Ali Koskela

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299:

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Vottonen, Linda; Koskela, Ali; Felszeghy, Szabolcs; Wylegala, Adam; Kryszan, Katarzyna; Gurubaran, Iswariyaraja Sridevi; Kaarniranta, Kai; Wylegala, Edward. 2023. Journal of clinical medicine. 12:

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Koskela, Ali; Manai, Federico; Basagni, Filippo; Liukkonen, Mikko; Rosini, Michela; Govoni, Stefano; Monte, Massimo Dal; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura. 2022. Antioxidants. 11: . 1385

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Pacwa, Anna; Machowicz, Joanna; Wojtyniak, Alicja; Pietrucha-Dutczak, Marita; Toropainen, Elisa; Koskela, Ali; Mrukwa-Kominek, Ewa; Lewin-Kowalik, Joanna; Smedowski, Adrian. 2022. Journal of inflammation research. 15: 793-806

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 1684

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Liukkonen, Mikko PK; Paterno, Jussi J; Kivinen, Niko; Siintamo, Leea; Koskela, Ali KJ; Kaarniranta, Kai. 2021. Acta ophthalmologica. [Epub ahead of print 26 Oct 2021]: 1-10

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali]. 2021. Autophagy. 17: 1-382

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai. 2021. Oxidative medicine and cellular longevity. 2021:

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. 2020. Genes. 11: 1318

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2020. International journal of molecular sciences. 21: 2066

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. 2019. International journal of molecular sciences. 20: 3773

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. 2019. Oxidative medicine and cellular longevity. 2019: 9682318

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. 2019. Journal of cellular and molecular medicine. 23: 8464-8471

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Biochimie. 159: 49-54

Using online game-based platforms to improve student performance and engagement in histology teaching

Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A. 2019. Bmc medical education. 19: 273

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Oxidative medicine and cellular longevity. 2018: 4956080

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Duodecim. 133: 641-646

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Felszeghy Szabolcs, Pasonen-Seppänen Sanna, Koskela Ali, Mahonen Anitta. 2017. MedEd publish. 6: 40

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. European journal of pharmacology. 788: 12-20

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutrients. 8: 284

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Oxidative medicine and cellular longevity. 2015, Article ID 340520: 24 p.

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

Törrönen R, McDougall GJ, Dobson G, Stewart D, Hellström J, Mattila P, Pihlava J-M, Koskela A, Karjalainen R. 2012. Journal of functional foods. 4: 746-756

Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells

Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. 2012.

Postprandial glycaemic responses after polyphenol enriched black currant juice consumption

Törrönen, R., McDougall, G., Stewart, D., Dobson, G., Hellström, J., Mattila, P., Pihlava, J-M., Koskela, A., Karjalainen, R.. 2011.

Variksenmarjan (Empetrum nigrum) bioaktiiviset yhdisteet

Koskela, A., Karjalainen, R.. 2011.

Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations

Koskela Ali, Anttonen Mikko, Soininen Tuula, Auriola Seppo, Julkunen-Tiitto Riitta, Karjalainen Reijo. 2010.

Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum ssp. hermaphroditum) populations

Ali KJ Koskela, Mikko J Anttonen, Tuula H Soininen, Riitta Julkunen-Tiitto, Seppo Auriola, Reijo O Karjalainen. 2010.

Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).

Koskela, A., Anttonen, M., Soininen, T., Saviranta, N., Auriola, S., Julkunen-Tiitto, R. and Karjalainen, R.. 2010. Journal of agricultural and food chemistry. 58: 12289-12295

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Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Using online game-based platforms to improve student performance and engagement in histology teaching

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells

Postprandial glycaemic responses after polyphenol enriched black currant juice consumption

Variksenmarjan (Empetrum nigrum) bioaktiiviset yhdisteet

Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations

Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum ssp. hermaphroditum) populations

Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).