Tiit Örd

Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; Laari, Milla-Iida; Constantinou, Yiannis; Tamarov, Konstantin; Hakkarainen, Henri; Montaser, Ahmed Bisher; Leinonen, Henri; Küblbeck, Jenni; Örd, Tiit; Taipale, Mari; Kaikkonen, Minna; Liu, Ruixian; Klefström, Juha; Yu, Haijun; Xu, Zhiai; Lehto, Vesa-Pekka; Xu, Wujun, 2025, Acs applied materials and interfaces, 17, 33, 46521-46534. A1 Journal article (refereed), original research

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis

Beter, M.; Pulkkinen, HH.; Örd, T; Sormunen, A; Kilpeläinen, L; Dunford, JE; Kaikkonen, MU; Aavik, E; Laham-Karam, N; Oppermann, U; Laakkonen, JP; Ylä-Herttuala, S, 2025, Scientific reports, 15, 1, 1628. A1 Journal article (refereed), original research

MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution

de Sande, Ana Hernández; Turunen, Tanja; Bouvy-Liivrand, Maria; Örd, Tiit; Palani, Senthil; Lahnalampi, Mari; Tundidor-Centeno, Celia; Liljenbäck, Heidi; Virta, Jenni; Niskanen, Henri; Jayasingha, Buddika; Smålander, Olli-Pekka; Sinkkonen, Lasse; Mikkola, Lea; Sauter, Thomas; Roivainen, Anne; Lönnberg, Tapio; Kaikkonen, Minna U; Heinäniemi, Merja, 2025, Genome medicine, 17, 1, 112. A1 Journal article (refereed), original research

Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis

Boccuni, Laura; Marka, Frieda; Salzmann, Manuel; Schirripa, Alessia; Ableitner, Elisabeth; Siller, Magdalena; Brekalo, Mira; Haider, Patrick; Stojkovic, Stefan; Neumayer, Christoph; Örd, Tiit; Kollmann, Karoline; Assinger, Alice; Decker, Thomas; Köcher, Thomas; Fischer, Michael B.; Mußbacher, Marion; Bergthaler, Andreas; Hengstenberg, Christian; Podesser, Bruno K; Kaikkonen, Minna U.; Wojta, Johann; Hohensinner, Philipp J, 2025, Science advances, 11, 35, 1-25. A1 Journal article (refereed), original research

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J.; Diez Benevante, Ernest; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Buyandelger, Byambajav; Koplev, Simon; Lendahl, Urban; Vanlandewijck, Michael; Singha, Prosanta; Örd, Tiit; Beter, Mustafa; Selvarajan, Ilakya; Laakkonen, Johanna P.; Väli, Marika; den Ruijter, Hester M.; Civelek, Mete; Hao, Ke; Ruusalepp, Arno; Betsholtz, Christer; Järve, Heli; Kovacic, Jason C.; Miller, Clint L.; Romanoski, Casey; Kaikkonen, Minna U.; Bj, 2025, Nature cardiovascular research, 4, 4, 412–432. A1 Journal article (refereed), original research

Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis

Örd, Tiit; Palani, Senthil; Giroud Gerbetant, Judith; Bodoy, Susanna; Lönnberg, Tapio; Niskanen, Henri; Ravindran, Aarthi; Holappa, Lari; Chemaly, Melody; Taipale, Mari; Õunap, Kadri; Haikonen, Retu; Talukdar, Husain; Sukhavasi, Katyayani; Liljenbäck, Heidi; Virta, Jenni; Ruotsalainen, Anna-Kaisa; Pierrot-Blanchet, Clara; Miner, Maxwell W G; Moisio, Olli; Rajala, Noora; Li, Xiang-Guo; Low, Philip S; Saraste, Antti; Heinäniemi, Merja; Ylä-Herttuala, Seppo; Björkegren, Johan L M; Hedin, Ulf; Matic, 2025, Cardiovascular research, 121, 16, 2503-2519. A1 Journal article (refereed), original research

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis

Benhmammouch, Saloua; Borowczyk, Coraline; Pierrot-Blanchet, Clara; Barouillet, Thibault; Murcy, Florent; Dussaud, Sébastien; Blanc, Marina; Blériot, Camille; Örd, Tiit; Habbouche, Lama; Vaillant, Nathalie; Gerber, Yohan; Cochain, Clément; Gautier, Emmanuel L; Ginhoux, Florent; Thorp, Edward B.; Biessen, Erik AL; Sluimer, Judith C.; Bodoy, Susanna; Palacin, Manuel; Bailly-Maitre, Béatrice; Kaikkonen, Minna U; Yvan-Charvet, Laurent, 2025, Nature metabolism, 7, 9, 1924–1938. A1 Journal article (refereed), original research

Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro

Selvarajan, Ilakya; Kiema, Miika; Huang, Ru Ting; Li, Jin; Zhu, Jiayu; Pölönen, Petri; Örd, Tiit; Õunap, Kadri; Godiwala, Mehvash; Golebiewski, Anna Kathryn; Ravindran, Aarthi; Mäklin, Kiira; Toropainen, Anu; Stolze, Lindsey K; Arce, Maximiliano; Magnusson, Peetra U; White, Stephen; Romanoski, Casey E; Heinäniemi, Merja; Laakkonen, Johanna P; Fang, Yun; Kaikkonen, Minna U, 2024, Arteriosclerosis, thrombosis, and vascular biology, 44, 6, 1330-1345. A1 Journal article (refereed), original research

Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

Aherrahrou, Rédouane; Baig, Ferheen; Theofilatos, Konstantinos; Lue, Dillon; Beele, Alicia; Örd, Tiit; Kaikkonen, Minna U; Aherrahrou, Zouhair; Cheng, Qi; Ghosh, Saikat Kumar B; Karnewar, Santosh; Karnewar, Vaishnavi; Finn, Aloke V; Owens, Gary K; Joner, Michael; Mayr, Manuel; Civelek, Mete, 2024, Arteriosclerosis, thrombosis, and vascular biology, 44, 4, 898-914. A1 Journal article (refereed), original research

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi, 2024, EBioMedicine, 106, 105232. A1 Journal article (refereed), original research

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci, Giuseppe; Sukhavasi, Katyayani; Örd, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Mäkinen, Petri; Ma, Lijiang; Hodonsky, Chani J; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary; Leeper, Nicholas J; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Ylä-Herttuala, Seppo; Väli, Marika; Järve, Heli; Mokry, Michal; C, 2024, Circulation research, 134, 11, 1405-1423. A1 Journal article (refereed), original research

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

Linna-Kuosmanen, Suvi; Schmauch, Eloi; Galani, Kyriakitsa; Ojanen, Johannes; Boix, Carles A; Örd, Tiit; Toropainen, Anu; Singha, Prosanta K; Moreau, Pierre R; Harju, Kristiina; Blazeski, Adriana; Segerstolpe, Åsa; Lahtinen, Veikko; Hou, Lei; Kang, Kai; Meibalan, Elamaran; Agudelo, Leandro Z; Kokki, Hannu; Halonen, Jari; Jalkanen, Juho; Gunn, Jarmo; MacRae, Calum A; Hollmén, Maija; Hartikainen, Juha EK; Kaikkonen, Minna U; García-Cardeña, Guillermo; Tavi, Pasi; Kiviniemi, Tuomas; Kellis, Manolis, 2024, Cell reports medicine, 5, 5, 101556. A1 Journal article (refereed), original research

Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis

Ravindran, Aarthi; Holappa, Lari; Niskanen, Henri; Skovorodkin, Ilya; Kaisto, Susanna; Beter, Mustafa; Kiema, Miika; Selvarajan, Ilakya; Nurminen, Valtteri; Aavik, Einari; Aherrahrou, Rédouane; Pasonen-Seppänen, Sanna; Fortino, Vittorio; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Vainio, Seppo; Örd, Tiit; Kaikkonen, Minna U, 2024, Cardiovascular research, 120, 8, 869-882. A1 Journal article (refereed), original research

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Babu, Mohan; Devi, Durga; Mäkinen, Petri; Örd, Tiit; Aavik, Einari; Kaikkonen, Minna; Ylä-Herttuala, Seppo, 2023, Arteriosclerosis, thrombosis, and vascular biology, 43, 1, e46–e61. A1 Journal article (refereed), original research

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi, 2023, EBioMedicine, 92, 104620. A1 Journal article (refereed), original research

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Örd, Tiit; Suoranta, Tuisku; Heikkilä, Janne; Kaikkonen, Minna U.; Laham-Karam, Nihay; Ylä-Herttuala, Seppo, 2023, Frontiers in cardiovascular medicine, 10, 1113890. A1 Journal article (refereed), original research

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

Örd, Tiit; Lönnberg, Tapio; Nurminen, Valtteri; Ravindran, Aarthi; Niskanen, Henri; Kiema, Miika; Õunap, Kadri; Maria, Maleeha; Moreau, Pierre R; Mishra, Pashupati P; Palani, Senthil; Virta, Jenni; Liljenbäck, Heidi; Aavik, Einari; Roivainen, Anne; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Lehtimäki, Terho; Kaikkonen, Minna U, 2023, American journal of human genetics, 110, 5, 722-740. A1 Journal article (refereed), original research

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Jauhiainen, Suvi; Ilmonen, Henna; Vuola, Pia; Rasinkangas, Heta; Pulkkinen, Heidi H; Keränen, Sara; Kiema, Miika; Liikkanen, Jade J; Laham Karam, Nihay; Laidinen, Svetlana; Beter, Mustafa; Aavik, Einari; Lappalainen, Kimmo; Lohi, Jouko; Aronniemi, Johanna; Örd, Tiit; Kaikkonen, Minna U; Salminen, Päivi; Tukiainen, Erkki; Ylä-Herttuala, Seppo; Laakkonen, Johanna P, 2023, eLife, 12, e82543. A1 Journal article (refereed), original research

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Aherrahrou, Rédouane; Lue, Dillon; Perry, R Noah; Aberra, Yonathan Tamrat; Khan, Mohammad Daud; Soh, Joon Yuhl; Örd, Tiit; Singha, Prosanta; Yang, Qianyi; Gilani, Huda; Benavente, Ernest Diez; Wong, Doris; Hinkle, Jameson; Ma, Lijiang; Sheynkman, Gloria M; den Ruijter, Hester M; Miller, Clint L; Björkegren, Johan LM; Kaikkonen, Minna U; Civelek, Mete, 2023, Circulation research, 132, 3, 323-338. A1 Journal article (refereed), original research

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

Örd, Tiit; Örd, Daima; Adler, Priit; Örd, Tõnis, 2023, PLoS genetics, 19, 10, e1011014. A1 Journal article (refereed), original research

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Anisimov, Andrey; Fang, Shentong; Hemanthakumar, Karthik Amudhala; Örd, Tiit; van Avondt, Kristof; Chevre, Raphael; Toropainen, Anu; Singha, Prosanta; Gilani, Huda; Nguyen, Su D; Karaman, Sinem; Korhonen, Emilia A; Adams, Ralf H.; Augustin, Hellmut G; Öörni, Katariina; Soehnlein, Oliver; Kaikkonen, Minna U; Alitalo, Kari, 2023, Nature cardiovascular research, 2, 3, 307-321. A1 Journal article (refereed), original research

Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine

Palani, Senthil; Miner, Maxwell WG; Virta, Jenni; Liljenbäck, Heidi; Eskola, Olli; Örd, Tiit; Ravindran, Aarthi; Kaikkonen, Minna U; Knuuti, Juhani; Li, Xiang-Guo; Saraste, Antti; Roivainen, Anne, 2022, Frontiers in immunology, 13, 821423. A1 Journal article (refereed), original research

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations

Toropainen, Anu; Stolze, Lindsey K; Örd, Tiit; Whalen, Michael B; Torrell, Paula Martí; Link, Verena M; Kaikkonen, Minna U; Romanoski, Casey E, 2022, Genome research, 32, 3, 409-424. A1 Journal article (refereed), original research

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M, 2022, Cells, 11, 4, 676. A1 Journal article (refereed), original research

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Maria, Maleeha; Pouyanfar, Negar; Örd, Tiit; Kaikkonen, Minna U, 2022, Genes, 13, 3, 502. A2 Review article, Literature review, Systematic review

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U., 2021, American journal of human genetics, 108, 3, 411-430. A1 Journal article (refereed), original research

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Conklin, Austin C.; Nishi, Hitoo; Schlamp, Florencia; Örd, Tiit; Õunap, Kadri; Kaikkonen, Minna U.; Fisher, Edward A.; Romanoski, Casey E., 2021, Immunometabolism, 3, 3, e210022. A1 Journal article (refereed), original research

Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

Örd, Tiit; Örd, Daima; Kaikkonen, Minna U.; Örd, Tõnis, 2021, Cancers, 13, 10, 2341. A1 Journal article (refereed), original research

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU, 2021, Arteriosclerosis, thrombosis, and vascular biology, 41, 7, 2149-2167. A1 Journal article (refereed), original research

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Örd, Tiit; Õunap, Kadri; Stolze, Lindsey; Aherrahrou, Rédouane; Nurminen, Valtteri; Selvarajan, Ilakya; Toropainen, Anu; Lönnberg, Tapio; Aavik, Einari; Yla-Herttuala, Seppo; Civelek, Mete; Romanoski, Casey E; Kaikkonen, Minna U, 2021, Circulation research, 129, 2, 240-258. A1 Journal article (refereed), original research

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt, Marie Ac; Prange, Koen Hm; Slenders, Lotte; Örd, Tiit; Elbersen, Danny; Boltjes, Arjan; de Jager, Saskia Ca; Asselbergs, Folkert W; de Borst, Gert J; Aavik, Einari; Lönnberg, Tapio; Lutgens, Esther; Glass, Christopher K; den Ruijter, Hester M; Kaikkonen, Minna U; Bot, Ilze; Slütter, Bram; van der Laan, Sander W; Ylä-Herttuala, Seppo; Mokry, Michal; et al, 2020, Circulation research, 127, 11, 1437-1455. A1 Journal article (refereed), original research

Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages

Moisio, Olli; Palani, Senthil; Virta, Jenni; Elo, Petri; Liljenbäck, Heidi; Tolvanen, Tuula; Käkelä, Meeri; Miner, Maxwell G; Herre, Erika Atencio; Marjamäki, Päivi; Örd, Tiit; Heinäniemi, Merja; Kaikkonen, Minna U; Zhang, Fenghua; Srinivasarao, Madduri; Knuuti, Juhani; Low, Philip S; Saraste, Antti; Li, Xiang-Guo; Roivainen, Anne, 2020, Scientific reports, 10, 1, 13593. A1 Journal article (refereed), original research

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Stolze, Lindsey; Conklin, Austin; Whalen, Michael; López Rodríguez, Maykel; Õunap, Kadri; Selvarajan, Ilakya; Toropainen, Anu; Örd, Tiit; Li, Jin; Eshghi, Anna; Solomon, Alice; Fang, Yun; Kaikkonen, Minna; Romanoski, Casey, 2020, American journal of human genetics, 106, 6, P748-763. A1 Journal article (refereed), original research

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells

Moreau, Pierre R; Örd, Tiit; Downes, Nicholas L; Niskanen, Henri; Bouvy-Liivrand, Maria; Aavik, Einari; Ylä-Herttuala, Seppo; Kaikkonen, Minna U, 2018, Frontiers in cardiovascular medicine, 5, 159, 12. A1 Journal article (refereed), original research

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Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis

MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution

Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis

Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro

Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells