Paula Korhonen

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre, . 2024. Cell reports. 43:

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12:

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24:

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna. 2022. Journal of biological chemistry. 298:

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14:

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178

Microglial amyloid beta clearance is driven by PIEZO1 channels

Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A.. 2022. PLoS ONE. 17:

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Ugidos, Irene F; Pistono, Cristiana; Korhonen, Paula; Gómez-Budia, Mireia; Sitnikova, Valeriia; Klecki, Pamela; Stanová, Iveta; Jolkkonen, Jukka; Malm, Tarja. 2022. Stroke. 53: 1500-1509

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M. 2022. Neurotoxicology. 89: 55-66

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6:

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports. 11: 3518

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 106

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Scientific reports. 11: 13076

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 124

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences. 110: 3953-3962

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Neurochemistry international. 136: 104715

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation. 17: 194

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell. 2021; 20: e13287

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Particle and fibre toxicology. 17: 18

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Scientific reports. 9: 10332

Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke

Mu, Jingwei; Bakreen, Abdulhameed; Juntunen, Miia; Korhonen, Paula; Oinonen, Ella; Cui, Lili; Myllyniemi, Mikko; Zhao, Shanshan; Miettinen, Susanna; Jolkkonen, Jukka. 2019. Frontiers in neurology. 10: 235

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports. 6: 74-86

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports. 13: 669-683

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology. 2020; 267: 76-86

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Korhonen, Paula; Malm, Tarja; White, Anthony R. 2018. Neurochemistry international. 120: 191-199

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia. 2019; 67: 146-159

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. Neurotherapeutics. 14: 519-532

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Glia. 64: 1492-507

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports. 6: 33176

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling

Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. 2016. Cephalalgia. 2017; 37: 1373-1383

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease. [epub ahead of print 3 Dec 2015]: -

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Brain behavior and immunity. 49: 322-336

Impact of the peripheral immune system to disease-induced neuroinflammation

Korhonen Paula. 2015. Itä-Suomen yliopisto

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Brain behavior and immunity. 2014 Aug 18 ePub ahead of print: --

Tarkenna hakuasi

Tutkimusryhmät

Particulate matter from car exhaust alters function of human iPSC-derived microglia

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Microglial amyloid beta clearance is driven by PIEZO1 channels

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Impact of the peripheral immune system to disease-induced neuroinflammation

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury