ISAAC AFARA

Yhteystiedot

Tutkimusryhmät

• Biophysics of Bone and Cartilage (BBC)

Julkaisut

• Korkalainen, Henri; Leppänen, Timo; Duce, Brett; Kainulainen, Samu; Aakko, Juhani; Leino, Akseli; Kalevo, Laura; Afara, Isaac O; Myllymaa, Sami; Töyräs, Juha. 2021. Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea IEEE journal of biomedical and health informatics [Published online 09 Dec 2020]: -. 2021
• Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Torniainen, Jari; Rieppo, Lassi; Saarakkala, Simo; Afara, Isaac O; Töyräs, Juha. 2021. Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries Journal of raman spectroscopy [Epub ahead of print 7 Jan 2021]: 1-9. 2021
• Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. 2021. Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects Osteoarthritis and cartilage [Publ online December 21, 2020]: 1-39. 2021
• Korkalainen, H; Aakko, J; Duce, B; Kainulainen, S; Leino, A; Nikkonen, S; Afara, I O; Myllymaa, S; Töyräs, J; Leppänen, T. 2020. Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea Sleep 43 11: zsaa098. 2020
• Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J. 2020. Open-source python module for automated preprocessing of near infrared spectroscopic data Analytica chimica acta 1108: 1-9. 2020
• Te Moller, Nikae CR; Mohammadi, Ali; Plomp, Saskia; Serra Bragança, Filipe M; Beukers, Martijn; Pouran, Behdad; Afara, Isaac O; Nippolainen, Ervin; Mäkelä, Janne TA; Korhonen, Rami K; Töyräs, Juha; Brommer, Harold; René van Weeren, P. 2020. Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine groove model study Journal of orthopaedic research [Published online 24 Dec 2020]: 1-29. 2020
• Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Saarakkala, Simo; Töyräs, Juha; Afara, Isaac. 2020. Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries Annals of biomedical engineering [Online ahead of print 2020 Apr 16]: 1-11. 2020
• Mid-infrared spectroscopic assessment of cartilage degeneration. Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Rieppo, Lassi; Haas, Julian; Mizaikoff, Boris; Artyushenko, Viacheslav; Bibikova, Olga; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha / Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019. 2020. 2020
• Mid-infrared and Near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage. Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha / Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019. 2020. 2020
• Optical properties of articular cartilage in the near-infrared spectral range are related to its proteoglycan content. Kafian-Attari, Iman; Semenov, Dmitry; Nippolainen, Ervin; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O / Proceedings Volume 11363, Tissue Optics and Photonics. 2020. 2020
• Kainulainen, Samu; Töyräs, Juha; Oksenberg, Arie; Korkalainen, Henri; Afara, Isaac O; Leino, Akseli; Kalevo, Laura; Nikkonen, Sami; Gadoth, Natan; Kulkas, Antti; Myllymaa, Sami; Leppänen, Timo. 2020. Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness Sleep medicine 73: 231-237. 2020
• Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. 2020. Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination Annals of biomedical engineering [Epub ahead of print 20 Aug 2020]: 1-10. 2020
• Automated Preprocessing of Near Infrared Spectroscopic Data. Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J / Bio-Optics: Design and Application 2019. 2020. 2020
• Afara, Isaac O; Sarin, Jaakko K; Ojanen, Simo; Finnilä, Mikko A J; Herzog, Walter; Saarakkala, Simo; Korhonen Rami K; Töyräs, Juha. 2020. Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy Cellular and molecular bioengineering 13 3: 219-228. 2020
• Arthroscopic near-infrared spectroscopic prediction of human meniscus properties. Ala-Myllymäki, Juho; Paakkonen, Tommi; Töyräs, Juha; Afara, Isaac O / Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019. 2020. 2020
• Ala-Myllymäki, Juho; Paakkonen, Tommi; Joukainen, Antti; Kröger, Heikki; Lehenkari, Petri; Töyräs, Juha; Afara, Isaac O. 2020. Near-Infrared Spectroscopy for Mapping of Human Meniscus Biochemical Constituents Annals of biomedical engineering [Online ahead of print 2020 Jul 27]: 1-8. 2020
• Kafian-Attari, Iman; Nippolainen, Ervin; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O. 2020. Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity Biomedical optics express 11 11: 6480-6494. 2020
• Rasel, MAI; Singh, S; Nguyen, TD; Afara, IO; Gu, Y. 2019. Impact of Nanoparticle Uptake on the Biophysical Properties of Cell for Biomedical Engineering Applications Scientific reports 9: 5859. 2019
• Sarin, JK; Torniainen, J; Prakash, M; Rieppo, L; Afara, IO; Töyräs, J. 2019. Dataset on equine cartilage near infrared spectra, composition, and functional properties Scientific data 6 1: 164. 2019
• Sarin, JK; Nykänen, O; Tiitu, V; Mancini, IAD; Brommer, H; Visser, J; Malda, J; van Weeren, PR; Afara, IO; Töyräs, J. 2019. Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy Annals of biomedical engineering 47 8: 1815-1826. 2019
• Nikkonen, S; Afara, IO; Leppänen, T; Töyräs, J. 2019. Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea Scientific reports 9 1: 13200. 2019
• Prakash, M; Joukainen, A; Torniainen, J; Honkanen, MKM; Rieppo, L; Afara, IO; Kröger, H; Töyräs, J; Sarin, JK. 2019. Near infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy Osteoarthritis and cartilage 27 8: 1235-1243. 2019
• Mancini, IAD; Rieppo, L; Pouran, B; Afara, IO; Braganca, FMS; van Rijen, MHP; Kik, M; Weinans, H; Toyras, J; van Weeren, PR; Malda, J. 2019. Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species Bone 127: 664-673. 2019
• Korkalainen, Henri; Aakko, Juhani; Nikkonen, Sami; Kainulainen, Samu; Leino, Akseli; Duce, Brett; Afara, Isaac Oluwaseun; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. 2019. Accurate Deep Learning-Based Sleep Staging in a Clinical Population with Suspected Obstructive Sleep Apnea IEEE journal of biomedical and health informatics 24 7: 2073-2081. 2019
• Torniainen, Jari; Ristaniemi, Aapo; Sarin, Jaakko K; Mikkonen, Santtu; Afara, Isaac O; Stenroth, Lauri; Korhonen, Rami K; Töyräs, Juha. 2018. Near Infrared Spectroscopic Evaluation of Ligament and Tendon Biomechanical Properties ANNALS OF BIOMEDICAL ENGINEERING 2019; 47 1: 213-222. 2018
• Prakash, M; Sarin, JK; Rieppo, L; Afara IO; Töyräs, J. 2018. Accounting for spatial dependency in multivariate spectroscopic data CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 182: 166-171. 2018
• Spectroscopic Evaluation of Post-Traumatic Osteoarthritis in Shetland Ponies. Sarin, Jaakko K; te Moller, Nikae; Brommer, Harold; van Weeren, René; Mancini, Irina; Malda, Josa; Afara, Isaac O; Töyräs, Juha / Optical Tomography and Spectroscopy 2018. 2018. 2018
• Sarin, Jaakko K; Te Moller, Nikae CR; Mancini, Irina AD; Brommer, Harold; Visser, Jetze; Malda, Jos; van Weeren, PR; Afara, Isaac O; Töyräs, Juha. 2018. Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo Scientific reports 8 1: 13409. 2018
• Arabshahi, Zohreh; Afara, Isaac Oluwaseun; Moody, Hayley Ruscoe; Schrobback, Karsten; Kashani, Jamal; Fischer, Nadine; Oloyede, Adekunle; Klein, Travis Jacob. 2018. A new mechanical indentation framework for functional assessment of articular cartilage. Journal of the Mechanical Behavior of Biomedical Materials 81: 83-94. 2018
• Near-infrared spectroscopy: A potential tool for mapping meniscus properties. Ala-Myllymäki, Juho P.; Töyräs, Juha; Afara, Isaac O. / Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS). 2018. 2018
• Moody, HR; Afara, IO; Singh, S; Oloyede, A. 2018. Potential enhancement of articular cartilage histological grading with collagen integrity. CLINICAL BIOMECHANICS 56: 1-10. 2018
• Deep Learning Classification of Cartilage Integrity Using Near Infrared Spectroscopy. Afara, Isaac O.; Sarin, Jaakko K.; Ojanen, Simo; Finnilä, Mikko; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami; Töyräs, Juha / Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS). 2018. 2018
• Afara, IO; Florea, C; Olumegbon, IA; Eneh, CT; Malo, MKH; Korhonen, RK; Töyräs, J. 2018. Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy Scientific Reports 8 1: 9733. 2018
• Near-infrared spectroscopy based arthroscopic evaluation of human knee joint cartilage, through automated selection of an anatomically specific regression model. Prakash, Mithilesh; Joukainen, Antti; Sarin, Jaakko; Rieppo, Lassi; Afara, Isaac; Töyräs, Juha / Optical Tomography and Spectroscopy 2018. 2018. 2018
• Olumegbon Ismail Adewale, Oloyede Adekunle, Afara Isaac Oluwaseun. 2017. Near-infrared (NIR) spectroscopic evaluation of articular cartilage: A review of current and future trends. Applied Spectroscopy Reviews 52 6: 541-559. 2017
• Sarin Jaakko Kalevi, Brommer Harold, Argüelles David, Puhakka Pia Henriikka, Inkinen Satu Irene, Afara Isaac Oluwaseun, Saarakkala Simo, Töyräs Juha. 2017. Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo. OSTEOARTHRITIS AND CARTILAGE 25 5: 790-798. 2017
• Prakash M, Sarin JK, Rieppo L, Afara IO, Töyräs J. 2017. Optimal Regression Method for Near-Infrared Spectroscopic Evaluation of Articular Cartilage. APPLIED SPECTROSCOPY 71 10: 2253-2262. 2017
• Sarin Jaakko K, Rieppo Lassi, Brommer Harold, Afara Isaac O, Saarakkala Simo, Töyräs Juha. 2017. Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure. Scientific Reports 7 1: 10586. 2017
• Eneh Chibuzor TM, Afara Isaac O, Malo Markus KH, Jurvelin Jukka S, Töyräs Juha. 2017. Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment. The Journal of the Acoustical Society of America 141 1: 575-585. 2017
• Ala-Myllymäki Juho, Danso Elvis K, Honkanen Juuso TJ, Korhonen Rami K, Töyräs J, Afara Isaac O. 2017. Optical spectroscopic characterization of human meniscus biomechanical properties. Journal of Biomedical Optics 22 12: 125008 (10 pages). 2017
• Afara Isaac Oluwaseun, Singh Sanjleena, Moody Hayley, Zhang Lihai, Oloyede Adekunley. 2017. Characterization of Articular Cartilage Recovery and Its Correlation with Optical Response in the Near-Infrared Spectral Range. Cartilage 8 3: 307-316. 2017
• Afara IO, Prasadam I, Arabshahi Z, Xiao Y, Oloyede A. 2017. Monitoring osteoarthritis progression using near infrared (NIR) spectroscopy. Scientific Reports 7 1: 11463. 2017
• Pawlak Zenon, Urbaniak Wieslaw, Afara Isaac O, Yusuf Kehinde Q, Banaszak-Piechowska Agnieszka, Oloyede Adekunle. 2016. Tribological efficacy and stability of phospholipid-based membrane lubricants in varying pH chemical condition. Biointerphases 11 1: 019002. 2016
• Sarin Jaakko K, Amissah Michael, Brommer Harold, Argüelles David, Töyräs Juha, Afara Isaac O. 2016. Near Infrared Spectroscopic Mapping of Functional Properties of Equine Articular Cartilage. ANNALS OF BIOMEDICAL ENGINEERING 44 11: 3335-3345. 2016
• Te Moller NC, Pitkänen M, Sarin JK, Väänänen S, Liukkonen J, Afara IO, Puhakka PH, Brommer H, Niemelä T, Tulamo RM, Arqüelles Capilla D, Töyräs J. 2016. Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images. EQUINE VETERINARY JOURNAL [Epub ahead of print 20 Oct 2016]: -. 2016
• Afara Isaac O, Hauta-Kasari Markku, Jurvelin Jukka S, Oloyede Adekunle, Töyräs Juha. 2015. Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition. PHYSIOLOGICAL MEASUREMENT 36 9: 1913-1928. 2015
• Afara Isaac O, Moody Hayley, Singh Sanjleena, Prasadam Indira, Oloyede Adekunle. 2015. Spatial mapping of proteoglycan content in articular cartilage using near-infrared (NIR) spectroscopy. Biomedical Optics Express 6 1: 144-154. 2015
• Ala-Myllymäki Juho, Honkanen Juuso TJ, Töyräs Juha, Afara Isaac O. 2015. Optical spectroscopic determination of human meniscus composition. JOURNAL OF ORTHOPAEDIC RESEARCH 2016; 34 2: 270-278. 2015
• Puhakka Jani, Afara Isaac O, Paatela Teemu, Sormaala Markus J, Timonen Matti A, Virén Tuomas, Jurvelin Jukka S, Töyräs Juha, Kiviranta Ilkka. 2015. In Vivo Evaluation of the Potential of High-Frequency Ultrasound for Arthroscopic Examination of the Shoulder Joint. Cartilage 2016; 7 3: 248-255. 2015
• Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2015. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. OSTEOARTHRITIS AND CARTILAGE 23 12: 2206-2213. 2015
• Singh Sanjleena, Afara Isaac O, Tehrani Ashkan H, Oloyede Adekunle. 2015. Effect of decellularization on the load-bearing characteristics of articular cartilage matrix. Tissue Engineering and Regenerative Medicine 12 5: 294-305. 2015