MARJA RYTKöNEN-NISSINEN

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Julkaisut

• Kirvesniemi, Julia; Rytkönen-Nissinen, Marja; Karppinen, Minna; Lindstedt, Sirpa; Kumpulainen, Jonna; Kullaa, Arja. 2019. Poistettujen hampaiden desinfektiomenetelmät Suomen hammaslääkärilehti 26 4: 34-38. 2019
• Virtanen, Tuomas; Rytkönen-Nissinen, Marja. 2019. Commentary: Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma Frontiers in immunology 10: 2266. 2019
• Kailaanmäki A, Kinnunen T, Rönkä A, Rytkönen-Nissinen M, Lidholm J,Mattsson L, Randell J, Virtanen T. 2016. Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein. Clinical & Experimental Allergy 46 5: 720-729. 2016
• Niemi Merja H, Rytkönen-Nissinen Marja, Miettinen Ilja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2015. Dimerization of lipocalin allergens. Scientific Reports 5: 13841. 2015
• Rytkönen-Nissinen Marja, Saarelainen Soili, Randell Jukka, Häyrinen Jukka, Kalkkinen Nisse, Virtanen Tuomas. 2015. IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification. ALLERGY, ASTHMA & IMMUNOLOGY RESEARCH 7 4: 384-392. 2015
• Rönkä Aino L, Kinnunen Tuure T, Goudet Amélie, Rytkönen-Nissinen Marja A, Sairanen Joni, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2015. Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 136 4: 1047-1054.e10. 2015
• Liukko Aino LK, Kinnunen Tuure T, Rytkönen-Nissinen Marja A, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2014. Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other. PLOS ONE [ONLINE] 9: 1-11. 2014
• Niemi Merja H, Rytkönen-Nissinen Marja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2014. Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4. MOLECULAR IMMUNOLOGY 61 1: 7-15. 2014
• Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2014. Mammalian Allergens: Richard F. Lockey, Dennis K. Ledford, Allergens and Allergen Immunotherapy subcutaneous, sublingual and oral. 217-234. 2014
• Kailaanmäki Anssi, Kinnunen Tuure, Kwok William W, Rytkönen-Nissinen Marja, Randell Jukka, Virtanen Tuomas. 2013. Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. IMMUNOLOGY 141 1: 52-60. 2013
• Parviainen S, Kinnunen T, Rytkönen-Nissinen M, Nieminen A, Liukko A, Virtanen T. 2013. Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 77: 171-176. 2013
• Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2012. Mammalian lipocalin allergens--insights into their enigmatic allergenicity Clinical & Experimental Allergy 42: 494-504. 2012
• Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217 1: 8-12. 2012
• Kinnunen T, Nieminen A, Kwok W W, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Taivainen A & Virtanen T.. 2010. Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. EUROPEAN JOURNAL OF IMMUNOLOGY 40 9: 2460-2469. 2010
• Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. MOLECULAR IMMUNOLOGY 46: 3320-3327. 2009
• Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008
• Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues IMMUNOLOGY 123: 358-366. 2008
• Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T. 2007. The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes. CLINICAL AND EXPERIMENTAL ALLERGY 37: 939-947. 2007
• Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy. IMMUNOLOGY 120: 38-46. 2007
• Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119: 965-972. 2007
• Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa. DUODECIM 123: 775-776. 2007
• Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1 CLINICAL AND EXPERIMENTAL ALLERGY 35: 797-803. 2005
• Porre S, Heinonen S, Mäntyjärvi R, Rytkönen-Nissinen M, Perola O, Rautiainen J, Virtanen T. 2005. Psoriasin, a calcium-binding protein with chemotactic properties is present in the third trimester amniotic fluid MOLECULAR HUMAN REPRODUCTION 11 2: 87-92. 2005
• Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy. JOURNAL OF IMMUNOLOGY (BALTIMORE) 175 6: 3614-3620. 2005
• Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. INTERNATIONAL IMMUNOLOGY (OXFORD) 17 12: 1573-1581. 2005
• Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004
• Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. CLINICAL AND EXPERIMENTAL ALLERGY 33: 834-841. 2003
• Saarelainen S, Zeiler T, Rautiainen J, Närvänen A, Rytkönen-Nissinen M, Mäntyjärvi R, Vilja P, Virtanen T. 2002. Lipocalin allergen Bos d 2 is a weak immunogen. INTERNATIONAL IMMUNOLOGY (OXFORD) 14 4: 401-409. 2002
• Zeiler T, Taivainen A, Mäntyjärvi R, Tukiainen H, Rautiainen J, Rytkönen-Nissinen M, Virtanen T. 2002. Threshold levels of purified natural Bos d 2 for inducing bronchial airway response in asthmatic patients. CLINICAL AND EXPERIMENTAL ALLERGY 32 10: 1454-1460. 2002
• Ruoppi P, Virtanen T, Zeiler T, Rytkönen-Nissinen M, Rautiainen J, Nuutinen J, Taivainen A. 2001. In vitro and in vivo responses to the recombinant bovine dander allergen Bos d 2 and its fragments. CLINICAL AND EXPERIMENTAL ALLERGY 31: 915-919. 2001
• Kauppinen J, Zeiler T, Rautiainen J, Rytkönen-Nissinen M, Taivainen A, Mäntyjärvi R, Virtanen T. 1999. Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule. CLINICAL AND EXPERIMENTAL ALLERGY 29: 989-996. 1999
• Rytkönen-Nissinen M, Hurwitz JL, Pelkonen S, Levelt C, Pelkonen J. 1999. Early activation of TCR alpha gene rearrangement in fetal thymocytes. EUROPEAN JOURNAL OF IMMUNOLOGY 29: 2288-2296. 1999
• Zeiler T, Mäntyjärvi R, Rautiainen J, Rytkönen-Nissinen M, Vilja P, Taivainen A, Kauppinen J, Virtanen T. 1999. T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule. JOURNAL OF IMMUNOLOGY (BALTIMORE) 162: 1415-1422. 1999
• Santa H, Saarela JTA, Laatikainen R, Rautiainen J, Virtanen T, Rytkönen M, Mäntyjärvi R. 1998. A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins. PROTEIN JOURNAL 17 7: 657-662. 1998
• Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Recombinant allergen fragments as candidate preparations for allergen immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100: 721-727. 1997
• Rautiainen J, Rytkönen M, Virtanen T, Pentikäinen J, Zeiler T, Mäntyjärvi R. 1997. BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100: 251-252. 1997
• Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Clinical aspects of allergic disease. Recombinant allergen fragments as candidate preparations for allergen immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100 6: 721-727. 1997
• Mäntyjärvi R, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1996. Complementary DNA cloning of the predominant allergen of bovine dander: A new member in the lipocalin family. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 97: 1297-1303. 1996
• Rautiainen J, Pentikäinen J, Rytkönen M, Linnala-Kankkunen A, Pelkonen J, Virtanen T, Mäntyjärvi R. 1996. Molecular analysis of allergenic proteins in bovine dander. ALLERGY 51: 378-382. 1996
• Rytkönen M. 1996. T-cell Receptor Alpha and Delta Gene Rearrangements in the Regulation of T-cell Development. Kuopion yliopiston julkaisuja D. Lääketiede. 1996
• Rytkönen MA, Hurwitz JL, Thompson SD, Pelkonen J. 1996. Restricted onset of T cell receptor alfa gene rearrangement in fetal and neonatal thymocytes EUROPEAN JOURNAL OF IMMUNOLOGY 26: 1892-1896. 1996
• Virtanen T, Zeiler T, Rautiainen J, Taivainen A, Pentikäinen J, Rytkönen M, Parkkinen S, Pelkonen J, Mäntyjärvi R. 1996. Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy. CLINICAL AND EXPERIMENTAL ALLERGY 26: 188-196. 1996
• Mäntyjärvi RA, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1995. cDNA cloning and molecular characterization of bovine dander allergens. Teoksessa: Basomba A, Hernandez F. de Rojas (toim.), XVI European Congress of Allergology and Clinical Immunnlogy ECACI 95.Monduzzi. European Academy of Allergology and Clinical Immunology. ss. 111-115. 1995
• Parkkinen S, Rytkönen M, Pentikäinen J, Virtanen T, Mäntyjärvi R. 1995. Homology of a bovine allergen and the oligomycin sensitivity-conferring protein of the mitochondrial adenosine triphosphate synthase complex. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 95: 1255-1260. 1995
• Rautiainen J, Rytkönen M, Parkkinen S, Pentikäinen J, Linnala-Kankkunen A, Virtanen T, Pelkonen J, Mäntyjärvi R. 1995. cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin. JOURNAL OF INVESTIGATIVE DERMATOLOGY 105 5: 660-663. 1995
• Rytkönen MA, Hurwitz J L.,Tolonen K & Pelkonen J. 1994. Evidence for recombinatorial hot spots at the T cell receptor Jalpha locus. EUROPEAN JOURNAL OF IMMUNOLOGY 24: 107-115. 1994
• Thompson SD, Pelkonen J, Rytkönen M, Samaridis J, Hurwitz JL. 1990. Non-random rearrangement of T-cell receptor J-alpha genes in bone marrow T-differentation cultures. JOURNAL OF IMMUNOLOGY (BALTIMORE) 144: 2829-2834. 1990

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