Gundars Goldsteins

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, Šárka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo Scientific reports 11 1: 3518. 2021

Studying non-cell-autonomous neurodegeneration in Parkinson's disease with induced pluripotent stem cells. Sonninen, Tuuli-Maria; Plotnikova, Lidiia; Laham-Karam, Nihay; Goldsteins, Gundars; Koistinaho, Jari; Lehtonen, Šárka / iPSCs for Modeling Central Nervous System Disorders. 2021. 2021

Rolova, Taisia; Lehtonen, Sárka; Goldsteins, Gundars; Kettunen, Pinja; Koistinaho, Jari. 2020. Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models Stem cells 2021; 39 3: 256-265. 2020

Sonninen, Tuuli-Maria; Goldsteins, Gundars; Laham-Karam, Nihay; Koistinaho, Jari; Lehtonen, Sarka. 2020. Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases Cells 9 10: 2183. 2020

Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, Šárka. 2020. Metabolic alterations in Parkinson's disease astrocytes Scientific reports 10 1: 14474. 2020

Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke Neurotherapeutics 16: 1304-1319. 2019

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis IBRO Reports 6: 74-86. 2019

Lehtonen, Š; Sonninen, TM; Wojciechowski, S; Goldsteins, G; Koistinaho, J. 2019. Dysfunction of Cellular Proteostasis in Parkinson's Disease Frontiers in neuroscience 13: 457. 2019

Oksanen, M; Lehtonen, S; Jaronen, M; Goldsteins, G; Hämäläinen, RH; Koistinaho, J. 2019. Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms Cellular and molecular life sciences 76 14: 2739-2760. 2019

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes GLIA 2019; 67 1: 146-159. 2018

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14 11: 237. 2017

Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 15. 2016

Lehtonen Šárka, Jaronen Merja, Vehviläinen Piia, Lakso Merja, Rudgalvyte Martina, Keksa-Goldsteine Velta, Wong Garry, Courtney Michael J, Koistinaho Jari, Goldsteins Gundars. 2016. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models. ANTIOXIDANTS AND REDOX SIGNALING 25 8: 485-497. 2016

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy Scientific Reports 6: 33176. 2016

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 10. 2016

Aarnio Vuokko, Heikkinen Liisa, Peltonen Juhani, Goldsteins Gundars, Lakso Merja, Wong Gary. 2014. Transcriptional profiling reveals differential expression of a neuropeptide-like protein and pseudogenes in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans. Comparative biochemistry and physiology. Part D, Genomics & proteomics 2014 Mar;9:: 40-48. 2014

Jaronen M, Goldsteins G, Koistinaho J. 2014. ER stress and unfolded protein response in amyotrophic lateral sclerosis - a controversial role of protein disulphide isomerase. Frontiers in Cellular Neuroscience 2014 Dec 2;8:402.: --. 2014

Pollari Eveliina, Goldsteins Gundars, Bart Genevieve, Koistinaho Jari, Giniatullin Rashid. 2014. The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience 2014 May 13;8:131.: --. 2014

Vehviläinen P, Koistinaho J, Goldsteins, G. 2014. Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience 126 8: -. 2014

Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production. HUMAN MOLECULAR GENETICS 2012 Nov 1. [Epub ahead of print]: - -. 2012

Koistinaho J, Goldsteins G.. 2012. Mutant Cu/Zn-Superoxide Dismutase Induced Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis: Maurer, Martin H., Amyotrophic Lateral Sclerosis. 249-264. 2012

Koistinaho J, Malm T, Goldsteins G. 2011. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International Journal of Alzheimer's Disease 2011;2011:129753. Epub 2011 May 4: --. 2011

Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 84: 1-14. 2011

Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 7: 90. 2010

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. JOURNAL OF NEUROCHEMISTRY 105: 584-594. 2008

Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Jaronen M, Arens E, Åkerman K, Chan PH, Koistinaho J. 2008. Deleterious role of superoxide dismutase in the mitochondrial intermembrane space. JOURNAL OF BIOLOGICAL CHEMISTRY 283 13: 8446-8452. 2008

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008

Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. 2008. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 103: e1-e9. 2008

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis MOLECULAR PHARMACOLOGY 71: 30-37. 2007

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007

Korolainen MA, Goldsteins G, Nyman TA, Alafuzoff I, Koistinaho J, Pirttilä T, Korolainen MA, Pirttilä T. 2006. Oxidative modification of proteins in the frontal cortex of Alzheimer¿s disease brain NEUROBIOLOGY OF AGING 27: 42-53. 2006

Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103 23: 8852-8857. 2006

Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia. FREE RADICAL BIOLOGY & MEDICINE 40 10: 1776-1784. 2006

Semenov A, Goldsteins G, Castrén E. 2006. Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brain. CELLULAR AND MOLECULAR NEUROBIOLOGY 26 2: 163-175. 2006

Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25: 460-467. 2005

Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. The microglia-activating potential of thrombin. JOURNAL OF BIOLOGICAL CHEMISTRY 279 50: 51880-51887. 2004

Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach. NEUROSCIENCE LETTERS 367 2: 235-240. 2004

Nurmi A, Vartiainen N, Pihlaja R, Goldsteins G, Yrjänheikki J, Koistinaho J. 2004. Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window. JOURNAL OF NEUROCHEMISTRY 91 3: 755-765. 2004

Vartiainen N, Goldsteins G, Keksa-Goldsteine V, Chan PH, Koistinaho J. 2003. Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage. STROKE 34 3: 752-757. 2003

Kaasinen SK, Goldsteins G, Alhonen L, Jänne J, Koistinaho J. 2002. Induction and activation of protein kinase Cdelta in hippocampus and cortex after kainic acid treatment EXPERIMENTAL NEUROLOGY 176: 203-212. 2002

Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J. 2002. Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99 3: 1610-1615. 2002

Korolainen MA, Goldsteins G, Alafuzoff I, Koistinaho J, Pirttilä T. 2002. Proteomic analysis of protein in Alzheimer's disease brain. ELECTROPHORESIS 23 19: 3428-3433. 2002

Tikka TM, Vartiainen NE, Goldsteins G, Oja SS, Andersen PM, Marklund SL, Koistinaho J. 2002. Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease. BRAIN 125: 722-731. 2002

Vartiainen N, Keksa-Goldsteine V, Goldsteins G, Koistinaho J. 2002. Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. JOURNAL OF NEUROCHEMISTRY 82: 329-335. 2002

Kurkinen K, Busto R, Goldsteins G, Koistinaho J, Perez-Pinzon MA. 2001. Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning. NEUROCHEMICAL RESEARCH 26 10: 1139-1144. 2001

Tikka T, Fiebich BL, Goldsteins G, Keinänen R, Koistinaho J. 2001. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia JOURNAL OF NEUROSCIENCE 21 8: 2580-2588. 2001

Vartiainen N, Huang C-Y, Salminen A, Goldsteins G, Chan PH, Koistinaho J. 2001. Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition JOURNAL OF NEUROCHEMISTRY 76 2: 480-489. 2001

Koponen S, Goldsteins G, Keinänen R, Koistinaho J. 2000. Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 93-102. 2000

Yrjänheikki J, Tikka T, Goldsteins G, Koistinaho M, Keinänen R, Chan PH, Koistinaho J. 2000. Inhibition of inflammation and neuroprotection by tetracyclines. Teoksessa: Krieglstein J, Klumpp S (toim.), Pharmacology of Cerebral Ischemia 2000.Medpharm Scientific Publishers. ss. 267-274. 2000

Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH, Koistinaho J. 1999. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96 23: 13496-13500. 1999

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