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Gundars Goldsteins

Gundars Goldsteins

Yliopistotutkija

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

gundars.goldsteins@uef.fi | 050 386 6832

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Human Brain Disease Modelling (Lehtonen lab) 01.01.2021 -

Julkaisut

53/53 kappaletta

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
Goldsteins, Gundars; Hakosalo, Vili; Jaronen, Merja; Keuters, Meike Hedwig; Lehtonen, Šárka; Koistinaho, Jari. 2022. Antioxidants. 11:
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M. 2022. Neurobiology of disease. 170:
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports. 11: 3518
Studying non-cell-autonomous neurodegeneration in Parkinson's disease with induced pluripotent stem cells
Sonninen, Tuuli-Maria; Plotnikova, Lidiia; Laham-Karam, Nihay; Goldsteins, Gundars; Koistinaho, Jari; Lehtonen, ¦árka. Teoksessa: Birbrair, Alexander(toim.) , 2021. iPSCs for Modeling Central Nervous System Disorders. s. 251-276. Academic press
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, ¦árka. 2020. Scientific reports. 10: 14474
Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models
Rolova, Taisia; Lehtonen, Sárka; Goldsteins, Gundars; Kettunen, Pinja; Koistinaho, Jari. 2020. Stem cells. 2021; 39: 256-265
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Sonninen, Tuuli-Maria; Goldsteins, Gundars; Laham-Karam, Nihay; Koistinaho, Jari; Lehtonen, Sarka. 2020. Cells. 9: 2183
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
Oksanen, M; Lehtonen, S; Jaronen, M; Goldsteins, G; Hämäläinen, RH; Koistinaho, J. 2019. Cellular and molecular life sciences. 76: 2739-2760
Dysfunction of Cellular Proteostasis in Parkinson's Disease
Lehtonen, ¦; Sonninen, TM; Wojciechowski, S; Goldsteins, G; Koistinaho, J. 2019. Frontiers in neuroscience. 13: 457
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports. 6: 74-86
Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Neurotherapeutics. 16: 1304-1319
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia. 2019; 67: 146-159
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Journal of neuroinflammation. 14: 237
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 10
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports. 6: 33176
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 15
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models
Lehtonen ¦árka, Jaronen Merja, Vehviläinen Piia, Lakso Merja, Rudgalvyte Martina, Keksa-Goldsteine Velta, Wong Garry, Courtney Michael J, Koistinaho Jari, Goldsteins Gundars. 2016. Antioxidants and redox signaling. 25: 485-497
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Journal of neuroinflammation. 13: 1-14
ER stress and unfolded protein response in amyotrophic lateral sclerosis - a controversial role of protein disulphide isomerase
Jaronen M, Goldsteins G, Koistinaho J. 2014. Frontiers in cellular neuroscience. : --
Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
Vehviläinen P, Koistinaho J, Goldsteins, G. 2014. Frontiers in cellular neuroscience. 126: -
The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis
Pollari Eveliina, Goldsteins Gundars, Bart Genevieve, Koistinaho Jari, Giniatullin Rashid. 2014. Frontiers in cellular neuroscience. 2014 May 13;8:131.: --
Transcriptional profiling reveals differential expression of a neuropeptide-like protein and pseudogenes in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans
Aarnio Vuokko, Heikkinen Liisa, Peltonen Juhani, Goldsteins Gundars, Lakso Merja, Wong Gary. 2014. Comparative biochemistry and physiology d: genomics and proteomics. 2014 Mar;9:: 40-48
Mutant Cu/Zn-Superoxide Dismutase Induced Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis
Koistinaho J, Goldsteins G.. Teoksessa: Maurer, Martin H.(toim.) , 2012. Amyotrophic Lateral Sclerosis. s. 249-264. Intech media
Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production
Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Human molecular genetics. 2012 Nov 1. [Epub ahead of print]: - -
Glycogen synthase kinase-3&#946 : a mediator of inflammation in Alzheimer's disease?
Koistinaho J, Malm T, Goldsteins G. 2011. International journal of alzheimers disease. : --
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Journal of neuroinflammation. 84: 1-14
Human intravenous immunoglobulin provides protection against A&#946 toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Journal of neuroinflammation. 7: 90
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry. 105: 584-594
Deleterious role of superoxide dismutase in the mitochondrial intermembrane space
Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Jaronen M, Arens E, Åkerman K, Chan PH, Koistinaho J. 2008. Journal of biological chemistry. 283: 8446-8452
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. 2008. Circulation research. 103: e1-e9
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience. 39: 302-313
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Molecular pharmacology. 71: 30-37
Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia
Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Free radical biology and medicine. 40: 1776-1784
Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Proceedings of the National Academy of Sciences of the United States of America. 103: 8852-8857
Oxidative modification of proteins in the frontal cortex of Alzheimer¿s disease brain
Korolainen MA, Goldsteins G, Nyman TA, Alafuzoff I, Koistinaho J, Pirttilä T, Korolainen MA, Pirttilä T. 2006. Neurobiology of aging. 27: 42-53
Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brain
Semenov A, Goldsteins G, Castrén E. 2006. Cellular and molecular neurobiology. 26: 163-175
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice
Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Journal of cerebral blood flow and metabolism. 25: 460-467
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Neuroscience letters. 367: 235-240
Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window
Nurmi A, Vartiainen N, Pihlaja R, Goldsteins G, Yrjänheikki J, Koistinaho J. 2004. Journal of neurochemistry. 91: 755-765
The microglia-activating potential of thrombin
Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. Journal of biological chemistry. 279: 51880-51887
Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage
Vartiainen N, Goldsteins G, Keksa-Goldsteine V, Chan PH, Koistinaho J. 2003. Stroke. 34: 752-757
Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture
Vartiainen N, Keksa-Goldsteine V, Goldsteins G, Koistinaho J. 2002. Journal of neurochemistry. 82: 329-335
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J. 2002. Proceedings of the National Academy of Sciences of the United States of America. 99: 1610-1615
Induction and activation of protein kinase Cdelta in hippocampus and cortex after kainic acid treatment
Kaasinen SK, Goldsteins G, Alhonen L, Jänne J, Koistinaho J. 2002. Experimental neurology. 176: 203-212
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease
Tikka TM, Vartiainen NE, Goldsteins G, Oja SS, Andersen PM, Marklund SL, Koistinaho J. 2002. Brain. 125: 722-731
Proteomic analysis of protein in Alzheimer's disease brain
Korolainen MA, Goldsteins G, Alafuzoff I, Koistinaho J, Pirttilä T. 2002. Electrophoresis. 23: 3428-3433
Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning
Kurkinen K, Busto R, Goldsteins G, Koistinaho J, Perez-Pinzon MA. 2001. Neurochemical research. 26: 1139-1144
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
Tikka T, Fiebich BL, Goldsteins G, Keinänen R, Koistinaho J. 2001. Journal of neuroscience. 21: 2580-2588
Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition
Vartiainen N, Huang C-Y, Salminen A, Goldsteins G, Chan PH, Koistinaho J. 2001. Journal of neurochemistry. 76: 480-489
Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia
Koponen S, Goldsteins G, Keinänen R, Koistinaho J. 2000. Journal of cerebral blood flow and metabolism. 20: 93-102
Inhibition of inflammation and neuroprotection by tetracyclines
Yrjänheikki J, Tikka T, Goldsteins G, Koistinaho M, Keinänen R, Chan PH, Koistinaho J. Teoksessa: Krieglstein J, Klumpp S(toim.) , 2000. Pharmacology of Cerebral Ischemia 2000. s. 267-274. Medpharm Scientific Publishers
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH, Koistinaho J. 1999. Proceedings of the National Academy of Sciences of the United States of America. 96: 13496-13500

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Näytä asetukset

{title} {title} {title}

Tarkenna hakuasi

Gundars Goldsteins

Tutkimusryhmät

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Studying non-cell-autonomous neurodegeneration in Parkinson's disease with induced pluripotent stem cells

Metabolic alterations in Parkinson's disease astrocytes

Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms

Dysfunction of Cellular Proteostasis in Parkinson's Disease

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

ER stress and unfolded protein response in amyotrophic lateral sclerosis - a controversial role of protein disulphide isomerase

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

Transcriptional profiling reveals differential expression of a neuropeptide-like protein and pseudogenes in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans

Mutant Cu/Zn-Superoxide Dismutase Induced Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis

Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production

Glycogen synthase kinase-3&#946 : a mediator of inflammation in Alzheimer's disease?

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis

Human intravenous immunoglobulin provides protection against A&#946 toxicity by multiple mechanisms in a mouse model of Alzheimer's disease

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Deleterious role of superoxide dismutase in the mitochondrial intermembrane space

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia

Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits

Oxidative modification of proteins in the frontal cortex of Alzheimer¿s disease brain

Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brain

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach

Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window

The microglia-activating potential of thrombin

Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage

Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation

Induction and activation of protein kinase Cdelta in hippocampus and cortex after kainic acid treatment

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

Proteomic analysis of protein in Alzheimer's disease brain

Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia

Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition

Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia

Inhibition of inflammation and neuroprotection by tetracyclines

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window