Tarja Malm
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
tarja.malm@uef.fi | +358 40 355 2209
I lead the Neuroinflammation research group. We aim to find regulators of microglial dysfunctions in neurodegenerative diseases.
To find out more of our research, please visit:
https://sites.uef.fi/tarja-malm-group/research-details/
Research groups
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Biomedical MRI 01.01.1995 - -
In vitro and ex vivo electrophysiology core facil… 01.01.2020 - -
Neuroinflammation research group 01.01.2017 - -
NPH and Early AD 01.01.2010 -
Projects
Publications
140/140 items-
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 -
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari. 2024. Nature cardiovascular research. [Published: 15 March 2024]: 1-41 -
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre, . 2024. Cell reports. 43: -
Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974 -
Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location
Ojala, Ronja; Hentilä, Jaakko; Lietzén, Martin S; Arponen, Milja; Heiskanen, Marja A; Honkala, Sanna M; Virtanen, Heidi; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Heinonen, Olli J; Malm, Tarja; Lahti, Leo; Rinne, Juha; Eskola, Olli; Rajander, Johan; Pietiläinen, Kirsi H; Kaprio, Jaakko; Ivaska, Kaisa K.; Hannukainen, Jarna C. 2023. Diabetes obesity and metabolism. 2024; 26: 251-261 -
Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles
Es-Haghi, Masoumeh; Neustroeva, Olga; Chowdhury, Iftekhar; Laitinen, Pia; Väänänen, Mari-Anna; Korvenlaita, Nea; Malm, Tarja; Turunen, Mikko P; Turunen, Tiia A. 2023. Genes. 14: -
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: -
Early Alzheimer's disease pathology in human cortex involves transient cell states
Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 -
Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment
Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M. 2023. Science of the total environment. 905: -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118