KRISTA LAINE

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Julkaisut

• Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake INTERNATIONAL JOURNAL OF PHARMACEUTICS 544 1: 91-99. 2018
• Rautio Jarkko, Huttunen Kristiina, Gynther Mikko, Laine Krista, Leppänen Jukka, Kärkkäinen Jussi, Malmioja Kalle. 2014. Aihiolääketeknologia lääkekehityksessä. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 209. 2014
• Ylikangas Henna, Malmioja Kalle, Peura Lauri, Gynther Mikko, Nwachukwu Emmanuel O, Leppänen Jukka, Laine Krista, Rautio Jarkko, Lahtela-Kakkonen Maija, Huttunen Kristiina M, Poso Antti. 2014. Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1). CHEMMEDCHEM 9: 2699-2707. 2014
• Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko. 2013. Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 49: 624-628. 2013
• Peura Lauri, Malmioja Kalle, Huttunen Kristiina, Leppänen Jukka, Hämäläinen Miia, Forsberg Markus M, Gynther Mikko, Rautio Jarkko, Laine Krista. 2013. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. PHARMACEUTICAL RESEARCH 30: 2523-2537. 2013
• Rautio Jarkko, Gynther Mikko, Laine Krista. 2013. LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?. Therapeutic Delivery 4 3: 281-284. 2013
• Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko. 2012. In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin. JOURNAL OF PHARMACEUTICAL SCIENCES 101 8: 2854-2860. 2012
• Vig Balvinder S, Huttunen Kristiina M, Laine Krista, Rautio Jarkko. 2012. Amino acids as promoieties in prodrug design and development. ADVANCED DRUG DELIVERY REVIEWS 2013:65: 1370-1385. 2012
• Ylikangas Henna, Peura Lauri, Malmioja Kalle, Leppänen Jukka, Laine Krista, Poso Antti, Lahtela-Kakkonen Maija, Rautio Jarkko. 2012. Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2013:48: 523-531. 2012
• Kalle Malmioja, Lauri Peura, Krista Laine, Jukka Leppänen, Mikko Gynther, Jarkko Rautio. 2011. New Prodrug Design Ideas for Transporter-Mediated CNS Drug Delivery. Teoksessa: (toim.), Current Medicinal Chemistry Special Issue Abstracts. ss. 181. 2011
• Laine Krista, Huttunen Kristiina. 2011. Enzyme-activated prodrug strategies for site-selective drug delivery: Rautio Jarkko, Prodrugs and Targeted Delivery. Methods and Principles in Medicinal Chemistry 47. 231-252. 2011
• Peura L, Malmioja K, Laine K, Leppänen J, Gynther M & Rautio J. 2011. New Prodrug Desing Ideas for Large Amino Acid Transporter 1 -Mediated Drug Brain Delivery, BioMedical Transporters 2011: Membrane Transporters in Drug Discovery. P30. 2011
• Peura Lauri, Malmioja Kalle, Laine Krista, Leppänen Jukka, Gynther Mikko, Isotalo Antti, Rautio Jarkko. 2011. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery. Molecular Pharmaceutics 8 5: 1857-1866. 2011
• Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. Brain uptake of ketoprofen-lysine prodrug in rats. INTERNATIONAL JOURNAL OF PHARMACEUTICS 399: 121-128. 2010
• Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 20: 2614 - 2616. 2010
• Rautio Jarkko, Laine Krista, Fang Lanyan, Han Bing, Huttunen Kristiina, Sun Duxin. 2010. Enzyme-activated prodrug strategies for targeted drug action: Ram I. Mahato and Ajit S. Narang, Targeted Delivery of Small and Macromolecular Drugs.CRC Press, Taylor& Francis Group. 311-348. 2010
• Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. 2009. The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption. JOURNAL OF MEDICINAL CHEMISTRY 52: 4142-4148. 2009
• Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J. 2009. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats. JOURNAL OF MEDICINAL CHEMISTRY 52: 3348-3353. 2009
• Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. 2008. Large neutral amino acid transporter enables brain drug delivery via prodrugs. JOURNAL OF MEDICINAL CHEMISTRY 51: 932-936. 2008
• Rautio J, Laine K, Gynther M. 2008. Enhanced brain drug delivery and targeting. PHARMACEUTICAL TECHNOLOGY EUROPE 20 4: 27-33. 2008
• Rautio Jarkko, Laine Krista, Gynther Mikko, Savolainen Jouko. 2008. Prodrug approaches for CNS delivery. AAPS JOURNAL [ONLINE:HTTP://WWW.AAPSPHARMSCI.ORG/] 10: 92-102. 2008
• Niemi R, Huuskonen J, Laine K, Järvinen T. 2005. Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs. INTERNATIONAL JOURNAL OF PHARMACEUTICS 295: 121-127. 2005
• Laine K. 2004. Elimistön kannabinoidijärjestelmään vaikuttavat yhdisteet alentavat kaniinien silmänpainetta DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 20 4: 319-324. 2004
• Laine K. 2004. Intraocular Pressure Lowering Activities of Endogenous Cannabinoids, and Their Uptake and Enzyme Hydrolysis Inhibitors in Normotensive Rabbits. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2004
• Laine K, Järvinen K, Järvinen T. 2003. Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits LIFE SCIENCES 72: 837-842. 2003
• Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. 2003. Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether JOURNAL OF MEDICINAL CHEMISTRY 46: 5083-5086. 2003
• Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T. 2003. Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: 37-43. 2003
• Järvinen T, Pate DW, Laine K. 2002. Cannabinoids in the treatment of glaucoma. PHARMACOLOGY AND THERAPEUTICS 95: 203-220. 2002
• Laine K, Järvinen K, Mechoulam R, Breuer A, Järvinen T. 2002. Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 43 10: 3216-3222. 2002
• Laine K, Järvinen K, Pate DW, Urtti A, Järvinen T. 2002. Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 43 2: 393-397. 2002
• Laine K, Järvinen K, Järvinen T. 2001. Kannabinoidit - tulevaisuuden lääkeaineita?. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 17 1: 39-50. 2001
• Laine K, Järvinen T, Savinainen J, Laitinen JT, Pate DW, Järvinen K. 2001. Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits. PHARMACEUTICAL RESEARCH 18 4: 494-499. 2001
• Savinainen JR, Järvinen T, Laine K, Laitinen JT. 2001. Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes. BRITISH JOURNAL OF PHARMACOLOGY 134: 664-672. 2001
• Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 11: 157-163. 2000
• Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery JOURNAL OF MEDICINAL CHEMISTRY 43 8: 1489-1494. 2000