VELI-PEKKA RANTA

Contact info

Research groups - UEF

• 
  Ocular Drug Delivery group (ODD)

Publications

• Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye European journal of pharmaceutics and biopharmaceutics 166: 155-162. 2021
• Valtola, Antti; Laakso, Maisa; Hakomäki, Henriikka; Anderson, Brian J; Kokki, Hannu; Ranta, Veli-Pekka; Rinne, Valtteri; Kokki, Merja. 2021. Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery Clinical pharmacokinetics 60 7: 907-919. 2021
• Hakomäki, Henriikka; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2021. Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep European journal of pharmaceutical sciences 165: 105936. 2021
• Hakomäki, Henriikka; Kokki; Hannu; Lehtonen, Marko; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2021. Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection Pharmacology research & perspectives 9 2: e00726. 2021
• Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits European journal of pharmaceutical sciences 159: 105720. 2021
• Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits European journal of pharmaceutical sciences 155: 105553. 2020
• Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor Pharmaceutical research 37 11: 226. 2020
• Naageshwaran, Vatsala; Ranta, Veli-Pekka; Gum, Glenwood; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2020. Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration Journal of pharmaceutical sciences 2021; 110 1: 529-535. 2020
• Ranta, Veli-Pekka; Ilmavirta, Heikki; Hämäläinen, Sari; Kokki, Merja. 2020. Vankomysiinin annoksen säätäminen munuaisten toimintakyvyn ja pitoisuusmääritysten perusteella Duodecim 136 11: 1301-1310. 2020
• Rytkönen, J; Ranta, VP; Kokki, M; Kokki, H; Hautajärvi, H; Rinne, V; Heikkinen, AT. 2020. Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions Biopharmaceutics and drug disposition 41 1-2: 72-88. 2020
• Valtola, Antti; Morse, James D; Florkiewicz, Pawel; Hautajärvi, Heidi; Lahtinen, Pasi; Musialowicz, Tadeusz; Anderson, Brian J; Ranta, Veli-Pekka; Kokki, Hannu. 2020. Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients - a randomized trial Journal of drug assessment 9 1: 117-128. 2020
• Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates Basic and clinical pharmacology and toxicology 125 2: 123-132. 2019
• Piirainen, P; Kokki, H; Anderson, BJ; Hannam, JA; Hautajärvi, H; Ranta, VP; Kokki, M. 2019. Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecologic laparoscopy - a randomised, double blind, active control, double-dummy clinical comparison with intravenous administration British journal of clinical pharmacology 85 8: 1798-1807. 2019
• Lamminsalo, M; Piirainen, P; Kokki, H; Knibbe, CAJ; Ranta, VP; Välitalo, P; Kokki, M. 2019. Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration Expert opinion on drug delivery 16 6: 649-656. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits Molecular pharmaceutics 12 4: e007045. 2019
• Biofarmaseuttiset tutkimukset teollisuuden lääkekehityksessä. Honkakoski; Paavo; Korjamo; Timo; Ranta, Veli-Pekka / Biofarmasian perusteet. 2018. 2018
• Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. Esterase activity in porcine and albino rabbit ocular tissues European journal of pharmaceutical sciences 123: 106-110. 2018
• Kinnunen, Mari; Kokki, Hannu; Hautajärvi, Heidi; Huhta, Heikki; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2018. Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe Acta obstetricia et gynecologica scandinavica 97 10: 1200-1205. 2018
• Kokki, Hannu; Maaroos, Martin; Ellam, Sten; Halonen, Jari; Ojanperä, Ilkka; Ranta, Merja; Ranta, Veli-Pekka; Tolonen, Aleksandra; Lindberg, Oscar; Viitala, Matias; Hartikainen, Juha. 2018. How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 74 6: 785-792. 2018
• Lamminsalo, Marko; Taskinen, Ella; Karvinen, Timo; Subrizi, Astrid; Murtomäki, Lasse; Urtti, Arto: Ranta, Veli-Pekka. 2018. Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways Pharmaceutical research 35 8: 153. 2018
• Piirainen, Panu; Kokki, Hannu; Hautajärvi, Heidi; Ranta, Veli-Pekka; Kokki, Merja. 2018. The analgesic efficacy and pharmacokinetics of epidural oxycodone after gynaecological laparotomy: a randomized, double-blind, double-dummy comparison with intravenous administration British journal of clinical pharmacology 84 9: 2088-2096. 2018
• Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye European journal of pharmaceutical sciences 119: 83-89. 2018
• Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Bioekvivalenssi ja biosimilaarit. Ranta, Veli-Pekka; Honkakoski, Paavo / Biofarmasian perusteet. 2018. 2018
• Piirainen A, Kokki M, Lidsle HM, Lehtonen M, Ranta VP, Kokki H. 2017. Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study. CURRENT MEDICAL RESEARCH AND OPINION 2018; 34 4: 683-688. 2017
• Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko (ed.) . 2017. Farmakokinetiikan perusteet. Farmasian opiskelijayhdistys Fortis ry. 2017
• Välitalo P, Kokki M, Ranta V-P, Olkkola KT, Hooker AC, Kokki H. 2017. Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials. PHARMACEUTICAL RESEARCH 34 5: 1125-1133. 2017
• Piirainen Annika, Kokki Merja, Hautajärvi Heidi, Lehtonen Marko, Miettinen Hannu, Pulkki Kari, Ranta Veli-Pekka, Kokki Hannu. 2016. The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty. CLINICAL DRUG INVESTIGATION 36 7: 545-555. 2016
• Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling. Molecular Pharmaceutics 13 4: 1358-1365. 2016
• Kokki Merja, Heikkinen Marja, Välitalo Pyry, Hautajärvi Heidi, Hokkanen Juho, Pitkänen Hanna, Sankilampi Ulla, Ranta Veli-Pekka, Kokki Hannu. 2016. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2017; 83 4: 791-800. 2016
• Heikkinen Emma M, Kokki Hannu, Heikkinen Aki, Ranta Veli-Pekka, Räsänen Juha, Voipio Hanna-Marja, Kokki Merja. 2016. Foetal Fentanyl Exposure and Ion Trapping after Intravenous and Transdermal Administration to the Ewe. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2017; 120 2: 195-198. 2016
• Deng Feng, Ranta Veli-Pekka, Kidron Heidi, Urtti Arto. 2016. General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms. PHARMACEUTICAL RESEARCH 33 11: 2680-2690. 2016
• Kokki Merja, Heikkinen Aki T, Raatikainen Kaisa, Ranta Veli-Pekka, Hautajärvi H, Kokki Hannu. 2015. Pharmacokinetics of intranasal fentanyl in parturient. BRITISH JOURNAL OF ANAESTHESIA 115 4: 635-636. 2015
• Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship: Pellinen Riikka, The First PhD student Symposium of the Faculty of Health Sciences : Health research within life span : Abstracts.Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Reports and Studies in Health Sciences 12. 44. 2014
• Välitalo Pyry, Ranta Veli-Pekka, Hooker AC, Kokki Merja, Kokki Hannu. 2014. Population pharmacometrics in support of analgesics studies. ACTA ANAESTHESIOLOGICA SCANDINAVICA 58: 143-156. 2014
• Kokki Merja, Välitalo Pyry, Kuusisto M, Ranta Veli-Pekka, Raatikainen Kaisa, Hautajärvi H, Kokki Hannu. 2013. Central nervous system penetration of oxycodone after intravenous and epidural administration. BRITISH JOURNAL OF ANAESTHESIA 2014:112: 133-140. 2013
• Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. Ahonen Riitta, Laitinen Kirsti, Lapinjoki Seppo, Mensalo Päivi, Ranta Veli-Pekka, Ylikangas Henna. 2013 2013
• Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 81: 178-183. 2012
• Korjamo Timo, Tolonen Ari, Ranta Veli-Pekka, Turpeinen Miia, Kokki Hannu. 2012. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance FRONTIERS IN PHARMACOLOGY 2: 1-7. 2012
• Ranta Veli-Pekka, Välitalo Pyry, Kokki Merja, Kokki Hannu. 2012. Populaatiofarmakokinetiikan perusteita anestesia- ja tehohoitolääkäreille. FINNANEST 45 2: 128-135. 2012
• Välitalo Pyry, Kumpulainen Elina, Manner Minna, Kokki Merja, Lehtonen Marko, Hooker Andrew C, Ranta Veli-Pekka, Kokki Hannu. 2012. Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children. JOURNAL OF CLINICAL PHARMACOLOGY 52: 1516-1526. 2012
• Välitalo Pyry, Olkkola Klaus, Kokki Merja, Kokki Hannu, Ranta Veli-Pekka, Hooker Andrew. 2012. Pharmacokinetics of Oxycodone in Neonates: Modelling the Development of Clearance. In: (ed.) , FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:326. 2012
• Kumpulainen E, Välitalo P, Kokki M, Lehtonen M, Hooker A, Ranta V-P & Kokki H. 2010. Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 70 4: 557-566. 2010
• Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. Filter-cultured ARPE-19 cells as outer blood-retinal barrier model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 289-296. 2010
• Ranta V-P, Mannermaa E, Lummepuro K, Subrizi A, Laukkanen A, Antopolsky M, Murtomäki L, Hornof M & Urtti A. 2010. Barrier analysis of periocular drug delivery to the posterior segment. JOURNAL OF CONTROLLED RELEASE 148 1: 42-48. 2010
• Ruponen M, Arkko S, Urtti A, Reinisalo M, Ranta V-P. 2009. Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection. JOURNAL OF CONTROLLED RELEASE 136: 226-231. 2009
• Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. 2009. Efflux protein expression in human retinal pigment epithelium cell lines. PHARMACEUTICAL RESEARCH 26 7: 1785-1791. 2009
• Linnankoski J, Ranta V-P, Yliperttula M, Urtti A. 2008. Passive oral drug absorption can be predicted more reliably by experimental than computational models-Fact or myth EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 34: 129-139. 2008
• Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2007. Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium. PHARMACEUTICAL RESEARCH 24 11: 2063-2070. 2007
• Valtola A, Kokki H, Gergov M, Ojanperä I, Ranta V-P, Hakala T. 2007. Does coronary artery bypass surgery affect metoprolol bioavailability. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 63: 471-478. 2007
• Kokki H, Rasanen I, Lasalmi M, Lehtola S, Ranta V-P, Vanamo K, Ojanperä I. 2006. Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children. CLINICAL PHARMACOKINETICS 45 7: 745-754. 2006
• Linnankoski J, Mäkelä JM, Ranta V-P, Urtti A, Yliperttula M. 2006. Computational prediction of oral drug absorption based on absorption rate constants in humans. JOURNAL OF MEDICINAL CHEMISTRY 49: 3674-3681. 2006
• Ranta V-P, Urtti A. 2006. Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling. ADVANCED DRUG DELIVERY REVIEWS 58: 1164-1181. 2006
• Ranta V-P. 2005. Ocular Delivery of Peptides and Beta-Blocking Agents. Development of Analytical, Cell Culture and Computational Study Methods. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2005
• Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2005. Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46 2: 641-646. 2005
• Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells. PHARMACEUTICAL RESEARCH 20 9: 1409-1416. 2003
• Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 20: 99-106. 2003
• Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 772: 81-87. 2002
• Toropainen E, Ranta V-P, Talvitie A, Suhonen P, Urtti A. 2001. Culture model of human corneal epithelium for prediction of ocular drug absorption. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 42 12: 2942-2948. 2001
• Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 9: 265-270. 2000
• Hämäläinen KM, Määttä E, Piirainen H, Sarkola M, Väisänen A, Ranta V-P, Urtti A. 1998. Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride). JOURNAL OF CONTROLLED RELEASE 56: 273-283. 1998
• Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 709: 1-10. 1998
• Ranta V-P, Urtti A, Auriola S. 1997. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection. JOURNAL OF CHROMATOGRAPHY A 766: 85-97. 1997