Timo Lakka
Professor
Professor of Medical Physiology
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
timo.lakka@uef.fi | +358 40 770 7329
Timo Lakka is a Professor of Medical Physiology at University of Eastern Finland, a Specialist in Internal Medicine, and an Adjunct Professor of Public Health. His research is focused on the identification of individuals at increased risk of overweight, metabolic syndrome, type 2 diabetes, and atherosclerotic cardiovascular diseases and the prevention of these diseases and conditions by increasing physical activity and improving diet since childhood. He is a Principal Investigator in the Physical Activity and Nutrition in Children (PANIC) study and a Co-Principal Investigator in the Stop Diabetes (StopDia) study and the Dose Responses to Exercise Training (DR’s EXTRA) study. He has also acted as a senior researcher in many other large-scale lifestyle intervention studies, long-term epidemiological follow-up studies, and wide international genetic-epidemiological studies. He has published over 360 scientific articles in international journals, and these articles have almost 60 000 citations and a h-index of 106 (Google Scholar). He has supervised 24 doctoral theses and is a supervisor of another 13 doctoral students.
Research groups
Publications
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Accelerated early childhood growth associates with the development of earlier adrenarche and puberty
Liimatta, Jani; Jääskeläinen, Jarmo; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Flück, Christa E; Lakka, Timo A. 2024. Journal of the Endocrine Society. 8: . bvae026 -
Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence
Haapala, Eero A; Leppänen, Marja H; Lee, Earric; Savonen, Kai; Laukkanen, Jari A; Kähönen, Mika; Brage, Soren; Lakka, Timo A. 2024. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 13: -
Association between arterial health and cognition in adolescents: The PANIC study
Jalanko, Petri; Bond, Bert; Laukkanen, Jari A; Brage, Soren; Ekelund, Ulf; Laitinen, Tomi; Määttä, Sara; Kähönen, Mika; Haapala, Eero A; Lakka, Timo A. 2024. Physiological reports. 12: . e16024 -
Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes
Manninen, Suvi; Tilles‐Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Karhunen, Leila; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; the Stop Diabetes study group. 2024. Molecular nutrition and food research. 68: -
Associations of physical fitness with cortical inhibition and excitation in adolescents and young adults
Skog, Hanna Mari; Määttä, Sara; Säisanen, Laura; Lakka, Timo A; Haapala, Eero A. 2024. Frontiers in neuroscience. 18: -
Childhood Physical Fitness as a Predictor of Cognition and Mental Health in Adolescence: The PANIC Study
Haapala, Eero A; Leppänen, Marja H; Skog, Hannamari; Lubans, David R; Viitasalo, Anna; Lintu, Niina; Jalanko, Petri; Määttä, Sara; Lakka, Timo A. 2024. Sports medicine. [Published: 10 September 2024]: 1-11 -
Cross-sectional and longitudinal associations between the 24-hour movement behaviours, including muscle and bone strengthening activity, with bone and lean mass from childhood to adolescence
Skinner, Annie M; Barker, Alan R; Moore, Sarah A; Soininen, Sonja; Haapala, Eero A; Väistö, Juuso; Westgate, Kate; Brage, Soren; Lakka, Timo A; Vlachopoulos, Dimitris. 2024. Bmc public health. 24: . 227 -
Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: -
Increased adiposity in juvenile idiopathic arthritis – A comparison of the bioelectrical impedance analysis and dual‐energy X‐ray absorptiometry for the assessment of body composition
Räsänen, Kati; Soisalo, Katja; Markula‐Patjas, Kati; Kantanen, Saija; Sipilä, Kalle; Lakka, Timo A; Valve‐Dietz, Anna‐Kaisa; Piippo‐Savolainen, Eija; Arikoski, Pekka. 2024. Acta paediatrica. 113: 2072-2080 -
Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence
Healy, Darren R; Zarei, Iman; Mikkonen, Santtu; Soininen, Sonja; Viitasalo, Anna; Haapala, Eero A; Auriola, Seppo; Hanhineva, Kati; Kolehmainen, Marjukka; Lakka, Timo A. 2024. Communications biology. 7: . 890 -
Luonnossa vietetyn ajan ja liikunnan yhteydet positiiviseen mielenterveyteen työelämän ulkopuolella olevilla pohjoissavolaisilla
Rekola, Hanna; Kurkinen, Karoliina; Tolmunen, Tommi; Pentikäinen, Heikki; Lakka, Timo A; Mäki-Opas, Tomi. 2024. Liikunta ja tiede. 61: 105-111 -
Maternal gestational hypertension, smoking and pre‐eclampsia are associated with metabolic dysfunction‐associated fatty liver disease in overweight offspring
de Ruyter, Hanna; Aitokari, Linnea; Lahti, Siiri; Riekki, Hanna; Huhtala, Heini; Lakka, Timo; Laivuori, Hannele; Kurppa, Kalle. 2024. Acta obstetricia et gynecologica scandinavica. 103: 1183-1191 -
Multiple androgen pathways contribute to the steroid signature of adrenarche
Liimatta, Jani; du Toit, Therina; Voegel, Clarissa D; Jääskeläinen, Jarmo; Lakka, Timo A; Flück, Christa E. 2024. Molecular and cellular endocrinology. 592: -
Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood
Gonçalves Soares, Ana; Santos, Susana; Seyve, Emie; Nedelec, Rozenn; Puhakka, Soile; Eloranta, Aino-Maija; Mikkonen, Santtu; Yuan, Wen Lun; Lawlor, Deborah A.; Heron, Jon; Vrijheid, Martine; Lepeule, Johanna; Nieuwenhuijsen, Mark; Fossati, Serena; Jaddoe, Vincent W.V.; Lakka, Timo; Sebert, Sylvain; Heude, Barbara; Felix, Janine F.; Elhakeem, Ahmed; Timpson, Nicholas J.. 2024. JACC : advances. 3: -
Psychological well-being of children and adolescents with inflammatory bowel disease
Vekara, Laura; Kantanen, Saija; Kolho, Kaija Leena; Räsänen, Kati; Lakka, Timo; Huhtala, Heini; Piippo-Savolainen, Eija; Arikoski, Pekka; Hiltunen, Pauliina. 2024. Journal of pediatric gastroenterology and nutrition. 78: 1287-1296 -
The associations of depressive symptoms and perceived stress with arterial health in adolescents
Toivonen, Emmi; Lee, Earric; Leppänen, Marja H; Laitinen, Tomi; Kähoenen, Mika; Lakka, Timo A; Haapala, Eero A. 2024. Physiological reports. 12: -
Alanine aminotransferase cutoffs for the pediatric fatty liver disease: Major impact of the reference population
Aitokari, Linnea; Lahti, Siiri; Kivelä, Laura; Riekki, Hanna; Hiltunen, Pauliina; Vuorela, Nina; Viitasalo, Anna; Soininen, Sonja; Huhtala, Heini; Lakka, Timo; Kurppa, Kalle. 2023. Journal of pediatric gastroenterology and nutrition. 2024; 78: 488-496 -
Associations Between Engagement with the BitHabit Digital Lifestyle Intervention and Changes in Type 2 Diabetes Risk Factors
Liedes, Hilkka; Mattila, Elina; Honka, Anita; Absetz, Pilvikki; Aittola, Kirsikka; Manninen, Suvi; Lintu, Niina; Schwab, Ursula; Eloranta, Aino-Maija; Umer, Adil; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Ruotsalainen, Ilona; Van Gils, Mark; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Vuorinen, Anna-Leena. 2023. Studies in health technology and informatics -
Associations between physical fitness and cerebellar gray matter volume in adolescents
Jalanko, Petri; Säisänen, Laura; Kallioniemi, Elisa; Könönen, Mervi; Lakka, Timo A; Määttä, Sara; Haapala, Eero A. 2023. Scandinavian journal of medicine and science in sports. 2024; 34: -
Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study
Laamanen, Suvi E; Eloranta, Aino Maija; Haapala, Eero A; Sallinen, Taisa; Schwab, Ursula; Lakka, Timo A. 2023. European journal of nutrition. 2024; 63: 623-637 -
Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis
Medina-Gomez, Carolina; Mullin, Benjamin H.; Chesi, Alessandra; Prijatelj, Vid; Kemp, John P.; Shochat-Carvalho, Chen; Trajanoska, Katerina; Wang, Carol; Joro, Raimo; Evans, Tavia E.; Schraut, Katharina E.; Li-Gao, Ruifang; Ahluwalia, Tarunveer S.; Zillikens, M. Carola; Zhu, Kun; Mook-Kanamori, Dennis O.; Evans, Daniel S.; Nethander, Maria; Knol, Maria J.; Thorleifsson, Gudmar; Prokic, Ivana; Zemel, Babette; Broer, Linda; McGuigan, Fiona E.; van Schoor, Natasja M.; Reppe, Sjur; Pawlak, Mikolaj A. 2023. Communications biology. 6: -
Cross-Lagged Associations between Physical Activity, Motor Performance, and Academic Skills in Primary-School Children
Haapala, Eero A; Widlund, Anna; Poikkeus, Anna-Maija; Lima, Rodrigo Antunes; Brage, Soren; Aunio, Pirjo; Lakka, Timo A. 2023. Medicine and science in sports and exercise. 55: 1465-1470 -
Cross-sectional associations between physical fitness and biomarkers of inflammation in children—The PANIC study
Haapala, Eero A; Kuronen, Emmi; Ihalainen, Johanna K; Lintu, Niina; Leppänen, Marja H; Tompuri, Tuomo; Atalay, Mustafa; Schwab, Ursula; Lakka, Timo A. 2023. Scandinavian journal of medicine and science in sports. 33: 1000-1009 -
Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood
Nguyen, Dao T A; Julkunen, Petro; Säisänen, Laura; Määttä, Sara; Rissanen, Saara M; Lintu, Niina; Könönen, Mervi; Lakka, Timo; Karjalainen, Pasi A. 2023. Scientific reports. 13: -
Digitaalisella hyvinvointisovelluksella voidaan mitata mielen hyvinvointia ja elintapoja sekä toteuttaa näiden edistämistä tukevia interventioita
Rekola, Hanna; Sveins, Petteri; Tenhunen, Juha; Strömmer, Juho; Borgström, Joni; Paronen, Elsa; Surakka, Anne; Saijonkari, Maija; Pentikäinen, Heikki; Lakka, Timo; Mäki-Opas, Tomi. 2023. . . Itä-Suomen yliopisto -
Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study
Liimatta, Jani; Flück, Christa E; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Jääskelainen, Jarmo; Lakka, Timo A. 2023. Journal of clinical endocrinology and metabolism. 108: e1603-e1613 -
Effects of 2‐year dietary and physical activity intervention on cognition in children—a nonrandomized controlled trial
Naveed, Sehrish; Sallinen, Taisa; Eloranta, Aino‐Maija; Skog, Hannamari; Jalkanen, Henna; Brage, Soren; Ekelund, Ulf; Pentikäinen, Heikki; Savonen, Kai; Lakka, Timo A.; Haapala, Eero A.. 2023. Scandinavian journal of medicine and science in sports. 33: 2340-2350 -
European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network
Ortega, Francisco B; Leskošek, Bojan; Blagus, Rok; Gil-Cosano, José J; Mäestu, Jarek; Tomkinson, Grant R; Ruiz, Jonatan R; Mäestu, Evelin; Starc, Gregor; Milanovic, Ivana; Tammelin, Tuija H; Sorić, Maroje; Scheuer, Claude; Carraro, Attilio; Kaj, Mónika; Csányi, Tamás; Sardinha, Luis B; Lenoir, Matthieu; Emeljanovas, Arunas; Mieziene, Brigita; Sidossis, Labros S; Pihu, Maret; Lovecchio, Nicola; Konstabel, Kenn; Tambalis, Konstantinos D; Štefan, Lovro; Drenowatz, Clemens; Rubín, Lukáš; Gontarev, S. 2023. British journal of sports medicine. 57: 299-310 -
Evidence for protein leverage in a general population sample of children and adolescents
Saner, Christoph; Senior, Alistair M; Zhang, Hanyue; Eloranta, Aino-Maija; Magnussen, Costan G; Sabin, Matthew A; Juonala, Markus; Janner, Marco; Burgner, David P; Schwab, Ursula; Haapala, Eero A; Heitmann, Berit L; Simpson, Stephen J; Raubenheimer, David; Lakka, Timo A. 2023. European journal of clinical nutrition. 77: 652-659 -
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
de las Fuentes, Lisa; Schwander, Karen L; Brown, Michael R; Bentley, Amy R; Winkler, Thomas W; Sung, Yun Ju; Munroe, Patricia B; Miller, Clint L; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M; Bielak, Lawrence F; Chai, Jin Fang; Cheng, Ching-Yu; Dorajoo, Rajkumar; Feitosa, Mary F; Guo, Xiuqing; Hartwig, Fernando P; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K; Marten, Jonathan; Musani, Solomon K; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard,. 2023. Frontiers in genetics. 14: . 1235337 -
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983 -
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, H. 2023. Nature genetics. 55: 1807-1819 -
Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study in the era of biologic drug therapies
Räsänen, Kati; Markula-Patjas, Kati; Kantanen, Saija; Sipilä, Kalle; Lakka, Timo A.; Arikoski, Pekka; Piippo-Savolainen, Eija. 2023. Pediatric rheumatology. 21: -
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
Willems, Sara M; Ng, Natasha H J; Fernandez, Juan; Fine, Rebecca S; Wheeler, Eleanor; Wessel, Jennifer; Kitajima, Hidetoshi; Marenne, Gaelle; Sim, Xueling; Yaghootkar, Hanieh; Wang, Shuai; Chen, Sai; Chen, Yuning; Chen, Yii-Der Ida; Grarup, Niels; Li-Gao, Ruifang; Varga, Tibor V; Asimit, Jennifer L; Feng, Shuang; Strawbridge, Rona J; Kleinbrink, Erica L; Ahluwalia, Tarunveer S; An, Ping; Appel, Emil V; Arking, Dan E; Auvinen, Juha; Bielak, Lawrence F; Bihlmeyer, Nathan A; Bork-Jensen, Jette; Bro. 2023. Wellcome open research. 8: -
Parempaa mielenterveyden edistämistä Pohjois-Savossa kuntien mielenterveysjohtamisen käsitettä ja tavoitteita täsmentämällä sekä tiedolla johtamista kehittämällä
Rekola, Hanna; Surakka, Anne; Saijonkari, Maija; Mäki-Opas, Tomi; Lakka, Timo; Paronen, Elsa. 2023. . . Itä-Suomen yliopisto -
Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents
Riekki, Hanna; Aitokari, Linnea; Kivela, Laura; Lahti, Siiri; Hiltunen, Pauliina; Vuorela, Nina; Huhtala, Heini; Lakka, Timo A.; Kurppa, Kalle. 2023. Frontiers in endocrinology. 14: -
Promotive and preventive interventions for mental health and well-being in adult populations: a systematic umbrella review
Saijonkari, Maija; Paronen, Elsa; Lakka, Timo; Tolmunen, Tommi; Linnosmaa, Ismo; Lammintakanen, Johanna; Isotalo, Jenni; Rekola, Hanna; Mäki-Opas, Tomi. 2023. Frontiers in public health. 11: . 1201552 -
A participatory arts programme – Shared experience for family caregivers and care recipients
Vaajoki, Anne; Turjamaa, Riitta; Lakka, Timo; Mäkinen, Eeva; Välimäki, Tarja. 2022. Nursing open. 2023; 10: 3011-3017 -
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215: -
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19
El-Sayed Moustafa, Julia S.; Jackson, Anne U.; Brotman, Sarah M.; Guan, Li; Villicaña, Sergio; Roberts, Amy L.; Zito, Antonino; Bonnycastle, Lori; Erdos, Michael R.; Narisu, Narisu; Stringham, Heather M.; Welch, Ryan; Yan, Tingfen; Lakka, Timo; Parker, Stephen; Tuomilehto, Jaakko; Seow, Jeffrey; Graham, Carl; Huettner, Isabella; Acors, Sam; Kouphou, Neophytos; Wadge, Samuel; Duncan, Emma L.; Steves, Claire J.; Doores, Katie J.; Malim, Michael H.; Collins, Francis S.; Pajukanta, Päivi; Boehnke, M. 2022. International journal of obesity. 46: 1478-1486 -
Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study
Halali, F; Lapveteläinen, A; Aittola, K; Männikkö, R; Tilles-Tirkkonen, T; Järvelä-Reijonen, E; Absetz, P; Kolehmainen, M; Schwab, U; Lindström, J; Lakka, TA; Pihlajamäki, J; Karhunen, L. 2022. International journal of obesity. 46: 935-942 -
Associations of diet quality, food consumption, eating frequency, and eating behaviour with dental caries experience in Finnish children: A 2-year longitudinal study
Virkkala, Veera; Eloranta, Aino-Maija; Suominen, Anna Liisa; Vierola, Anu; Ikävalko, Tiina; Väistö, Juuso; Mikkonen, Santtu; Methuen, Mirja; Schwab, Ursula; Viljakainen, Heli; Leinonen, Jukka; Närhi, Matti; Lakka, Timo A.. 2022. British journal of nutrition. [Published 08 August 2022]: 1-11 -
Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children – the PANIC study
Haapala, Eero A.; Leppänen, Marja H.; Lehti, Maarit; Lintu, Niina; Tompuri, Tuomo; Viitasalo, Anna; Schwab, Ursula; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 954418 -
Determinants of Cognitive Performance in Children and Adolescents : A Populational Longitudinal Study
Lima, Rodrigo Antunes; Soares, Fernanda Cunha; van Poppel, Mireille; Savinainen, Saija; Mäntyselkä, Aino; Haapala, Eero A; Lakka, Timo. 2022. International journal of environmental research and public health. 19: . 8955 -
Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial
Lavikainen, Piia; Mattila, Elina; Absetz, Pilvikki; Harjumaa, Marja; Lindström, Jaana; Järvelä-Reijonen, Elina; Aittola, Kirsikka; Männikkö, Reija; Tilles-Tirkkonen, Tanja; Lintu, Niina; Lakka, Timo; van Gils, Mark; Pihlajamäki, Jussi; Martikainen, Janne. 2022. Journal of medical internet research. 24: -
Is low cardiorespiratory fitness a feature of metabolic syndrome in children and adults?
Haapala, Eero A.; Tompuri, Tuomo; Lintu, Niina; Viitasalo, Anna; Savonen, Kai; Lakka, Timo A.; Laukkanen, Jari A.. 2022. Journal of science and medicine in sport. 25: 923-929 -
Lapsuuden suun terveydenhuollon käynnit ja vanhempien sosioekonominen asema
Tolonen, Ville; Ikävalko, Tiina; Suominen, Liisa; Lakka, Timo; Karvinen, Henri; Törmälehto, Soili; Raittio, Eero. 2022. Suomen hammaslääkärilehti. 29: 44-50 -
LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; de. 2022. Environmental epidemiology. 6: -
Mielenterveys- ja päihdeongelmat työelämän ulkopuolella olevilla pohjoissavolaisilla
Kurkinen, Karoliina; Karjalainen, Panu; Rekola, Hanna; Pietikäinen, Liisa; Laakso, Seija; Laine, Katja; Surakka, Anne; Saijonkari, Maija; Lakka, Timo; Mäki-Opas, Tomi; Tolmunen, Tommi. 2022. University of Eastern Finland -
Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children
Skinner, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Rowlands, Alex V.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Westgate, Kate; Brage, Soren; Lakka, Timo A.. 2022. Scandinavian journal of medicine and science in sports. 2023; 33: 267-282 -
Prevalence of erosive tooth wear and associated dietary factors among a group of Finnish adolescents
Methuen, Mirja; Kangasmaa, Hanna; Alaraudanjoki, Viivi Karoliina; Suominen, Anna L.; Anttonen, Vuokko; Vähänikkilä, Hannu; Karjalainen, Panu; Väistö, Juuso; Lakka, Timo A.; Laitala, Marja-Liisa. 2022. Caries research. 56: 477-487 -
Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk – A stop diabetes pragmatic randomised trial
Lakka, Timo A.; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lintu, Niina; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Mattila, Elina; Järvenpää, Riia; Ermes, Miikka; Mikkonen, Santtu; Martikainen, Janne; Poutanen, Kaisa; Schwab, Ursula; Absetz, Pilvikki; Lindström, Jaana; Pihlajamäki, Jussi. 2022. The Lancet regional health – Europe. 2023; 24: -
Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents
Soininen, Sonja; Eloranta, Aino-Maija; Schwab, Ursula; Lakka, Timo A. 2022. European journal of nutrition. 2023; 62: 1011-1025 -
The Composition and Functional Capacities of Saliva Microbiota Differ Between Children With Low and High Sweet Treat Consumption
Lommi, Sohvi; Manzoor, Muhammed; Engberg, Elina; Agrawal, Nitin; Lakka, Timo A.; Leinonen, Jukka; Kolho, Kaija-Leena; Viljakainen, Heli. 2022. Frontiers in nutrition. 9: . 864687 -
The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
Constable, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Jääskeläinen, Jarmo; Voutilainen, Raimo; Auriola, Seppo; Häkkinen, Merja R.; Laitinen, Tomi; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 850448 -
The effects of an 8-year individualised lifestyle intervention on food consumption and nutrient intake from childhood to adolescence: the PANIC Study
Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Soininen, Sonja; Jalkanen, Henna; Haapala, Eero A.; Mikkonen, Santtu; Schwab, Ursula; Lakka, Timo A.; Eloranta, Aino-Maija. 2022. Journal of nutritional science. 11: -
Työelämän ulkopuolella olevien positiivista mielenterveyttä tulee parantaa edistämällä terveellisiä elintapoja ja tarjoamalla matalan kynnyksen palveluita
Rekola, Hanna; Kurkinen, Karoliina; Tolmunen, Tommi; Saijonkari, Maija; Surakka, Anne; Pentikäinen, Heikki; Lakka, Timo A; Paronen, Elsa; Mäki-Opas, Tomi. 2022. University of Eastern Finland -
Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children
Haapala, Eero A; Väistö, Juuso; Ihalainen, Johanna K; Tomaselli González, Claudia; Leppänen, Marja H; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; Brage, Soren; Atalay, Mustafa; Lakka, Timo A. 2021. European journal of sport science. [Epub ahead of print 14 March 2021]: 1-10 -
Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study
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Response
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Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children
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High Leisure-Time Physical Activity Is Associated With Reduced Risk of Sudden Cardiac Death Among Men With Low Cardiorespiratory Fitness
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Is there a duty to participate in a health research? A viewpoint of children 6-8 years of age and their parents
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Maternal and fetal genetic contribution to gestational weight gain
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New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
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Predictors of sleep disordered breathing in children: the PANIC study
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Rare and low-frequency coding variants alter human adult height
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Relation of oxygen uptake to work rate in prepubertal healthy children - reference for VO2/W-slope and effect on cardiorespiratory fitness assessment
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Vähäinen fyysinen aktiivisuus ja runsas fyysinen passiivisuus ovat yhteydessä 6-8-vuotiaiden lasten ylipainoon
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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
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Adiposity, physical activity and neuromuscular performance in children
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Associations of Sedentary Behavior, Physical Activity, Cardiorespiratory Fitness, and Body Fat Content With Pain Conditions in Children: The Physical Activity and Nutrition in Children Study
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Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study
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Comparison between parameters from maximal cycle ergometer test first without respiratory gas analysis and thereafter with respiratory gas analysis among healthy prepubertal children
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Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
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Cross-sectional associations of objectively-measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid-childhood: the PANIC study
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Determinants of cardiorespiratory fitness in a population sample of girls and boys aged 6-8 years
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Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study
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Diet quality and academic achievement: a prospective study among primary school children
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Dietary quality indices in relation to cardiometabolic risk among Finnish children aged 6-8 years - The PANIC study
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Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study
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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
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Food sources of energy and nutrients in Finnish girls and boys 6-8 years of age - the PANIC study
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Genome-wide associations for birth weight and correlations with adult disease
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Physical activity and sedentary time in relation to academicachievement in children
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Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children
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Prevalence and associated factors of abnormal liver values in children with celiac disease
Aarela Linnea, Nurminen Samuli, Kivela Laura, Huhtala Heini, Maki Markku, Viitasalo Anna, Kaukinen Katri, Lakka Timo, Kurppa Kalle. 2016. Digestive and liver disease. 48: 1023-1029 -
Response: food fortification as a means to increase vitamin D intake
Soininen Sonja, Eloranta Aino-Maija, Lindi Virpi, Lakka Timo A. 2016. British journal of nutrition. 116: 1134-1135 -
The Effects of a 2-year Individualized and Family-based Lifestyle Intervention on Physical Activity, Sedentary Behavior and Diet in Children
Viitasalo Anna, Eloranta Aino-Maija, Lintu Niina, Väistö Juuso, Venäläinen Taisa, Kiiskinen Sanna, Karjalainen Panu, Peltola Jaana, Lampinen Eeva-Kaarina, Haapala Eero A, Paananen Jussi, Schwab Ursula, Lindi Virpi, Lakka Timo A. 2016. Preventive medicine. 87: 81-88 -
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
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Tieteelliset perusteet varhaisvuosien fyysisen aktiivisuuden suosituksille
Sääkslahti Arja, Muuronen Kaisu, Haapala Eero, Pulakka Anna, Haapala Henna, Lakka Timo A, Laukkanen Arto, Määttä Suvi, Reunamo Jyrki, Roos Eva, Soini Anne, Mäki Päivi, Iivonen Susanna, Asunta Piritta, Viholainen Helena, Ahonen Timo, Rintala Pauli, Cantell Marja, Kyhälä Anna-Liisa. 2016. Opetus- ja kulttuuriministeriön julkaisuja. . -
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Nature genetics. 48: 1151-1161 -
Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
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Associations of Physical Performance and Adiposity with Cognition in Children
Haapala Eero A, Lintu Niina, Väistö Juuso, Robinson Leah E, Viitasalo Anna, Lindi Virpi, Lakka Timo A. 2015. Medicine and science in sports and exercise. 47: 2166-2174 -
Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children
Veijalainen A, Tompuri T, Haapala EA, Viitasalo , Lintu N, Väistö J, Laitinen T, Lindi V, Lakka TA. 2015. Scandinavian journal of medicine and science in sports. [epub ahead of print 29 Jul 2015]: - -
Associations of diet quality with cognition in children - the Physical Activity and Nutrition in Children Study
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Biological interpretation of genome-wide association studies using predicted gene functions
Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel N, Franke Lude. 2015. Nature communications. 6: 5890 -
Cardiopulmonary fitness is a function of lean mass, not total body weight: The DR's EXTRA study
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VO2max/kg is expected to be lower in obese individuals!
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A Central Role for GRB10 in Regulation of Islet Function in Man
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Clustering of Metabolic Risk Factors Is Associated with High-Normal Levels of Liver Enzymes among 6- to 8-Year-Old Children: The PANIC Study
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
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Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men
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Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6-8 years of age: the PANIC Study
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Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability
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Liikunta. Käypä hoito -suositus
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The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study
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Aikuisten liikunta
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Hassinen M, Lakka TA, Hakola L, Savonen K, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, & Rauramaa R. 2010. Diabetes care. 33: 1655-1657 -
Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study
Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Tremoli E; IMPROVE study group.. 2010. European heart journal. 614-22: 614-622 -
Exercise, fitness and cognition - A randomised controlled trial in older indivuals: The DR's EXTRA study
Komulainen P, Kivipelto M, Lakka TA, Savonen K, Hassinen M, Kiviniemi V, Hänninen T & Rauramaa R. 2010. European geriatric medicine. 1: 266-272 -
Lasten liikunta ja ravitsemus -tutkimus selvittää alakoululaisten elintapoja
Eloranta A-m, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lintu N, Karjalainen P, Himanen A, Karjalainen J, Tompuri T, Viitasalo A, Lakka H-M, Lakka T & Lasten liikunta ja ravitsemus -tutkimus, Itä-Suomen yliopisto. 2010. BOLUS : RAVITSEMUSTERAPEUTTIEN YHDISTYKSEN LEHTI. : 30-33 -
Leisure-time physical activity and the metabolic syndrome in the Finnish diabetes prevention study
Ilanne-Parikka P, Laaksonen DE, Eriksson JG, Lakka TA, Lindström J, Peltonen M, Aunola S, Keinänen-Kiukaanniemi S, Uusitupa M & Tuomilehto J. On behalf of the Finnish diabetes prevention study group. 2010. Diabetes care. 33: 1610-1617 -
Reproducibility of pulse contour analysis in children before and after maximal exercise stress test: The Physical Activity and Nutrition in Children (PANIC) Study
Veijalainen A, Tompuri T, Lakka HM, Laitinen T & Lakka TA. 2010. Clinical physiology and functional imaging. online: 1-7 -
Sedentary lifestyle and emergence of hopelessness in middle-aged men
Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Mursu J, Savonen K, Lakka TA, Niskanen L & Kauhanen J. 2010. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 17: 524-9 -
Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease
Laukkanen JA, Laaksonen D, Lakka TA, Savonen K, Rauramaa R, Mäkikallio T, Kurl S. 2009. American journal of cardiology. 103: 1598-1604 -
Exercise and type 2 diabetes prevention
Hu G, Lakka TA, Barengo NC, Tuomilehto J. Teoksessa: Lignalli AT(toim.) , 2009. Handbook of Type 2 Diabetes in the Middle Aged and Elderly [E-Book]. s. 93-111. Nova Science Publisher -
Kardiorespiratorinen suorituskyky ja metabolinen oireyhtymä
Hassinen M, Savonen K, Lakka TA, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, Hakola L, Rauramaa R. 2009. Liikunta ja tiede. 46: 34-35 -
Kardiorespiratorinen suorituskyky muistin ennustajana ikääntyneillä miehillä ja naisilla
Komulainen P, Savonen K, Litmanen H, Lakka TA, Kiviniemi V, Hassinen M, Kivipelto M, Hänninen T, Heikkilä H, Kouki R, Hakola L, Rauramaa R. 2009. Liikunta ja tiede. 46: 41 -
Lasten ruokavaliossa on huolestuttavia piirteitä
Kiiskinen S, Schwab U, Kalinkin M, Lindi V, Tompuri T, Lakka H-M, Lakka T. 2009. Lääkärilehti. 64: 144-145 -
Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Kauhanen J, Lakka T, Niskanen L. 2009. Bmc public health. 9: -
Physical activity, fitness, and the preventioon of type 2 diabetes
Hu G, Lakka TA, Tuomilehto J. Teoksessa: Lee I-M(toim.) , 2009. Epidemiologic Methods in Physical Avtivity Studies. s. 201-224. Oxford University Press -
Association of age and education with different types of leisure-time physical activity among 4437 Finnish adults
Borodulin K, Laatikainen T, Lahti-Koski M, Jousilahti P, Lakka TA. 2008. Journal of physical activity and health. 5: 242-251 -
BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study
Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. 2008. Neurobiology of learning and memory. 90: 596-603 -
Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women
Hassinen M, Lakka TA, Savonen K, Litmanen H, Kiviaho L, Laaksonen DE, Komulainen P, Rauramaa R. 2008. Diabetes care. 31: 1242-1247 -
Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease
Savonen KP, Kiviniemi V, Laukkanen JA, Lakka TA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. European heart journal. 29: 1896-1902 -
Dyslipidaemia as a predictor of hypertension in middle-aged men
Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT. 2008. European heart journal. 29: 2561-2568 -
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study
Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2008. Metabolism: clinical and experimental. 57: 428-436 -
Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study
Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Diabetes care. 31: 230-232 -
Physical activity, fitness, and prevention of type 2 diabetes
Hu G, Lakka TA, Tuomilehto J. Teoksessa: Lee IM(toim.) , 2008. Epidemiologic Methods in Physical Activity Studies. s. 201-224. Oxford University Press -
SNPs in PPARG associte with type 2 diabetes and intract with physival activity
Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. 2008. Medicine and science in sports and exercise. 40: 25-33 -
Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. American journal of cardiology. 101: 992-998 -
Workload at the heart rate of 100 beats/min and mortality in middle-aged men known or suspected coronary heart disease
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2008. Heart. 94: E14 -
Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women
Hassinen M, Lakka TA, Komulainen P, Haapala I, Nissinen A, Rauramaa R. 2007. International journal of obesity. 31: 1406-1411 -
Carotid intima-media thickness and cognitive function in elderly women: a population-based study
Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala E-L, Patja K, Nissinen A, Rauramaa R. 2007. Neuroepidemiology. 28: 207-213 -
Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline
Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. 2007. American journal of cardiology. 100: 563-568 -
Epidemiological studies of exercise in diabetes prevention
Hu G, Lakka TA, Kilpeläinen T, Tuomilehto J. 2007. Applied physiology nutrition and metabolism-physiologie appliquee nutrition et metabolisme. 32: 583-595 -
Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study
Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. 2007. Diabetes care. 30: 1618-1620 -
Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women
Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala E-L, Haapala I, Nissinen A, Rauramaa R. 2007. Dementia and geriatric cognitive disorders. 23: 29-34 -
Obesity, physical activity, and nutrition in the metabolic syndrome
Hu G, Lakka TA, Lakka H-M, Tuomilehto J, Lakka TA. Teoksessa: Krentz AJ, Wong ND(toim.) , 2007. Metabolic Syndrome and Cardiovascular Disease. s. 241-278. Informa Healthcare -
Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women
Hu G, Jousilahti P, Borodulin K, Barengo NC, Lakka TA, Nissinen A, Tuomilehto J. 2007. Atherosclerosis. 194: 490-497 -
Physical activity in prevention and treatment of the metabolic syndrome
Lakka TA, Laaksonen DE. 2007. Applied physiology nutrition and metabolism-physiologie appliquee nutrition et metabolisme. 32: 76-88 -
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2007. Physiological genomics. 31: 264-272 -
Serum high sensitivity C-reactive protein and cognitive function in elderly women
Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala E-L, Gylling H, Nissinen A, Rauramaa R. 2007. Age and ageing. 36: 443-448 -
Association of leisure time physical activity abdomimal obesity with fsting serum insulin and 2-h postchallenge plasma glucose levels
Borodulin K, Tuomilehto J, Peltonen M, Lakka TA, Sundvall J, Jousilahti P. 2006. Diabetic medicine. 23: 1025-1028 -
C-reactive protein and metabolic syndrome in elderly women. A 12-year follow-up study
Hassinen M, Lakka TA, Komulainen P, Gylling H, Nissinen A, Rauramaa R. 2006. Diabetes care. 29: 931-932 -
Different forms of physical activity and cardiovascular risk factors among 24-64-year-old men and women in Finland
Barengo NC, Kastarinen M, Lakka T, Nissinen A, Tuomilehto J. 2006. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 13: 51-59 -
Exercise, genetics and prevention of type 2 diabetes
Hu G, Rico-Sanz J, Lakka TA, Tuomilehto J. 2006. Essays in biochemistry. 42: 177-192 -
Heart rate response during exercise test and cardiovascular mortality in middle-aged men
Savonen KP, Lakka TA, Laukkanen JA, Halonen PM, Rauramaa TH, Salonen JT, Rauramaa R. 2006. European heart journal. 27: 582-588 -
High dietary methionine intake increases the risk of acute coronary events in middle-aged men
Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT. 2006. Nutrition metabolism and cardiovascular diseases. 16: 113-120 -
Letter to the editor (Exercise and inflammation: reply)
Lakka TA, Lakka H-M, Rankinen T, Bouchard C. 2006. European heart journal -
Lifestyle management in the metabolic syndrome
Hu G, Lakka TA, Lakka H-M, Tuomilehto J. 2006. Metabolic syndrome and related disorders. 4: 270-286 -
Metabolic syndrome and the progression of carotid intima-media thickness in elderly women
Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Haapala I, Gylling H, Alen M, Schmidt-Trucksäss A, Nissinen A, Rauramaa R. 2006. Archives of internal medicine. 166: 444-449 -
Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death
Laukkanen JA, Kurl S, Salonen JT, Lakka TA, Rauramaa R. 2006. Heart. 92: 1219-1224 -
Quantitative trait locus on chromosme 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE family sudy
Lakka TA, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C. 2006. Physiological genomics. 27: 103-107 -
Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes. Results from the Finnish diabes prevention study
Herder C, Peltonen M, Koenig W, Kräft I, Mûller-Scholze S, Martin S, Lakka T, Ilanne-Parikka P, Eriksson JG, Hämäläinen H, Keinänen-Kiukaanniemi S, Valle TT, Uusitupa M, Lindström J, Kolb H, Tuomilehto J. 2006. Diabetes. 55: 2340-2346 -
The TNF-a G-308A polymorphism is associated with C-reactive protein levels: The HERITAGE Family Study
Lakka H-M, Lakka TA, Rankinen T, Rice T, Rao DC, Leon AS, Skinner JS, Bouchard C. 2006. Vascular pharmacology. 44: 377-383 -
Associations between estimated aerobic fitness and cardiovascular risk factors in adults with different levels of abdominal obesity
Borodulin K, Laatikainen T, Lahti-Koski M, Lakka TA, Laukkanen R, Sarna S, Jousilahti P. 2005. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION. 12: 126-131 -
Associations of body composition and physical activity with balance and walking ability in the elderly
Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. 2005. Journal of physical activity and health. 3: 298-306 -
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE family study
Lakka TA, Lakka H-M, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. 2005. European heart journal. 26: 2018-2025 -
Effects of exercise training on glucose homeostasis. The Heritage family studies
Boulé NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. 2005. Diabetes care. 28: 108-114 -
Low physical activity as a predictor for antihypertensive drug treatment in 25- 64-year-old populations in Eastern and south-western Finland
Barengo NC, Hu G, Kastarinen M, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. 2005. Journal of hypertension. 23: 293-299 -
Physical activity in the prevention of type 2 diabetes. The Finnish diabetes prevention study
Laaksonen DE, Lindström J, Lakka TA, Eriksson JG, Niskanen L, Wikström K, Aunola S, Keinänen-Kiukaanniemi S, Laakso M, Valle TT, Ilanne-Parikka P, Louheranta A, Hakumäki M, Kaikkonen H, Härkönen P, Sundvall J, Tuomilehto J, Uusitupa M, Louheranta A. 2005. Diabetes. 54: 158-165 -
Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes
Hu G, Jousilahti P, Barengo NC, Qiao Q, Lakka TA, Tuomilehto J. 2005. Diabetes care. 28: 799-805 -
Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
Ukkola O, Rankinen T, Lakka T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Kesäniemi YA, Bouchard C. 2005. Obesity. 13: 829-834 -
Epidemiology and treatment of the metabolic syndrome
Laaksonen DE, Niskanen L, Lakka H-M, Lakka TA, Uusitupa M, Laaksonen DE. 2004. Annals of medicine. 36: 332-346 -
Low physical activity as a predictor for total and cardiovascular disease mortality in middle-aged men and women in Finland
Barengo NC, Hu G, Lakka TA, Pekkarinen H, Nissinen A, Tuomilehto J. 2004. European heart journal. 25: 2204-2211 -
Physical activity in the prevention of type 2 diabetes
Hu G, Lakka TA, Barengo NC, Tuomilehto J. 2004. KARDIOVASKULÄRE MEDIZIN. 7: 394-405 -
Relationship of physical activity and body mass index to the risk of hypertension: a prospective study in Finland
Hu G, Barengo NC, Tuomilehto J, Lakka TA, Nissinen A, Jousilahti P. 2004. Hypertension. 43: 25-30 -
Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men
Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. 2004. Hypertension. 44: 820-825 -
Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
Laaksonen DE, Lakka H-M, Lynch J, Lakka TA, Niskanen L, Rauramaa R, Salonen JT, Kauhanen J. 2003. Diabetes care. 26: 2156-2164 -
Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
Lakka TA, Laaksonen DE, Lakka H-M, Männikkö N, Niskanen LK, Rauramaa R, Salonen JT. 2003. Medicine and science in sports and exercise. 35: 1279-1286 -
Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men
Lakka TA, Lakka H-M, Salonen R, Kaplan GA, Salonen JT. 2001. Atherosclerosis. 154: 497-504 -
Cardiovascular fitness as a predictor of mortality in men
Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R, Venäläinen JM, Salonen R, Salonen JT. 2001. Archives of internal medicine. 161: 825-831 -
Leisure-time physical activity and rate of bone loss among peri- and postmenopausal women: a longitudinal study
Puntila E, Kröger H, Lakka T, Tuppurainen M, Jurvelin J, Honkanen R. 2001. Bone. 29: 442-446 -
Liikuntaa sepelvaltimotaudin ehkäisyyn ja hoitoon
Rauramaa R, Lakka TA. 2001. Duodecim. 117: 633-638 -
Low dietary folate intake is associated with an excess incidence of acute coronary events. The Kuopio Ischemic Heart Disease Risk Factor Study
Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. 2001. Circulation. 103: 2674-2680 -
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Valkonen V-P, Päivä H, Salonen JT, Lakka TA, Lehtimäki T, Laakso J, Laaksonen R. 2001. The Lancet. 358: 2127-2128 -
Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study
Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. 2000. European journal of clinical nutrition. 54: 424-428 -
Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study
Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H, Salonen JT. 1999. The Lancet. 354: 2112-2115 -
Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men
Salonen JT, Lakka TA, Lakka H-M, Valkonen V-P, Everson SA, Kaplan GA. 1998. Diabetes. 47: 270-275 -
Weight gain and the risk of developing insulin resistance syndrome
Everson SA, Goldberg DE, Helmrich SP, Lakka TA, Lynch JW, Kaplan GA, Salonen JT. 1998. Diabetes care. 21: 1637-1643 -
Body iron stores are associated with serum insulin and blood glucose concentrations
Tuomainen T-P, Nyyssönen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT. 1997. Diabetes care. 20: 426-428 -
Frequent hangovers and cardiovascular mortality in middle-aged men
Kauhanen J, Kaplan GA, Goldberg DD, Cohen RD, Lakka TA, Salonen JT. 1997. Epidemiology. 8: 310-314 -
Physical activity in adolescence and bone density in peri- and postmenopausal women: A population-based study
Puntila E, Kröger H, Lakka T, Honkanen R, Tuppurainen M. 1997. Bone. 21: 363-367 -
The physical activity questionnaires of the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD)
Lakka TA, Salonen JT. 1997. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. SUPPLEMENT. 29: S46-S58 -
Conditioning leisure time physical activity and cardiorespiratory fitness in sociodemographic groups of middle-aged men in Eastern Finland
Lakka TA, Kauhanen J, Salonen JT. 1996. International journal of epidemiology. 25: 86-93 -
Hyperinsulinemia and the risk of coronary heart disease
Lakka TA, Lakka H-M, Salonen JT. 1996. The new england journal of medicine -
Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men
Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT. 1996. Archives of internal medicine. 156: 1307-1314 -
Religious affiliation and all-cause mortality: a prospective population study in middle-aged men in Eastern Finland
Räsänen J, Kauhanen J, Lakka TA, Kaplan GA, Salonen JT. 1996. International journal of epidemiology. 25: 1244-1249 -
Higher levels of conditioning leisure time physical activity are associated with reduced levels of stored iron in Finnish men
Lakka TA, Nyyssönen K, Salonen JT. 1994. American journal of epidemiology. 140: 148-160 -
Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men
Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. 1994. The new england journal of medicine. 330: 1549-1554