MIKKO NISSI

Yhteystiedot

Avainsanat

Opetustehtävät

Tutkimusryhmät ja -projektit

Tutkimusryhmät

• Biophysics of Bone and Cartilage (BBC)

• Linkki EAKR-hanke: Mikromagneettikuvaukseen perustuva kehitys- ja innovaatioympäristö materiaalitutkimuksen teollisiin sovelluksiin, kehitys ja investointi (MikroMRI)

Julkaisut

• Bolcos, PO; Mononen, ME; Tanaka, MS; Yang, M; Suomalainen, JS; Nissi, MJ; Töyräs, J; Ma, B; Li, X; Korhonen, RK. 2020. Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imaging Clinical biomechanics 79: 104844. 2020
• Filip, Pavel; Svatkova, Alena; Carpenter, Adam F; Eberly, Lynn E; Nestrasil, Igor; Nissi, Mikko J; Michaeli, Shalom; Mangia, Silvia. 2020. Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis Neuroimage. clinical 26: 102234. 2020
• Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. 2020. Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination Annals of biomedical engineering Published: 20 August 2020: 1-10. 2020
• Hänninen, Nina Elina; Nykänen, Olli; Prakash, Mithilesh; Hanni, Matti; Nieminen, Miika Tapio; Nissi, Mikko Johannes. 2020. Orientation anisotropy of quantitative MRI parameters in degenerated human articular cartilage Journal of orthopaedic research [Online ahead of print]: -. 2020
• Kajabi, Abdul Wahed; Casula, Victor; Ojanen, Simo; Finnilä, Mikko A; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami K; Nissi, Mikko J; Nieminen, Miika T. 2020. Multiparametric MR Imaging Reveals Early Cartilage Degeneration at 2 and 8 Weeks After ACL Transection in a Rabbit Model Journal of orthopaedic research [Epub ahead of print 10 Mar 2020]: 1-13. 2020
• Kajabi, Abdul Wahed; Casula, Victor; Sarin, Jaakko K; Ketola, Juuso H; Nykänen, Olli; Te Moller, Nikae C R; Mancini, Irina A D; Visser, Jetze; Brommer, Harold; René van Weeren, P; Malda, Jos; Töyräs, Juha; Nieminen, Miika T; Nissi, Mikko J. 2020. Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis Journal of orthopaedic research [Online ahead of print 16 June 20]: 1-11. 2020
• Nykänen, Olli; Leskinen, Henri P P; Finnilä, Mikko; Karhula, Sakari S; Turunen, Mikael J; Töyräs, Juha; Saarakkala, Simo; Nissi, Mikko J. 2020. The bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage Journal of orthopaedic research [Online ahead of print]: -. 2020
• Chary, Karthik; Nissi, Mikko J; Nykänen, Olli; Manninen, Eppu; Rey, Ramón I; Shmueli, Karin; Sierra, Alejandra; Gröhn, Olli. 2020. Quantitative susceptibility mapping of the rat brain after traumatic brain injury Nmr in biomedicine [First published: 21 November 2020]: e4438. 2020
• Ellermann, JM; Ludwig, KD; Nissi, MJ; Johnson, CP; Strupp, JP; Wang, L; Zbýn, Š; Tóth, F; Arendt, E; Tompkins, M; Shea, K; Carlson, CS. 2019. Three-Dimensional Quantitative Magnetic Resonance Imaging of Epiphyseal Cartilage Vascularity Using Vessel Image Features: New Insights Into Juvenile Osteochondritis Dissecans Journal of bone and joint surgery open access 4 4: e0031. 2019
• Husso, M; Nissi, MJ; Kuivanen, A; Halonen, P; Tarkia, M; Teuho, J; Saunavaara, V; Vainio, P; Sipola, P; Manninen, H; Ylä-Herttuala, S; Knuuti, J; Töyräs, J. 2019. Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference Bmc medical imaging 19 1: 58. 2019
• Nykänen, O; Sarin, JK; Ketola, JH; Leskinen, H; te Moller, NCR; Tiitu, V; Mancini, IAD; Visser, J; Brommer, H; van Weeren, P René; Malda, J; Töyräs, J; Nissi, MJ. 2019. T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis: assessment of mechanical and structural properties of articular cartilage Osteoarthritis and cartilage 27 10: 1481-1490. 2019
• Tóth, F; Johnson, CP; Mills, B; Nissi, MJ; Nykänen, O; Ellermann, J; Ludwig, KD; Tompkins, M; Carlson, CS. 2019. Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans Journal of orthopaedic research 37 10: 2130-2137. 2019
• Salonius, E; Rieppo, L; Nissi, MJ; Pulkkinen, HJ; Brommer, H; Brünott, A; Silvast, TS; Van Weeren, PR; Muhonen, V; Brama, PAJ; Kiviranta, I. 2018. Critical-sized cartilage defects in the equine carpus Connective tissue research 2019; 60 2: 95-106. 2018
• Nykänen, O; Rieppo, L; Töyräs, J; Kolehmainen, V; Saarakkala, S; Shmueli, K; Nissi, MJ. 2018. Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments Magnetic resonance in medicine 80 6: 2702-2716. 2018
• Kajabi, AW; Casula, V; Nissi, MJ; Peuna, A; Podlipská, J; Lammentausta, E; Saarakkala, S; Guermazi, A; Nieminen, MT. 2018. Assessment Of Meniscus With Adiabatic T1p And T2p Relaxation Time In Asymptomatic Subjects And Patients With Mild Osteoarthritis: A Feasibility Study. OSTEOARTHRITIS AND CARTILAGE 26 4: 580-587. 2018
• Casula Victor, Nissi Mikko J, Podlipská Jana, Haapea Marianne, Koski Juhani M, Saarakkala Simo, Guermazi Ali, Lammentausta Eveliina, Nieminen Miika T. 2017. Elevated adiabatic T1p and T2p in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study. JOURNAL OF MAGNETIC RESONANCE IMAGING 43 3: 678-689. 2017
• Henn LL, Hughes J, Iisakka E, Ellermann J, Mortazavi S, Ziegler C, Nissi MJ, Morgan P. 2017. Disease severity classification using quantitative magnetic resonance imaging data of cartilage in femoroacetabular impingement. STATISTICS IN MEDICINE 36 9: 1491-1505. 2017
• Hänninen N, Rautiainen J, Rieppo L, Saarakkala S, Nissi MJ. 2017. Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue. Scientific Reports 7: 9606. 2017
• Mangia Silvia, Svatkova Alena, Mascali Daniele, Nissi Mikko J, Burton Philip C, Bednarik Petr, Auerbach Edward J, Giove Federico, Eberly Lynn E, Howell Michael J, Nestrasil Igor, Tuite Paul J, Michaeli Shalom. 2017. Multi-modal Brain MRI in Subjects with PD and iRBD Frontiers in Neuroscience 11: 1-12. 2017
• Morgan, Patrick; Nissi, Mikko J; Hughes, John; Mortazavi, Shabnam; Ellerman, Jutta. 2017. T2* Mapping Provides Information That Is Statistically Comparable to an Arthroscopic Evaluation of Acetabular Cartilage Cartilage [First Published July 17, 2017]: 1-4. 2017
• Casula V, Autio J, Nissi M.J, Auerbach E.J, Ellermann J, Lammentausta E, Nieminen M.T. 2016. Validation and optimization of adiabatic T1[rho] and T2[rho] for quantitative imaging of articular cartilage at 3 T. MAGNETIC RESONANCE IN MEDICINE 2017; 77 3: 1265-1275. 2016
• Nieminen MT, Nissi MJ, Hanni M, Xia Y. 2016. Physical Properties of Cartilage by Relaxation Anisotropy, in Biophysics and Biochemistry of Cartilage by NMR and MRI. Teoksessa: Yang Xia, Konstantin Momot (toim.) Biophysics and Biochemistry of Cartilage by NMR and MRI. Royal society of chemistry. s. 145-175. 2016
• Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage. OSTEOARTHRITIS AND CARTILAGE 24 9: 1656-1664. 2016
• Wang L, Nissi MJ, Toth F, Johnson CP, Garwood M, Carlson CS, Ellermann J. 2016. Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. MAGNETIC RESONANCE IN MEDICINE 2017; 77 3: 1276-1283. 2016
• Zhang J, Nissi MJ, Idiyatullin D, Michaeli S, Garwood M, Ellermann J. 2016. Capturing fast relaxing spins with SWIFT adiabatic rotating frame spin-lattice relaxation (T1p) mapping. NMR IN BIOMEDICINE 29 4: 420-430. 2016
• Nissi Mikko J, Toth Ferenc, Wang Luning, Carlson Cathy S, Ellermann Jutta M. 2015. Improved Visualization of Cartilage Canals Using Quantitative Susceptibility Mapping. PLOS ONE [ONLINE] 10 7: e0132167. 2015
• Tóth Ferenc, Nissi Mikko J, Ellermann Jutta M, Wang Luning, Shea Kevin G, Polousky John, Carlson Cathy S. 2015. Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans. AMERICAN JOURNAL OF SPORTS MEDICINE 43 10: 2522-2527. 2015
• Luning Wang, Nissi Mikko J, Tóth Ferenc, Shaver Jonah, Johnson Casey P., Zhang Jinjin, Garwood Michael, Carlson Cathy S, Ellermann Jutta M. 2015. Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model. PLOS ONE [ONLINE] 10 10: e0140400. 2015
• Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Liimatainen Timo, Michaeli Shalom, Mangia Silvia, Ellermann Jutta, Nieminen Miika T. 2015. Multi-parametric MRI characterization of enzymatically degraded articular cartilage. JOURNAL OF ORTHOPAEDIC RESEARCH 2016; 34 7: 1111-1120. 2015
• Morgan Patrick, Spiridonov Stanislav, Goebel Rainer, Nissi Mikko, Frei Robert, Ellermann Jutta. 2015. MR Imaging with T2*- mapping for improved acetabular cartilage assessment in FAI - a case report with arthroscopic correlation. Orthopaedics & Traumatology: Surgery & Research 100 8: 971-973. 2015
• Ellermann Jutta, Ziegler Connor, Nissi Mikko J, Goebel Rainer, Hughes John, Benson Michael, Holmberg Peter, Morgan Patrick. 2014. Acetabular cartilage assessment in patients with femoroacetabular impingement by using T2* mapping with arthroscopic verification. RADIOLOGY 271 2: 512-523. 2014
• Nikolaev Alexandre, Pääkkönen Ari, Niemi Jussi, Nissi Mikko J, Niskanen Eini, Könönen Mervi, Mervaala Esa, Soininen Hilkka. 2014. Behavioural and ERP effects of paradigm complexity on visual word recognition. Language, Cognition and Neuroscience 29 10: 1295-1310. 2014
• Nissi Mikko J, Lehto Lauri J, Corum Curtis A, Idiyatullin Djaudat, Ellermann Jutta M, Gröhn Olli HJ, Nieminen Miika T. 2014. Measurement of T1 relaxation time of osteochondral specimens using VFA-SWIFT. MAGNETIC RESONANCE IN MEDICINE - -: -. 2014
• Rautiainen Jari, Nissi Mikko J, Liimatainen Timo, Herzog Walter, Korhonen Rami K, Nieminen Miika T. 2014. Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection. OSTEOARTHRITIS AND CARTILAGE 22 10: 1444-1452. 2014
• Rautiainen Jari, Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Finnilä Mikko AJ, Aho Olli-Matti, Saarakkala Simo, Lehenkari Petri, Ellermann Jutta, Nieminen Miika T. 2014. Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties. MAGNETIC RESONANCE IN MEDICINE Epub ahead of print: -. 2014
• Jari Rautiainen; Lauri J. Lehto; Virpi Tiitu; Outi Kiekara; Hertta Pulkkinen; Anne Brünott; René van Weeren; Harold Brommer; Pieter A. J. Brama; Jutta Ellermann; Ilkka Kiviranta; Miika T. Nieminen; Mikko J. Nissi. 2013. Osteochondral Repair: Evaluation with Sweep Imaging with Fourier Transform in an Equine Model. RADIOLOGY epub ahead of print: epub ahead of print. 2013
• Nieminen MT, Nissi MJ, Mattila L, Kiviranta I. 2012. Evaluation of chondral repair using quantitative MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING 36 6: 1287-1299. 2012
• Niskanen E, Könönen M, Villberg V, Nissi M, Ranta-aho P, Säisänen L, Karjalainen P, Äikiä M, Kälviäinen R, Mervaala E, Vanninen R. 2012. The effect of fMRI task combinations on determining the hemispheric dominance of language functions. NEURORADIOLOGY 54: 393-405. 2012
• Salo E-N, Nissi MJ, Kulmala KAM, Tiitu V, Töyräs J, Nieminen MT. 2012. Diffusion of Gd-DTPA2- into articular cartilage. OSTEOARTHRITIS AND CARTILAGE 20 2: 117-126. 2012
• Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. 2010. Dynamics of contrast agent enhancement of intact and enzymatically degraded articular cartilage, Proceedings of the International Society of Magnetic Resonance in Medicine 18. 3177. 2010
• Prantner V, Isaksson H, Närväinen J, Lammentausta E, Nissi MJ, Avela J, Gröhn OH, Jurvelin JS. 2010. NMR relaxation times of trabecular bone - reproducibility, relationships to tissue structure and effects of sample freezing. PHYSICS IN MEDICINE AND BIOLOGY 55(2010): 1-13. 2010
• Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. 2010. Diffusivity and kinetics of gadopentetate in articular cartilage in vitro. Teoksessa: (toim.), Proceedings of the International Society of Magnetic Resonance in Medicine 18. ss. 234. 2010
• Salo E-N., Nissi M. J., Kulmala K., Töyräs J., Nieminen M. T.. 2010. Temporal dynamics and diffusion of gadopentetate in articular cartilage at MRI concentrations in vitro, Transactions of the Orthopaedic Research Society 35. 1348. 2010
• Berberat JE, Nissi MJ, Jurvelin JS, Nieminen MT. 2009. Assessment of interstitial water content of articular cartilage with T1 relaxation. MAGNETIC RESONANCE IMAGING 27: 727-732. 2009
• Julkunen P, Korhonen RK, Nissi MJ, Jurvelin JS. 2008. Mechanical characterization of articular cartilage by combining magnetic resonance imaging and finite-element analysis - a potential functional imaging technique PHYSICS IN MEDICINE AND BIOLOGY 53: 2425-2438. 2008
• Nissi M. 2008. Magnetic Resonance Parameters in Quantitative Evaluation of Articular Cartilage. Studies on T(1) and T(2) Relaxation Time. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2008
• Kiviranta P, Töyräs J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, Nissi MJ, Jurvelin J. 2007. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration. EUROPEAN CELLS AND MATERIALS 13: 46-55. 2007
• Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS. 2007. Estimation of mechanical properties of articular cartilage with MRI - dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation OSTEOARTHRITIS AND CARTILAGE 15: 1141-1148. 2007
• Lammentausta E, Kiviranta P, Nissi MJ, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS. 2006. T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: relationships with tissue mechanical properties JOURNAL OF ORTHOPAEDIC RESEARCH 24(3): 366-374. 2006
• Kurkijärvi JE, Nissi MJ, Kiviranta I, Jurvelin JS, Nieminen MT. 2004. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 characteristics of human knee articular cartilage: Topographical variation and relationships to mechanical properties MAGNETIC RESONANCE IN MEDICINE 52: 41-46. 2004
• Nissi MJ, Töyräs J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS, Nieminen MT. 2004. Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. JOURNAL OF ORTHOPAEDIC RESEARCH 22: 557-564. 2004