Anne Koivisto

Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. 5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus Journal of neurology [Published online 02 Mar 2021]: 1-11. 2021

Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C. et al. [incl. Leinonen,. 2021. Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 80 4: 1629-1642. 2021

Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;. 2021. The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease Journal of Alzheimer's disease 81 3: 1117-1130. 2021

Saari, Toni; Koivisto, Anne; Hintsa, Taina; Hänninen, Tuomo; Hallikainen, Ilona. 2021. Psychometric Properties of the Neuropsychiatric Inventory: A Review Journal of Alzheimer's disease Pre-press 26 Aug 2020: 1-15. 2021

Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils. 2021. Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus Acta neurochirurgica [Epub ahead of print 8 July 2021]: -. 2021

Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus Journal of clinical medicine 10 5: 1105. 2021

Ylä-Herttuala, Salla; Hakulinen, Mikko; Poutiainen, Pekka; Laitinen, Tiina M; Koivisto, Anne M; Remes, Anne M; Hallikainen, Merja; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Könönen, Mervi; Vanninen, Ritva; Mussalo, Hanna; Laitinen, Tomi; Mervaala, Esa. 2021. Severe Obstructive Sleep Apnea and Increased Cortical Amyloid-ß Deposition Journal of Alzheimer's disease 79 1: 153-161. 2021

Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Journal of neurology neurosurgery and psychiatry Online First: 29 June 2021: 1 - 8. 2021

Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus European journal of neurology 2021; 28 2: 389-400. 2020

Saari, TT; Hallikainen, I; Hintsa, T; Koivisto, AM. 2020. Network structures and temporal stability of self- and informant-rated affective symptoms in Alzheimer's disease Journal of affective disorders 276: 1084-1092. 2020

Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members Fluids and barriers of the cns 17: 57. 2020

Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease. Journal of Alzheimer's disease 74 1: 277-286. 2020

Koivisto, Anne. 2020. Lewyn kappale -patologian kaksierilaistaetenemistapaa Lääkärilehti 75 17-18: 1015. 2020

Kaipainen, Aku; Jääskeläinen, Olli; Liu, Yawu; Haapalinna, Fanni; Nykänen, Niko; Vanninen, Ritva; Koivisto, Anne M; Julkunen, Valtteri; Remes, Anne M; Herukka, Sanna-Kaisa. 2020. Cerebrospinal Fluid and MRI Biomarkers in Neurodegenerative Diseases: A Retrospective Memory Clinic-Based Study Journal of Alzheimer's disease 75 3: 751-765. 2020

Frederiksen, Kristian Steen; Nielsen, T Rune; Appollonio, Ildebrando; Andersen, Birgitte Bo; Riverol, Mario; Boada, Mercè; Ceccaldi, Mathieu; Dubois, Bruno; Engelborghs, Sebastiaan; Frölich, Lutz; Hausner, Lucrezia; Gabelle, Audrey; Gabryelewicz, Tomasz; Grimmer, Timo; Hanseeuw, Bernard; Hort, Jakub; Hugon, Jacques; Jelic, Vesna; Koivisto, Anne; Kramberger, Milica G et al.. 2020. Biomarker counselling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's Disease Consortium survey International journal of geriatric psychiatry 2021; 36 2: 324-333. 2020

Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito Duodecim 135 3: 265-273. 2019

Saari, Toni; Hallikainen, Ilona; Hintsa, Taina; Koivisto, Anne M. 2019. Neuropsychiatric symptoms and activities of daily living in Alzheimer's disease: ALSOVA 5-year follow-up study International psychogeriatrics 2020; 32 6: 741-751. 2019

Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. [11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus Journal of Alzheimer's disease 67 4: 1343-1351. 2019

Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 71 4: 1233-1243. 2019

Junkkari, A; Luikku, A J; Danner, N; Jyrkkänen, H K; Rauramaa, T; Korhonen, V E; Koivisto, A M; Nerg, O; Kojoukhova, M; Huttunen, T J; Jääskeläinen, J E; Leinonen, V. 2019. The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients Fluids and barriers of the cns 16: 21. 2019

Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nature genetics 51 3: 414-430. 2019

Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Dementia and geriatric cognitive disorders 47 1-2: 91-103. 2019

Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Journal of neurology 2020; 267: 76-86. 2019

Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Journal of Alzheimer's disease 72 1: 127-137. 2019

Leinonen, V; Rauramaa, T; Johansson, J; Bottelbergs, A; Tesseur, I; van der Ark, P; Pemberton, D; Koivisto, AM; Jääskeläinen, JE; Hiltunen, M; Herukka, SK; Blennow, K; Zetterberg, H; Jokinen, P; Rokka, J; Helin, S; Haaparanta-Solin, M; Solin, O; Okamura, N; Kolb, HC; et al.. 2018. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-ß Plaques and Tau in Brain Biopsies Journal of Alzheimer's Disease 64 1: 171-179. 2018

Välimäki, Tarja; Gilmartin-Thomas, Julia FM; Nell, Simon J; Selander, Tuomas; Koivisto, Anne M. 2018. Longitudinal study of medication use in caregivers of people with Alzheimer's disease - Kuopio ALSOVA study Dementia [First published 2 Oct 2018]: 1-13. 2018

Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus Neurosurgery 2019; 84 4: 883-889. 2018

Saari, Toni; Hallikainen, Ilona; Hänninen, Tuomo; Räty, Hannu; Koivisto, Anne. 2018. Relationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study Journal of Alzheimer's disease 64 1: 269-279. 2018

Ruokostenpohja, Nora; Välimäki, Tarja; Martikainen, Janne; Hallikainen, Merja; Vehviläinen-Julkunen, Katri; Koivisto, Anne. 2018. Entitlement of carer's allowance to support home care of persons with Alzheimer's disease: evaluation of current decision criteria European Geriatric Medicine 9 4: 477-483. 2018

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus. WORLD NEUROSURGERY 112: e624-e631. 2018

Peloso, GM; van der Lee, SJ; International Genomics of Alzheimer's Project (IGAP); Destefano, AL; Seshardi, S; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Helisalmi, Seppo; Koivisto, Anne). 2018. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 10: 595-598. 2018

Hallikainen, Ilona; Hongisto, Kristiina; Välimäki, Tarja; Hänninen, Tuomo; Martikainen, Janne; Koivisto, Anne M. 2018. The Progression of Neuropsychiatric Symptoms in Alzheimer's Disease During a Five-Year Follow-Up: Kuopio ALSOVA Study. Journal of Alzheimer's Disease 61 4: 1367-1376. 2018

Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients Acta neuropathologica communications 6: 102. 2018

Koivisto, Anne M; Paajanen, Teemu; Rinne, Juha; Hokkanen, Laura; Vanninen, Ritva; Herukka, Sanna-Kaisa; Lötjönen, Jyrki; Hallikainen, Merja. 2018. Alzheimerin taudin varhainen tunnistaminen Duodecim 134 24: 2519-2528. 2018

Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. The association between frontotemporal lobar degeneration and bullous pemphigoid Journal of Alzheimer's disease 66 2: 743-750. 2018

Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 62 2: 789-794. 2018

Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers JOURNAL OF NEUROIMMUNOLOGY 321: 29-35. 2018

Hallikainen, Ilona; Koivisto, Anne M; Välimäki, Tarja. 2018. The influence of the individual neuropsychiatric symptoms of people with Alzheimer disease on family caregiver distress - A longitudinal ALSOVA study International journal of geriatric psychiatry 33 9: 1207-1212. 2018

Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject Journal of Alzheimer's Disease 62 1: 165-174. 2018

Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH Neurology : Genetics 4 6: e291. 2018

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADG. 2017. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. NATURE GENETICS 49 9: 1373-1384. 2017

Törmälehto Soili, Martikainen Janne, Bell J Simon, Hallikainen Ilona, Koivisto Anne M. 2017. Use of psychotropic medications in relation to neuropsychiatric symptoms, cognition and functional performance in Alzheimer's disease over a three-year period : Kuopio ALSOVA study. INTERNATIONAL PSYCHOGERIATRICS 29 10: 1723-1733. 2017

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 60 3: 1077-1085. 2017

Rosenvall Ari, Koivisto Anne. 2017. Muistisairaan potilaan hoito. Teoksessa: Jousimaa Jukkapekka, Alenius Heidi, Atula Sari, Berghem Nora, Kattainen Anna, Kunnamo Ilkka, Pelttari Hanna, Teikari Martti (toim.) Lääkärin käsikirja, 12. uudistettu painos. Duodecim. s. 1464-1466. 2017

Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?. WORLD NEUROSURGERY 108: 356-366. 2017

Hongisto K, Hallikainen I, Selander T, Törmälehto S, Väätäinen S, Martikainen J, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. 2017. Quality of Life in relation to neuropsychiatric symptoms in Alzheimer's disease: 5-year prospective ALSOVA cohort study International journal of geriatric psychiatry 2018; 33 1: 47-57. 2017

Kokkonen N, Herukka SK, Huilaja L, Kokki M, Koivisto AM, Hartikainen P, Remes AM, Tasanen K. 2016. Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2017; 137 1: 71-76. 2016

Törmälehto Soili, Bell Simon J, Väätäinen Saku, Hallikainen Ilona, Koivisto Anne, Martikainen Janne. 2016. Alzheimerin taudin lääkehoito, sen muutokset ja kustannukset pitkäaikaisseurannassa: yhteys kognitiiviseen suoriutumiseen, toimintakykyyn ja käytösoireisiin - ALSOVA seurantatutkimus. Teoksessa: Mäklin Suvi (toim.) Terveystaloustiede 2016. Terveyden ja hyvinvoinnin laitos. Työpaperi / Terveyden ja hyvinvoinnin laitos 1/2016. s. 16-19. 2016

Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus Acta neurochirurgica 158 12: 2311-2319. 2016

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. JOURNAL OF CELL SCIENCE 129: 2224-2238. 2016

Väätäinen Saku, Hongisto Kristiina, Välimäki Tarja, Hallikainen Ilona, Koivisto Anne, Martikainen Janne. 2016. Alzheimerin tautia sairastavan potilaan ja tämän omaishoitajan elämänlaatu suhteessa sairauden vaikeusasteeseen - ALSOVA seurantatutkimus. Teoksessa: Mäklin Suvi (toim.) Terveystaloustiede 2016. Terveyden ja hyvinvoinnin laitos. Työpaperi / Terveyden ja hyvinvoinnin laitos 1/2016. s. 13-15. 2016

Kojoukhova Maria, Vanha Krista-Irina, Timonen Matti, Koivisto Anne M, Nerg Ossi, Rummukainen Jaana, Rauramaa Tuomas, Vanninen Ritva, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2016. Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus Acta neurochirurgica 2017; 159 1: 51-61. 2016

Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study. EUROPEAN JOURNAL OF NEUROLOGY 24 1: 58-66. 2016

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Familial idiopathic normal pressure hydrocephalus. JOURNAL OF THE NEUROLOGICAL SCIENCES 368: 11-18. 2016

Haapalinna F, Paajanen T, Penttinen J, Kokki H, Kokki M, Koivisto AM, Hartikainen P, Solje E, Hänninen T, Remes AM, Herukka SK. 2016. Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women. Dementia and geriatric cognitive disorders extra 6 2: 303-312. 2016

Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1. Journal of Alzheimer's Disease 52 2: 497-507. 2016

Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Feasibility of radiological markers in idiopathic normal pressure hydrocephalus. ACTA NEUROCHIRURGICA (WIEN) 157 10: 1709-1719. 2015

Välimäki Tarja H, Martikainen Janne A, Hongisto Kristiina, Väätäinen Saku, Sintonen Harri, Koivisto Anne M. 2015. Impact of Alzheimer's disease on the family caregiver's long-term quality of life: results from an ALSOVA follow-up study. QUALITY OF LIFE RESEARCH [epub ahead of print 9 Sep 2015]: -. 2015

Välimäki Tarja H, Martikainen Janne A, Hallikainen Ilona T, Väätäinen Saku T, Koivisto Anne M. 2015. Depressed Spousal Caregivers Have Psychological Stress Unrelated to the Progression of Alzheimer Disease: A 3-Year Follow-Up Report, Kuopio ALSOVA Study. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY online before print August 6, 2015: 1-9. 2015

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach. Journal of Alzheimer's Disease 43 2: 565-573. 2015

Leinonen Ville, Koivisto Anne. 2015. Normaalipaineinen hydrokefalia. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen (toim.) Muistisairaudet. KUSTANNUS OY DUODECIM. s. 187-193. 2015

Törmälehto Soili M, Martikainen Janne A, Väätäinen Saku T, Hallikainen Ilona T, Hallikainen Merja, Bell J. Simon, Koivisto Anne M. 2015. Use of anti-dementia drugs in relation to change in cognition, behavior, and functioning in Alzheimer's disease over a three-year period: Kuopio ALSOVA Study. Journal of Alzheimer's Disease 48 4: 1033-1041. 2015

Koivisto Anne M, Hallikainen Ilona, Välimäki Tarja, Hongisto Kristiina, Hiltunen Asta, Karppi Pertti, Sivenius Juhani, Soininen Hilkka, Martikainen Janne. 2015. Early psychosocial intervention does not delay institutionalization in persons with mild Alzheimer disease and has impact on neither disease progression nor caregivers' well-being: ALSOVA 3-year follow-up. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 31(2016) 3: 273-283. 2015

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. Health-related quality of life in patients with idiopathic normal pressure hydrocephalus. EUROPEAN JOURNAL OF NEUROLOGY published online 24 JUN 2015: 9 p. 2015

Hongisto Kristiina, Väätäinen Saku, Martikainen Janne, Hallikainen Ilona, Välimäki Tarja, Hartikainen Sirpa, Suhonen Jaana, Koivisto Anne M. 2015. Self-rated and caregiver-rated quality of life in Alzheimer Disease with a focus on evolving patient ability to respond to questionnaires: 5-year prospective ALSOVA Cohort Study. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 23 12: 1280-1289. 2015

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. Journal of Alzheimer's Disease 46 1: 261-269. 2015

Haanpää RM, Suhonen N-M, Hartikainen P, Koivisto A M, Moilanen V, Herukka S-K, Hänninen T, Remes AM. 2015. The CERAD Neuropsychological Battery in Patients with Frontotemporal Lobar Degeneration. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 5 1: 147-154. 2015

Gilmartin Julia F, Väätäinen Saku, Törmälehto Soili, Bell J. Simon, Lönnroos Eija, Salo Lotta, Hallikainen Ilona, Martikainen Janne, Koivisto Anne M; the ALSOVA Study Group. 2015. Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. PLOS ONE [ONLINE] 10 2: e0117926. 2015

Välimäki Tarja, Martikainen Janne, Hongisto Kristiina, Fraunberg Mikael, Hallikainen Ilona, Sivenius Juhani, Vehviläinen-Julkunen Katri, Pietilä Anna-Maija, Koivisto Anne M.. 2014. Decreasing sense of coherence and its determinants in spousal caregivers of persons with mild Alzheimer's disease in three year follow-up: ALSOVA study. INTERNATIONAL PSYCHOGERIATRICS Epub 2014 Mar 21: -. 2014

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus. PLOS ONE [ONLINE] 9 3; e91974: 1-10. 2014

Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients. NEURODEGENERATIVE DISEASES 14 4 (Online First Articles): 204-208. 2014

Hallikainen I, Martikainen J, Lin P-J, Cohen JT, Lahoz R, Välimäki T, Hongisto K, Väätäinen S, Vanhanen M, Neuman PJ, Hänninen T, Koivisto AM. 2014. The Progression of Alzheimer's Disease Can Be Assessed with a Short Version of the CERAD Neuropsychological Battery: The Kuopio ALSOVA Study. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 4 3: 494-508. 2014

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLOS ONE [ONLINE] 8 4: e59676. 2013

Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto AM. 2013. Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study. INTERNATIONAL PSYCHOGERIATRICS 25 8: 1335-1344. 2013

Hallikainen M, Hänninen T, Koivisto A. 2013. Muistisairauden tunnistaminen, tutkiminen ja varhainen kuntoutussuunnitelma: Hallikainen M, Mönkäre R, Nukari T, Folder M, Muistisairaan kuntouttava hoito. 33-42. 2013

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus. NEUROSURGERY 72 1: 1-8. 2013

Välimäki Tarja, Vehviläinen-Julkunen Katri, Pietilä Anna-Maija, Koivisto Anne. 2012. Puoliso-omaishoitajien koherenssin tunne - Kuopion ALSOVA -tutkimuksen tuloksia: Kääriäinen Maria, Elo Satu, Kaakinen Pirjo, Helvi Kyngäs, Alakko nää mua? Yhteistyöllä vaikuttavaa hoitotieteellistä tutkimusta, XII Kansallinen hoitotieteellinen konferenssi 27.-28.9.2012, Oulun yliopisto, Proceedings. 102-107. 2012

Välimäki Tarja, Vehviläinen-Julkunen Katri, Pietilä Anna-Maija, Koivisto Anne. 2012. Life orientation in Finnish family caregivers' of persons with Alzheimer's disease: A diary study. NURSING AND HEALTH SCIENCES 14: 480-487. 2012

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings NEUROLOGY 78: 1568-1575. 2012

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 83 11: 1119-1124. 2012

Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease Journal of Alzheimer's Disease 28: 553-559. 2012

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 38 1: 72-86. 2012

Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus NEURODEGENERATIVE DISEASES 10 1-4: 166-169. 2012

Hallikainen I, Koivisto AM, Paajanen T, Hiltunen A, Karppi P, Vanhanen M, Välimäki T, Herukka S-K, Soininen H, Hänninen T. 2012. Cognitive and neuropsychiatric symptom differences in early stages of Alzheimer's Disease: Kuopio ALSOVA Study DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2: 209-218. 2012

Bell J Simon, Lönnroos Eija, Koivisto Anne M, Lavikainen Piia, Laitinen Marja-Liisa, Soininen Hilkka, Hartikainen Sirpa. 2011. Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland. Journal of Alzheimer's Disease 26: 231-237. 2011

Rummukainen J, Koivisto AM, Alafuzoff I, Leinonen V. 2011. Amyloid-beeta and Hyperphospholated Tau in the Prediction of Azheimer's Disease European Neurological Review 6 2: 84-88. 2011

Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Longitudinal changes of CSF biomarkers in Alzheimer's Disease. Journal of Alzheimer's Disease 25: 583-594. 2011

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J & Alafuzoff I. 2010. Amyloid and Tau proteins in cortical brain biopsy and Alzheimer's Disease. ANNALS OF NEUROLOGY 68: 446-453. 2010

Muistisairaudet. Erkinjuntti T, Rinne J & Soininen H. 2010 2010

Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. An association study of 21 potential Alzheimer's disease risk genes in a Finnish population. Journal of Alzheimer's Disease 21 3: 763-767. 2010

Välimäki T, Vehviläinen-Julkunen K, Pietilä A-M & Koivisto A. 2010. Omaishoitajan kokemus Alzheimerin tautia sairastavan läheisen hoitamisesta SAIRAANHOITAJA 83 9: 50-52. 2010

Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease. NEUROSCIENCE LETTERS 441 2: 233-236. 2008

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease. JOURNAL OF NEUROLOGY 255: 668-673. 2008

Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients. JOURNAL OF NEUROLOGY 254: 1504-1508. 2007

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006

Koivisto A, Koivisto A. 2006. Genetic Components of Late-Onset Alzheimer¿s Disease with Special Emphasis on ApoE, IL-6, CYP46, SERPINA3 and PPARgamma. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No. 2006

Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 77: 421-422. 2006

Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population. NEUROLOGY 63: 173-175. 2004

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Genetic variation in apolipoprotein D and Alzheimer¿s disease. JOURNAL OF NEUROLOGY 251: 951-957. 2004

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 75: 1746-1748. 2004

Berdel B, Koivisto A, Soininen H, Laakso M, Alafuzoff I. 2003. The density of endothelial cells in brain tissue is influenced by gender, age and concomitant brain pathology. BRAIN AGING 3 2: 29-32. 2003

Laakso MP, Hiltunen Y, Könönen M, Kivipelto M, Koivisto A, Hallikainen M, Soininen H, Laakso MP. 2003. Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers. JOURNAL OF NEURAL TRANSMISSION 110: 267-275. 2003

Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 14: 123-127. 2002

Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland. NEUROLOGY 57: 1663-1668. 2001

Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin. NEUROGENETICS 3: 171-172. 2001

Helisalmi S, Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Alafuzoff I, Ryynänen M, Soininen H. 2000. Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer¿s disease?. NEUROSCIENCE LETTERS 278: 65-68. 2000

Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination? EUROPEAN JOURNAL OF HUMAN GENETICS 8: 259-266. 2000

Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study. NEUROEPIDEMIOLOGY 19: 327-332. 2000

Helisalmi S, Hiltunen M, Valonen P, Mannermaa A, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 1999. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer¿s disease patients and control individuals. JOURNAL OF NEUROLOGY 246: 821-824. 1999

Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Helisalmi S, Ryynänen M, Riekkinen P Sr, Soininen H. 1999. Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients. EUROPEAN JOURNAL OF HUMAN GENETICS 7: 652-658. 1999

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