JUKKA LEPPäNEN

Yhteystiedot

Avainsanat

Opetustehtävät

Tutkimusryhmät

• Farmasian analytiikkayksikkö
• Soveltava kemia

Julkaisut

• Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing Molecular pharmaceutics 17 6: 1945-1953. 2020
• Xu, Wujun; Cui, Pang; Happonen, Emilia; Leppänen, Jukka; Liu, Lizhi; Rantanen, Jimi; Majda, Dorota; Saukko, Annina; Thapa, Rinez; Nissinen, Tuomo; Tynkkynen, Tuulia; Töyräs, Juha; Fan, Li; Liu, Wenchao; Lehto, Vesa-Pekka. 2020. Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion Acs applied materials and interfaces 12 42: 47233-47244. 2020
• Pocasap, P; Weerapreeyakul, N; Timonen, J; Järvinen, J; Leppänen, J; Kärkkäinen, J; Rautio, J. 2020. Tyrosine-chlorambucil conjugates facilitate cellular uptake through L-type amino acid transporter 1 (LAT1) in human breast cancer cell line MCF-7 International journal of molecular sciences 21 6: 2132. 2020
• Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET) American journal of clinical nutrition 110 5: 1108-1118. 2019
• Turhanen, Petri; Leppänen, Jukka; Vepsäläinen, Jouko J. 2019. Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach ACS omega 4 5: 8974-8984. 2019
• Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. Diets rich in whole grains increase betainized compounds associated with glucose metabolism American journal of clinical nutrition 108 5: 971-979. 2018
• Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes Scientific reports 8: 13036. 2018
• Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. 2018. Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase Bioorganic chemistry 80: 655-667. 2018
• Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 97-111. 2017
• Sangthonga S, Weerapreeyakulb N, Lehtonen M, Leppanen J, Rautio J. 2017. High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish). Journal of Functional Foods 31: 237-247. 2017
• Gynther Mikko, Peura Lauri, Vernerová Monika, Leppänen Jukka, Kärkkäinen Jussi, Lehtonen Marko, Rautio Jarkko, Huttunen Kristiina M. 2016. Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure. NEUROCHEMICAL RESEARCH 41 10: 2797-2809. 2016
• Riikonen Joakim, Correia Alexandra, Kovalainen Miia, Näkki Simo, Lehtonen Marko, Leppänen Jukka, Rantanen Jimi, Xu Wujun, Araújo Francisca, Hirvonen Jouni, Järvinen Kristiina, Santos Hélder A, Lehto Vesa-Pekka. 2015. Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib. BIOMATERIALS 52: 44-55. 2015
• Rautio Jarkko, Huttunen Kristiina, Gynther Mikko, Laine Krista, Leppänen Jukka, Kärkkäinen Jussi, Malmioja Kalle. 2014. Aihiolääketeknologia lääkekehityksessä. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 209. 2014
• Tani Niina, Juvonen Risto O, Raunio Hannu, Fashe Muluneh, Leppänen Jukka, Zhao Bin, Tyndale Rachel F, Rahnasto-Rilla Minna. 2014. Rational design of novel CYP2A6 inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 22 23: 6655-6664. 2014
• Ylikangas Henna, Malmioja Kalle, Peura Lauri, Gynther Mikko, Nwachukwu Emmanuel O, Leppänen Jukka, Laine Krista, Rautio Jarkko, Lahtela-Kakkonen Maija, Huttunen Kristiina M, Poso Antti. 2014. Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1). CHEMMEDCHEM 9: 2699-2707. 2014
• Peura Lauri, Malmioja Kalle, Huttunen Kristiina, Leppänen Jukka, Hämäläinen Miia, Forsberg Markus M, Gynther Mikko, Rautio Jarkko, Laine Krista. 2013. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. PHARMACEUTICAL RESEARCH 30: 2523-2537. 2013
• Patel Jayendra Z, Parkkari Teija, Laitinen Tuomo, Kaczor Agnieszka A, Saario Susanna M, Savinainen Juha R, Navia-Paldanius Dina, Cipriano Mariateresa, Leppänen Jukka, Koshevoy Igor O, Poso Antti, Fowler Christopher J, Laitinen Jarmo T, Nevalainen Tapio. 2013. Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 56: 8484-8496. 2013
• Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko. 2013. Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 49: 624-628. 2013
• Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko. 2012. In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin. JOURNAL OF PHARMACEUTICAL SCIENCES 101 8: 2854-2860. 2012
• Ylikangas Henna, Peura Lauri, Malmioja Kalle, Leppänen Jukka, Laine Krista, Poso Antti, Lahtela-Kakkonen Maija, Rautio Jarkko. 2012. Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2013:48: 523-531. 2012
• Huhtiniemi Tero, Salo Heikki S, Suuronen Tiina, Poso Antti, Salminen Antero, Leppänen Jukka, Jarho Elina, Lahtela-Kakkonen Maija. 2011. Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2 JOURNAL OF MEDICINAL CHEMISTRY 54: 6456-6468. 2011
• Kalle Malmioja, Lauri Peura, Krista Laine, Jukka Leppänen, Mikko Gynther, Jarkko Rautio. 2011. New Prodrug Design Ideas for Transporter-Mediated CNS Drug Delivery. Teoksessa: (toim.), Current Medicinal Chemistry Special Issue Abstracts. ss. 181. 2011
• Peura L, Malmioja K, Laine K, Leppänen J, Gynther M & Rautio J. 2011. New Prodrug Desing Ideas for Large Amino Acid Transporter 1 -Mediated Drug Brain Delivery, BioMedical Transporters 2011: Membrane Transporters in Drug Discovery. P30. 2011
• Peura Lauri, Malmioja Kalle, Laine Krista, Leppänen Jukka, Gynther Mikko, Isotalo Antti, Rautio Jarkko. 2011. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery. Molecular Pharmaceutics 8 5: 1857-1866. 2011
• Rahnasto Minna K, Raunio Hannu A, Wittekindt Carsten, Salminen Kaisa A, Leppänen Jukka, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija K. 2011. Identification of novel CYP2A6 inhibitors by virtual screening BIOORGANIC AND MEDICINAL CHEMISTRY 19: 7186-7193. 2011
• Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics. DRUG METABOLISM AND DISPOSITION 39 3: 412 - 418. 2011
• Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. Brain uptake of ketoprofen-lysine prodrug in rats. INTERNATIONAL JOURNAL OF PHARMACEUTICS 399: 121-128. 2010
• Huhtiniemi T, Suuronen T, Lahtela-Kakkonen M, Bruijn T, Jääskeläinen S, Poso A, Salminen A, Leppänen J & Jarho E. 2010. N(epsilon)-modified lysine containing inhibitors for SIRT1 and SIRT2. BIOORGANIC AND MEDICINAL CHEMISTRY 18: 5616-5625. 2010
• Partanen HA, El-Nezami HS, Leppänen JM, Myllynen PK, Woodhouse HJ & Vähäkangas KH. 2010. Aflatoxin B1 transfer and metabolism in human placenta. TOXICOLOGICAL SCIENCES 113 1: 216 - 225. 2010
• Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 20: 2614 - 2616. 2010
• Minkkilä A, Myllymäki MJ, Saario SM, Castillo-Melendez JA, Koskinen AMP, Fowler CJ, Leppänen J, Nevalainen T. 2009. The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44: 2994-3008. 2009
• Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. 2009. Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. CHEMMEDCHEM 4: 1253-1259. 2009
• Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J. 2009. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats. JOURNAL OF MEDICINAL CHEMISTRY 52: 3348-3353. 2009
• Kiviranta PH, Suuronen T, Wallén EAA, Leppänen J, Tervonen J, Kyrylenko S, Salminen A, Poso A, Jarho EM. 2009. N(epsilon)-Thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 52: 2153-2156. 2009
• Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P. 2009. Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 50: 469-474. 2009
• Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. 2009. The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption. JOURNAL OF MEDICINAL CHEMISTRY 52: 4142-4148. 2009
• Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. 2008. Large neutral amino acid transporter enables brain drug delivery via prodrugs. JOURNAL OF MEDICINAL CHEMISTRY 51: 932-936. 2008
• Huhtiniemi T, Suuronen T, Rinne VM, Wittekindt C, Lahtela-Kakkonen M, Jarho E, Wallén EAA, Salminen A, Poso A, Leppänen J. 2008. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 51: 4377-4380. 2008
• Huttunen KM, Leppänen J, Kemppainen E, Palonen P, Rautio J, Järvinen T, Vepsäläinen J. 2008. Towards metformin prodrugs SYNTHESIS 22: 3619-3624. 2008