Heikki Tanila
Laitoksen varajohtaja
Professori
Translationaalisen neurotieteen professori
A.I. Virtanen -instituutti, Terveystieteiden tiedekunta
[email protected] | 040 355 2084
Johdan Muistin neurobiologian tutkimusryhmää A. I. Virtanen -instituutissa. Selvitämme, millä mekanismeilla varhaiset Alzheimerin taudin solutason muutokset johtavan valikoivaan lähimuistin heikkenemiseen.
Tutkimusryhmät
Projektit
Julkaisut
230/230 kappaletta-
Correlation of zero echo time functional MRI with neuronal activity in rats
Valjakka, Juha S; Paasonen, Jaakko; Salo, Raimo A; Paasonen, Ekaterina; Stenroos, Petteri; Gureviciene, Irina; Kettunen, Mikko; Idiyatullin, Djaudat; Tanila, Heikki; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2025. Journal of cerebral blood flow and metabolism. [Epub ahead of print 23 Jan 2025]: 1-16 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
Kamondi, Anita; Grigg-Damberger, Madeleine; Löscher, Wolfgang; Tanila, Heikki; Horvath, Andras Attila. 2024. Nature reviews neurology. 20: 162-182 A2 Katsausartikkeli tieteellisessä aikakauslehdessä -
Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model
Autio, Kaija J; Koivisto, Hennariikka; Schmitz, Werner; Puronurmi, Anna; Tanila, Heikki; Kastaniotis, Alexander J. 2024. Journal of nutritional biochemistry. 131: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Ala-Nisula, Tuulia; Halmetoja, Riikka; Leinonen, Henri; Kurkela, Margareta; Lipponen, Henna-Riikka; Sakko, Samuli; Karpale, Mikko; Salo, Antti M; Sissala, Niina; Röning, Tapio; Raza, Ghulam S; Mäkelä, Kari A; Thevenot, Jérôme; Herzig, Karl-Heinz; Serpi, Raisa; Myllyharju, Johanna; Tanila, Heikki; Koivunen, Peppi; Dimova, Elitsa Y. 2024. Pflugers archiv: european journal of physiology. 476: 1339-1351 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Resting-state functional MRI of the nose as a novel investigational window into the nervous system
Ponticorvo, Sara; Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A.; Tanila, Heikki; Filip, Pavel; Rothman, Douglas L.; Eberly, Lynn E.; Garwood, Michael; Metzger, Gregory J.; Gröhn, Olli; Michaeli, Shalom; Mangia, Silvia. 2024. Scientific reports. 14: . 26352 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari. 2024. Nature cardiovascular research. 3: 474-491 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Three‐dimensional view of microglia—amyloid plaque interactions
Gotkiewicz, Maria; Capra, Janne; Miettinen, Pasi O; Natunen, Teemu; Tanila, Heikki. 2024. Glia. 2025; 73: 196-209 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Whole-brain responses to visual and auditory stimuli in anesthetized and minimally restrained awake mice using quiet zero echo time fMRI
Dvořáková, Lenka; Stenroos, Petteri; Salo, Raimo A.; Paasonen, Ekaterina; Tanila, Heikki; Michaeli, Shalom; Mangia, Silvia; Zehnder, Tamara; Mueggler, Thomas; Künnecke, Basil; Paasonen, Jaakko; Gröhn, Olli. 2024. Imaging neuroscience. 2: 1-16 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Alzheimerin taudin amyloidivasta-ainehoidot koetuksella
Tanila, Heikki; Tienari, Pentti. 2023. Duodecim. 139: 343-344 D1 Artikkeli ammattilehdessä -
Incidence and Risk Factors of Transient Global Amnesia
Komulainen, Tiina; Bärlund, Venla; Tanila, Heikki; Koivisto, Anne; Jäkälä, Pekka. 2023. Neuroepidemiology. 57: 246-252 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals
Mabrouk, R; Miettinen, PO; Tanila, H. 2023. Neurobiology of disease. 182: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala
Gureviciene, Irina; Laakso, Hanne; Narvaez, Omar; Paasonen, Ekaterina; Lehto, Lauri; Gurevicius, Kestutis; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli; Sierra, Alejandra; Tanila, Heikki. 2023. Frontiers in neuroscience. 17: . 1147547 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Activation of the hypoxia response protects mice from amyloid-β accumulation
Ollonen, Teemu; Kurkela, Margareta; Laitakari, Anna; Sakko, Samuli; Koivisto, Henna; Myllyharju, Johanna; Tanila, Heikki; Serpi, Raisa; Koivunen, Peppi. 2022. Cellular and molecular life sciences. 79: . 432 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
DAPI (4’,6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques
Mabrouk, Rana; Gotkiewicz, Maria; Rauramaa, Tuomas; Tanila, Heikki. 2022. Journal of Alzheimer's disease. 88: 949-955 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat
Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli. 2022. Magnetic resonance in medicine. 87: 2872-2884 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Kiistanalaiset beeta-amyloidivasta-aineet
Tienari, Pentti; Tanila, Heikki. 2022. Lääkärilehti. 77: 213 D1 Artikkeli ammattilehdessä -
Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition
Wu, Lin; Canna, Antonietta; Narvaez, Omar; Ma, Jun; Sang, Sheng; Lehto, Lauri J.; Sierra, Alejandra; Tanila, Heikki; Zhang, Yuan; Gröhn, Olli; Low, Walter C.; Filip, Pavel; Mangia, Silvia; Michaeli, Shalom. 2022. Scientific reports. 12: . 8565 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Preclinical evaluation of drug treatment options for sleep‐related epileptiform spiking in Alzheimer's disease
Jin, Nanxiang; Gureviciene, Irina; Atalay, Aysu Naz; Häkli, Sara; Ziyatdinova, Sofya; Tanila, Heikki. 2022. Alzheimer's & dementia : Translational research & clinical interventions. 8: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models
Jin, Nanxiang; Babiloni, Claudio; Drinkenburg, Wilhelmus H; Hajós, Mihály; Nygaard, Haakon B; Tanila, Heikki. 2022. Journal of Alzheimer's disease. 88: 849-865 A2 Katsausartikkeli tieteellisessä aikakauslehdessä -
Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury
Virenque, Anaïs; Koivisto, Hennariikka; Antila, Salli; Zub, Emma; Rooney, Erin Jane; Miszczuk, Diana; Müller, Adrian; Stoka, Enija; Marchi, Nicola; Alitalo, Kari; Tanila, Heikki; Noe, Francesco Mattia. 2022. Brain, behavior, & immunity : health. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI
Paasonen, Jaakko; Stenroos, Petteri; Laakso, Hanne; Pirttimäki, Tiina; Paasonen, Ekaterina; Salo, Raimo A.; Tanila, Heikki; Idiyatullin, Djaudat; Garwood, Michael; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2022. Neuroimage. 250: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia
Koskuvi, Marja; Lehtonen, ¦árka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Tohka, Jussi; Giniatullin, Rashid; Rivera, Claudio; Hovatta, Iiris; Tanila, Heikki; Tiihonen, Jari; Koi. 2021. Glia -
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens V.; Skotte, Niels H.; Christensen, Sofie K.; Polli, Filip S.; Shabani, Mohammad; Markussen, Kia H.; Haukedal, Henriette; Westi, Emil W.; Diaz-delCastillo, Marta; Sun, Ramon C.; Kohlmeier, Kristi A.; Schousboe, Arne; Gentry, Matthew S.; Tanila, Heikki; Freude, Kristine K.; Aldana, Blanca I.; Mann, Matthias; Waagepetersen, Helle S.. 2021. Cell death and disease -
Isoflurane affects brain functional connectivity in rats 1 month after exposure
Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Neuroimage -
Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme
Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW. 2021. Cells -
Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa
Tienari, Pentti; Tanila, Heikki; Hiltunen, Mikko. 2021. Duodecim -
Neuronal spreading and plaque induction of intracellular Aß and its disruption of Aß homeostasis
Roos, TT; Garcia, MG; Martinsson, I; Mabrouk, R; Israelsson, B; Deierborg, T; Kobro-Flatmoen, A; Tanila, H; Gouras, GK. 2021. Acta neuropathologica -
Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats
Savolainen, Katja; Ihalainen, Jouni; Hämäläinen, Elina; Tanila, Heikki; Forsberg, Markus M. 2021. Behavioural brain research -
Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa
Tanila, Heikki. 2020. Duodecim -
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation -
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, Jens V; Christensen, Sofie K; Westi, Emil W; Diaz-delCastillo, Marta; Tanila, Heikki; Schousboe, Arne; Aldana, Blanca I; Waagepetersen, Helle S. 2020. Neurobiology of disease -
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration -
Iron-oxide minerals in the human tissues
Svobodova, H; Kosnác, D; Tanila, H; Wagner, A; Trnka, M; Vitovic, P; Hlinkova, J; Vavrinsky, E; Ehrlich, H; Polák, ¦; Kopani, M. 2020. Biometals -
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat
Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Neuroimage -
Orientation selective deep brain stimulation of the subthalamic nucleus in rats
Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Neuroimage -
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs
Jin, Nanxiang; Ziyatdinova, Sofya; Gureviciene, Irina; Tanila, Heikki. 2020. Scientific reports -
Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease
Hiltunen, Anniina E; Kangas, Salla M; Ohlmeier, Steffen; Pietilä, Ilkka; Hiltunen, Jori; Tanila, Heikki; McKerlie, Colin; Govindan, Subashika; Tuominen, Hannu; Kaarteenaho, Riitta; Hallman, Mikko; Uusimaa, Johanna; Hinttala, Reetta. 2020. Molecular medicine -
Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway
Gabbouj, Sami; Ryhanen, Simo; Marttinen, Mikael; Wittrahm, Rebekka; Takalo, Mari; Kemppainen, Susanna; Martiskainen, Henna; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko; Natunen, Teemu. 2019. Frontiers in neuroscience -
Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice
Gureviciene, I; Ishchenko, I; Ziyatdinova, S; Jin, N; Lipponen, A; Gurevicius, K; Tanila, H. 2019. Frontiers in neurology -
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility
Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Epilepsy research -
Elevated Age-Related Cortical Iron, Ferritin and Amyloid Plaques in APP(swe)/PS1(Delta E9) Transgenic Mouse Model of Alzheimer's Disease
Svobodova, H; Kosn, D; Balazsiova, Z; Tanila, H; Miettinen, P O; Sierra, A; Vitovic, P; Wagner, A; Polak, S; Kopani, M. 2019. Physiological research -
Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease
Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Scientific reports -
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics -
Metabolic state as a modulator of neural event-related potentials for food stimuli in an implicit association test
Lahtinen, Aapeli; Juvonen, Kristiina; Lapveteläinen, Anja; Kolehmainen, Marjukka; Lindholm, Mikko; Tanila, Heikki; Kantanen, Teuvo; Sinikallio, Sanna; Karhunen, Leila; Närväinen, Johanna. 2019. Physiology and behavior -
Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice
Leinonen, H; Koivisto, H; Lipponen, HR; Matilainen, A; Salo, AM; Dimova, EY; Hämäläinen, E; Stavén, S; Miettinen, P; Myllyharju, J; Koivunen, P; Tanila, H. 2019. Neuropharmacology -
Progressive age-dependent motor impairment in human tau P301S overexpressing mice
Koivisto, H; Ytebrouck, E; Carmans, S; Naderi, R; Miettinen, PO; Roucourt, B; Tanila, H. 2019. Behavioural brain research -
Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease
Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. eNeuro -
What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons
Babiloni, C; Blinowska, K; Bonanni, L; Cichocki, A; De Haan, W; Del Percio, C; Dubois, B; Escudero, J; Fernández, A; Frisoni, G; Guntekin, B; Hajos, M; Hampel, H; Ifeachor, E; Kilborn, K; Kumar, S; Johnsen, K; Johannsson, M; Jeong, J; LeBeau, F; et al. (Incl. Tanila, H). 2019. Neurobiology of aging -
Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease
Emmerzaal, Tim L; Rodenburg, Richard J; Tanila, Heikki; Verweij, Vivienne; Kiliaan, Amanda J; Kozicz, Tamas. 2018. Journal of Alzheimer's disease -
Alzheimerin taudin patofysiologia - mitä uutta?
Tanila, Heikki; Hiltunen, Mikko; Myllykangas, Liisa. 2018. Duodecim -
Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit
Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience -
Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury
Zainul, Z; Heikkinen, A; Koivisto, H; Rautalahti, I; Kallio, M; Lin, S; Härönen, H; Norman, O; Rüegg, MA; Tanila, H; Pihlajaniemi, T. 2018. Journal of neuroscience -
Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo
Herrala, Mikko; Kumari, Kajal; Koivisto, Hennariikka; Luukkonen, Jukka; Tanila, Heikki; Naarala, Jonne; Juutilainen, Jukka. 2018. Environmental research -
Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice
Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J. 2018. Journal of neuroscience -
Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice
Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki. 2018. Neurobiology of aging -
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging -
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology -
Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Frontiers in neurology -
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia -
Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging
Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Journal of cerebral blood flow and metabolism -
Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives
Tanila, Heikki. 2018. Behavioural brain research -
Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex
Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Frontiers in neuroscience -
Vision in laboratory rodents - Tools to measure it and implications for behavioral research
Leinonen, H; Tanila, H. 2018. Behavioural brain research -
Alcohol consumption during adolescence is associated with reduced grey matter volumes
Heikkinen N, Niskanen E, Könönen M, Tolmunen T, Kekkonen V, Kivimäki P, Tanila H, Laukkanen E, Vanninen R. 2017. Addiction -
Assessment of Health Risks of Intermediate Frequency Magnetic Fields
Herrala M, Kumari K, Blomme A, Khan MW, Koivisto H, Naarala J, Roivainen P, Tanila H, Viluksela M, Juutilainen J. 2017. IFMBE proceedings -
Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment
Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. PLoS ONE -
Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields
Kumari, Kajal; Koivisto, Hennariikka; Myles, Capstick; Naarala, Jonne; Viluksela, Matti; Tanila, Heikki; Juutilainen, Jukka. 2017. Environmental research -
Characteristics of CA1 place fields in a complex maze with multiple choice points
Tanila H, Ku S, Kloosterman F, Wilson MA. 2017. Hippocampus -
Effects of intermediate frequency magnetic fields on male fertility indicators in mice
Kumari K, Capstick M, Cassara AM, Herrala M, Koivisto H, Naarala J, Tanila H, Viluksela M, Juutilainen J. 2017. Environmental research -
Epilepsy in Models of Alzheimer's Disease
Tanila H, Pitkänen A. 2017. Elsevier -
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports -
Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease
Andersen JV, Christensen SK, Aldana BI, Nissen JD, Tanila H, Waagepetersen HS. 2016. Neurochemical research -
Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß
Gureviciene Irina, Gurevicius Kestutis, Mugantseva Ekaterina, Kislin Mikhail, Khiroug Leonard, Tanila Heikki. 2016. Journal of Alzheimer's disease -
Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AßPP/PS1 Mouse Model of Alzheimer's Disease
Guillot Florence, Kemppainen Susanna, Lavasseur Gregoire, Miettinen Pasi O, Laroche Serge, Tanila Heikki, Davis Sabrina. 2016. Journal of Alzheimer's disease -
Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
Koivisto H, Leinonen H, Puurula M, Hafez HS, Barrera GA, Stridh MH, Waagepetersen HS, Tiainen M, Soininen P, Zilberter Y, Tanila H.. 2016. Frontiers in aging neuroscience -
Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats
Ihalainen Jouni, Savolainen Katja, Tanila Heikki, Forsberg Markus M. 2016. Behavioural brain research -
Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI
Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. PLoS ONE -
Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease
Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Current alzheimer research -
Lack of P4H-TM in mice results in age-related retinal and renal alterations
Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P. 2016. Human molecular genetics -
Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AßPP/PS1 Mice
Leinonen Henri, Lipponen Arto, Gurevicius Kestutis, Tanila Heikki. 2016. Journal of Alzheimer's disease -
SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science -
The role of BDNF in Alzheimer's disease
Tanila Heikki. 2016. Neurobiology of disease -
Voiko terveiden henkilöiden muistia parantaa lääkkeillä?
Tanila Heikki. 2016. Duodecim -
APP intracellular domain derived from amyloidogenic ß-and y-secretase cleavage regulates neprilysin expression
Grimm Marcus OW, Mett Janine, Stahlmann Christoph P, Grösgen Sven, Haupenthal Viola J, Blümel Tamara, Hundsdörfer Benjamin, Zimmer Valerie C, Mylonas Nadine T, Tanila Heikki, Müller Ulrike, Grimm Heike S, Hartmann Tobias. 2015. Frontiers in aging neuroscience -
Alzheimerin taudin parantava hoito viipyy yhä - onko amyloidiplakkihypoteesi väärä lähtökohta?
Tanila Heikki. 2015. Duodecim -
Alzheimerin taudin patogeneesi
Tienari Pentti, Myllykangas Liisa, Polvikoski Tuomo, Tanila Heikki. 2015. Kustannus Oy Duodecim -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease -
Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo
Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Journal of Alzheimer's disease -
Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice
Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki. 2015. Behavioural brain research -
Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage
Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease -
Kognitiivisten toimintojen neurobiologinen tausta
Tanila Heikki, Hänninen Tuomo. 2015. Kustannus Oy Duodecim -
Meneekö muisti menopaussin myötä - voiko ikääntyvä nainen suojautua muistisairaudelta?
Remes Anne, Tanila Heikki, Hallikainen Merja. 2015. Duodecim -
Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo
Kärkkäinen Elisa, Yavich Leonid, Miettinen Pasi O, Tanila Heikki. 2015. Brain research -
Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation
Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Epilepsy research -
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease -
Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease
Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Molecular neurobiology -
Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice
Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Epilepsy and behavior -
Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice
Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H. 2014. Behavioural brain research -
Early Retinal Function Deficit without Prominent Morphological Changes in the R6/2 Mouse Model of Huntington's Disease
Ragauskas Symantas, Leinonen Henri, Puranen Jooseppi, Rönkkö Seppo, Nymark Soile, Gurevicius Kestutis, Lipponen Arto, Kontkanen Outi, Puoliväli Jukka, Tanila Heikki, Kalesnykas Giedrius. 2014. PLoS ONE -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry -
Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology
Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE -
Intravenous immunoglobulins for Alzheimer's disease
Puli Lakshman, Tanila Heikki, Relkin Norman. 2014. Current alzheimer research -
Lääketieteen Nobelin palkinto aivojen paikannusjärjestelmän tutkijoille
Tanila, Heikki. 2014. Duodecim -
Miten muisti toimii?
Tanila Heikki. 2014. Lääkärilehti -
PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease
Grimm MOW, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T. 2014. Cellular physiology and biochemistry -
Short- and long-term habituation of auditory event-related potentials in the rat
Gurevicius Kestutis, Lipponen Arto, Minkeviciene Rimante, Tanila Heikki. 2014. F1000research -
Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition
Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H. 2014. Journal of nutritional biochemistry -
Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin
Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Aging and disease -
Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2
Wang W, Mutka AL, Zmrzljak UP, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ, Ikonen E. 2013. Faseb journal -
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease -
Pharmacological Characterisation of a Structurally Novel α (2C) -Adrenoceptor Antagonist ORM-10921 and its Effects in Neuropsychiatric Models
Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. 2013. Basic and clinical pharmacology and toxicology -
Plant sterols the better cholesterol in Alzheimer's Disease? A mechanistical study
Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lutjohann D, Hartmann T, Grimm MOW. 2013. Journal of neuroscience -
The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. 2013. PLoS ONE -
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease
Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko. 2012. Journal of nutritional biochemistry -
Artificial Theta Stimulation Impairs Encoding of Contextual Fear Memory
Lipponen A, Woldemichael BT, Gurevicius K, Tanila H. 2012. PLoS ONE -
Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation
Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T.. 2012. Proceedings of the National Academy of Sciences of the United States of America -
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine -
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease
Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Journal of neurochemistry -
Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease
Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Journal of neuroinflammation -
Excitability in Freely Moving APPswe/PS1dE9 Mice Modeling Epileptic Activity
Gurevicius K, Lipponen A, Tanila H.. 2012. Cerebral cortex -
Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice
Kärkkäinen E, Tanila H, Laitinen JT. 2012. Cns and neurological disorders-drug targets -
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice
Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H.. 2012. Neurobiology of aging -
Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an α -synuclein-dependent mechanism
Chadchankar Heramb, Ihalainen Jouni, Tanila Heikki, Yavich Leonid. 2012. Journal of pharmacology and experimental therapeutics -
Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease
Lendvai D, Morawski M, Négyessy L, Gáti G, Jäger C, Baksa G, Glasz T, Attems J, Tanila H, Arendt T, Harkany T, Alpár A. 2012. Acta neuropathologica -
Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein
Oksman M, Wisman LA, Jiang H, Miettinen P, Kirik D, Tanila H. 2012. Neurodegenerative diseases -
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β (1-42)
Janickova H, Rudajev V, Zimcik P, Jakubik J, Tanila H, El-Fakahany EE, Dolezal V. 2012. Neuropharmacology -
Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease
Tanila Heikki. 2012. Frontiers in aging neuroscience -
Characterization of a novel transgenic rat carrying human tau with mutation P301L
Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen M-L, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. 2011. Neurobiology of aging -
Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein
Chadchankar Heramb, Ihalainen Jouni, Tanila Heikki, Yavich Leonid. 2011. Brain research -
Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats
Ihalainen Jouni, Sarajärvi Timo, Rasmusson Doug, Kemppainen Susanna, Keski-Rahkonen Pekka, Lehtonen Marko, Banerjee Pradeep K, Semba Kazue, Tanila Heikki. 2011. Neuropharmacology -
From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin¿plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry
Grimm MO, Grösgen S, Riemenschneider M, Tanila H, Grimm HS, Hartmann T. 2011. Journal of chromatography a -
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
Mulder Jan, Zilberter Misha, Pasquaré Susana J, Alpár Alán, Schulte Gunnar, Ferreira Samira G, Köfalvi Attila, Martín-Moreno Ana M, Keimpema Erik, Tanila Heikki, Watanabe Masahiko, Mackie Ken, Hortobágyi Tibor, de Ceballos Maria L, Harkany Tibor. 2011. Brain -
Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes.
Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M. 2011. Glia -
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Epilepsy research -
WNT signaling in activated microglia is proinflammatory
Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T & Schulte G. 2011. Glia -
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis
Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. Journal of neuroscience methods -
Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
Machová E, Rudajev V, Smycková H, Koivisto H, Tanila H & Dolezal V. 2010. Neurobiology of disease -
Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice
Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK & Lahiri DK. 2010. Journal of neuroscience research -
Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus
Gureviciene I, Gurevicius K, Tanila H. 2009. Journal of neural transmission -
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Journal of neuroscience -
Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA
Oksman M, Tanila H, Yavich L. 2009. Neuropharmacology -
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment
Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H, Soininen H. 2009. Hippocampus -
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T, Pirttilä T. 2009. Neurobiology of aging -
Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials
Myllymaa S, Myllymaa K, Korhonen H, Töyräs J, Jääskeläinen JE, Djupsund K, Tanila H, Lappalainen R. 2009. Biosensors and bioelectronics -
Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo
Gurevicius K, Kuang F, Stoenica L, Irintchev A, Gureviciene I, Dityatev A, Schachner M, Tanila H. 2009. Hippocampus -
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America -
Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice
Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK, Lahiri DK. 2009. Journal of neuroscience research -
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry -
Cognition-enhancing and anxiolytic effects of memantine
Minkeviciene R, Banerjee P, Tanila H. 2008. Neuropharmacology -
Development of flexible microelectrode arrays for recording cortical surface field potentials
Myllymaa S, Myllymaa K, Korhonen H, Gureviciene I, Djupsund K, Tanila H, Lappalainen R. 2008. Annual international conference of the IEEE engineering in medicine and biology society -
Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice
Machová E, Jakubík J, Michal P, Oksman M, Iivonen H, Tanila H, Dolezal V. 2008. Neurobiology of aging -
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Neuroscience letters -
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience -
Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Aß overproduction
Zhou XW , Tanila H , Pei JJ. 2008. Febs letters -
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JÅ, Winblad B, Pei JJ. 2008. Journal of cellular and molecular medicine -
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ. 2008. Neurobiology of disease -
Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice
Hooijmans CR, Graven C, Dederen PJ, Tanila H, van Groen T, Kiliaan AJ. 2007. Brain research -
Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)
Hooijmans CR, Rutters F, Dederen PJ, Gambarota G, Veltien A, van Groen T, Broersen LM, Lütjohann D, Heerschap A, Tanila H, Kiliaan AJ. 2007. Neurobiology of disease -
Increased fMRI responses during encoding in mild cognitive impairment
Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H, Soininen H, Tervo S. 2007. Neurobiology of aging -
Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase
Gurevicius K, Gureviciene I, Sivukhina E, Irintchev A, Schachner M, Tanila H. 2007. Molecular and cellular neuroscience -
Mechanics of self-stimulation and dopamine release in the nucleus accumbens
Yavich L, Tanila H. 2007. Neuroreport -
Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats
Kumlin T, Iivonen H, Miettinen P, Juvonen A, van Groen T, Puranen L, Pitkäaho R, Juutilainen J, Tanila H. 2007. Radiation research -
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience -
Role of alpha-synuclein in synaptic glutamate release
Gureviciene I, Gurevicius K, Tanila H. 2007. Neurobiology of disease -
Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P trasgenic mice
Yavich L, Jäkälä P, Tanila H. 2006. Journal of neurochemistry -
Brain reward in the absence of alpha-synuclein
Oksman M, Tanila H, Yavich L. 2006. Neuroreport -
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice
Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Neuroscience -
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, Leenders I, Broersen L, Lütjohann D, Hartmann T, Tanila H. 2006. Neurobiology of disease -
Miksi vanha ei muista?
Wilson I, Tanila H. 2006. Duodecim -
Neurocognitive aging: prior memories hinder new hippocampal encoding
Wilson IA, Gallagher M, Eichenbaum H, Tanila H, Tanila H. 2006. Trends in neurosciences -
Neurotrophins and dementia - keeping in touch
Castén E, Tanila H. 2006. Neuron -
Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors
Shemer I, Holmgren C, Min R, Fülöp L, Zilberter M, Sousa KM, Farkas T, Härtig W, Penke B, Burnashev N, Tanila H, Zilberter Y, Harkany T. 2006. European journal of neuroscience -
Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus of APP/PS1 transgenic mice
Siegemund T, Paulke B-R, Schmiedel H, Bordag N, Hoffmann A, Harkany T, Tanila H, Kacza J, Härtig W. 2006. International journal of developmental neuroscience -
Age-associated alterations of hippocampal place cells are subregion specific
Wilson IA, Ikonen S, Gallagher M, Eichenbaum H, Tanila H. 2005. Journal of neuroscience -
Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man
Aalto S, Ihalainen J, Hirvonen J, Kajander J, Scheinin H, Tanila H, Någren K, Vilkman H, Gustafsson LL, Syvälahti E, Hietala J. 2005. Psychopharmacology -
Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects
Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Aronen HJ, Soininen H, Soininen H, könönen m. 2005. European journal of neuroscience -
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated alpha-synuclein
Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P. 2005. Neurobiology of disease -
Noradrenaline overflow in mouse dentate gyrus following locus coeruleus and natural stimulation: real-time monitoring by in vivo voltammetry
Yavich L, Jäkälä P, Tanila H, Yavich L. 2005. Journal of neurochemistry -
Orexin loss in Huntington¿s disease
Petersen Å, Gil J, Maat-Schieman MLC, Björkqvist M, Tanila H, Araújo IM, Smith R, Popovic N, Wierup N, Norlén P, Li J-Y, Roos RAC, Sundler F, Mulder H, Brundin P. 2005. Human molecular genetics -
Place cells of aged rats in two visually identical compartments
Wilson IA, Ikonen S, Gurevicius K, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2005. Neurobiology of aging -
Cognitive aging and the hippocampus: How old rats represent new environments
Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2004. Journal of neuroscience -
Effects of NMDA-receptor antagonist treatment on c-fos expression in rat brain areas implicated in schizophrenia
Väisänen J, Ihalainen J, Tanila H, Castrén E. 2004. Cellular and molecular neurobiology -
Effects of long-term ovariectomy and estrogen treatment on maze learning in aged mice
Heikkinen T, Puoliväli J, Tanila H. 2004. Experimental gerontology -
Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R
Gurevicius K, Gureviciene I, Valjakka A, Schachner M, Tanila H. 2004. Molecular and cellular neuroscience -
Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation
Heikkinen T, Kalesnykas G, Rissanen A, Tapiola T, Iivonen S, Wang J, Chaudhuri J, Tanila H, Miettinen R, Puoliväli J. 2004. Experimental neurology -
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens
Ihalainen JA, Tanila H. 2004. Journal of neurochemistry -
Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
Liu L, Herukka S-K, Minkeviciene R, van Groen T, Tanila H. 2004. Neurobiology of disease -
Memantine improves spatial learning in a transgenic mouse model of Alzheimer¿s disease
Minkeviciene R, Banerjee P, Tanila H. 2004. Journal of pharmacology and experimental therapeutics -
Normal induction by accelerated decay of LTP in APP + PS1 transgenic mice
Gureviciene I, Ikonen S, Gurevicius K, Sarkaki A, van Groen T, Pussinen R, Ylinen A, Tanila H. 2004. Neurobiology of disease -
Role of alfa-synuclein in presynaptic dopamine recruitment
Yavich L, Tanila H, Vepsäläinen S, Jäkälä P, Yavich L, Vepsäläinen S. 2004. Journal of neuroscience -
Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment
Kaasinen SK, Oksman M, Alhonen L, Tanila H, Jänne J. 2004. Pharmacology biochemistry and behavior -
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Hämäläinen A, Soininen H, Aronen HJ, Könönen M, Soininen H. 2004. European journal of neuroscience -
Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
Liu L, Tapiola T, Herukka S-K, Heikkilä M, Tanila H. 2003. Neuroreport -
Altered auditory-evoked potentials in mice carrying mutated human amyloid precursor protein and presenilin-1 transgenes
Wang J, Ikonen S, Gurevicius K, van Groen T, Tanila H. 2003. Neuroscience -
Encoding of novel picture pairs activates the perirhinal cortex: An fMRI study
Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Mikkonen M, Jalkanen V, Partanen K, Aronen HJ, Soininen H. 2003. Hippocampus -
Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice
Gureviciene I, Puoliväli J, Pussinen R, Wang J, Tanila H, Ylinen A. 2003. Neurobiology of learning and memory -
Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice
Wang J, Tanila H, Puoliväli J, Kadish I, van Groen T. 2003. Neurobiology of disease -
Hypothermia in mice tested in Morris water maze
Iivonen H, Nurminen L, Harri M, Tanila H, Puoliväli J. 2003. Behavioural brain research -
Place cell rigidity correlates with impaired spatial learning in aged rats
Wilson IA, Ikonen S, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. 2003. Neurobiology of aging -
Alpha2C-adrenoceptor mediated regulation of cortical EEG arousal
Puoliväli J, Björklund M, Holmberg M, Ihalainen JA, Scheinin M, Tanila H. 2002. Neuropharmacology -
Alteration of cortical EEG in mice carrying mutated human APP transgene
Wang J, Ikonen S, Gurevicius K, van Groen T, Tanila H. 2002. Brain research -
Cholinergic system regulation of spatial representation by the hippocampus
Ikonen S, McMahan R, Gallagher M, Eichenbaum H, Tanila H. 2002. Hippocampus -
Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice
Liu L, Ikonen S, Heikkinen T, Heikkilä M, Puoliväli J, van Groen T, Tanila H. 2002. Behavioural brain research -
Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice
Heikkinen T, Puoliväli J, Liu L, Rissanen A, Tanila H. 2002. Hormones and behavior -
Elevated levels of Abeeta1-40 and Abeeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice
Marutle A, Unger C, Hellström-Lindahl E, Wang J, Puoliväli J, Tanila H, Nordberg A, Zhang X. 2002. Neuroscience letters -
Fimbria-fornix lesion does not affect APP levels and amyloid deposition in the hippocampus of APP+PS1 double transgenic mice
Liu L, Ikonen S, Tapiola T, Tanila H, van Groen T. 2002. Experimental neurology -
Hippocampal Abeeta42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice
Puoliväli J, Wang J, Heikkinen T, Heikkilä M, Tapiola T, van GroenT, Tanila H. 2002. Neurobiology of disease -
In vivo regulation of dopamine and noradrenaline release by alfa2A-adrenoceptors in the mouse prefrontal cortex
Ihalainen JA, Tanila H. 2002. European journal of neuroscience -
The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice
Liu L, Ikonen S, Heikkinen T, Tapiola T, van Groen T, Tanila H. 2002. Experimental neurology -
Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation
Laitinen KSM, van Groen T, Tanila H, Venäläinen J, Männistö PT, Alafuzoff I. 2001. Neuroreport -
Effects of metrifonate on the hippocampal theta rhythm of freely moving intact and MS-lesioned mice
Ikonen S, Tanila H. 2001. Pharmacology biochemistry and behavior -
Noradrenergic regulation of hippocampal place cells
Tanila H. 2001. Hippocampus -
Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C- adrenoceptor
Björklund M, Siverina I, Heikkinen T, Tanila H, Sallinen J, Scheinin M, Riekkinen P. 2001. Progress in neuro-psychopharmacology and biological psychiatry -
alpha2c-Adrenoceptors modulate the effect of methylphenidate on response rateand discrimination accuracy in an operant test
Ihalainen JA, Tanila H, Scheinin M, Riekkinen P Jr. 2001. Brain research bulletin -
Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study
Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen HJ. 2000. Annals of neurology -
Hippocampal place cells can develop distinct representations of two visually identical environments
Tanila H. 1999. Hippocampus -
Role of alfa2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alfa2C-adrenoceptor gene
Tanila H, Mustonen K, Sallinen J, Scheinin M, Riekkinen P Jr. 1999. European journal of neuroscience -
The hippocampus, memory, and place cells: is it spatial memory or a memory space?
Eichenbaum H, Dudchenko P, Wood E, Shapiro M, Tanila H. 1999. Neuron -
Vanhenevat aivot, huononeva muisti
Tanila H. 1999. KEMIA-KEMI -
Abnormal hippocampal spatial representations in alfaCaMKII T286A and CREBalfa delta- Mice
Cho YH, Giese KP, Tanila H, Silva AJ, Eichenbaum H. 1998. Science -
Cognitive changes in mice following moderate MPTP exposure
Tanila H, Björklund M, Riekkinen P Jr. 1998. Brain research bulletin -
Unique features in the processing of spatial information by the aged hippocampus as shown by place cell recording studies: a response to Peter Rapp¿s commentary "Representational organization in the aged hippocampus
Tanila H. 1998. Hippocampus -
Brain aging:changes in the nature of information coding by the hippocampus
Tanila H, Shapiro M, Gallagher M, Eichenbaum H. 1997. Journal of neuroscience -
Brain aging:impaired coding of novel environmental cues
Tanila H, Sipilä P, Shapiro M, Eichenbaum H. 1997. Journal of neuroscience -
Cues that hippocampal place cells encode: dynamic and hierarchical representation of local and distal stimuli
Shapiro ML, Tanila H, Eichenbaum H. 1997. Hippocampus -
Discordance of spatial representation in ensembles of hippocampal place cells
Tanila H, Shapiro ML, Eichenbaum H. 1997. Hippocampus -
Leikkaus, joka vei muistin
Tanila H. 1996. Duodecim