric cognitive disorders. 6: 142-149 -
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003 -
Familial idiopathic normal pressure hydrocephalus
Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18 -
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319 -
The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966
Solje Eino, Miettunen Jouko, Marttila Riikka, Helisalmi Seppo, Laitinen Marjo, Koivumaa-Honkanen Heli, Isohanni Matti, Hiltunen Mikko, Jääskeläinen Erika, Remes Anne M. 2016. Psychiatric genetics. 26: 92-94 -
The role of the FTD-ALS associated C9orf72 expansion in suicide victims
Solje Eino, Riipinen Pirkko, Helisalmi Seppo, Särkioja Terttu, Laitinen Marjo, Hiltunen Mikko, Hakko Helinä, Remes Anne M. 2016. Amyotrophic lateral sclerosis & frontotemporal degeneration. 17: 589-592 -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269 -
Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion
Kämäläinen A, Herukka S-K, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM. 2015. Dementia and geriatric cognitive disorders. 39: 287-293 -
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 -
Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease
Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516 -
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Steinberg Stacy, Stefansson Hreinn, Jonsson Thorlakur, Johannsdottir Hrefna, Ingason Andres, Helgason Hannes, Sulem Patrick, Magnusson Olafur Th, Gudjonsson Sigurjon A, Unnsteinsdottir Unnur, Kong Augustine, Helisalmi Seppo, Soininen Hilkka, Lah James J, DemGene, Aarsland Dag, Fladby Tormod, Ulstein Ingun D, Djurovic Srdjan, Sando Sigrid B (incl. Hiltunen Mikko). 2015. Nature genetics. 47: 445-447 -
The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968 -
ADAMTS9 locus associates with increased risk of wet AMD
Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. Acta ophthalmologica. 2014: 1 -
High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms
Kurki MI, Gaál EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, van 't Hof FN, von Und Zu Fraunberg M, Helisalmi S, Hiltunen M, Lehto H2, Laakso A, Kivisaari R, Koivisto T, Ronkainen A, Rinne J, Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, Aromaa A, Perola M, Lehtimäki T, Raitakari OT, Salomaa V, Gunel M, Dermitzakis ET, Ruigrok YM, Rinkel GJ, Niemelä M, Hernesniemi J, Ripatti S, de Bakker PI, Palotie A, Jääskeläinen JE. 2014. PLoS genetics. 10: e1004134 -
The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients
Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. Neurodegenerative diseases. 14: 204-208 -
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 -
CSF biomarkers for Alzheimer's pathology and the effect size of APOE epsilon4
Andreasson U, Lautner R, Schott JM, Mattson N, Hansson P, Herukka S-K, Helisalmi S, Ewers M, Hampel H, Wallin A, Minthon L, Hardy J, Blennow K, Zetterberg H. 2013. Molecular psychiatry. [Epub ahead of print]: 1-2 -
Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease
Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 -
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease
Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Journal of Alzheimer's disease. 37: 217-232 -
GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. Journal of Alzheimer's disease. 33: 23-27 -
Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort
Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. PLoS ONE. 8: e59676 -
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's Disease patients alter calcium homeostasis
Rubio-Moscardo Fanny, Seto-Salvia Nuria, Pera Marta, Bosch-Morato Monica, Plata Christina, Belbin Olivia, Gene Gemma, Dols-Icardo Oriol, Ingelsson Martin, Helisalmi Seppo, Soininen Hilkka, Hiltunen Mikko, Giedraitis Vilmantas, Lannfelt Lars, Frank Ana, Bullido Ma Jesus, Combarros Onofre, Sanchez-Juan Pascual et.al.. 2013. PLoS ONE. 8: e74203 -
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124 -
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575 -
Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease
Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Journal of Alzheimer's disease. 28: 553-559 -
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fievet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S et al.. 2011. Molecular psychiatry. 16: 903-907 -
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking
Sarajärvi Timo, Tuusa Jussi T, Haapasalo Annakaisa, Lackman Jarkko T, Sormunen Raija, Helisalmi Seppo, Roehr Johannes T, Parrado Antonio R, Mäkinen Petra, Bertram Lars, Soininen Hilkka, Tanzi Rudolph E, Petäjä-Repo Ulla E, Hiltunen Mikko. 2011. Molecular and cellular biology. 31: 2326-2340 -
Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations
Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri F, Delepine M et al.. 2011. Neurobiology of aging. 32: 756.e11-756.e15 -
Longitudinal changes of CSF biomarkers in Alzheimer's Disease
Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Journal of Alzheimer's disease. 25: 583-594 -
Metabolome in progression to Alzheimer's disease
Oresic M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H. 2011. Translational psychiatry. 1: e57 -
No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease
Turunen Mari, Vepsäläinen Saila, Mäkinen Petra, Helisalmi Seppo, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2011. Neurobiology of aging. 32: 547.e7-547.e9 -
Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Negative results
Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M & Soininen H.. 2011. Neurobiology of aging. 32: 546.e7-546.e9 -
An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. Journal of Alzheimer's disease. 21: 763-767 -
CALHM1 P86L polymorphism does not alter amyloid-beeta or tau in cerebrospinal fluid
Giedraitis V, Glaser A, Sarajärvi T, Brundin RM, Degerman Gunnarsson M, Schjeide BM, Tanzi RE, Helisalmi S et al. 2010. Neuroscience letters. 469: 265-267 -
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
Lambert JC, Sleegers K, Gonzalez-Perez A, Ingelsson M, Beecham GW, Hiltunen M et al. 2010. Journal of Alzheimer's disease. 22: 247-255 -
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population
Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M, Soininen H, Hiltunen M, Helisalmi S. 2009. American journal of medical genetics. Part B : neuropsychiatric genetics. 150B: 747-750 -
Beta-amyloid deposition in brains of subjects with diabetes
Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H, Soininen H. 2009. Neuropathology and applied neurobiology. 1: 60-68 -
Combined risk effects of IDE and NEP gene variants on Alzheimer disease
Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Journal of neurology neurosurgery and psychiatry. 80: 1268-1270 -
Flanking markers of cyntation C (CST3) gene do not show association with Alzheimer's disease
Helisalmi S, Väkevä A, Hiltunen M, Soininen H, Soininen H, Helisalmi S. 2009. Dementia and geriatric cognitive disorders. 27: 318-321 -
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Lambert JC, Heath S, Even G..., Hiltunen M, Combarros O..., Helisalmi S, Porcellini E..., Licastro F, Soininen H, Ritchie K..., Amouyel P, Hiltunen M, Helisalmi S, Soininen H. 2009. Nature genetics. 41: 1047-1048 -
Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease
Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Journal of neurology. 255: 668-673 -
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Neurobiology of aging. 29: 848-855 -
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Neuroscience letters. 438: 216-220 -
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease
Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Neuroscience letters. 441: 233-236 -
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease
Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M, Helisalmi S, Soininen H, Hiltunen M. 2008. European journal of human genetics. 16: 171-175 -
CSF Abeta42, tau and phosphorylated tau, APOE epsilon4 allele and MCI type in progressive MCI
Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T, Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T. 2007. Neurobiology of aging. 28: 507-514 -
Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population
Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Journal of medical genetics. 44: 606-608 -
Lipid profile factors and apolipoprotein E polymorphism in Alzheimer¿s disease
Helisalmi S, Helisalmi S. 2007. Future neurology. 2: 25-27 -
Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients
Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Journal of neurology. 254: 1504-1508 -
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Dementia and geriatric cognitive disorders. 24: 146-150 -
The association study between DHCR24 polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. American journal of medical genetics. Part B : neuropsychiatric genetics. 144B: 906-910 -
Adiponectin gene haplotype is associated with preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. GENETIC TESTING. 10: 35-39 -
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population
Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453 -
Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary
Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Journal of neurology neurosurgery and psychiatry. 77: 421-422 -
Cerebrospinal fluid Abeta42, tau and phosphorylated tau predict progression in patients with cognitive impairment
Herukka S-K, Hallikainen M, Tervo S, Helisalmi S, Tapiola T, Soininen H, Pirttilä T, Hallikainen M, Tervo S, Helisalmi S, Soininen H, Pirttilä T. Teoksessa: Vellas B, Winblad B, Grundman M, Fitten LJ, Feldman H, Giacobini E, Kurz A(toim.) , 2006. Research and Practice in Alzheimer¿s Disease. s. 245-250. Serdi -
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice
Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Neuroscience. 137: 1143-1152 -
Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas
Tuhkanen H, Anttila M, Kosma V-M, Heinonen S, Juhola M, Helisalmi S, Kataja V, Mannermaa A, Helisalmi S. 2006. International journal of cancer. 119: 1345-1353 -
MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in finnish women
Jääskeläinen E, Keski-Nisula L, Toivonen S, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S, Helisalmi S. 2006. Hypertension in pregnancy. 25: 73-80 -
Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Gynecologic and obstetric investigation. 61: 124-127 -
Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. European journal of obstetrics and gynecology and reproductive biology. 128: 175-179 -
Associations between two single nucleotide polymorphism in the adiponectin gene and polycystic ovary syndrome
Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen J, Hippeläinen M, Laakso M. 2005. Gynecological endocrinology. 21: 165-169 -
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in finnish women
Toivonen S, Keski-Nisula L, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S. 2005. Fetal diagnosis and therapy. 20: 508-511 -
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women
Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. European journal of human genetics. 13: 1000-1006 -
Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease
Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Journal of neurology. 252: 423-428 -
Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia
Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. 2005. Molecular human reproduction. 11: 437-440 -
Alzheimerin taudin genetiikka
Hiltunen M, Helisalmi S, Kivipelto M, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2004. Duodecim. 120: 2425-2431 -
Genetic variation in apolipoprotein D and Alzheimer¿s disease
Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Journal of neurology. 251: 951-957 -
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption
Toivonen S, Romppanen E-L, Hiltunen M, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION. 11: 540-544 -
M385T polymorphism in the factor V gene, but not leiden mutation, is associated with placental abruption in finnish women
Jääskeläinen E, Toivonen S, Romppanen E-L, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. Placenta. 25: 730-734 -
Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients
Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Journal of neurology neurosurgery and psychiatry. 75: 1746-1748 -
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease
Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A, Vepsäläinen S, Hänninen T, Soininen H, Hiltunen M, Iivonen S, Hiltunen M, Soininen H, Helisalmi S, Vepsäläinen S. 2004. Neurology. 62: 1170-1176 -
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population
Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Neurology. 63: 173-175 -
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation
Faisel F, Romppanen E-L, Hiltunen M, Helisalmi S, Laasanen J, Punnonen K, Salonen JT, Heinonen S, Hiltunen M, Helisalmi S. 2004. European journal of human genetics. 12: 187-191 -
The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome
Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen JS, Laakso M, Laakso M. 2004. Fertility and sterility -
Heparan sulfate proteoglycan 2 polymorphism in Alzheimer¿s disease and correlation with neuropathology
Iivonen S, Helisalmi S, Mannermaa A, Alafuzoff I, Lehtovirta M, Soininen H, Hiltunen M. 2003. Neuroscience letters. 352: 146-150 -
Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease
Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Dementia and geriatric cognitive disorders. 14: 123-127 -
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease
Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Neuroscience. 113: 301-310 -
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia
Laasanen J, Romppanen E-L, Hiltunen M, Helisalmi S, Mannermaa A, Punnonen K, Heinonen S. 2002. European journal of human genetics. 10: 569-573 -
An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin
Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. Neurogenetics -
Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland
Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Neurology. 57: 1663-1668 -
Maternal susceptibility locus for obstetric cholestasis maps to chromosone region 2p13 in finnish patients
Heinonen S, Eloranta M-L, Heiskanen J, Punnonen K, Helisalmi S, Mannermaa A, Hiltunen M. 2001. Scandinavian journal of gastroenterology. 36: 766-770 -
The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer¿s disease
Kraszpulski M, Soininen H, Helisalmi S, Alafuzoff I. 2001. Acta neurologica scandinavica. 103: 88-92 -
A longitudinal quantitative EEG study of Alzheimer¿s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Hiltunen J, Helisalmi S, Hartikainen P, Riekkinen P Sr, Soininen H. 2000. Dementia and geriatric cognitive disorders. 11: 29-35 -
DNA fragmentation, gliosis and histological hallmarks of Alzheimer¿s disease
Overmyer M, Kraszpulski M, Helisalmi S, Soininen H, Alafuzoff I. 2000. Acta neuropathologica. 100: 681-687 -
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination?
Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. European journal of human genetics. 8: 259-266 -
Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer¿s disease?
Helisalmi S, Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Alafuzoff I, Ryynänen M, Soininen H. 2000. Neuroscience letters. 278: 65-68 -
Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs
Alafuzoff I, Overmyer M, Helisalmi S, Soininen H. 2000. Journal of Alzheimer's disease. 2: 37-46 -
Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer¿s disease
Alafuzoff I, Helisalmi S, Heinonen EH, Reinikainen K, Hallikainen M, Soininen H, Koivisto K. 2000. European journal of clinical pharmacology. 55: 815-819 -
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia
Alafuzoff I, Helisalmi S, Mannermaa A, Soininen H. 2000. Annals of the New York Academy of Sciences. 903: 244-251 -
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E
Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. Neuroscience letters. 287: 25-28 -
Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Dementia and geriatric cognitive disorders. 10: 252-257 -
Beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients
Alafuzoff I, Helisalmi S, Mannermaa A, Riekkinen P Sr, Soininen H. 1999. Stroke. 30: 613-618 -
Beta-amyloid load, astroglia and microglia in Alzheimer¿s disease: association with apoE genotype
Alafuzoff I, Overmyer M, Helisalmi S, Riekkinen P Sr, Soininen H. 1999. ALZHEIMER'S RESEARCH. 2: 283-289 -
Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients
Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Helisalmi S, Ryynänen M, Riekkinen P Sr, Soininen H. 1999. European journal of human genetics. 7: 652-658 -
Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer¿s disease patients and control individuals
Helisalmi S, Hiltunen M, Valonen P, Mannermaa A, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 1999. Journal of neurology. 246: 821-824 -
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Acta neuropathologica. 97: 383-392 -
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer¿s disease patients
Hiltunen M, Mannermaa A, Helisalmi S, Koivisto A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Neuroscience letters. 250: 69-71 -
CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease
Tapiola T, Lehtovirta M, Ramberg J, Helisalmi S, Linnaranta K, Riekkinen P Sr, Soininen H. 1998. Neurology. 50: 169-174 -
Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 64: 742-746 -
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer`s disease carrying the apolipoprotein E epsilon4 allele
Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 65: 322-327 -
Molecular Genetics of Alzheimer¿s Disease. With Special Emphasis on Presenilin, Amyloid Beta Precursor Protein and Apolipoprotein E Genes
Helisalmi S. 1998. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No -
Lack of association between presenilin-1 polymorphism, Alzheimer's disease and apolipoprotein E
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. ALZHEIMER'S RESEARCH. 3: 159-161 -
No association between alfa1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer`s disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. Neuroscience letters. 231: 56-58 -
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer`s disease
Tapiola T, Overmyer M, Lehtovirta M, Helisalmi S, Ramberg J, Alafuzoff I, Riekkinen P Sr, Soininen H. 1997. Neuroreport. 8: 3961-3963 -
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders
Helisalmi S, Linnaranta K, Lehtovirta M, Mannermaa A, Heinonen O, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 61-64 -
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ Sr. 1996. Neurology. 46: 413-419 -
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele
Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynänen M, Kuikka J, Hartikainen P, Riekkinen PJ Sr. 1996. Journal of neurology neurosurgery and psychiatry. 60: 644-649 -
Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 68-70 -
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Soininen H, Helisalmi S, Mannermaa A, Ryynänen M, Hartikainen P, Riekkinen P Sr. 1996. Neurobiology of aging. 17: 523-526 -
Alzheimer pathology of patients carrying apolipoprotein E epsilon4 allele
Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari H, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen PJ Sr. 1995. Neurobiology of aging. 16: 505-513 -
Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients
Kosunen O, Talasniemi S, Lehtovirta M, Heinonen O, Helisalmi S, Mannermaa A, Paljärvi L, Ryynänen M, Riekkinen PJ Sr, Soininen H. 1995. Stroke. 26: 743-748 -
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes
Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Partanen K, Ryynänen M, Vainio P, Hartikainen P, Riekkinen PJ Sr. 1995. Neuroscience. 67: 65-72