TARJA MALM

Contact info

Keywords

Research groups - UEF

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  In vitro and ex vivo electrophysiology core facility
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  Neuro-Innovation
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  Neuroinflammation research group

Publications

• Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. 2021. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats International journal of molecular sciences 22 4: 1512. 2021
• Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays Cells 2022; 11 1: 106. 2021
• Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease International journal of molecular sciences 22 16: 8715. 2021
• Wurm, Johannes; Konttinen, Henna; Andressen, Christian; Malm, Tarja; Spittau, Björn. 2021. Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs International journal of molecular sciences 22 6: 3088. 2021
• Sturchio, Andrea; Dwivedi, Alok K.; Young, Christina B.; Malm, Tarja; Marsili, Luca; Sharma, Jennifer S.; Mahajan, Abhimanyu; Hill, Emily J.; Andaloussi, Samir EL; Poston, Kathleen L.; Manfredsson, Fredric P.; Schneider, Lon S.; Ezzat, Kariem; Espay, Alberto J.. 2021. High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis EClinicalMedicine 38: 100988. 2021
• Puris, Elena; Kouril, Štepán; Najdekr, Lukáš; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice Scientific reports 11 1: 13076. 2021
• Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model Journal of pharmaceutical sciences 110 12: 3953-3962. 2021
• Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja. 2021. Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease Frontiers in cell and developmental biology 8: 623771. 2021
• Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut Duodecim 137 13: 1375- 1382. 2021
• Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, Šárka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo Scientific reports 11 1: 3518. 2021
• Jonavice, Ugne; Romenskaja, Diana; Kriauciunaite, Karolina; Jarmalaviciute, Akvile; Pajarskiene, Justina; Kašeta, Vytautas; Tunaitis, Virginijus; Malm, Tarja; Giniatulin, Rashid; Pivoriunas, Augustas. 2021. Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms International journal of molecular sciences 22 20: 10970. 2021
• Heiskanen, Marja A; Honkala, Sanna M; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S; Saunavaara, Virva; Saunavaara, Jani; Helmio, Mika; Löyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H; Kaprio, Jaakko; Rinne, Juha O; Hannukainen, Jarna C. 2021. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight BMC sports science, medicine & rehabilitation 13 1: 16. 2021
• Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2021. Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids Cells 2022; 11 1: 124. 2021
• Bosutti, Alessandra; Giniatullin, Arthur; Odnoshivkina, Yulia; Giudice, Luca; Malm, Tarja; Sciancalepore, Marina; Giniatullin, Rashid; D'Andrea, Paola; Lorenzon, Paola; Bernareggi, Annalisa. 2021. "Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation Acta physiologica 233 4: e13702. 2021
• Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020
• White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Editorial: Air Pollution and Brain Health Neurochemistry international 141: 104900. 2020
• Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid. 2020. Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages? Frontiers in cellular neuroscience 14: 548376. 2020
• Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J; Wright, Anthony P; El Andaloussi, Samir; Lindén, Anders; Ezzat, Kariem. 2020. Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology Frontiers in neuroscience 14: 256. 2020
• Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals Aging cell 2021; 20 1: e13287. 2020
• Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease Journal of neuroinflammation 17 1: 271. 2020
• Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Glial smog: Interplay between air pollution and astrocyte-microglia interactions Neurochemistry international 136: 104715. 2020
• Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells Particle and fibre toxicology 17 1: 18. 2020
• Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Impairment of mitochondrial function by particulate matter: Implications for the brain Neurochemistry international 135: 104694. 2020
• Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy Alzheimer's & dementia : diagnosis, assessment & disease monitoring 21 1: e12053. 2020
• Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. 2020. Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions Journal of extracellular vesicles 10 1: e12002. 2020
• Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine? Neuropharmacology 149: 113-123. 2019
• Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress Scientific reports 9: 10332. 2019
• Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice Human molecular genetics 28 11: 3309-3322. 2019
• Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid. 2019. Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges Frontiers in cellular neuroscience 13: 45. 2019
• Ezzat, K; Pernemalm, M; Pålsson, S; Roberts, TC; Järver, P; Dondalska, A; Bestas, B; Sobkowiak, MJ; Levänen, B; Sköld, M; Thompson, EA; Saher, O; Kari, OK; Lajunen, T; Sverremark Ekström, E; Nilsson, C; Ishchenko, Y; Malm, T; Wood, MJA; Power, UF; et al.. 2019. The viral protein corona directs viral pathogenesis and amyloid aggregation Nature communications 10 1: 2331. 2019
• Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametovez, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S; Lindsberg, Perttu J; Malm, Tarja Maarit; Giniatullin, Rashid. 2019. Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain Frontiers in cellular neuroscience 13: 195. 2019
• Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis IBRO Reports 6: 74-86. 2019
• Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Stem cell reports 13 4: 669-683. 2019
• Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke Neurotherapeutics 16: 1304-1319. 2019
• Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Journal of neurology 2020; 267: 76-86. 2019
• Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid. 2018. Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine Frontiers in cellular neuroscience 12: 326. 2018
• Nuglozeh, Edem; Feroze Fazaludeen, Mohammad; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B; Al-Hazmi, Awdah; Ashankyty, Ibraheem. 2018. Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects Indian Journal of Clinical Biochemistry 2019; 34 4: 444-450. 2018
• Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes. Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M / Astrocyte: Physiology and Pathology. 2018. 2018
• Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage Brain, behavior, and immunity 73: 670-681. 2018
• Korhonen, Paula; Malm, Tarja; White, Anthony R. 2018. 3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases NEUROCHEMISTRY INTERNATIONAL 120: 191-199. 2018
• Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes GLIA 2019; 67 1: 146-159. 2018
• Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. CuII(atsm) Attenuates Neuroinflammation Frontiers in neuroscience 12: 668. 2018
• Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
• Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration Frontiers in Neuroscience 12: 466. 2018
• 8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies. Malm, Tarja; Trevisan, Davide. 2018 2018
• Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
• Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder. Disease models & mechanisms 10 9: 1089-1100. 2017
• Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L. 2017. Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 77: 148-164. 2017
• Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE. 2017. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. Scientific Reports 7: 42270. 2017
• Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017
• Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017
• Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Scientific Reports 7: 1597. 2017
• Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu NEUROTHERAPEUTICS 14 2: 519-532. 2017
• Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. JOURNAL OF MEDICINAL CHEMISTRY 60 23: 9885-9904. 2017
• Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Lack of collagen XV is protective after ischemic stroke in mice. Cell Death and Disease 8 January: 1-8. 2017
• Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14 11: 237. 2017
• Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. 2017. Metals and lysosomal storage disorders. In: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I (ed.) Biometals in neurodegenerative diseases : mechanisms and therapeutics. Academic press. s. 195-215. 2017
• Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 10. 2016
• Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2016. Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment. Frontiers in Cellular Neuroscience 10: 279. 2016
• Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Exosomes in Alzheimer's disease NEUROCHEMISTRY INTERNATIONAL 97: 193-199. 2016
• Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016
• Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 15. 2016
• Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke Glia 64 9: 1492-507. 2016
• Kanninen K, Malm T. 2016. Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto. DUODECIM 132 21: 1957-63. 2016
• Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy Scientific Reports 6: 33176. 2016
• Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets. JOURNAL OF MOLECULAR NEUROSCIENCE 60 3: 390-404. 2016
• Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. 2016. Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling Cephalalgia 2017; 37 14: 1373-1383. 2016
• Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Exosomes as new diagnostic tools in CNS diseases. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE 2016; 1862 3: 403-410. 2015
• Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Applications of the Keap1-Nrf2 system for gene and cell therapy. FREE RADICAL BIOLOGY & MEDICINE 88 Part B: 350-361. 2015
• Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation Brain, behavior, and immunity 49: 322-336. 2015
• Malm Tarja, Mariani Monica, Donovan Lauren J, Neilson Lee, Landreth Gary E. 2015. Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 12 7: 15 p. 2015
• Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M. 2015. A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow & Metabolism [epub ahead of print Sep 30, 2015]: -. 2015
• Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging and disease [epub ahead of print 3 Dec 2015]: -. 2015
• Savage Julie C, Jay Taylor, Goduni Elanda, Quigley Caitlin, Mariani Monica M, Malm Tarja, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E. 2015. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. JOURNAL OF NEUROSCIENCE 35 16: 6532-6543. 2015
• Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. Brain, behavior, and immunity 2014 Aug 18 ePub ahead of print: --. 2014
• Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. 2014. Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury. Cell Transplantation 2014 Sep 8. [Epub ahead of print]: - -. 2014
• Skerrett R, Malm T, Landreth G. 2014. Nuclear receptors in neurodegenerative diseases. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 72 Part A: 104-116. 2014
• Malm Tarja M, Jay Taylor R, Landreth Gary E. 2014. The Evolving Biology of Microglia in Alzheimer's Disease. NEUROTHERAPEUTICS - 2014 Nov 18. [Epub ahead of print]: -. 2014
• Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin. Aging and disease 2014 Apr 1;5(2): 76-87. 2014
• Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity. STEM CELLS 32 7: 1904-1916. 2014
• Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J. 2013. Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection. Aging cell 2013 Jun 3. (Epub ahead of print): --. 2013
• Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. 2013. Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2013 Aug 20;10(1):102: --. 2013
• Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013
• Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) [Epub ahead of print] 64C: 16-29. 2013
• Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production. HUMAN MOLECULAR GENETICS 2012 Nov 1. [Epub ahead of print]: - -. 2012
• Kärkkäinen V, Magga J, Koistinaho J, Malm T. 2012. Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells. CURRENT ALZHEIMER RESEARCH 2012 Aug 30. [Epub ahead of print]: --. 2012
• Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. 2012. Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2012 May;16(5): 1060-73. 2012
• Malm T, Magga J, Koistinaho J. 2012. Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance. Current Translational Geriatrics and Gerontology Reports - -: - -. 2012
• Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2012 May 29;9:105: - -. 2012
• Malm T, Koistinaho J, Kanninen K. 2011. Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications International Journal of Alzheimer's Disease 2011;2011:517160. Epub 2011 Oct 30: --. 2011
• Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 84: 1-14. 2011
• Koistinaho J, Malm T, Goldsteins G. 2011. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International Journal of Alzheimer's Disease 2011;2011:129753. Epub 2011 May 4: --. 2011
• Kanninen K, White AR, Koistinaho J, Malm T. 2011. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway International Journal of Alzheimer's Disease 2011;2011:985085. Epub 2011 May 2: --. 2011
• Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 7: 90. 2010
• Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J. 2010. The role and therapeutic potential of monocytic cells in Alzheimer's disease GLIA 58 8: 889-900. 2010
• Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009
• Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008
• Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. JOURNAL OF NEUROCHEMISTRY 105: 584-594. 2008
• Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M. 2008. Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease GLIA 56: 154-163. 2008
• Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. 2008. Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS LETTERS 582: 2397-2401. 2008
• Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis MOLECULAR PHARMACOLOGY 71: 30-37. 2007
• Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007
• Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103 23: 8852-8857. 2006
• Malm T. 2006. Glial Cells in Alzheimer's Disease Models. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. 2006
• Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006
• Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25: 460-467. 2005
• Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J. 2005. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 18 1: 134-142. 2005