MARIKA RUPONEN

Yhteystiedot

Tutkimusryhmät - UEF

• 
  Silmälääketutkimusryhmä

Julkaisut

• del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations International journal of pharmaceutics 613: 121361. 2022
• Ruponen, Marika; Kettunen, Konsta; Santiago Pires, Monica; Laitinen, Riikka. 2021. Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs Pharmaceutics 13 2: 171. 2021
• Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin Pharmaceutics 13 4: 452. 2021
• Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits European journal of pharmaceutical sciences 159: 105720. 2021
• Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues Pharmaceutics 13 5: 658. 2021
• Pilipenko, Iuliia; Korzhikov-Vlakh, Viktor; Valtari, Annika; Anufrikov, Yurii; Kalinin, Stanislav; Ruponen, Marika; Krasavin, Mikhail; Urtti, Arto; Tennikova, Tatiana. 2021. Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers International journal of biological macromolecules 186: 864-872. 2021
• Junnuthula, Vijayabhaskarreddy; Sadeghi Boroujeni, Amir; Cao, Shoupeng; Tavakoli, Shirin; Ridolfo, Roxane; Toropainen, Elisa; Ruponen, Marika; van Hest, Jan CM; Urtti, Arto. 2021. Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region Pharmaceutics 13 4: 445. 2021
• Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye European journal of pharmaceutics and biopharmaceutics 166: 155-162. 2021
• Bassetto M, Ajoy D, Poulhes F, Obringer C, Walter A, Messadeq N, Sadeghi A, Puranen J, Ruponen M, Kettunen M, Toropainen E, Urtti A, Dollfus H, Zelphati O, Marion V. 2021. Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice Pharmaceutics 13 10: 1650. 2021
• Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits European journal of pharmaceutical sciences 155: 105553. 2020
• Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery Pharmaceutics 12 2: 176. 2020
• Hemmilä, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi. 2020. Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies SLAS technology 25 5: 455-462. 2020
• Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G; Urtti, Arto. 2020. Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models Pharmaceutics 12 7: E611. 2020
• Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models. Pharmaceutics 12 7: 667. 2020
• Ruponen, Marika; Rusanen, Henna; Laitinen, Riikka. 2020. Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide Journal of pharmaceutical sciences 109 7: 2252-2261. 2020
• Tavakoli, Shirin; Peynshaert, Karen; Lajunen, Tatu; Devoldere, Joke; Del Amo, Eva M; Ruponen, Marika; De Smedt, Stefaan C; Remaut, Katrien; Urtti, Arto. 2020. Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface Journal of controlled release 328: 952-961. 2020
• Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing Molecular pharmaceutics 17 6: 1945-1953. 2020
• Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function Acta ophthalmologica [Epub ahead of print 10 Oct 2019]: 1-10. 2019
• Turunen, Veera; Peräniemi, Sirpa; Tolvanen, Katariina; Kokki, Merja; Ruponen, Marika; Kokki, Hannu. 2019. The permeability of magnesium across the skin is enhanced by menthol cream Magnesium research 32 4: 118-123. 2019
• Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties Drug discovery today 24 8: 1446-1457. 2019
• Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier European journal of pharmaceutics and biopharmaceutics 140: 91-99. 2019
• Sormunen, Henri; Ruponen, Marika; Laitinen, Riikka. 2019. The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer International journal of pharmaceutics 570: 118653. 2019
• Serri, Carla; Frigione, Mariaenrica; Ruponen, Marika; Urtti, Arto; Borzacchiello, Assunta; Biondi, Marco; Mayol, Laura. 2019. Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles Colloids and surfaces b: biointerfaces 181: 896-901. 2019
• Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar'in, Dmitry; Urtti, Arto; Supuran, Claudiu T; Krasavin, Mikhail. 2019. Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhi bitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure Bioorganic and medicinal chemistry 27 11: 115086. 2019
• Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019
• Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model Scientific reports 9 1: 13761. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation European journal of pharmaceutics and biopharmaceutics 143: 18-23. 2019
• Peräsuoli lääkeaineen antoreittinä. Ruponen, Marika; Mönkkönen, Jukka; Pajula, Katja / Biofarmasian perusteet. 2018. 2018
• Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi. 2018. Expression, activity and pharmacokinetic impact of ocular transporters ADVANCED DRUG DELIVERY REVIEWS 126: 3-22. 2018
• Suuontelo lääkeaineen antoreittinä. Ruponen, Marika; Pajula, Katja / Biofarmasian perusteet. 2018. 2018
• Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Ruponen, Marika; Pajula, Katja; Honkakoski, Paavo; Urtti, Arto (toim.). 2018. Biofarmasian perusteet. Farmasian opiskelijayhdistys Fortis ry. 2018
• Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye European journal of pharmaceutical sciences 119: 83-89. 2018
• Lääkkeenanto laskimoon, lihakseen ja ihan alle. Urtti, Arto; Ruponen, Marika / Biofarmasian perusteet. 2018. 2018
• Nenä lääkeaineen antoreittinä. Ruponen, Marika; Mönkkönen, Jukka; Pajula, Katja / Biofarmasian perusteet. 2018. 2018
• Lääkkeiden antoreitit. Ruponen, Marika; Pajula, Katja / Biofarmasian perusteet. 2018. 2018
• Lääkemuodot ja antoreitit. Mönkkönen, Jukka; Ruponen, Marika / Farmakologia ja toksikologia. 2018. 2018
• Lajunen, T; Nurmi, R; Wilbie, D; Ruoslahti, T; Johansson, NG; Korhonen, O; Rog, T; Bunker, A; Ruponen, M; Urtti, A. 2018. The effect of light sensitizer localization on the stability of indocyanine green liposomes JOURNAL OF CONTROLLED RELEASE 284: 213-223. 2018
• Keuhkot lääkeaineen antoreittinä. Ruponen, Marika; Pajula, Katja; Mönkkönen, Jukka; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Iho lääkeaineiden antoreittinä. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. Esterase activity in porcine and albino rabbit ocular tissues European journal of pharmaceutical sciences 123: 106-110. 2018
• Biofarmasian perustekijät. Urtti, Arto; Yliperttula, Marjo; Ruponen, Marika / Biofarmasian perusteet. 2018. 2018
• Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
• Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model. JOURNAL OF PHARMACEUTICAL SCIENCES 106 9: 2463-2471. 2017
• Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko (toim.). 2017. Farmakokinetiikan perusteet. Farmasian opiskelijayhdistys Fortis ry. 2017
• Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 109: 162-168. 2017
• del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017
• Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling. Molecular Pharmaceutics 13 4: 1358-1365. 2016
• Ilina Polina, Partti Susanna, Niklander Johanna, Ruponen Marika, Lou Yan-Ru, Yliperttula Marjo. 2015. Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models. EXPERIMENTAL CELL RESEARCH 332 1: 89-101. 2015
• Ruponen Marika, Urtti Arto. 2015. Undefined role of mucus as a barrier in ocular drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 96: 442-446. 2015
• Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship: Pellinen Riikka, The First PhD student Symposium of the Faculty of Health Sciences : Health research within life span : Abstracts.Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Reports and Studies in Health Sciences 12. 44. 2014
• Nomani Alireza, Hyvönen Zanna, Pulkkinen Eveliina, Hiekkala Marjo, Ruponen Marika. 2014. Intracellular gene delivery is dependent on the type of non-viral carrier and defined by the cell surface glycosaminoglycans. JOURNAL OF CONTROLLED RELEASE 187: 59-65. 2014
• Soininen Suvi K, Lehtolainen-Dalkilic Pauliina, Karppinen Tanja, Puustinen Tiina, Dragneva Galina, Kaikkonen Minna U, Jauhiainen Marjo, Allart Brigitte, Selwood David L, Wirth Thomas, Lesch Hanna P, Määttä Ann-Marie, Mönkkönen Jukka, Ylä-Herttuala Seppo, Ruponen Marika. 2012. Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 47: 848-856. 2012
• Ilina Polina, Hyvonen Zanna, Saura Maeva, Sandvig Kirsten, Yliperttula Marjo, Ruponen Marika. 2012. Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems. JOURNAL OF CONTROLLED RELEASE 163: 385-395. 2012
• Ruponen M, Arkko S, Urtti A, Reinisalo M, Ranta V-P. 2009. Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection. JOURNAL OF CONTROLLED RELEASE 136: 226-231. 2009
• Pitkänen L, Pelkonen J, Ruponen M, Rönkkö S, Urtti A. 2004. Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an vitro bovine eye model. AAPS JOURNAL [ONLINE:HTTP://WWW.AAPSPHARMSCI.ORG/] 6 3: 1-9. 2004
• Ruponen M, Honkakoski P, Tammi M, Urtti A. 2004. Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer. JOURNAL OF GENE MEDICINE 6: 405-414. 2004
• Ruponen M, Honkakoski P, Rönkkö S, Pelkonen J, Tammi M, Urtti A. 2003. Extracellular and intracellular barriers in non-viral gene delivery. JOURNAL OF CONTROLLED RELEASE 93: 213-217. 2003
• Ruponen M, Rönkkö S, Honkakoski P, Pelkonen J, Tammi M, Urtti A. 2001. Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes. JOURNAL OF BIOLOGICAL CHEMISTRY 276 36: 33875-33880. 2001
• Ruponen M, Ylä-Herttuala S, Urtti A. 1999. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies BIOCHIMICA ET BIOPHYSICA ACTA 1415: 331-341. 1999