Marja Rytkönen-Nissinen

Ihantola, Emmi-Leena; Ilmonen, Henna; Kailaanmäki, Anssi; Rytkönen-Nissinen, Marja; Azam, Aurélien; Maillère, Bernard; Lindestam Arlehamn, Cecilia; Sette, Alessandro; Motwani, Keshav; Seay, Howard; Brusko, Todd; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules Journal of immunology 204 9: 2349-2359. 2020

Mammalian Allergens. Virtanen, Tuomas; Rytkönen-Nissinen, Marja / Allergens and Allergen Immunotherapy. Subcutaneous, Sublingual, and Oral. 2020. 2020

Kirvesniemi, Julia; Rytkönen-Nissinen, Marja; Karppinen, Minna; Lindqvist, Sirpa; Kumpulainen, Jonna; Kullaa, Arja. 2019. Poistettujen hampaiden desinfektiomenetelmät Suomen hammaslääkärilehti 26 4: 34-38. 2019

Virtanen, Tuomas; Rytkönen-Nissinen, Marja. 2019. Commentary: Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma Frontiers in immunology 10: 2266. 2019

Kailaanmäki A, Kinnunen T, Rönkä A, Rytkönen-Nissinen M, Lidholm J,Mattsson L, Randell J, Virtanen T. 2016. Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein. Clinical & Experimental Allergy 46 5: 720-729. 2016

Niemi Merja H, Rytkönen-Nissinen Marja, Miettinen Ilja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2015. Dimerization of lipocalin allergens. Scientific Reports 5: 13841. 2015

Rytkönen-Nissinen Marja, Saarelainen Soili, Randell Jukka, Häyrinen Jukka, Kalkkinen Nisse, Virtanen Tuomas. 2015. IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification. ALLERGY, ASTHMA & IMMUNOLOGY RESEARCH 7 4: 384-392. 2015

Rönkä Aino L, Kinnunen Tuure T, Goudet Amélie, Rytkönen-Nissinen Marja A, Sairanen Joni, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2015. Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 136 4: 1047-1054.e10. 2015

Liukko Aino LK, Kinnunen Tuure T, Rytkönen-Nissinen Marja A, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2014. Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other. PLOS ONE [ONLINE] 9: 1-11. 2014

Niemi Merja H, Rytkönen-Nissinen Marja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2014. Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4. MOLECULAR IMMUNOLOGY 61 1: 7-15. 2014

Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2014. Mammalian Allergens: Richard F. Lockey, Dennis K. Ledford, Allergens and Allergen Immunotherapy subcutaneous, sublingual and oral. 217-234. 2014

Parviainen S, Kinnunen T, Rytkönen-Nissinen M, Nieminen A, Liukko A, Virtanen T. 2013. Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 77: 171-176. 2013

Kailaanmäki Anssi, Kinnunen Tuure, Kwok William W, Rytkönen-Nissinen Marja, Randell Jukka, Virtanen Tuomas. 2013. Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. IMMUNOLOGY 141 1: 52-60. 2013

Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217 1: 8-12. 2012

Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2012. Mammalian lipocalin allergens--insights into their enigmatic allergenicity Clinical & Experimental Allergy 42: 494-504. 2012

Kinnunen T, Nieminen A, Kwok W W, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Taivainen A & Virtanen T.. 2010. Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. EUROPEAN JOURNAL OF IMMUNOLOGY 40 9: 2460-2469. 2010

Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. MOLECULAR IMMUNOLOGY 46: 3320-3327. 2009

Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008

Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues IMMUNOLOGY 123: 358-366. 2008

Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T. 2007. The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes. CLINICAL AND EXPERIMENTAL ALLERGY 37: 939-947. 2007

Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy. IMMUNOLOGY 120: 38-46. 2007

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119: 965-972. 2007

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa. DUODECIM 123: 775-776. 2007

Porre S, Heinonen S, Mäntyjärvi R, Rytkönen-Nissinen M, Perola O, Rautiainen J, Virtanen T. 2005. Psoriasin, a calcium-binding protein with chemotactic properties is present in the third trimester amniotic fluid MOLECULAR HUMAN REPRODUCTION 11 2: 87-92. 2005

Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1 CLINICAL AND EXPERIMENTAL ALLERGY 35: 797-803. 2005

Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy. JOURNAL OF IMMUNOLOGY (BALTIMORE) 175 6: 3614-3620. 2005

Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. INTERNATIONAL IMMUNOLOGY (OXFORD) 17 12: 1573-1581. 2005

Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004

Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. CLINICAL AND EXPERIMENTAL ALLERGY 33: 834-841. 2003

Kinnunen T, Buhot C, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Pouvelle-Moratille S, Rautiainen J, Taivainen A, Maillere B, Mäntyjärvi R, Virtanen T. 2003. The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells EUROPEAN JOURNAL OF IMMUNOLOGY 33: 1717-1726. 2003

Saarelainen S, Zeiler T, Rautiainen J, Närvänen A, Rytkönen-Nissinen M, Mäntyjärvi R, Vilja P, Virtanen T. 2002. Lipocalin allergen Bos d 2 is a weak immunogen. INTERNATIONAL IMMUNOLOGY (OXFORD) 14 4: 401-409. 2002

Zeiler T, Taivainen A, Mäntyjärvi R, Tukiainen H, Rautiainen J, Rytkönen-Nissinen M, Virtanen T. 2002. Threshold levels of purified natural Bos d 2 for inducing bronchial airway response in asthmatic patients. CLINICAL AND EXPERIMENTAL ALLERGY 32 10: 1454-1460. 2002

Ruoppi P, Virtanen T, Zeiler T, Rytkönen-Nissinen M, Rautiainen J, Nuutinen J, Taivainen A. 2001. In vitro and in vivo responses to the recombinant bovine dander allergen Bos d 2 and its fragments. CLINICAL AND EXPERIMENTAL ALLERGY 31: 915-919. 2001

Kauppinen J, Zeiler T, Rautiainen J, Rytkönen-Nissinen M, Taivainen A, Mäntyjärvi R, Virtanen T. 1999. Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule. CLINICAL AND EXPERIMENTAL ALLERGY 29: 989-996. 1999

Rytkönen-Nissinen M, Hurwitz JL, Pelkonen S, Levelt C, Pelkonen J. 1999. Early activation of TCR alpha gene rearrangement in fetal thymocytes. EUROPEAN JOURNAL OF IMMUNOLOGY 29: 2288-2296. 1999

Zeiler T, Mäntyjärvi R, Rautiainen J, Rytkönen-Nissinen M, Vilja P, Taivainen A, Kauppinen J, Virtanen T. 1999. T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule. JOURNAL OF IMMUNOLOGY (BALTIMORE) 162: 1415-1422. 1999

Santa H, Saarela JTA, Laatikainen R, Rautiainen J, Virtanen T, Rytkönen M, Mäntyjärvi R. 1998. A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins. PROTEIN JOURNAL 17 7: 657-662. 1998

Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Recombinant allergen fragments as candidate preparations for allergen immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100: 721-727. 1997

Rautiainen J, Rytkönen M, Virtanen T, Pentikäinen J, Zeiler T, Mäntyjärvi R. 1997. BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100: 251-252. 1997

Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Clinical aspects of allergic disease. Recombinant allergen fragments as candidate preparations for allergen immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 100 6: 721-727. 1997

Mäntyjärvi R, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1996. Complementary DNA cloning of the predominant allergen of bovine dander: A new member in the lipocalin family. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 97: 1297-1303. 1996

Rautiainen J, Pentikäinen J, Rytkönen M, Linnala-Kankkunen A, Pelkonen J, Virtanen T, Mäntyjärvi R. 1996. Molecular analysis of allergenic proteins in bovine dander. ALLERGY 51: 378-382. 1996

Rytkönen M. 1996. T-cell Receptor Alpha and Delta Gene Rearrangements in the Regulation of T-cell Development. Kuopion yliopiston julkaisuja D. Lääketiede. 1996

Rytkönen MA, Hurwitz JL, Thompson SD, Pelkonen J. 1996. Restricted onset of T cell receptor alfa gene rearrangement in fetal and neonatal thymocytes EUROPEAN JOURNAL OF IMMUNOLOGY 26: 1892-1896. 1996

Virtanen T, Zeiler T, Rautiainen J, Taivainen A, Pentikäinen J, Rytkönen M, Parkkinen S, Pelkonen J, Mäntyjärvi R. 1996. Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy. CLINICAL AND EXPERIMENTAL ALLERGY 26: 188-196. 1996

Mäntyjärvi RA, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1995. cDNA cloning and molecular characterization of bovine dander allergens. Teoksessa: Basomba A, Hernandez F. de Rojas (toim.), XVI European Congress of Allergology and Clinical Immunnlogy ECACI 95.Monduzzi. European Academy of Allergology and Clinical Immunology. ss. 111-115. 1995

Parkkinen S, Rytkönen M, Pentikäinen J, Virtanen T, Mäntyjärvi R. 1995. Homology of a bovine allergen and the oligomycin sensitivity-conferring protein of the mitochondrial adenosine triphosphate synthase complex. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 95: 1255-1260. 1995

Rautiainen J, Rytkönen M, Parkkinen S, Pentikäinen J, Linnala-Kankkunen A, Virtanen T, Pelkonen J, Mäntyjärvi R. 1995. cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin. JOURNAL OF INVESTIGATIVE DERMATOLOGY 105 5: 660-663. 1995

Rytkönen MA, Hurwitz J L.,Tolonen K & Pelkonen J. 1994. Evidence for recombinatorial hot spots at the T cell receptor Jalpha locus. EUROPEAN JOURNAL OF IMMUNOLOGY 24: 107-115. 1994

Thompson SD, Pelkonen J, Rytkönen M, Samaridis J, Hurwitz JL. 1990. Non-random rearrangement of T-cell receptor J-alpha genes in bone marrow T-differentation cultures. JOURNAL OF IMMUNOLOGY (BALTIMORE) 144: 2829-2834. 1990

MARJA A. RYTKöNEN-NISSINEN

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