Veli-Matti Kosma
Professor
Head of the School of Medicine Tasks of the head of the medical department, such as management and personnel and financial management. Teaching and research.
School of Medicine, Institute of Clinical Medicine
veli-matti.kosma@uef.fi | +358 50 067 5780
0500675780
050 0675780
050 067 5780
+358 50 067 5780
+35850 067 5780
050 0675 780
+358 50 0675 780
+35850 0675 780
+358 50 0675780
+35850 0675780
+358500675780
050 0675780
050 067 5780
+358 50 067 5780
+35850 067 5780
050 0675 780
+358 50 0675 780
+35850 0675 780
+358 50 0675780
+35850 0675780
+358500675780
–
Research groups
Keywords
Publications
500 items-
A FinnGen pilot clinical recall study for Alzheimer’s disease
Julkunen, Valtteri; Schwarz, Claudia; Kalapudas, Juho; Hallikainen, Merja; Piironen, Aino-Kaisa; Mannermaa, Arto; Kujala, Hanna; Laitinen, Timo; Kosma, Veli-Matti; Paajanen, Teemu I.; Kälviäinen, Reetta; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kärkkäinen, Sari; Kokkola, Tarja; Urjansson, Mia; FinnGen; Perola, Markus; Palotie, Aarno; Vuoksimaa, Eero; Runz, Heiko. 2023. Scientific reports. 13: . 12641 -
Predicting cell type counts in whole slide histology images using evidential multi-task learning
Gudhe, Naga Raju; Sudah, Mazen; Mannermaa, Arto; Kosma, Veli-Matti; Behravan, Hamid. Teoksessa: Tomaszewski, John E; Ward, Aaron D(toim.) , 2023. Medical Imaging 2023: Digital and Computational Pathology. s. 239-247. SPIE -
A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women
Wang, Xiaoliang; Chen, Hongjie; Kapoor, Pooja Middha; Su, Yu-Ru; Bolla, Manjeet K.; Dennis, Joe; Dunning, Alison M.; Lush, Michael; Wang, Qin; Michailidou, Kyriaki; Pharoah, Paul D.P.; Hopper, John L.; Southey, Melissa C.; Koutros, Stella; Freeman, Laura E. Beane; Stone, Jennifer; Rennert, Gad; Shibli, Rana; Murphy, Rachel A.; Aronson, Kristan; Guénel, Pascal; Truong, Thérèse; Teras, Lauren R.; Hodge, James M.; Canzian, Federico; Kaaks, Rudolf; Brenner, Hermann; Arndt, Volker; Hoppe, Reiner; Lo,. 2022. Cancer research communications. 2: 211-219 -
Area-based breast percentage density estimation in mammograms using weight-adaptive multitask learning
Gudhe, Naga Raju; Behravan, Hamid; Sudah, Mazen; Okuma, Hidemi; Vanninen, Ritva; Kosma, Veli-Matti; Mannermaa, Arto. 2022. Scientific reports. 12: . 12060 -
Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors
Kujala, Jouni; Hartikainen, Jaana M.; Tengström, Maria; Sironen, Reijo; Auvinen, Päivi; Kosma, Veli Matti; Mannermaa, Arto. 2022. Cancers. 14: . 1332 -
Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies
Jung, Audrey Y; Ahearn, Thomas U; Behrens, Sabine; Middha, Pooja; Bolla, Manjeet K; Wang, Qin; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Beane Freeman, Laura E; Becher, Heiko; Brenner, Hermann; Canzian, Federico; Carey, Lisa A; CTS Consortium; Czene, Kamila; Eliassen, A Heather; Eriksson, Mikael; Evans, D Gareth; Figueroa, Jonine D; Fritschi, Lin; Gabrielson, Marike; Giles, Graham G; Guénel, Pascal; Hadjisavvas, Andreas; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann. 2022. Journal of the national cancer institute. 114: 1706-1719 -
Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M.. 2022. Scientific reports. 12: . 22614 -
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
Ruotsalainen, Sanni E.; Surakka, Ida; Mars, Nina; Karjalainen, Juha; Kurki, Mitja; Kanai, Masahiro; Krebs, Kristi; Graham, Sarah; Mishra, Pashupati P.; Mishra, Binisha H.; Sinisalo, Juha; Palta, Priit; Lehtimäki, Terho; Raitakari, Olli; Esko, Tõnu; Metspalu, Andres; Mägi, Reedik; Nelis, Mari; Milani, Lili; Matsuda, Koichi; Yamanashi, Yuji; Furukawa, Yoichi; Morisaki, Takayuki; Murakami, Yoshinori; Kamatani, Yoichiro; Muto, Kaori; Nagai, Akiko; Obara, Wataru; Yamaji, Ken; Takahashi, Kazuhisa; Asa. 2022. Communications biology. 5: . 802 -
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
Tamlander, Max; Mars, Nina; Pirinen, Matti; Palotie, Aarno; Daly, Mark; Riley-Gills, Bridget; Jacob, Howard; Paul, Dirk; Runz, Heiko; John, Sally; Plenge, Robert; Maranville, Joseph; Okafo, George; Lawless, Nathan; Salminen-Mankonen, Heli; McCarthy, Mark; Hunkapiller, Julie; Ehm, Meg; Auro, Kirsi; Longerich, Simonne; Fox, Caroline; Mälarstig, Anders; Klinger, Katherine; Raipal, Deepak; Green, Eric; Graham, Robert; Yang, Robert; O’Donnell, Chris; Mäkelä, Tomi; Kaprio, Jaakko; Virolainen, Petri; H. 2022. Communications biology. 5: . 158 -
Rare germline copy number variants (CNVs) and breast cancer risk
Dennis, Joe; Tyrer, Jonathan P.; Walker, Logan C.; Michailidou, Kyriaki; Dorling, Leila; Bolla, Manjeet K.; Wang, Qin; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Castelao, Jose E.; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Clarke, Christine L.; Kristensen, . 2022. Communications biology. 5: . 65 -
A case-only study to identify genetic modifiers ofbreast cancer risk for BRCA1/BRCA2mutationcarriers
Coignard, Juliette; Lush, Michael; Beesley, Jonathan; O'Mara, Tracy A; Dennis, Joe; Tyrer, Jonathan P; Barnes, Daniel R; McGuffog, Lesley; Leslie, Goska; Bolla, Manjeet K; Adank, Muriel A; Agata, Simona; Ahearn, Thomas; Aittomäki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Arnold, Norbert; Aronson, Kristan J.; Arun, Banu K. et al [Incl. Kosma, Veli-Matti; Mannermaa, Arto]. 2021. Nature communications. 12: 1078 -
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Dorling, Leila; Carvalho, Sara; Allen, Jamie; González-Neira, Anna; Luccarini, Craig; Wahlström, Cecilia; Pooley, Karen A.; Parsons, Michael T.; Fortuno, Cristina; Wang, Qin; Bolla, Manjeet K.; Dennis, Joe; Keeman, Renske M.; Alonso, Rosario; Álvarez, Nuria; Herraez, Belen; Fernandez, Victoria; Núñez-Torres, Rocio; Osorio, Ana; Valcich, Jeanette et al. [incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto]. 2021. The new england journal of medicine. 384: 428-439 -
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers
Johnson, Nichola; Maguire, Sarah; Morra, Anna; Kapoor, Pooja Middha; Tomczyk, Katarzyna; Jones, Michael E; Schoemaker, Minouk J; Gilham, Clare; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Baynes, Caroline; Freeman, Laura E et al. [Incl. Kosma, Veli-Matti; Mannermaa, Arto]. 2021. British journal of cancer. 124: 842-854 -
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Natarajan, Pradeep; Pampana, Akhil; Graham, Sarah E; Ruotsalainen, Sanni E; Perry, James A; de Vries, Paul S;. Broome, Jai G; Pirruccello, James P; Honigberg, Michael C; Aragam, Krishna; Wolford, Brooke; Brody, Jennifer A; Antonacci-Fulton, Lucinda; Arden, Moscati; Aslibekyan, Stella; Assimes, Themistocles L; Ballantyne, Christie M; Bielak, Lawrence F; Bis, Joshua C.; Cade, Brian E; et al. [incl. FinGen; Kosma, Veli-Matti; Mannermaa, Arto]. 2021. Nature communications. 12: 2182 -
Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
Baxter, Joseph S.; Johnson, Nichola; Tomczyk, Katarzyna; Gillespie, Andrea; Maguire, Sarah; Brough, Rachel; Fachal, Laura; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Becher, Heiko; Beckmann, Matthias W. [incl. Kosma, Veli-Matti, Mannermaa, Arto]. 2021. American journal of human genetics. 108: 1190-1203 -
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L et al. [incl FinGen; Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature communications. 12: 1258 -
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James P.; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven A.; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana et al. [incl. Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature medicine. 27: 1012-1024 -
High Cell-Free DNA Integrity Is Associated with Poor Breast Cancer Survival
Lamminaho, Maria; Kujala, Jouni; Peltonen, Hanna; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto. 2021. Cancers. 13: 4679 -
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
Palomäki, Antti; FinnGen Rheumatology Clinical Expert Group; Palotie, Aarno; Koskela, Jukka; Eklund, Kari K; Pirinen, Matti; FinnGen; Ripatti, Samuli; Laitinen, Tarja; Mars, Nina; [incl. collaborators Kosma, Veli-Matti; Mannermaa, Arto; Heikkinen, Sami]. 2021. Annals of the rheumatic diseases. 80: 1530-1536 -
Multi-level dilated residual network for biomedical image segmentation
Gudhe, Naga Raju; Behravan, Hamid; Sudah, Mazen; Okuma, Hidemi; Vanninen, Ritva; Kosma, Veli-Matti; Mannermaa, Arto. 2021. Scientific reports. 11: 14105 -
The debatable presence of PIWI-interacting RNAs in invasive breast cancer
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M. 2021. Cancer medicine. 10: 3593 - 3603 -
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; Kar, S; Pooley, KA; Dennis, J; Michailidou, K; Turman, C; Soucy, P; Lemaçon, A; Lush, M; Tyrer, JP; Ghoussaini, M; Marjaneh, MM; Jiang, X; Agata, S; Aittomäki, K; Alonso, MR; et al. [incl. Hartikainen, J; Kosma, VM; Mannermaa, A; Tengström, M]. 2020. Nature genetics. 52: 56-73 -
High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival
Kujala, J; Hartikainen, JM; Tengström, M; Sironen, R; Kosma, VM; Mannermaa, A. 2020. Cancer medicine. 9: 5922-5931 -
High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
Sopo, Minna; Sallinen, Hanna; Hämäläinen, Kirsi; Kivelä, Annukka; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Anttila, Maarit. 2020. PLoS ONE. 15: e0241484 -
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Bao, Erik L; Nandakumar, Satish K; Liao, Xiaotian; Bick, Alexander G; Karjalainen, J; Tabaka, Marcin; Gan, Olga I; Havulinna, Aki S; Kiiskinen, Tuomo TJ; Lareau, Caleb A; de Lapuente Portilla, Aitzkoa L; Li, Bo; Emdin, Connor; Codd, Veryan; Nelson, Christopher P; Walker, Christopher J; Churchhouse, Claire; de la Chapelle, Albert; Klein, Daryl E; et al. (incl. Kosma, V-M; Heikkinen, S; Mannermaa, A). 2020. Nature. 586: 769-775 -
MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer
Eneh, Stralina; Heikkinen, Sami; Hartikainen, Jaana M; Kuopio, Teijo; Mecklin, Jukka-Pekka; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Anticancer research. 40: 3713-3722 -
Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors
Sopo, Minna; Anttila, Maarit; Muukkonen, Oona-Tuuli; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Sallinen, Hanna. 2020. Anticancer research. 40: 6923-6931 -
Peritumor to Tumor Apparent Diffusion Coefficient Ratio Is Associated With Biologically More Aggressive Breast Cancer Features and Correlates With the Prognostication Tools
Okuma, H; Sudah, M; Kettunen, T; Niukkanen, A; Sutela, A; Masarwah, A; Kosma, VM; Auvinen, P; Mannermaa, A; Vanninen, R. 2020. PLoS ONE. 15: e0235278 -
Predicting Breast Cancer Risk Using Interacting Genetic and Demographic Factors and Machine Learning
Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Scientific reports. 10: 11044 -
The role of polygenic risk and susceptibility genes in breast cancer over the course of life
Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. Nature communications. 11: 6383 -
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis
Shu, Xiang; Wu, Lang; Khankari, Nikhil K; Shu, Xiao-Ou; Wang, Thomas J; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Milne, Roger L; Schmidt, Marjanka K; Pharoah, Paul DP; Andrulis, Irene L; Hunter, David J; Simard, Jacques; Easton, Douglas F; Zheng, Wei; Alicia, Beeghly-Fadiel J; Anton-Culver, Hoda; Antonenkova, Natalia; et al. (Incl. Kosma, Veli-Matti). 2019. International journal of epidemiology. 48: 795-806 -
Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
Sopo, M; Anttila, M; Hämäläinen, K; Kivelä, A; Ylä-Herttuala, S; Kosma, VM; Keski-Nisula, L; Sallinen, H. 2019. Bmc cancer. 19: 584 -
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta). 2019. Nature communications. 10: 4329 -
Genome-wide association study of germline variants and breast cancer-specific mortality
Escala-Garcia, M; Guo, Q; Dörk, T; Canisius, S; Keeman, R; Dennis, J; Beesley, J; Lecarpentier, J; Bolla, MK; Wang, Q; Abraham, J; Andrulis, IL; Anton-Culver, H; Arndt, V; Auer, PL; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; et al. (Incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto; Tengström, Maria). 2019. British journal of cancer. 120: 647-657 -
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; Beesley, J; Bolla, MK; Shu, X-O; Lu, Y; Cai, Q; Al-Ejeh, F; Rozali, E; Wang, Q; Dennis, J; Li, B; Zeng, C; Feng, H; Gusev, A; Barfield, RT; Andrulis, IL; et al. [Incl Kosma, Veli-Matti; Mannermaa, Arto]. 2018. Nature genetics. 50: 968-978 -
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium
Rudolph, A; Song, M; Brook, MN; Milne, RL; Mavaddat, N; Michailidou, K; Bolla, MK; Wang, Q; Dennis, J; Wilcox, AN; Hopper, JL; Southey, MC; Keeman, R; Fasching, PA; Beckmann, MW; Gago-Dominguez, M; Castelao, JE; Guénel, P; Truong, T; Bojesen, SE; et al. [Incl. Kosma, V-M]. 2018. International journal of epidemiology. 47: 526-536 -
Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls
Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Pylkäs, Katri; Winqvist, Robert; Kosma, Veli-Matti; Mannermaa, Arto. 2018. Scientific reports. 8: 13149 -
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, TH; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson KJ; et al [Incl Auvinen, Päivi; Kataja, Vesa; Kosma, Veli-Matti; Mannermaa, Arto]. 2018. American journal of human genetics. 2019; 104: 21-34 -
The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity
Colombo, M; Lòpez-Perolio, I; Meeks, HD; Caleca, L; Parsons, M; Li, H;, De Vecchi, G; Tudini, E; Foglia, C; Mondini, P; Manoukian, S; Behar, R; Garcia, EBG; Meindl, A; Montagna, M; Niederacher, D; Schmidt, AY; Varesco, L; Wappenschmidt, B; Bolla, M; et al. [Incl Mannermaa, Arto; Kosma, Veli-Matti]. 2018. Human mutation. 39: 729-741 -
Tumor-infiltrating lymphocytes associate with outcome in non-endemic nasopharyngeal carcinoma : a multicenter study
Almangush, Alhadi; Ruuskanen, Miia; Hagström, Jaana; Hirvikoski, Pasi; Tommola, Satu; Kosma, Veli-Matti; Nieminen, Pentti; Mäkitie, Antti; Leivo, Ilmo. 2018. Human pathology. 81: 211-219 -
Association analysis identifies 65 new breast cancer risk loci
Michailidou K, Lindstrom S, Dennis J, Beesley J, Hui S, Kar S, Lemacon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang ZM, Allen J, Keeman R, Eilber U, French JD et al.. 2017. Nature. 551: 92-94 -
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L, Martin C, Calleja FMGR, Meeks H, Hallberg E, Hinton J, Lilyquist J, Hu CL, Aalfs CM, Aittomaki K, Andrulis I, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV et al., KConFab AOCS Investigators, NBCS Collaborators. 2017. Cancer research. 77: 2789-2799 -
Body mass index and breast cancer survival: a Mendelian randomization analysis
Guo Q, Burgess S, Turman C, Bolla MK, Wang Q, Lush M, Abraham J, Aittomäki K, Andrulis IL, Apicella C, Arndt V, Barrdahl M, Benitez J, Berg CD, Blomqvist C, Bojesen SE, Bonanni B, Brand JS, Brenner H, Broeks A et al. [Incl. Hartikainen J, Kataja V, Kosma V-M, Mannermaa A]. 2017. International journal of epidemiology. 46: 1814-1822 -
Combined gene therapy using AdsVEGFR2 and AdsTie2 with chemotherapy reduces the growth of human ovarian cancer and formation of ascites in mice
Tuppurainen L, Sallinen H, Karvonen A, Valkonen E, Laakso H, Liimatainen T, Hytönen E, Hämäläinen K, Kosma V-M, Anttila M, Ylä-Herttuala S. 2017. International journal of gynecological cancer. 27: 879-886 -
FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population
Kiiski JI, Tervasmäki A, Pelttari LM, Khan S, Mantere T, Pylkäs K, Mannermaa A, Tengström M, Kvist A, Borg Å, Kosma V-M, Kallioniemi A, Schleutker J, Bützow R, Blomqvist C, Aittomäki K, Winqvist R, Nevanlinna H. 2017. Breast cancer research and treatment. 166: 217-226 -
Genetic modifiers of CHEK2*1100delC-associated breast cancer risk
Muranen TA, Greco D, Blomqvist C, Aittomaki K, Khan S, Hogervorst F, Verhoef S, Pharoah PDP, Dunning AM, Shah M, Luben R, Bojesen SE, Nordestgaard BG, Schoemaker M, Swerdlow A, Garcia-Closas M, Figueroa J, Dork T, Bogdanova NV, Hall P et al., NBCS Investigators, KConFab AOCS Investigators, Breast Canc Assoc Consortium. 2017. Genetics in medicine. 19: 599-603 -
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J et al [incl. Hartikainen Juha, Mannermaa Arto, Tengström Maria]. 2017. Nature genetics. 49: 1767-1778 -
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1
Jiao X, Aravidis C, Marikkannu R, Rantala J, Picelli S, Adamovic T, Liu T, Maguire P, Kremeyer B, Luo L, von Holst S, Kontham V, Thutkawkorapin J, Margolin S, Du Q, Lundin J, Michailidou K, Bolla MK, Wang Q, Dennis J et al.. 2017. Oncotarget. 8: 102769-102782 -
Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI
Lindgren A, Anttila M, Rautiainen S, Arponen O, Kivelä A, Mäkinen P, Härmä K, Hämäläinen K, Kosma V-M, Ylä-Herttuala S, Vanninen R, Sallinen H. 2017. European radiology. 27: 4002-4012 -
Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study
Brouckaert O, Rudolph A, Laenen A, Keeman R, Bolla MK, Wang Q, Soubry A, Wildiers H, Andrulis IL, Arndt V, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Brauch H, Brennan P, Brenner H, Chenevix-Trench G, Choi JY, Cornelissen S et al.. 2017. Breast cancer research. 19: 119 -
TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer
Fagerholm R, Khan S, Schmidt MK, García-Closas M, Heikkilä P, Saarela J, Beesley J, Jamshidi M, Aittomäki K, Liu J, Ali HR, Andrulis IL, Beckmann MW, Behrens S, Blows FM, Brenner H, Chang-Claude J, Couch FJ, Czene K, Fasching PA et al [Incl Kosma V-M]. 2017. Oncotarget. 8: 18381-18398 -
Tenascin-C and fibronectin expression divide early stage tongue cancer into low-and high-risk groups
Sundquist E, Kauppila JH, Veijola J, Mroueh R, Lehenkari P, Laitinen S, Risteli J, Soini Y, Kosma V-M, Sawazaki-Calone I, MacEdo CCS, Bloigu R, Coletta RD, Salo T. 2017. British journal of cancer. 116: 640-648 -
Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers
Schmidt MK, Hogervorst F, van Hien R, Cornelissen S, Broeks A, Adank MA, Meijers H, Waisfisz Q, Hollestelle A, Schutte M, van den Ouweland A, Hooning M, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Arndt V, Bermisheva M, Bogdanova NV, Bolla MK et al. 2016. Journal of clinical oncology. 34: 2750-60 -
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
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High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome
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Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
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No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing
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PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS
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Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer
Masarwah Amro, Auvinen Päivi, Sudah Mazen, Dabravolskaite Vaiva, Arponen Otso, Sutela Anna, Oikari Sanna, Kosma Veli-Matti, Vanninen Ritva. 2016. Bmc cancer. 16: 833 -
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
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A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
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A simple novel prognostic model for early stage oral tongue cancer
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Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
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Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy
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BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers
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Common germline polymorphisms associated with breast cancer specific survival
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Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer
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Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest
Arponen Otso, Sudah Mazen, Masarwah Amro, Taina Mikko, Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Kosma Veli-Matti, Sutela Anna, Hakumäki Juhana, Vanninen Ritva. 2015. PLoS ONE. 10: e0138702 -
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk
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Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Orr Nick, Dudbridge Frank, Dryden Nicola, Maguire Sarah, Novo Daniela, Perrakis Eleni, Johnson Nichola, Ghoussaini Maya, Hopper John L, Southey Melissa C, Apicella Carmel, Stone Jennifer, Schmidt Marjanka K, Broeks Annegien, Van't Veer Laura J, Hogervorst Frans B, Fasching Peter A, Haeberle Lothar, Ekici Arif B, Beckmann Matthias W et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Human molecular genetics. 24: 2966-2984 -
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1
Glubb Dylan M, Maranian Mel J, Michailidou Kyriaki, Pooley Karen A, Meyer Kerstin B, Kar Siddhartha, Carlebur Saskia, O'Reilly Martin, Betts Joshua A, Hillman Kristine M, Kaufmann Susanne, Beesley Jonathan, Canisius Sander, Hopper John L, Southey Melissa C, Tsimiklis Helen, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Hogervorst Frans B et al (incl. Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti KosmaI). 2015. American journal of human genetics. 96: 5-20 -
For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality
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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Michailidou Kyriaki, Beesley Jonathan, Lindstrom Sara, Canisius Sander, Dennis Joe, Lush Michael J, Maranian Mel J, Bolla Manjeet K, Wang Qin, Shah Mitul, Perkins Barbara J, Czene Kamila, Eriksson Mikael, Darabi Hatef, Brand Judith S, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Nielsen Sune F, Rahman Nazneen et al (incl. Arto Mannermaa, Jaana Hartikainen, Veli-Matti Kosma, Vesa Kataja). 2015. Nature genetics. 47: 373-380 -
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization
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Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
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Identification of Novel Genetic Markers of Breast Cancer Survival
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Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
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KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes
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Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
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Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival
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Negligible respiratory irritation and inflammation potency of pigmentary TiO2 in mice
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Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
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Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Mavaddat Nasim, Pharoah Paul DP, Michailidou Kyriaki, Tyrer Jonathan, Brook Mark N, Bolla Manjeet K, Wang Qin, Dennis Joe, Dunning Alison M, Shah Mitul, Luben Robert, Brown Judith, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Czene Kamila, Darabi Hatef, Eriksson Mikael, Peto Julian et al (incl. Arto Mannermaa). 2015. Journal of the national cancer institute. 107: djv036 -
SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma
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SNP-SNP interaction analysis of NF-kappaB signaling pathway on breast cancer survival
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The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome
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Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer
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Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function
Virtakoivu Reetta, Mai Anja, Mattila Elina, De Franceschi Nicola, Imanishi Susumu Y., Corthals Garry, Kaukonen Riina, Saari Markku, Cheng Fang, Torvaldson Elin, Kosma Veli-Matti, Mannermaa Arto, Muharram Ghaffar, Gilles Christine, Eriksson John, Soini Ylermi, Lorens James B., Ivaska Johanna. 2015. Cancer research. 75: 2349-2362 -
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
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A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium
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Depth of invasion, tumor budding and worst pattern of invasion: Prognostic indicators in early-stage oral tongue cancer
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Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
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FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
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Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer
Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. 2014. Clinical genetics. 88: 68-73 -
Genetic predisposition to in situ and invasive lobular carcinoma of the breast
Sawyer Elinor, Roylance Rebecca, Petridis Christos, Brook Mark N, Nowinski Salpie, Papouli Efterpi, Fletcher Olivia, Pinder Sarah, Hanby Andrew, Kohut Kelly, Gorman Patricia, Caneppele Michele, Peto Julian, dos Santos Silva Isabel, Johnson Nichola, Swann Ruth, Dwek Miriam, Perkins Katherine-Anne, Gillett Cheryl, Houlston Richard et al (incl. Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M,). 2014. PLoS genetics. 10: e1004285 -
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Johnson Nichola, Dudbridge Frank, Orr Nick, Gibson Lorna, Jones Michael E, Schoemaker Minouk J, Folkerd Elizabeth J, Haynes Ben P, Hopper John L, Southey Melissa C, Dite Gillian S, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Van T Veer Laura J, Atsma Femke et al. 2014. Breast cancer research and treatment. 16: R51 -
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, ...,Hartikainen JM, Kosma VM, Kataja V, et al.. 2014. Human molecular genetics. 23: 6034-6046 -
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple negative breast cancer
Purrington Kristen S, Slager Susan, Eccles Diana, Yannoukakos Drakoulis, Fasching Peter A, Miron Penelope, Carpenter Jane, Chang-Claude Jenny, Martin Nicholas G, Montgomery Grant W, Kristensen Vessela, Anton-Culver Hoda, Goodfellow Paul, Tapper William J, Rafiq Sajjad, Gerty Susan M, Durcan Lorraine, Konstantopoulou Irene, Fostira Florentia, Vratimos Athanassios et.al. (including Kosma Veli-Matti, Mannermaa Arto). 2014. Carcinogenesis. 35: 1012-1019 -
High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer
Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. Histopathology. 2014; 66: 873-883 -
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Breast cancer research and treatment. 143: 277-286 -
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, Apicella C, Southey MC, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Th Rutgers EJ, Muir K, Lophatananon A, Stewart-Brown S, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab Investigators; Australian Ovarian Cancer Study Group, et al.. 2014. Human molecular genetics. 2014: 1-14 -
Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions
Schoeps Anja, Rudolph Anja, Seibold Petra, Dunning Alison M, Milne Roger L, Bojesen Stig E, Swerdlow Anthony, Andrulis Irene, Brenner Hermann, Behrens Sabine, Orr Nicholas, Jones Michael, Ashworth Alan, Li Jingmei, Cramp Helen, Connley Dan, Czene Kamila, Darabi Hatef, Chanock Stephen J, Lissowska Jolanta et al (incl Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana M, Mannermaa Arto). 2014. Genetic epidemiology. 38: 84-93 -
Inhaled silica-coated TiO2 nanoparticles induced airway irritation, airflow limitation and inflammation in mice
Leppänen Maija, Korpi Anne, Mikkonen Santtu, Yli-Pirilä Pasi, Lehto Maili, Pylkkänen Lea, Wolff Henrik, Kosma Veli-Matti, Alenius Harri, Joutsensaari Jorma, Pasanen Pertti. 2014. Nanotoxicology. 2015; 9: 210-218 -
Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Rudolph A, Milne RL, Truong T, Knight JA, Seibold P, Flesch-Janys D, Behrens S, Eilber U, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. International journal of cancer. 136: E685-E696 -
MicroRNA Related Polymorphisms and Breast Cancer Risk
Khan Sofia, Greco Dari, Michailidou Kyriaki, Milne Roger L, Muranen Taru A, Heikkinen Tuomas, Aaltonen Kirsimari, Dennis Joe, Bolla Manjeet K, Liu Jianjun, Hall Per, Irwanto Astrid, Humphreys Keith, Li Jingmei, Czene Kamila, Chang-Claude Jenny, Hein Rebecca, Rudolp Anja, Seibold Petra, Flesch-Janys Dieter et at (including Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Mannermaa Arto). 2014. PLoS ONE. 9: e109973 (1-12) -
MnSOD rs4880 and XPD rs13181 polymorphisms predict the survival of breast cancer patients treated with adjuvant tamoxifen
Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Soini Ylermi, Hirvonen Ari, Kataja Vesa. 2014. Acta oncologica. 53: 769-775 -
Overexpression of MicroRNA-200c Predicts Poor Outcome in Patients with PR-Negative Breast Cancer
Tuomarila M, Luostari K, Soini Y, Kataja V, Kosma VM, Mannermaa A. 2014. PLoS ONE. 9: e109508: 1-8 -
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Perry John RB, Day Felix, Elks Cathy E, Sulem Patrick, Thompson Deborah J, Ferreira Teresa, He Chunyan, Chasman Daniel I, Esko Tõnu, Thorleifsson Gudmar, Albrecht Eva, Ang Wei Q, Corre Tanguy, Cousminer Diana L, Feenstra Bjarke, Franceschini Nora, Ganna Andrea, Johnson Andrew D, Kjellqvist Sanela, Lunetta Kathryn L et al. 2014. Nature. 514: 92-97 -
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
Spurdle Amanda B, Couch Fergus J, Parsons Michael T, McGuffog Lesley, Barrowdale Daniel, Bolla Manjeet K, Wang Qin, Healey Sue, Schmutzler Rita Katharina, Wappenschmidt Barbara, Rhiem Kerstin, Hahnen Eric, Engel Christoph, Meindl Alfons, Ditsch Nina, Norbert Arnold, Plendl Hansjoerg, Niede et al. (incl. Hartikainen Jaana)racher Dieter, Sutter Christian, Wang-Gohrke Shan,. 2014. Breast cancer research. 16: 3419 -
Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
Sallinen H, Heikura T, Koponen J, Kosma VM, Heinonen S, Ylä-Herttuala S, Anttila M. 2014. Bmc cancer. 14: 1-10 -
Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer
Luostari Kaisa, Hartikainen Jaana M, Tengström Maria, Palvimo Jorma J, Kataja Vesa, Mannermaa Arto, Kosma Veli-Matti. 2014. PLoS ONE. 9: e102519 -
XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer
Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Hirvonen Ari, Kataja Vesa. 2014. Anticancer research. 34: 3031-3037 -
γ -Secretase Components as Predictors of Breast Cancer Outcome
Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. 2013. PLoS ONE. 8: e79249, 1-13 -
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication
Hein R, Flesch-Janys D, Dahmen N, Beckmann L, Lindström S, Schoof N, Czene K, Mittelstraß K, Illig T, Seibold P, Behrens S, Humphreys K, Li J, Liu J, Olson et al. 2013. Breast cancer research and treatment. 138: 529-42 -
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
Nickels S, Truong T, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt M, Häberle L, Vrieling A, Gaudet M, Figueroa J, Schoof N, Spurdle AB, Rudolph A, Fasching PA, Hopper JL, Makalic E, Schmidt DF, Southey MC, Beckmann MW, Ekici AB, Fletcher O, Gibson L, Silva Idos S, Peto J, Humphreys MK, Wang J, Cordina-Duverger E, Menegaux F, Nordestgaard BG, Bojesen SE, Lanng C, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Brauch H, Brüning T, Harth V; G. 2013. PLoS genetics. 9: e1003284 -
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1
Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2013. American journal of human genetics. 93: 1046-1060 -
Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model
Tuppurainen L, Sallinen H, Hakkarainen H, Liimatainen T, Hassan M, Ylä-Herttuala E, Anttila M, Hämäläinen K, Veli-Matti Kosma, Heinonen S, Alitalo K, Ylä-Herttuala S. 2013. Journal of genetic syndromes & gene therapy. 4: x-x -
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E et.al.. 2013. American journal of human genetics. 92: 489-503 -
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, et. al. 2013. Nature genetics. 45: 392-8 -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A et. al. 2013. Nature genetics. 45: 353-61 -
Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer
Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A.. 2013. International journal of cancer. 133: 2334-2340 -
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz et al. 2013. Nature genetics. 45: 371-84 -
Pathology at the interface of basic and clinical research
Carpén O, Kosma VM. 2013. Duodecim. 129: 1080-7 -
Preclinical Safety, Toxicology, and Biodistribution Study of Adenoviral Gene Therapy with sVEGFR-2 and sVEGFR-3 Combined with Chemotherapy for Ovarian Cancer
Tuppurainen L, Sallinen H, Kokki E, Koponen J, Anttila M, Pulkkinen K, Heikura T, Toivanen P, Hämäläinen K, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2013. Human gene therapy. clinical development. 24: 29-37 -
The UGT1A6_19_GG genotype is a breast cancer risk factor
Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V, Pesch B, Brüning T, Baisch C, Hartikainen JM, Mannermaa A, Kosma VM, Kataja V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Fasching PA, Beckmann M, Ekici AB, Hein A, Hall P, Li J, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Hamann U, Ko YD, Brauch H. & al.. 2013. Frontiers in genetics. 4: 1-6 -
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI et.al.. 2012. Human mutation. 33: 1123-1132 -
19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus
Stevens Kristen N, Fredericksen Zachary, Vachon Celine M, Wang Xianshu, Margolin Sara, Lindblom Annika, Nevanlinna Heli, Greco Dario, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Vrieling Alina, Flesch-Janys Dieter, Sinn Hans-Peter, Wang-Gohrke Shan, Nickels Stefan, Brauch Hiltrud, Ko Yon-Dschun, Fischer Hans-Peter, Schmutzler Rita K. 2012. Cancer research. 72: 1795-1803 -
9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
Warren H, Dudbridge F, Fletcher O, Orr N, Johnson N, Hopper JL, Apicella C, Southey MC, Mahmoodi M, Schmidt MK, Broeks A, Cornelissen S, Braaf LM, Muir KR, Lophatananon A, Chaiwerawattana A, Wiangnon S, Fasching PA, Beckmann MW, Ekici AB et al. 2012. Cancer epidemiology biomarkers and prevention. 21: 1783-1791 -
Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma
Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. 2012. International journal of cancer. 131: 234-2401 -
Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Kirchhoff T, Gaudet MM, Antoniou AC, McGuffog L, Humphreys MK, Dunning AM, Bojesen SE, Nordestgaard BG, Flyger H, Kang D, Yoo KY, Noh DY, Ahn SH, Dork T, Schürmann P, Karstens JH, Hillemanns P, Couch FJ, Olson J, Vachon C, et.al.. 2012. PLoS ONE. 7: e35706 -
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions
Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R.. 2012. Science translational medicine. 4: 122-123 -
Bronkiaalinen karsinoidituumori
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 556-557. Kustannus Oy Duodecim -
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer
Weischer M, Nordestgaard BG, Pharoah P, Bolla MK, Nevanlinna H, van't Veer LJ, Garcia-Closas M, Jopper JL, Hall P, Andrulis IL, Devilee P, Fasching PA, Anton-Culver H, Lambrechts D, Hooning M, Cox A, Giles GG, Burwinkel B, Lindblom A, Couch FJ et.al.. 2012. Journal of clinical oncology. 30: 4308-16 -
Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association consortium (BCAC)
Hein R, Maranian M, Hopper J L, Kapuscinski M K, Southey M C, Park D J, Schmidt M K, Broeks A, Hogervorst F B L, Bueno-de-Mesquit H B, Muir K R, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching P A, Hein A, Ekici A B, Beckmann M W, Fletcher O, Johnson N, et.al.. 2012. PLoS ONE. 7: - -
Energia-aineenvaihduntaan vaikuttavat aineet
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 130. Duodecim -
Fibrinoidi nekroosi
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim -
Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer
Hartikainen JM,Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y.. 2012. Cancer research. 72: 5537-5546 -
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Drive K, Johnson N, Orr N, Dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, et al. 2012. Nature genetics. 44: 312-318 -
Genotoksiset ja karsinogeeniset aineet
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 122-123. Kustannus Oy Duodecim -
Glykogeenikertymät
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 147. Kustannus Oy Duodecim -
Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer.
Berdel B, Nieminen K, Soini Y, Tengström M, Malinen M, Kosma VM, Palvimo J, Mannermaa A. 2012. Bmc cancer. 12: e1-15 -
Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer
Auvinen P, Tammi R, Kosma VM, Sironen R, Soini Y, Mannermaa A, Tumelius R, Uljas E, Tammi M. 2012. International journal of cancer. 132: 531-539 -
Iskeeminen soluvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 131-133. Kustannus Oy Duodecim -
Juustonekroosi
Nukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 142. Kustannus Oy Duodecim -
Kemiallinen solvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 134-135. Kustannus Oy Duodecim -
Kertymät
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim -
Keuhko levyepiteelikarsinooma
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 550-551. Kustannus Oy Duodecim -
Keuhkojen sytologiset näytteet
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 557-558. Kustannus Oy Duodecim -
Keuhkon adenokarsinooma
Lappi-Blanco Elisa, Mäkinen Johanna, Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 551-553. Kustannus Oy Duodecim -
Keuhkon metastaattiset kasvaimet
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 557. Kustannus Oy Duodecim -
Keuhkon pienisoluinen karsinooma
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 553-555. Kustannus Oy Duodecim -
Keuhkon suurisoluinen karsinooma
Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 555-556. Kustannus Oy Duodecim -
Keukokasvaimet
Pirinen Risto, Lappi-Blanco Elisa, Mäkinen Johanna, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 547-550. Kustannus Oy Duodecim -
Koagulaationekroosi
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 141-142. Kustannus Oy Duodecim -
Kurkunpään kasvaimet
Hirvikoski Pasi & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 600-601. Kustannus Oy Duodecim -
Kurkunpään rakenne, kehityshäiriöt ja tulehdukset
Hirvikoski Pasi & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 599-600. Kustannus Oy Duodecim -
Lämpötilaan liittyvät vauriot soluissa
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 126. Kustannus Oy Duodecim -
Mekaaninen vaurio, vierasaineet ja syövyttävät aineet
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 126-127. Duodecim -
Nekroosi
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 141. Kustannus Oy Duodecim -
Nestemäinen nekroosi
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 142. Kustannus Oy Duodecim -
Oksidatiivinen stressi
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 119. Kustannus Oy Duodecim -
PREDICT Plus: Development and validation of a prognostic model for early breast cancer that includes HER2
Wishart GC, Bajdik CD, Dicks E, Provenzano E, Schmidt MK, Sherman M, Greenberg DC,. Green AR, Gelmon KA, Kosma V-M, Olson JE, Beckmann MW, Winqvist R, Cross SS, Severi G, Huntsman D, Pylkäs K, Ellis I, Nielsen TO, Giles G, et.al.. 2012. British journal of cancer. 107: 800-807 -
Palautumaton soluvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 137. Kustannus Oy Duodecim -
Palautuva soluvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 136-137. Kustannus Oy Duodecim -
Patologia
Mäkinen M, Carpén O, Kosma V-M, Lehto V-P, Paavonen T & Stenbäck F. 2012. . . Kustannus Oy Duodecim -
Perinnölliset lysosomaaliset kertymäsairaudet
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 147. Kustannus Oy Duodecim -
Pigmenttikertymät
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 145-147. Kustannus Oy Duodecim -
Proteiinikertymät
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 144-145. Kustannus Oy Duodecim -
Proteini G:n epänormaali aktiivisuus
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 135-136. Kustannus Oy Duodecim -
Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors
Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Molecular and cellular endocrinology. 2013; 365: 270-276 -
Pulmonary inflammation and tissue damage in the mouse lung after exposure to PM samples from biomass heating appliances of old and modern technologies
Happo MS, Uski O, Jalava PI, Kelz J, Brunner T, Hakulinen P, Mäki-Paakkanen J, Kosma VM, Jokiniemi J, Obernberger I, Hirvonen M-R. 2012. Science of the total environment. 443: 256-266 -
Rasva- ja kolesterolikertymät
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143-144. Kustannus Oy Duodecim -
Rasvanekroosi
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim -
Reperfuusiovaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 133. Kustannus Oy Duodecim -
Reseptorivälitteinen toksisuus
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 129. Duodecim -
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?
Tengström M, Mannermaa A, Kosma V-M, Hirvonen A, Kataja V. 2012. Bmc cancer. 12: 257 -
Sikiölle toksiset aineet
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 127-129. Duodecim -
Solumetabolia ja soluvaurio
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 117. Kustannus Oy Duodecim -
Soluvaurio ja nekroosi
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen M, Carpén O, Kosma V-M, Lehto V-P, Paavonen T, Stenbäck F (toim.)(toim.) , 2012. Patologia. s. 3-16. Kustannus Oy Duodecim -
Soluvauriomekanismit
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 130-131. Kustannus Oy Duodecim -
Soluvaurion morfologia
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 136. Kustannus Oy Duodecim -
Sopeutuminen
Böhm Jan, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 106-114. Kustannus Oy Duodecim -
Stressiproteiinit
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 119-112. Kustannus Oy Duodecim -
Säteilyn soluvaikutukset
Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 125-126. Kustannus Oy Duodecim -
The role of genetic breast cancer susceptibility variants as prognostic factors
Fasching PA, Pharoah PD, Cox A, Nevanlinna H, Bojesen SE, Karn T, Broeks A, Van Leeuwen FE, Van't Veer LJ, Udo R, Dunning AM, Greco D, Aittomäki K, Blomqvist C, Shah M, Nordestgaard BG, Flyger H, Hopper JL, Southey MC, Apicella C, et.al.. 2012. Human molecular genetics. 21: 3926-3939 -
Vapaiden radikaalien aiheuttama soluvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 133-134. Kustannus Oy Duodecim -
Virusten aiheuttama soluvaurio
Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 135. Kustannus Oy Duodecim -
7q21-rs6964587 and breast cancer risk: an extended case¿control study by the Breast Cancer Association Consortium
Milne Roger L, Lorenzo-Bermejo Justo, Burwinkel Barbara, Malats Nuria, Arias Jose Ignasio, Zamora Pilar M, Benitéz Javier, humphreys Manjeet K, Garciá-Closas Montserrat, Chanock Stephen J, Lissowska Jolanta, Sherman Mark E, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Nevanlinna Heli, Heikkinen Tuomas, Aittomäki Kristiina Blomqvist Carl, Anto-Culver Hoda, et al.. 2011. Journal of medical genetics. 48: 698-702 -
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, Wang X, Ademuyiwa F, Ahmed S, Ambrosone CB, Baglietto L, Balleine R, Bandera EV, Beckmann MW, Berg CD, Bernstein L, Blomqvist C, Blot WJ, Brauch H, Buring JE, Carey LA, Carpenter JE, Chang-Claude J, Chanock SJ, Chasman DI, Clarke CL, Cox A, Cross SS, Deming SL, Diasio RB, Dimopoulos AM, Driver WR, Dünnebier T, Durcan L, Eccles D, Edlund CK, Ekici AB, Fasching PA, Feigelson HS, Flesch-Janys D, Fostira F, Försti A, Fountzilas G, Ger. 2011. Nature genetics. 43: 1210-1214 -
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al. 2011. Journal of the national cancer institute. 103: 250-263 -
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
Figueroa JD, Garcia-Closas M, Humphreys M, Platte R, Hopper JL, Southey MC, Apicella C, Hammet F, Schmidt MK, Broeks A, Tollenaar RA, Van't Veer LJ, Fasching PA, Beckmann MW, Ekici AB, Strick R, Peto J, Dos Santos Silva I, Fletcher O, Johnson N, Sawyer E, Tomlinson I, Kerin M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Bojesen S, Flyger H, Nordestgaard BG, Benítez J, Milne RL, Ignacio Arias J, Zamora MP, Brenner H, Müller H, Arndt V, Rahman N, Turnbull C, Seal S, Renwick A, Brauch H, Justenhov. 2011. Human molecular genetics. 20: 4693-4706 -
Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H; GENICA consortium, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland R, Ekici AB, Tapper WJ, Gerty SM, Durcan L, Graham N, Hein R, Nickels S, Flesch-Janys D, Heinz J, Sinn HP, Konstantopoulou I, Fostira F, Pectasides D, Dimopoulos AM, Fountzilas G, Clarke CL, Balleine R, Olson JE, Fredericksen Z, Diasio RB, Patha. 2011. Cancer research. 71: 6240-6249 -
Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer.
Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Pérez JI, Benítez J, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JC, Huang CS, Hou MF, Nordestgaard BG, Bojesen SE, Lanng C, Alnæs GG, Kristensen V, Børrensen-Dale AL, Hopper JL, Dite GS, Apicella C, Southey MC, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Sangrajrang S, Gaborieau V, Brennan P, McKay. 2011. Cancer epidemiology biomarkers and prevention. 20: 2222-2231 -
Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.
Stevens KN, Garcia-Closas M, Fredericksen Z, Kosel M, Pankratz VS, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Fasching PA, Beckmann MW, Hein A, Ekici AB, Johnson N, Peto J, Dos Santos Silva I, Gibson L, Sawyer E, Tomlinson I, Kerin MJ, Chanock S, Lissowska J, Hunter DJ, Hoover RN, Thomas GD, Milne RL, Pérez JA, González-Neira A, Benítez J, Burwinkel B, Meindl A, Schmutzler RK, Bartrar CR, Hamann U, Ko YD, Brüning T, Chang-Claude J, Hein R, Wan. 2011. British journal of cancer. 105: 1934-9 -
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Vuorela M, Pylkäs K, Hartikainen JM, Sundfeldt K, Lindblom A, von Wachenfeldt Wäppling A, Haanpää M, Puistola U, Rosengren A, Anttila M, Kosma VM, Mannermaa A, Winqvist R.. 2011. Breast cancer research and treatment. 130: 1003-10 -
Hyaluronan in human malignancies
Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M & Kosma VM. 2011. Experimental cell research. 317: 383-391 -
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Broeks, Annegien; Schmidt, Marjanka K; Sherman, Mark E; Couch, Fergus J; Hopper, John L; Dite, Gillian S; Apicella, Carmen; Smith, Letitia D; Hammet, Fleur; Southey, Melissa C; Van't Veer, Laura J; de Groot, Renate; Smit, Vincent T. H. B. M; Fasching, Peter A; Beckmann, Matthias W; Jud, Sebastian; Ekici, Arif B; Hartmann, Arndt; Hein, Alexander; Schulz-Wendtland, Ruediger et al.. 2011. Human molecular genetics. 20: 3289-3303 -
Nanosized TiO2 caused minor airflow limitation in the murine airways
Leppänen Maija, Korpi Anne, Miettinen Mirella, Leskinen Jani, Torvela Tiina, Rossi Elina, Vanhala Esa, Wolff Henrik, Alenius Harri, Kosma Veli-Matti, Joutsensaari Jorma, Jokiniemi Jorma, Pasanen Pertti. 2011. Archives of toxicology. 85: 827-839 -
Transcription factors zeb1, twist and snai1 in breast carcinoma
Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer. 11: - -
Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma
Jouppila-Mättö A, Tuhkanen H, Soini Y, Pukkila M, Närkiö-Mäkelä M, Sironen R, Virtanen I, Mannermaa A, Kosma V-M. 2011. Histology and histopathology. 26: 443-449 -
Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression
Juoppila-Mättö Anna, Närkiö-Mäkelä Mervi, Soini Ylermi, Pukkila Matti, Sironen Reijo, Tuhkanen Hanna, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer. 11: 350 -
VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. Cancer gene therapy. 18: 100-9 -
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the Breast Cancer Association Consortium: a combined case-controt study
Milne RL, Gaudet MM, Spurdle AB, Fasching PA, Couch FJ & et al. 2010. Breast cancer research. 12: 110 -
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival
Azzato EM, Tyrer J, Fasching PA, Beckmann MW, Ekici AB, Schulz-Wendtland R, Bojesen SE, Nordestgaard BG, Flyger H, Milne RL, et.al.. 2010. Journal of the national cancer institute. 102: 650-662 -
Churg-Strauss syndrome manifested by appendicitis, cholecystitis and superficial micronodular liver lesions-an unusual clinicopathological presentation
Sironen RK, Seppä A, Kosma VM. 2010. Journal of clinical pathology. 63: 848-850 -
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cancer gene therapy. 18: 100-109 -
Downregulated CD44 and hyaluronan expression in vulvar intraepithelial neoplasia and squamous cell carcinomas
Hämäläinen K, Kosma V-M, Eloranta M-L, Tammi R, Tammi M, Leppänen M, Heinonen S & Anttila M. 2010. Acta obstetricia et gynecologica scandinavica. 89: 108-119 -
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Bmc cancer. 10: 512 -
Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Dormans JAMA, Gerlofs-Nijland ME, Cassee FR, Kosma V-M, Sillanpää M, Hillamo R & Hirvonen M-R. 2010. Inhalation toxicology. 22: 402-416 -
Missense Variants in ATM in 26,101 Breast Cancer Cases and 29,842 Controls
Fletcher O, Johnson N, Dos Santos Silva I, Orr N, Ashworth A, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Burwinkel B, et.al.. 2010. Cancer epidemiology biomarkers and prevention. 19: 2143-2151 -
Nutrient intakes during diets including unkilned and large amounts of oats in celiac disease
Kemppainen TA, Heikkinen MT, Ristikankare MK, Kosma VM, Julkunen RJ. 2010. European journal of clinical nutrition. 64: 62-67 -
Preoperative angiopoietin-2 serum levels. A marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer
Sallinen H, Heikura T, Laidinen S, Kosma V-M, Heinonen S, Ylä-Herttuala S & Anttila M. 2010. International journal of gynecological cancer. 20: 1498-1505 -
Prognostic impact of CD31-positive microvessel density in follicular lymphoma patients treated with immunochemotherapy
Taskinen Minna, Jantunen Esa, Kosma Veli-Matti, Bono Petri, Karjalainen-Lindsberg Marja-Liisa, Leppä Sirpa. 2010. European journal of cancer. 46: 2506-2512 -
ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival
Kauppinen J, Kosma V-M, Soini Y, Sironen R, Nissinen M, Nykopp T, Kärjä V, Eskelinen M, Kataja V, Mannermaa A. 2010. Cancer epidemiology biomarkers and prevention. 19: 2133-2142 -
Antiangiogenic gene therapy with soluble VEGFR-1, -2 and -3 reduces the growth of solid human ovarian carcinoma in mice
Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma V-M, Heinonen S, Alitalo K, Yla-Herttuala S. 2009. Molecular therapy. 17: 278-284 -
Association of ESR1 gene tagging SNPs with breast cancer risk
Dunning AM, Healey CS, Baynes C, Maia A-T, Scollen S, Vega A, Rodrígues R, Barbosa-Morais N L, Ponder BAJ..., Mannermaa A, Kosma V-M, ...Pooley KA, Chenevix-Trench G. 2009. Human molecular genetics. 18: 1131-1139 -
Depletion of cell surface CD44 in nonmelanoma skin tumors is associated with increased expression of matrix metalloproteinase 7
Hartmann-Petersen S, Tammi RH, Tammi MI, Kosma V-M. 2009. British journal of dermatology. 160: 1251-1257 -
Effect of unkilned and large amounts of oats on nutritional state of celiac patients in remission
Kemppainen T, Heikkinen M, Ristikankare M, Kosma V-M, Julkunen R. 2009. E-SPEN, THE EUROPEAN E-JOURNAL OF CLINICAL NUTRITION AND METABOLISM. 4: e30-e40 -
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content
Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Bmc cancer. 9: [9 p.] -
Five polymorphisms and breast cancer risk: results from the breast cancer association consortium
Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL..., Mannermaa A, Kataja V, Kosma V-M, Lindblom SM...et al. 2009. Cancer epidemiology biomarkers and prevention. 18: 1610-1616 -
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Mannermaa A, Kosma V-M, Kataja V, ...Easton DF. 2009. Nature genetics -
Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
Tuhkanen H, Soini Y, Kosma V-M, Anttila M, Sironen R, Hämäläinen K, Kukkonen L, Virtanen I, Mannermaa A. 2009. Bmc cancer. 9: -
Reduced gamma-catenin expression and poor survival in oral squamous cell carcinoma
Närkiö-Mäkelä M, Pukkila M, Lagerstedt E, Virtaniemi J, Pirinen R, Johansson R, Kosunen A, Lappalainen K, Hämäläinen K, Kosma V-M. 2009. Archives of otolaryngology : head and neck surgery. 135: 1035-1040 -
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042
Milne RL, Benítez J, Nevanlinna H, Heikkinen T..., Mannermaa A, Kataja V, Kosma V-M. 2009. Journal of the national cancer institute. 101: 1012-1018 -
Ruumiinavaukset opettavat yhä. Onko lääketieteellisten ruumiinavauksien väheneminen ongelma?
Kosma Veli-Matti. 2009. Duodecim -
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
Bergamaschi A, Tagliabue E, Sorlie T, Naume B, Triulzi T, Orlandi R, Russnes HG, Nesland JM, Tammi R, Auvinen P, Kosma V-M, Ménard S, Borresen-Dale A-L. 2008. Journal of pathology. 214: 357-367 -
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
Garcia-Closas M, Hall P, Nevanlinna H ..., Mannermaa A, Uusitupa M, Eskelinen M, Tengström M, Kosma V-M, Kataja V, Chenevix-Trench G .... 2008. PLoS genetics. 4: [e1000054] -
Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan
Tammi RH, Kultti A, Kosma V-M, Pirinen R, Auvinen P, Tammi MI. 2008. Seminars in cancer biology. 18: 288-295 -
Impact of germinal center and non-germinal center phenotypes on overall and failure-free survival after high-dose chemotherapy and auto-SCT in primary diffuse large B-cell lymphoma
Nyman H, Jantunen E, Juvonen E, Elonen E, Böhm J, Kosma V-M, Enblad G, Karjalainen-Lindsberg M-L, Leppä S. 2008. Bone marrow transplantation. 42: 93-98 -
Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumor recurrence and unfavourable outcome in non-small cell lung cancer
Leinonen T, Pirinen R, Böhm J, Johansson R, Kosma V-M. 2008. Histology and histopathology. 23: 693-700 -
NAD(P)H:quinone oxidoreductase 1 NQ01*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Fagerholm Rainer, Hofstetter Barbara, Tommiska Johanna, Aaltonen Kirsimari, Vrtel Radek, Syrjäkoski Kirsi, Kallioniemi Anne, Kilpivaara Outi, Mannermaa Arto, Kosma Veli-Matti, Uusitupa Matti, Eskelinen Matti, Kataja Vesa, Aittomäki Kristiina. 2008. Nature genetics. 40: 844-853 -
Penetrance analysis of the PALB2 c.1592delT founder mutation
Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja Vesa, Kosma V-M, Xia B, Livingston DM, Wingvist R, Hopper JL. 2008. Clinical cancer research. 14: 4667-4671 -
Two distinct local relapse subtypes in invasive breast cancer: effect on their prognostic impact
Casalini P, Carcangiu ML, Tammi R, Auvinen P, Kosma V-M, Valagussa P, Greco M, Balsari A, Ménard S, Tagliabue E. 2008. Clinical cancer research. 14: 25-31 -
Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study
Kemppainen TA, Heikkinen MT, Ristikankare MK, Kosma V-M, Sontag-Strohm TS, Brinck O, Salovaara HO, Julkunen RJ. 2008. Scandinavian journal of gastroenterology. 43: 1094-1101 -
WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells
Kuulasmaa T, Jääskeläinen J, Suppola S, Pietiläinen T, Heikkilä P, Aaltomaa S, Kosma V-M, Voutilainen R. 2008. Hormone and metabolic research. 40: 668-673 -
A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course
Hartikainen JM, Mannermaa A, Heinonen S, Kosma V-M, Kataja V. 2007. Anticancer research. 27: 4295-4300 -
A common coding variant in CASP8 is associated with breast cancer risk
Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MWR, Pooley KA..., Mannermaa A, Hartikainen J, Kataja V, Kosma V-M, ... Couch FJ .... 2007. Nature genetics. 39: 352-358 -
A recurrent mutation in PALB2 in Finnish cancer families
Erkko Hannele, Bing Xia, Nikkilä Jenni, Schleutker Johanna, Syrjäkoski Kirsi, Mannermaa Arto, Kallioniemi Anne, Pylkäs Katri, Karppinen Sanna-Maria, Rapakko Katrin, Alexander Miron, Qing Sheng, Guilan Li, Mattila Henna, Daphene W. Bell. 2007. Nature -
Activator protein-2 in carcinogenesis with a special reference to breast cancer-A mini review
Pellikainen JM, Kosma V-M. 2007. International journal of cancer. 120: 2061-2067 -
Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer
Leinonen T, Pirinen R, Böhm J, Johansson R, Rinne A, Weiber E, Kosma V-M. 2007. Journal of clinical pathology. 60: 515-519 -
CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma
Kosunen A, Pirinen R, Ropponen K, Pukkila M, Kellokoski J, Virtaniemi J, Sironen R, Juhola M, Kumpulainen E, Johansson R, Nuutinen J, Kosma V-M. 2007. Oral oncology. 43: 51-59 -
CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish caucasian population
Sillanpää P, Heikinheimo L, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Metsola K, Hirvonen A. 2007. Breast cancer research and treatment. 104: 287-297 -
DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification
Nowee ME, Snijders AM, Rockx DAP, de WIT RM, Kosma VM, Hämäläinen K, Schouten JP, Verheijen RHM, van Diest PJ, Albertson DG, Dorsman JC. 2007. Journal of pathology. 213: 46-55 -
Dose and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine particles from six European cities
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Kosma VM, Sillanpää M, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R. 2007. Inhalation toxicology. : 227-246 -
Dose- and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine and ultrafine particles from six European cities
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Kosma VM, Sillanpää M, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R.. 2007. Inhalation toxicology. 19: 227-246 -
Genome-wide association study identifies novel breast cancer susceptibility loci
Easton DF, Pooley KA, Dunning AM..., Mannermaa A, Kosma V-M, Kataja V, Hartikainen J. 2007. Nature. 447: 1087-1093 -
HER-2/neu and p27Kip1 in progression of fallopian tube carsinoma: an immunohistochemical and array comparative genomic hybridization study
Nowee ME, Dorsman JC, Piek JMJ, Kosma VM, Hämäläinen K, Verheijen RHM, van Diest PJ. 2007. Histopathology. 51: 666-673 -
High stromal versican expression predicts unfavourable outcome in oral squamous cell carcinoma
Pukkila M, Kosunen A, Ropponen K, Virtaniemi J, Kellokoski J, Kumpulainen E, Pirinen R, Nuutinen J, Johansson R, Kosma V-M. 2007. Journal of clinical pathology. 60: 267-272 -
Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation
Karihtala P, Soini Y, Auvinen P, Tammi R, Tammi M, Kosma V-M. 2007. Journal of histochemistry and cytochemistry. 55: 1191-1198 -
No observed local immunological response at cell level after five years of oats in adult coeliac disease
Kemppainen T, Janatuinen E, Holm K, Kosma V-M, Heikkinen M, Mäki M, Laurila K, Uusitupa M, Julkunen R. 2007. Scandinavian journal of gastroenterology. 42: 54-59 -
Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer
Sillanpää S, Anttila M, Suhonen K, Hämäläinen K, Turpeenniemi-Hujanen T, Puistola U, Tammi M, Sironen R, Saarikoski S, Kosma VM. 2007. Tumor biology. 28: 280-289 -
Prognostic significance of iNOS in epithelial ovarian cancer
Anttila MA, Voutilainen K, Merivalo S, Saarikoski S, Kosma V-M. 2007. Gynecologic oncology. 105: 97-103 -
Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer
Sillanpää S, Anttila M, Voutilainen K, Ropponen K, Turpeenniemi-Hujanen T, Puistola U, Tammi R, Tammi M, Sironen R, Saarikoski S, Kosma V-M. 2007. Gynecologic oncology. 104: 296-303 -
Quantification of angiogenesis by the Chalkley method and its prognostic significance in epithelial ovarian cancer
Suhonen KA, Anttila MA, Sillanpää SM, Hämäläinen KM, Saarikoski SV, Juhola M, Kosma V-M. 2007. European journal of cancer. 43: 1300-1307 -
Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families
Hartikainen JM, Kataja V, Pirskanen M, Arffman A, Ristomaa U, Vahteristo P, Ryynänen M, Heinonen S, Kosma V-M, Mannermaa A. 2007. Clinical genetics. 72: 311-320 -
A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up
Sallinen H, Anttila M, Narvainen J, Ordén M-R, Ropponen K, Kosma V-M, Heinonen S, Yla-Herttuala S. 2006. Gynecologic oncology. 103: 315-320 -
Commonly studied single-nucleotide polymorphism and breast cancer: results from the breast cancer association consortium
The Breast Cancer Association Consortium, Mannermaa A, Kataja V, Kosma V-M. 2006. Journal of the national cancer institute. 98: 1382-1396 -
Expression of matrix metalloproteinases 7 and 9 in non-smal cell lung cancer relation to clinicopathological factors,ß-catenin and prognosis
Leinonen T, Pirinen R, Böhm J, Johansson R, Ropponen K, Kosma V-M. 2006. Lung cancer. 51: 313-321 -
Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas
Tuhkanen H, Anttila M, Kosma V-M, Heinonen S, Juhola M, Helisalmi S, Kataja V, Mannermaa A, Helisalmi S. 2006. International journal of cancer. 119: 1345-1353 -
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 191-199 -
HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 1299-1304 -
Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer
Voutilainen KA, Anttila MA, Sillanpää SM, Ropponen KM, Saarikoski SV, Juhola MT, Kosma V-M. 2006. Journal of clinical pathology. 59: 460-467 -
Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression
Sillanpää SM, Anttila MA, Voutilainen KA, Ropponen KM, Sironen RK, Saarikoski SV, Kosma V-M. 2006. International journal of cancer. 119: 1792-1799 -
Refinement of the 22q12-q13 Breast Cancer-Associated Region:Evidence of TMPRSS6 as a Candidate in an Eastern Finnish Population
Hartikainen JM, Tuhkanen H, Kataja V, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2006. Clinical cancer research. 12: 1454-1462 -
An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in Eastern Finland: three candidate regions found
Hartikainen JM, Tuhkanen H, Kataja V, Dunning AM, Antoniou A, Smith P, Arffman A, Pirskanen M, Easton DF, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2005. Cancer epidemiology biomarkers and prevention. 14: 75-80 -
Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study
Kuusisto J, Räsänen K, Särkioja T, Alarakkola E, Kosma V-M. 2005. Heart. 91: 576-582 -
Elevated expression of hyaluronan and its CD44 receptor in the duodenall mucosa of coeliac patients
Kemppainen T, Tammi R, Tammi M, Ågren U, Julkunen R, Böhm J, Uusitupa M, Kosma V-M. 2005. Histopathology. 46: 64-72 -
Expression of CD44s, CD44v3 and CD44v6 in benign and malignant breast lesions:correlation and colocalization with hyaluronan
Auvinen P, Tammi R, Tammi M, Johansson R, Kosma V-M. 2005. Histopathology. 47: 420-428 -
Mitä uutta rintasyövän biologiasta ja ennustetekijöistä?
Kosma V-M. 2005. Duodecim -
NAT2 slow acetylator genotype as an important modifier of breast cancer risk
Sillanpää P, Hirvonen A, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K. 2005. International journal of cancer. 114: 579-584 -
Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women
Sillanpää P, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K, Hirvonen A. 2005. Pharmacogenetics and genomics. 15: 749-752 -
Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis
Pirinen R, Leinonen T, Böhm J, Johansson R, Ropponen K, Kumpulainen E, Kosma V-M. 2005. Human pathology. 36: 44-50 -
XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in the Finnish case-control study
Metsola K, Kataja V, Sillanpää P, Siivola P, Heikinheimo L, Eskelinen M, Kosma V-M, Uusitupa M, Hirvonen A. 2005. Breast cancer research. 7: R987-R997 -
CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies
The CHEK2 Breast Cancer Case-Control Consortium, Kataja V. 2004. American journal of human genetics. 74: 1175-1182 -
Expression of HER2 and its association with AP-2 in breast cancer
Pellikainen J, Naukkarinen A, Ropponen K, Rummukainen J, Kataja V, Kellokoski J, Eskelinen M, Kosma V-M. 2004. European journal of cancer. 40: 1485-1495 -
Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer
Suwiwat S, Ricciardelli C, Tammi R, Tammi M, Auvinen P, Kosma V-M, LeBaron RG, Raymond WA, Tilley WD, Horsfall DJ. 2004. Clinical cancer research. 10: 2491-2498 -
Expression of matrix metalloproteinase (MMP)-2 and MMP-2 in breast cancer with a special reference to activator protein-2, HER2, and prognosis
Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma V-M. 2004. Clinical cancer research. 10: 7621-7628 -
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p
Tuhkanen H, Anttila M, Kosma V-M, Ylä-Herttuala S, Heinonen S, Kuronen A, Juhola M, Tammi R, Tammi M, Mannermaa A. 2004. International journal of cancer. 109: 247-252 -
Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci
Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. American journal of medical genetics. Part A. 130: 345-350 -
Marked allelic imbalance on chromosome 5q31 does not explain a-catenin expression in epithelial ovarian cancer
Tuhkanen H, Anttila M, Kosma V-M, Puolakka J, Juhola M, Heinonen S, Mannermaa A. 2004. Gynecologic oncology. 94: 416-421 -
Morphometric analysis of the small intestine in wild type mice C57BL/6J - a developmental study
Gulbinowicz M, Berdel B, Wójcik S, Dziewiatkowski J, Oikarinen S, Mutanen M, Kosma V-M, Mykkänen H, Morys¿ J. 2004. Folia morphologica. 63: 423-430 -
Obstetric prognosis after placental abruption
Toivonen S, Heinonen S, Anttila M, Kosma V-M, Saarikoski S. 2004. Fetal diagnosis and therapy. 19: 336-341 -
Reduced expression of hyaluronan is a strong indicator of poor survival in oral squamous cell carcinoma
Kosunen A, Ropponen K, Kellokoski J, Pukkila M, Virtaniemi J, Valtonen H, Kumpulainen E, Johansson R, Tammi R, Tammi M, Nuutinen J, Kosma V-M. 2004. Oral oncology. 40: 257-263 -
The expression and prognostic value of alfa-, beeta- and gamma-catenins in renal cell carcinoma
Aaltomaa S, Lipponen P, Kärjä V, Lundstedt S, Lappi J, Kosma V-M. 2004. Anticancer research. 24: 2407-2414 -
Versican expression in pharyngeal squamous cell carcinoma: an immunohistochemical study
Pukkila MJ, Kosunen AST, Virtaniemi JA, Kumpulainen EJ, Johansson RT, Kellokoski JK, Nuutinen J, Kosma V-M. 2004. Journal of clinical pathology. 57: 735-739 -
Vitamin D receptor gene polymorphism as an important modifier of positive family history related breast cancer risk
Sillanpää P, Hirvonen A, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K. 2004. Pharmacogenetics and genomics. 14: 239-245 -
Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo
Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, Rutanen J, Kosma V-M, Mahonen A, Kröger H, Ylä-Herttuala S. 2003. Faseb journal. 17: 1147-1149 -
Alpha-, beta- and chi-catenin expression in human pancreatic cancer
Julkunen K, Mäkinen K, Kärjä V, Kosma V-M, Eskelinen M. 2003. Anticancer research. 23: 5043-5048 -
CD44 expression indicates favorable prognosis in epithelial ovarian cancer
Sillanpää S, Anttila MA, Voutilainen K, Tammi RH, Tammi MI, Saarikoski SV, Kosma V-M. 2003. Clinical cancer research. 9: 5318-5318 -
Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice
Heikkinen P, Kosma V-M, Alhonen L, Huuskonen H, Komulainen H, Kumlin T, Laitinen JT, Lang S, Puranen L, Juutilainen J. 2003. International journal of radiation biology. 79: 221-233 -
Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells
Liu J, Kuulasmaa T, Kosma V-M, Bützow R, Vänttinen T, Hydén-Granskog C, Voutilainen R. 2003. Journal of clinical endocrinology and metabolism. 88: 5002-5008 -
Hyaluronan, CD44 and versican in epidermal keratinocyte tumours
Karvinen S, Kosma V-M, Tammi MI, Tammi R. 2003. British journal of dermatology. 148: 86-94 -
Myometrial inflammation in human delivery and its association with labor and infection
Keski-Nisula LT, Aalto M-L, Kirkinen PP, Kosma V-M, Heinonen ST. 2003. American journal of clinical pathology. 120: 217-224 -
Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in min mice
Pajari A-M, Rajakangas J, Päivärinta E, Kosma V-M, Rafter J, Mutanen M. 2003. International journal of cancer. 106: 653-660 -
Slight respiratory irritation but not inflammation in mice exposed to (1-3)-beta-D-glucan aerosols
Korpi A, Kasanen J-P, Kosma V-M, Rylander R, Pasanen A-L. 2003. Mediators of inflammation. 12: 139-146 -
Systemic immunoresponses in mice after repeated exposure of lungs to spores of Streptomyces californicus
Jussila J, Pelkonen J, Kosma V-M, Mäki-Paakkanen J, Komulainen H, Hirvonen M-R. 2003. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. 10: 30-37 -
The effect of photodynamic therapy on rat urinary bladder with orthotopic urothelial carcinoma
Grönlund-Pakkanen S, Wahlfors J, Talja M, Kosma V-M, Pakkanen TM, Ala-Opas M, Alhava E, Moore RB. 2003. BJU international. 92: 125-130 -
Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis
Voutilainen K, Anttila M, Sillanpää S, Tammi R, Tammi M, Saarikoski S, Kosma V-M. 2003. International journal of cancer. 107: 359-364 -
p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis
Pellikainen MJ, Pekola TT, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma V-M. 2003. Journal of clinical pathology. 56: 214-220 -
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model
Tyynelä K, Sandmair A-M, Turunen M, Vanninen R, Vainio P, Kauppinen R, Johansson R, Vapalahti M, Ylä-Herttuala S. 2002. Cancer gene therapy. 9: 917-924 -
Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk
Mitrunen K, Kataja V, Eskelinen M, Kosma V-M, Kang D, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2002. Pharmacogenetics and genomics. 12: 67-72 -
Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways
Korpi A, Kasanen J-P, Raunio P, Kosma V-M, Virtanen T, Pasanen A-L. 2002. Inhalation toxicology. 14: 521-540 -
Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors
Hiltunen ELJ, Anttila M, Kultti A, Ropponen K, Penttinen J, Yliskoski M, Kuronen AT, Juhola M, Tammi R, Tammi M, Kosma V-M. 2002. Cancer research. 62: 6410-6413 -
Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)
Hakulinen P, Kosma V-M, Komulainen H. 2002. Anticancer research. 22: 703-706 -
Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells
Liu J, Kosma V-M, Vänttinen T, Hyden-Granskog C, Voutilainen R. 2002. Molecular human reproduction. 8: 136-141 -
Haimasyöpä
Hietanen T, Johansson R, Joensuu H. Teoksessa: Joensuu H, Kouri M, Ojala M, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 221-229. Duodecim -
Hyaluronan expression in differentiated thyroid carcinoma
Böhm J, Niskanen L, Tammi R, Tammi M, Eskelinen M, Pirinen R, Hollmen S, Alhava E, Kosma V-M. 2002. Journal of pathology. 196: 180-185 -
Hyvänlaatuiset sairaudet
Salminen E, Hakala T, Johansson R, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 368-374. Duodecim -
Ihomelanooma
Johansson R, Pyrhönen S, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 346-349. Duodecim -
Ihon levyepiteeli- ja tyvisolusyöpä
Johansson R, Pyrhönen S, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 350-353. Duodecim -
Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: Relation to p53 expression, clinicopathological data, and survival
Pukkila MJ, Kellokoski JK, Virtaniemi JA, Kumpulainen EJ, Johansson RT, Halonen PM, Kosunen AST, Nuutinen J, Kosma V-M. 2002. Laryngoscope. 112: 1084-1088 -
Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs
Jussila J, Komulainen H, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental toxicology and pharmacology. 12: 137-145 -
Murine respiratory and immunological responses to the inhaled aerosols of Stachybotrys chartarum extract
Korpi A, Kasanen J-P, Kosma V-M, Virtanen T, Pasanen A-L. 2002. ANNALS OF OCCUPATIONAL HYGIENE. SUPPLEMENT. 46: 272-276 -
Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs
Jussila J, Komulainen H, Huttunen K, Roponen M, Iivanainen E, Torkko P, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental health perspectives. 110: 1119-1125 -
No harm from five year ingestion of oats in coeliac disease
Janatuinen EK, Kemppainen TA, Julkunen RJK, Kosma V-M, Mäki M, Heikkinen M, Uusitupa MIJ. 2002. Gut. 50: 332-335 -
Nuclear and cytoplasmic p53 expression in pharyngeal squamous cell carcinoma: prognostic implications
Pukkila MJ, Kumpulainen EJ, Virtaniemi JA, Johansson RT, Halonen PM, Kellokoski JK, Kosunen AST, Nuutinen J, Kosma V-M. 2002. Head and neck: journal for the sciences and specialties of the head and neck. 24: 784-791 -
Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer
Pellikainen J, Kataja V, Ropponen K, Kellokoski J, Pietiläinen T, Böhm J, Eskelinen M, Kosma V-M. 2002. Clinical cancer research. 8: 3487-3495 -
Reproductive risk factors, doppler findings, and outcome of affected births in placental abruption: a population-based analysis
Toivonen S, Heinonen S, Anttila M, Kosma V-M, Saarikoski S. 2002. American journal of perinatology. 19: 451-459 -
Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs
Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R. 2002. Inhalation toxicology. 14: 1261-1277 -
Strong stromal hyaluronan expression is associated with PSA recurrence in local prostate cancer
Aaltomaa S, Lipponen P, Tammi R, Tammi M, Viitanen J, Kankkunen J-P, Kosma V-M. 2002. Urologia internationalis. 69: 266-272 -
Supraglottic and glottic carcinomas: clinically and biologically distinct entities?
Hirvikoski P, Virtaniemi J, Kumpulainen E, Johansson R, Kosma V-M. 2002. European journal of cancer. 38: 1717-1723 -
p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields
Kumlin T, Heikkinen P, Kosma V-M, Alhonen L, Jänne J, Juutilainen J. 2002. Radiation and environmental biophysics. 41: 155-158 -
Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes
Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Gene therapy. 8: 784-788 -
Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk
Mitrunen K, Sillanpää P, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Uusitupa M, Hirvonen A. 2001. Carcinogenesis. 22: 827-829 -
Decline after immobilisation and recovery after remobilisation of synovial fluid il1, timp, and chondroitin sulphate levels in young beagle dogs
Haapala J, Arokoski JPA, Rönkkö S, Ågren U, Kosma V-M, Lohmander LS, Tammi M, Helminen HJ, Kiviranta I. 2001. Annals of the rheumatic diseases. 60: 55-60 -
Effects of 50 Hz magnetic fields on cancer induced by ionizing radiation in mice
Heikkinen P, Kosma V-M, Huuskonen H, Komulainen H, Kumlin T, Penttilä I, Väänänen A, Juutilainen J. 2001. International journal of radiation biology. 77: 483-495 -
Effects of mobile phone radiation on X-ray-induced tumorigenesis in mice
Heikkinen P, Kosma V-M, Hongisto T, Huuskonen H, Hyysalo P, Komulainen H, Kumlin T, Lahtinen T, Lang S, Puranen L, Juutilainen J. 2001. Radiation research. 156: 775-785 -
Expression and prognostic value of CD44 standard and variant v3 and v6 isoforms in prostate cancer
Aaltomaa S, Lipponen P, Ala-Opas M, Kosma V-M. 2001. European urology. 39: 138-144 -
Expression of CD44 and its variant isoform v3 has no prognostic value in gastric cancer
Setälä L, Lipponen P, Tammi R, Tammi M, Eskelinen M, Alhava E, Kosma V-M. 2001. Histopathology. 38: 13-20 -
Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas: comparison of immunohistochemistry and in situ hybridisation
Ropponen KM, Kellokoski JK, Pirinen RT, Moisio KI, Eskelinen MJ, Alhava EM, Kosma V-M. 2001. Journal of clinical pathology. 54: 533-538 -
Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer
Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2001. Cancer epidemiology biomarkers and prevention. 10: 229-236 -
High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer
Lipponen P, Aaltomaa S, Tammi R, Tammi M, Ågren U, Kosma V-M. 2001. European journal of cancer. 37: 849-856 -
Inducible nitric oxide synthase (iNOS) expression and its prognostic value in prostate cancer
Aaltomaa SH, Lipponen PK, Kosma V-M. 2001. Anticancer research. 21: 3101-3106 -
Inflammatory responses in mice after intratracheal instillation of spores of streptomyces californicus isolated from indoor air of a molby building
Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R. 2001. Toxicology and applied pharmacology. 171: 61-69 -
Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma
Pukkila MJ, Virtaniemi JA, Kumpulainen EJ, Pirinen RT, Johansson RT, Valtonen HJ, Juhola MT, Kosma V-M. 2001. Journal of clinical pathology. 54: 42-47 -
Polymorphic GSTs and cancer predisposition
Hirvonen A, Bouchardy C, Mitrunen K, Kataja V, Eskelinen M, Kosma V-M, Saarikoski ST, Jourenkova N, Anttila S, Dayer P, Uusitupa M, Benhamou S. 2001. Chemico-biological interactions. 133: 75-80 -
Polymorphic catechol-O-methyltransferase gene and breast cancer risik
Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Kang D, Vainio H, Uusitupa M, Hirvonen A. 2001. Cancer epidemiology biomarkers and prevention. 10: 635-640 -
Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarsinoma
Pirinen R, Tammi R, Tammi M, Hirvikoski P, Parkkinen JJ, Johansson R, Böhm J, Hollmén S, Kosma V-M. 2001. International journal of cancer. 95: 12-17 -
Reduced expression of alfa-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer
Pirinen RT, Hirvikoski P, Johansson RT, Hollmén S, Kosma V-M. 2001. Journal of clinical pathology. 54: 391-395 -
Surgical management of irradiation failures in T1-T2 squamous cell carcinoma of the glottic larynx
Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Kosma VM. 2001. Anticancer research. 21: 4185-4188 -
Syövän vai hoidon aiheuttamat oireet
Johansson R. 2001. Lääkärilehti. 56: 4613-4615 -
The incidence and etiology of postlaryngectomy pharyngocutaneous fistulae
Virtaniemi JA, Kumpulainen EJ, Hirvikoski PP, Johansson RT, Kosma V-M. 2001. Head and neck: journal for the sciences and specialties of the head and neck. 23: 29-33 -
3-cloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a rat thyroid gland carcinogen, does not affect serum levels of TSH and thyroid hormones
Komulainen H, Tuominen RK, Kosma V-M, Huuskonen H. 2000. Environmental toxicology and pharmacology. 8: 267-273 -
Adenovirus-mediated gene transfer into an experimental pancreatic tumour
Mäkinen K, Loimas S, Kosma VM, Wahlfors J, Ylä-Herttuala S, Alhava E, Jänne J. 2000. Scandinavian journal of surgery. 89: 99-103 -
Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods
Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Faseb journal. 14: 2230-2236 -
Combined respiratory effects of cold air with SO2 of NO2 in repeated 10-minute exposures of hyperventilating guinea pigs
Hälinen AI, Salonen RO, Pennanen AS, Kosma V-M. 2000. Inhalation toxicology. 12: 671-691 -
Combined respiratory effects of cold air with SO2 or NO2 in single 1-hour exposures of hyperventilating guinea pigs
Hälinen AI, Salonen RO, Pennanen AS, Kosma V-M. 2000. Inhalation toxicology. 12: 693-713 -
Do pulse-modulated or continuous 900 MHz rf fields enhance the carcinogenic effect of ionising radiation in mice?
Juutilainen J, Heikkinen P, Kosma V-M, Hongisto T, Huuskonen H, Hyysalo P, Komulainen H, Kumlin T, Lahtinen T, Lang S, Penttilä I, Puranen L, Väänänen A. Teoksessa: (toim.) , 2000. Non-Ionizing High-Feguence EM Radiations: Researching the Epidemiological and Clilnical Evidences. 1st International Medical Scientific Congress. s. 49-52. Societa 'Italiana di Statistica Medica -
Enzyme replacement therapy in a mouse model of aspartylglycosaminuria
Dunder U, Kaartinen V, Valtonen P, Väänänen E, Kosma V-M, Heisterkamp N, Groffen J, Mononen I. 2000. Faseb journal. 14: 361-367 -
Evaluation of p21WAF1/CIP1 and cyclin D1 expression in the progression of superficial bladder cancer
Liukkonen T, Lipponen P, Raitanen M, Kaasinen E, Ala-opas M, Rajala P, Kosma V-M, Finnbladder Group. 2000. Urological research. 28: 285-292 -
Expression and prognostic value of alfa-, beta- and gamma-catenins in differentiated thyroid carcinoma
Böhm J, Niskanen L, Kiraly K, Kellokoski J, Eskelinen M, Hollmen S, Alhava E, Kosma V-M. 2000. Journal of clinical endocrinology and metabolism. 85: 4806-4811 -
Expression of activator protein 2 in prostate cancer is related to tumor differentiation and cell proliferation
Lipponen P, Aaltomaa S, Kellokoski J, Ala-Opas M, Kosma V-M. 2000. European urology. 37: 573-578 -
Expression of inducible nitric oxide synthase in colorectal cancer and its association with prognosis
Ropponen KM, Kellokoski JK, Lipponen PK, Eskelinen MJ, Alanne L, Alhava EM, Kosma V-M. 2000. Scandinavian journal of gastroenterology. 35: 1204-1211 -
Expression of transcription factor AP-2 alfa predicts survival in epithelial ovarian cancer
Anttila MA, Kellokoski JK, Moisio KI, Mitchell PJ, Saarikoski S, Syrjänen K, Kosma V-M. 2000. British journal of cancer. 82: 1974-1983 -
Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2 alfa in cutaneous melanoma
Karjalainen JM, Kellokoski JK, Mannermaa AJ, Kujala HE, Moisio KI, Mitchell PJ, Eskelinen MJ, Alhava EM, Kosma VM. 2000. British journal of cancer. 82: 2015-2021 -
High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer
Anttila MA, Tammi RH, Tammi MI, Syrjänen KJ, Saarikoski SV, Kosma V-M. 2000. Cancer research. 60: 150-155 -
Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
Auvinen P, Tammi R, Parkkinen J, Tammi M, Ågren U, Johansson R, Hirvikoski P, Eskelinen M, Kosma V-M. 2000. American journal of pathology. 156: 529-536 -
Hypothyroidism after radiotherapy for laryngeal cancer
Kumpulainen EJ, Hirvikoski PP, Virtaniemi JA, Johansson RT, Simonen PM, Terävä MT, Asikainen RJ, Nykänen KJ, Kosma V-M. 2000. Radiotherapy and oncology. 57: 97-101 -
Hyvänlaatuisten tilojen sädehoito - uusi vanha hoitomuoto
Salminen E, Hakala T, Mäntylä M, Johansson R. 2000. Duodecim. 116: 2333-2338 -
Is the subsite distribution of laryngeal cancer related to smoking habits?
Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Pukkala E, Kosma V-M. 2000. Acta oncologica. 39: 77-79 -
Lack of cellular and humoral immunological responses to oats in adults with coeliac disease
Janatuinen EK, Kemppainen TA, Pikkarainen PH, Holm KH, Kosma V-M, Uusitupa MIJ, Mäki M, Julkunen RJK. 2000. Gut. 46: 327-331 -
Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains1
Viluksela M, Bager Y, Tuomisto JT, Scheu G, Unkila M, Pohjanvirta R, Flodström S, Kosma V-M, Mäki-Paakkanen J, Vartiainen T, Klimm C, Schramm K-W, Wärngård L, Tuomisto J. 2000. Cancer research. 60: 6911-6920 -
Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer: correlation to clinicopathological variables
Launonen V, Mannermaa A, Stenbäck F, Kosma V-M, Puistola U, Huusko P, Anttila M, Bloigu R, Saarikoski S, Kauppila A, Winqvist R. 2000. Cancer genetics and cytogenetics. 122: 49-54 -
Merkel cell carcinoma of the auricle
Virtaniemi J, Hirvikoski P, Pukkila M, Kumpulainen E, Johansson R, Kosma V-M. 2000. European archives of oto-rhino-laryngology. 257: 558-560 -
No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)
Komulainen H, Hakulinen P, Servomaa K, Makkonen K, Vasara R, Mäki-Paakkanen J, Kosma V-M. 2000. Environmental and molecular mutagenesis. 36: 292-300 -
Prognostic value of CD44 standard, variant isoforms 3 and 6 and alpha-catenin expression in local prostate cancer treated by radical prostatectomy
Aaltomaa S, Lipponen P, Viitanen J, Kankkunen J-P, Ala-opas M, Kosma V-M. 2000. European urology. 38: 555-562 -
Reduced CD44 standard expression is associated with tumour recurrence and unfavourable outcome in differentiated thyroid carcinoma
Böhm JP, Niskanen LK, Pirinen RT, Kiraly K, Kellokoski JK, Moisio KI, Eskelinen MJ, Tulla HE, Hollmen S, Alhava EM, Kosma V-M. 2000. Journal of pathology. 192: 321-327 -
Reduced expression of CD44v3 variant isoform is associated with unfavorable outcome in non-small cell lung carcinoma
Pirinen R, Hirvikoski P, Böhm J, Kellokoski J, Moisio K, Virén M, Johansson R, Hollmén S, Kosma V-M. 2000. Human pathology. 31: 1088-1095 -
Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma
Karjalainen JM, Tammi RH, Tammi MI, Eskelinen MJ, Ågren UM, Parkkinen JJ, Alhava EM, Kosma V-M. 2000. American journal of pathology. 157: 957-965 -
Steroid metabolism gene CYP17 polymorpsm and the develpment of breast cancer
Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2000. Cancer epidemiology biomarkers and prevention. 9: 1343-1348 -
The morphological changes in rat bladder after photodynamic therapy with 5-aminolaevulinic acid-induced protoporphyrin IX
Grönlund-Pakkanen S, Pakkanen TM, Talja M, Kosma V-M, Ala-Opas M, Alhava E. 2000. BJU international. 86: 126-132 -
The prognostic value of inducible nitric oxide synthase in local prostate cancer
Aaltomaa SH, Lipponen PK, Viitanen J, Kankkunen J-P, Ala-opas MY, Kosma V-M. 2000. BJU international. 86: 234-239 -
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
Sandmair A-M, Loimas S, Puranen P, Immonen A, Kossila M, Puranen M, Hurskainen H, Tyynelä K, Turunen M, Vanninen R, Lehtolainen P, Paljärvi L, Johansson R, Vapalahti M, Ylä-Herttuala S. 2000. Human gene therapy. 11: 2197-2205 -
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women
Servomaa K, Kiuru A, Kosma V-M, Hirvikoski P, Rytömaa T. 2000. Journal of clinical pathology. 53: 24-30 -
Alfa-catenin expression has prognostic value in local and locally advanced prostate cancer
Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Kosma V-M. 1999. British journal of cancer. 80: 477-482 -
Association of p53, K-ras and proliferating cell nuclear antigen with rat lung lesions following exposure to simulated nuclear fuel particles
Kosma V-M, Lang PS, Servomaa MK, Leszczynski D, Rytömaa TJ. 1999. CANCER DETECTION AND PREVENTION. 23: 194-203 -
Bone recovery after a gluten-free diet: a 5-year follow-up study
Kemppainen T, Kröger H, Janatuinen E, Arnala I, Lamberg-Allardt C, Kärkkäinen M, Kosma V-M, Julkunen R, Jurvelin J, Alhava E, Uusitupa M. 1999. Bone. 25: 355-360 -
Downregulation of p21/WAF1 is related to advanced and dedifferentiated laryngeal squamous cell carcinoma
Hirvikoski P, Kellokoski JK, Kumpulainen EJ, Virtaniemi JA, Johansson RT, Kosma V-M. 1999. Journal of clinical pathology. 52: 440-444 -
Enhanced apoptosis correlates with poor survival in patients with laryngeal cancer but not with cell proliferation, bcl-2 or p53 expression
Hirvikoski P, Kumpulainen E, Virtaniemi J, Pirinen R, Salmi L, Halonen P, Johansson R, Kosma V-M. 1999. European journal of cancer. 35: 231-237 -
Evaluation of sensory irritation of delta3-carene and turpentine, and acceptable levels of monoterpenes in occupational and indoor environment
Kasanen J-P, Pasanen A-L, Pasanen P, Liesivuori J, Kosma V-M, Alarie Y. 1999. Journal of toxicology and environmental health: part a: current issues. 57: 89-114 -
Expression of cyclins A and D and p21 (waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survival
Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Syrjänen K, Kosma V-M. 1999. British journal of cancer. 80: 2001-2007 -
Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate
Setälä LP, Tammi MI, Tammi RH, Eskelinen MJ, Lipponen PK, Ågren UM, Parkkinen J, Alhava EM, Kosma V-M. 1999. British journal of cancer. 79: 1133-1138 -
Irregular expression of hyaluronan and its CD44 receptor is associated with metastatic phenotype in laryngeal squamous cell carcinoma
Hirvikoski P, Tammi R, Kumpulainen E, Virtaniemi J, Parkkinen J J, Tammi M, Johansson R, Ågren U, Karhunen J, Kosma V-M. 1999. Virchows archiv. 434: 37-44 -
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma
Hirvikoski P, Auvinen A, Servomaa K, Kiuru A, Rytömaa T, Makkonen K, Kosma V-M. 1999. Anticancer research. 19: 685-692 -
Laterality of laryngeal cancer
Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Kosma V-M. 1999. Acta oncologica -
Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women
Romppanen J, Keskikuru R, Kataja V, Eskelinen M, Kosma V-M, Savolainen K, Uusitupa M, Mononen I. 1999. British journal of cancer. 79: 1583-1587 -
Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbes
Hirvonen M-R, Ruotsalainen M, Roponen M, Hyvärinen A, Husman T, Kosma V-M, Komulainen H, Savolainen K, Nevalainen A. 1999. American journal of respiratory and critical care medicine. 160: 1943-1946 -
Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma
Böhm J, Kosma V-M, Eskelinen M, Hollmen S, Niskanen M, Tulla H, Alhava E, Niskanen L. 1999. European journal of endocrinology. 141: 460-467 -
Osteoporosis in adult patients with celiac disease
Kemppainen T, Kröger H, Janatuinen E, Arnala I, Kosma V-M, Pikkarainen P, Julkunen R, Jurvelin J, Alhava E, Uusitupa M. 1999. Bone. 24: 249-255 -
Preoperative high type I collagen degradation marker ICTP reflects advanced breast cancer
Keskikuru R, Kataja V, Kosma V-M, Eskelinen M, Uusitupa M, Johansson R, Risteli L, Risteli J, Jukkola A. 1999. Anticancer research. 19: 4481-4484 -
Prognostic value and expression of p21 (waf1/cip 1) protein in prostate cancer
Aaltomaa S, Lipponen P, Eskelinen M, Ala-Opas M, Kosma VM. 1999. Prostate. 39: 8-15 -
Receiver-operating characteristics (ROC) curve analysis of cathepsin D and pS2 in breast disease: results from a prospective study
Eskelinen M, Kataja V, Hämäläinen E, Kosma V-M. 1999. Anticancer research. 19: 3463-3468 -
Reduced expression of alfa catenin is associated with poor prognosis in colorectal carcinoma
Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava EM, Kosma V-M. 1999. Journal of clinical pathology. 52: 10-16 -
Reply to S Jameson (to Villous atrophy and nutritional status in celiac disease)
Kemppainen TA, Uusitupa MI, Kosma V-M, Julkunen RJ. 1999. American journal of clinical nutrition -
Sensory irritating potency of some microbial volatile organic compounds (MVOCs) and a mixture of five MVOCs
Korpi A, Kasanen J-P, Alarie Y, Kosma V-M, Pasanen A-L. 1999. ARCHIVES OF ENVIRONMENTAL HEALTH. 54: 347-352 -
Stent placement versus percutaneous transluminal angioplasty of human carotid arteries in cadavers in situ: distal embolization and findings at intravascular US, MR imaging, and histopathologic analysis
Manninen HI, Räsänen HT, Vanninen RL, Vainio P, Hippeläinen M, Kosma V-M. 1999. Radiology. 212: 483-492 -
p21 WAF1/CIP1 expression in stage I cutaneous malignant melanoma: its relationship with p53, cell proliferation and survival
Karjalainen JM, Eskelinen MJ, Kellokoski JK, Reinikainen M, Alhava EM, Kosma V-M. 1999. British journal of cancer. 79: 895-902 -
p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer
Anttila MA, Kosma V-M, Hongxiu J, Puolakka J, Juhola M, Saarikoski S, Syrjänen K. 1999. British journal of cancer. 79: 1870-1878 -
p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis
Ropponen KM, Kellokoski JK, Lipponen PK, Pietiläinen T, Eskelinen MJ, Alhava EM, Kosma V-M. 1999. British journal of cancer. 81: 133-140 -
Azaserine-induced rat pancreas tumor model with transplantable cultured cells
Mäkinen K, Loimas S, Kosma V-M, Wahlfors J, Pettengill OS, Longnecker DS, Johansson R, Alhava E. 1998. Pancreas. 16: 160-164 -
Clinical relevance of p53 index and expression of proliferating cell nuclear antigen and Ki-67 in gastric cancer
Setälä L, Kosma V-M, Lipponen P, Naukkarinen A, Nordling S, Hollmén S, Eskelinen M, Syrjänen K, Alhava E. 1998. Journal of cancer research and clinical oncology. 124: 497-502 -
Clinical significance of alfa-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer
Anttila M, Kosma V-M, Ji H, Wei-Ling X, Puolakka J, Juhola M, Saarikoski S, Syrjänen K. 1998. Journal of clinical oncology. 16: 2591-2600 -
Cytoplasmic accumulation of alpha-catenin is associated with aggressive features in laryngeal squamous-cell carcinoma
Hirvikoski P, Kumpulainen EJ, Virtaniemi JA, Helin HJ, Rantala I, Johansson RT, Juhola M, Kosma V-M. 1998. International journal of cancer. 79: 546-550 -
Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma
Karjalainen JM, Kellokoski JK, Eskelinen MJ, Alhava EM, Kosma V-M. 1998. Journal of clinical oncology. 16: 3584-3591 -
Effects of 50 Hz magnetic fields on UV-induced skin tumourigenesis in ODC-transgenic and non-transgenic mice
Kumlin T, Kosma V-M, Alhonen L, Jänne J, Komulainen H, Lang S, Rytömaa T, Servomaa K, Juutilainen J. 1998. International journal of radiation biology. 73: 113-121 -
Epidermal ornithine decarboxylase and polyamines in mice exposed to 50 Hz magnetic fields and UV radiation
Kumlin T, Alhonen L, Jänne J, Lang S, Kosma V-M, Juutilainen J. 1998. Bioelectromagnetics. 19: 388-391 -
Expression of CD44 and variant proteins in human colorectal cancer and its relevance for prognosis
Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M. 1998. Scandinavian journal of gastroenterology. 33: 301-309 -
Expression of CD44 standard and variant-v6 proteins in transitional cell bladder tumours and their relation to prognosis during a long-term follow-up
Lipponen P, Aaltoma S, Kosma V-M, Ala-Opas M, Eskelinen M. 1998. Journal of pathology. 186: 157-164 -
Expression of hyaluronan in normal and dysplastic bronchial epithelium and in squamous cell carcinoma of the lung
Pirinen RT, Tammi RH, Tammi MI, Pääkkö PK, Parkkinen JJ, Ågren UM, Johansson RT, Viren MMT, Törmänen U, Soini YMJ, Kosma V-M. 1998. International journal of cancer. 79: 251-255 -
Expression of p21(waf1/cip1) protein in transitional cell bladder tumours and its prognostic value
Lipponen P, Aaltomaa S, Eskelinen M, Ala-Opas M, Kosma V-M. 1998. European urology. 34: 237-243 -
Human carotid arteries: correlation of intravascular US with angiographic and histopathologic findings
Manninen HI, Räsänen H, Vanninen RL, Berg M, Hippeläinen M, Saari T, Yang X, Karkola K, Kosma V-M. 1998. Radiology. 206: 65-74 -
Kurkunpään primaarinen pahanlaatuinen melanooma
Virtaniemi J, Hirvikoski P, Kumpulainen E, Johansson R, Kulju T, Hujala K, Kosma V-M. 1998. Duodecim. 114: 1339-1342 -
Lipid peroxidation products and antioxidant capacity in portal venous and systemic arterial plasma during gradual intestinal ischemia and reperfusion in pigs
Juvonen PO, Paajanen HEK, Heino AA, Koski EJ, Merasto M, Hartikainen JEK, Kosma VM, Alhava EM, Takala JA. 1998. European surgical research. 30: 95-101 -
Markers of cartilage and synovial metabolism in joint fluid and serum of patients with chondromalacia of the patella
Väätäinen U, Lohmander LS, Thonar E, Hongisto T, Ågren U, Rönkkö S, Jaroma H, Kosma V-M, Tammi M, Kiviranta I. 1998. Osteoarthritis and cartilage. 6: 115-124 -
Mitotic rate and S-phase fraction as prognostic factors in stage I cutaneous malignant melanoma
Karjalainen JM, Eskelinen MJ, Nordling S, Lipponen PK, Alhava EM, Kosma V-M. 1998. British journal of cancer. 77: 1917-1925 -
Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet - association with the grade of mucosal villous atrophy1-3
Kemppainen TA, Kosma V-M, Janatuinen EK, Julkunen RJ, Pikkarainen PH, Uusitupa MI. 1998. American journal of clinical nutrition. 67: 482-487 -
Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers
Kasanen J-P, Pasanen A-L, Pasanen P, Liesivuori J, Kosma V-M, Alarie Y. 1998. Archives of toxicology. 72: 514-523 -
Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer
Ropponen K, Tammi M, Parkkinen J, Eskelinen M, Tammi R, Lipponen P, Ågren U, Alhava E, Kosma V-M. 1998. Cancer research. 58: 342-347 -
Carcinogenicity of the drinking water mutagen 3-Cloro-4-(dickloromethyl)-5-hydroxy-2(5H)-furanone in the rat
Komulainen H , Kosma V-M, Vaittinen S-L, Vartiainen T , Kaliste-Korhonen E , Lötjönen S , Tuominen RK, Tuomisto J. 1997. Journal of the national cancer institute. 89: 848-856 -
Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the rat
Komulainen H, Kosma V-M, Vaittinen S-L, Vartiainen T, Kaliste-Korhonen E, Lötjönen S, Tuominen RK, Tuomisto J. Teoksessa: Vartiainen T, Komulainen H(toim.) , 1997. 7th Nordic Symposium on Organic Pollutants. s. 118-121. -
Comparison of DNA ploidy and s-phase fraction with prognostic factors in gastric cancer
Setälä LP, Nordling S, Kosma V-M, Lipponen PK, Eskelinen MJ, Hollmén SM-L, Syrjänen KJ, Alhava EM. 1997. Analytical and quantitative cytology and histology. 19: 524-532 -
Correlation of MIB-1 antigen expression with transcription factors Skn-1, Oct-1, AP-2, and HPV type in cervical intraepithelial neoplasia
Hietala KA, Kosma V-M, Syrjänen KJ, Syrjänen SM, Kellokoski JK. 1997. Journal of pathology. 183: 305-310 -
Expression of hyaluronan in benign and malignant breast lesions
Auvinen PK, Parkkinen JJ, Johansson RT, Ågren UM, Tammi RH, Eskelinen MJ, Kosma V-M. 1997. International journal of cancer. 74: 477-481 -
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma
Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen S, Pääkkönen M, Marin S, Kosma V-M, Jänne J. 1997. International journal of cancer. 70: 644-648 -
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer
Hiltunen MO, Koistinaho J, Alhonen L, Myöhänen S, Marin S, Kosma V-M, Pääkkönen M, Jänne J. 1997. British journal of cancer. 76: 1124-1130 -
Molecular epidemiological study of human rectal cancer induced by radiotherapy
Rytömaa T, Servomaa K, Kiuru A, Auvinen A, Kosma V-M, Hirvikoski P, Makkonen K. Teoksessa: Daburon F, Martin M(toim.) , 1997. Proceedings of the 27th Annual Meeting of the European Society for Radiation Biology. 100th Becquerel Anniversary. s. 257-258. Éditions de Physique -
Mutations in the p53 tumour suppressor gene and other molecular changes in cancers among Chernobyl cleanup workers from Estonia
Servomaa K, Kiuru A, Kosma V-M, Tekkel M, Rahu M, Veidebaum T, Auvinen A, Hakulinen T, Boice JD Jr, Inskip P, Rytömaa T. Teoksessa: (toim.) , 1997. Health Effects of Low Dose Radiation. Challenges of the 21st Century. Proceedings. s. 92-95. British Nuclear Energy Society -
Nuclear morphometry as a predictor of disease outcome in gastric cancer
Setälä L, Lipponen P, Kosma V-M, Marin S, Eskelinen M, Syrjänen K, Alhava E. 1997. Journal of pathology. 181: 46-50 -
Prognostic factors in gastric carcinoma
Setälä L, Kosma V-M, Eskelinen M, Syrjänen K, Alhava E. 1997. British journal of cancer -
Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer
Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M,. 1997. Journal of pathology. 182: 318-324 -
Serum tumour markers CEA,AFP,CA 15-3,TPS and neu in diagnosis of breast cancer
Eskelinen M, Kataja V, Hämäläinen E, Kosma V-M, Penttilä I, Alhava E. 1997. Anticancer research. 17: 1231-1234 -
p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma
Hirvikoski P, Kumpulainen E, Virtaniemi J, Johansson R, Haapasalo H, Marin S, Halonen P, Helin H, Raitiola H, Pukander J, Kellokumpu-Lehtinen P, Kosma V-M. 1997. Journal of clinical oncology. 15: 3111-3120 -
Comparison of classic and quantitative prognostic factors in colorectal cancer
Ropponen K, Eskelinen M, Kosma V-M, Lipponen P, Paakkinen P, Alhava E. 1996. Anticancer research. 16: 3875-3882 -
Genotoxicity and carcinogenicity of MX and other chlorinated furanones
Tuomisto J, Komulainen H, Kosma V-M, Mäki-Paakkanen J, Vartiainen T. Teoksessa: Dybing E, Solbakken AL(toim.) , 1996. 25-års jubileum for toksikologien ved Statens institutt for folkehelse 1971-1996. Sammendrag fra jubileumseminaret og historiske tilbakeblikk. s. 17-19. Statens institutt for folkehelse -
Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration
Setälä LP, Kosma V-M, Marin S, Lipponen PK, Eskelinen MJ, Syrjänen KJ, Alhava EM. 1996. British journal of cancer. 74: 766-772 -
Standardized mitotic counts in breast cancer evaluation of the method
Collan YUI, Kuopio T, Baak JPA, Becker R, Bogomoletz WV, Deverell M, Diest P van, Galen C van, Gilchrist K, Javed A, Kosma V-M, Kujari H, Luzi P, Mariuzzi GM, Matze E, Montironi R, Scarpelli M, Sierra D, Sisti S, Toikkanen S, Tosi P, Whimster WF, Wis. 1996. Pathology research and practice. 192: 931-941 -
The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer
Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1996. Journal of cancer research and clinical oncology. 122: 687-692 -
A comparison of diets with and without oats in adults with celiac disease
Janatuinen EK, Pikkarainen PH, Kemppainen TA, Kosma V-M, Järvinen RMK, Uusitupa MIJ, Julkunen RJK. 1995. The new england journal of medicine. 333: 1033-1037 -
Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments
Salonen RO, Randell JT, Hälinen AI, Pennanen AS, Kosma V-M, Pekkarinen H, Ruuskanen J, Tukiainen H. Teoksessa: Kämäri J, Tolvanen M, Anttila P, Salonen RO(toim.) , 1995. Proceedings of the 10th World Clean Air Congress. Vol. 3. Impacts and Management. N:o 614. s. [3 p.]. -
Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis
Lipponen P, Pietiläinen T, Kosma V-M, Aaltomaa S, Eskelinen M, Syrjänen K. 1995. Journal of pathology. 177: 49-55 -
Biokinetics of nuclear fuel compounds and biological effects of nonuniform radiation
Lang S, Servomaa K, Kosma V-M, Rytömaa T. 1995. Environmental health perspectives. 103: 920-934 -
Dust toxicity in rat alveolar macrophage cultures
Collan Y, Kosma V-M. Teoksessa: O'Hare S, Atterwill CK(toim.) , 1995. Methods in Molecular Biology, vol 43: In Vitro Toxicity Testing Protocols. s. 43-49. Humana Press -
Effects of simulated nuclear fuel particles on the histopathology and CYP enzymes in the rat lung and liver
Pasanen M, Lang S, Kojo A, Kosma V-M. 1995. Environmental research. 70: 126-133 -
Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival
Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. Anticancer research. 15: 959-964 -
Expression of p53 protein has no independent prognostic value in breast cancer
Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. Journal of pathology. 177: 225-232 -
Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival
Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. European journal of cancer. 31A: 329-333 -
Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration
Alhonen L, Halmekytö M, Kosma V-M, Wahlfors J, Kauppinen R, Jänne J. 1995. International journal of cancer. 63: 402-404 -
Prognostic value of cathepsin-D expression in female breast cancer
Aaltonen M, Lipponen P, Kosma V-M, Aaltomaa S, Syrjänen K. 1995. Anticancer research. 15: 1033-1038 -
Subchronic toxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(2H)-furanone (MX) in Wistar rats
Vaittinen S-L, Komulainen H, Kosma V-M, Julkunen A, Mäki-Paakkanen J, Jansson K, Vartiainen T, Tuomisto J. 1995. Food and chemical toxicology. 33: 1027-1037 -
Apoptosis in breast cancer as related to histopathological characteristics and prognosis
Lipponen P, Aaltomaa S, Kosma V-M, Syrjänen K. 1994. European journal of cancer. 30A: 2068-2073 -
Apparent radiation-specific point mutation in the tumour suppressor gene p53 in malignant lung tumours in rat
Servomaa K, Leszczynski D, Lang S, Kosma V-M, Rytömaa T. Teoksessa: Chadwick KH, Cox R, Leenhouts HP, Thacker J(toim.) , 1994. Molecular Mechanisms in Radiation Mutagenesis and Carcinogenesis. s. 223-228. European Commission -
Distribution and short-term effects of intratracheally instilled neutron-irradiated UO2 particles in the rat
Lang Sakari, Kosma Veli-Matti, Kumlin Timo, Hälinen Arja, Salonen Raimo O, Servomaa Kristiina, Rytömaa Tapio, Ruuskanen Juhani. 1994. Environmental research. 65: 119-131 -
Radiation-induced concomitant overexpression of p53, p62c-fos and p21n-ras in mouse epidermis
Leszcynski D, Servomaa K, Lang S, Kosma V-M, Rytömaa T. 1994. Cell proliferation. 27: 517-528 -
Sapphire probe versus bare fiber in interstitial laser hyperthermia (ILH). An experimental study with wistar rats
Mäkinen K, Nuutinen P, Eskelinen M, Kosma V-M, Alhava E. 1994. Anticancer research. 14: 1023-1026 -
The influence of dichloromethylence bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat
Hyvönen PM, Karhi T, Kosma V-M, Liimola-Luoma L, Hanhijärvi H. 1994. Basic and clinical pharmacology and toxicology. 75: 384-390 -
The influence of dichloromethylene bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat
Hyvönen PM, Karhi T, Kosma V-M, Liimola-Luoma L, Hanhijärvi H. 1994. Basic and clinical pharmacology and toxicology. 75: 384-390 -
Toxic effects and execretion in urine of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX) in the rat after a single oral dose
Komulainen H, Huuskonen H, Kosma V-M, Lötjönen S, Vartiainen T. 1994. Archives of toxicology. 68: 398-400 -
Breast cancer in young women: clinical, histological and morphometric prognostic factors
Eskelinen M, Lipponen P, Aaltomaa S, Kosma VM, Syrjänen K, Alhava E. 1992. Anticancer research. 12: 1237-1242 -
Clinical, histological and quantitative prognostic factors in cutaneous malignant melanoma
Karjalainen J, Eskelinen M, Kosma VM, Lipponen P, Tuominen L, Alhava E. 1992. Anticancer research. 12: 1507-1512 -
DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors in female breast cancer
Eskelinen M, Lipponen P, Papinaho S, Aaltomaa S, Kosma VM, Klemi P, Syrjänen K. 1992. International journal of cancer. 51: 555-561 -
DNA ploidy, S-phase fraction and mitotic indices as predictors of female breast cancer
Lipponen P, Papinaho S, Eskelinen M, Klemi P, Aaltomaa S, Kosma VM, Syrjänen K. 1992. Anticancer research. 12: 1533-1538 -
Histological assessment of the prognostic factors in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Oncology. 49: 1-8 -
Lymphocyte infiltrates as a prognostic variable in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. European journal of cancer. 28: 859-864 -
Mitotic indexes as prognostic predictors in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Journal of cancer research and clinical oncology. 118: 75-81 -
Nuclear morphometry and DNA flow cytometry as prognostic factors in female breast cancer
Aaltomaa S, Lipponen P, Papinaho S, Klemi P, Kosma VM, Marin S, Eskelinen M, Alhava E, Syrjänen K. 1992. EUROPEAN JOURNAL OF SURGERY. 158: 135-141 -
Prediction of outcome after first recurrence of breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. EUROPEAN JOURNAL OF SURGERY. 158: 13-18 -
Primary malignant schwannoma of the small bowel
Eskelinen M, Pasanen P, Kosma VM. 1992. Scandinavian journal of surgery. 81: 326-328 -
Prognostic factors after 5 years follow-up in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Oncology. 49: 93-98 -
Prognostic factors in invasive lobular carcinoma of the breast
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. DIAGNOSTIC ONCOLOGY. 2: 74-79 -
Sex steroid receptors, S-phase fraction and DNA ploidy ad determinants of the risk of relapse and death of female breast cancer
Lipponen P, Eskelinen M, Papinaho S, Klemi P, Aaltomaa S, Kosma VM, Syrjänen K. 1992. Anticancer research. 12: 677-682 -
The changing importance of prognostic factors in breast cancer during a long-term follow-up
Lipponen P, Aaltomaa S, Eskelinen M, Kosma VM, Marin S, Syrjänen K. 1992. International journal of cancer. 51: 698-702 -
Tumor size, nuclear morphometry, mitotic indices as prognostic factors in axillary-lymphnode-positive breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. European surgical research. 24: 160-168 -
Xanthogranuloma Juvenile - a rare cause of orbital swelling in adulthood
Rouhiainen H, Nerdrum K, Puustjärvi T, Kosma VM. 1992. Ophthalmologica. 204: 162-165 -
Dithranol (anthralin)-induced skin irritation in sencar, C57 BL/6 and NMRI mice
Viluksela M, Kosma V-M. 1991. Basic and clinical pharmacology and toxicology. 69: 96-104 -
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma
Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Anticancer research. 11: 1701-1706 -
Hormone receptors as prognostic factors in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Annals of medicine. 23: 643-648 -
Mesenchymoma of the chest wall in children
Eskelinen M, Kosma V-M, Vainio J. 1991. Annals of thoracic surgery. 52: 285-290 -
Prognostic factors in axillary lymphonode negative (pN-) breast carcinomas
Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. European journal of cancer. 27: 1555-1559 -
Prognostic scores combining clinical, histological and morphometric variables in assessment of the disease outcome in female breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. International journal of cancer. : 49-886-892 -
The significance of nuclear morphometric variables as prognostic predictors in breast cancer
Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Anticancer research. 11: 1663-1670 -
Urinary excretion of ethylenethiourea and kidney morphology in rats after continuous oral exposure to nabam or ethylenethiourea
Kurttio P, Savolainen K, Naukkarinen A, Kosma V-M, Tuomisto L, Penttilä I, Jolkkonen J. 1991. Archives of toxicology. 65: 381-385 -
Potential of nuclear morphometry and volume corrected mitotic index (M/V-index) in grading transitional cell carcinoma of the urinary bladder
Lipponen PK, Kosma V-M, Collan Y, Kulju T, Kosunen O, Eskelinen M. 1990. European urology. 17: 333-337 -
Verrucous carcinoma of the anus containing human papillomavirus type 16 NDA detected by in situ hybridization. A *case report
Chang F, Kosunen O, Kosma V-M, Syrjänen S, Lahtinen J, Syrjänen K. 1990. Sexually transmitted infections. 66: 342-345 -
Morphometric study of human myocardium in acquired valvular diseases
Jantunen E, Halinen MO, Romppanen T, Kosma VM, Collan Y. 1989. Annals of medicine. 21: 435-440 -
Morphometry in cancer diagnostics
Collan Y, Kosma VM. Teoksessa: (toim.) , 1989. . s. 134-144.