Pirjo Käkelä

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Sehgal, Ratika; Perfilyev, Alexander; Männistö, Ville; Ågren, Jyrki; Nilsson, Emma; Käkelä, Pirjo; Ling, Charlotte; de Mello, Vanessa D.; Pihlajamäki, Jussi. 2023. Clinical epigenetics. 15: . 21

How Often Occult Inguinal or Spigelian Hernias Detected during Laparoscopy of Other Reasons Are Later Operated?

Paajanen, Paavo; Virkkunen, Antti; Paajanen, Hannu; Käkelä, Pirjo. 2022. Surgical laparoscopy endoscopy and percutaneous techniques. 32: 519-522

Incidence of acute diverticulitis compared to appendicitis in emergency wards: a 10-year nationwide register and cohort study from Finland

Saren, Roni; Aspegren, Sami; Paajanen, Hannu; Ukkonen, Mika; Käkelä, Pirjo. 2022. Scandinavian journal of gastroenterology. 2023; 58: 151-156

Lihavuusleikkaus on tehokas apu - muutos voi kuitenkin altistaa puutoksille ravitsemuksessa

Käkelä, Pirjo. 2022. Rosie. : .

Robotic versus hybrid assisted ventral hernia repair: a prospective one-year comparative study of clinical outcomes

Käkelä, Pirjo; Mustonen, Kirsi; Rantanen, Tuomo; Paajanen, Hannu. 2022. Acta chirurgica Belgica. [Published online: 04 May 2022]: 1-7

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Vaittinen, Maija; Lankinen, Maria A; Käkelä, Pirjo; Ågren, Jyrki; Wheelock, Craig E; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi. 2022. European journal of nutrition. 61: 3707-3718

Fatal complications after an interrupted gastric bypass operation in a patient with non-alcoholic fatty liver disease and massive obesity: a case report

Käkelä, Pirjo; Rantanen, Tuomo; Paajanen, Hannu; Virtanen, Kirsi A. 2021. Journal of surgical case reports. : rjab247

The Importance of Intestinal Length in Triglyceride Metabolism and in Predicting the Outcomes of Comorbidities in Laparoscopic Roux-en-Y Gastric Bypass-a Narrative Review

Käkelä, Pirjo; Rantanen, Tuomo; Virtanen, Kirsi A. 2021. Obesity surgery. 31: 3291-3295

Vatsanpeitteiden tyrän robottiavusteinen leikkaushoito: Viiden vuoden kokemuksen Kuopion yliopistollisessa sairaalassa

Käkelä, Pirjo. 2021. Pinsetti. 32: 5-7

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Männistö, Ville; Kaminska, Dorota; Käkelä, Pirjo; Neuvonen, Mikko; Niemi, Mikko; Alvarez, Marcus; Pajukanta, Päivi; Romeo, Stefano; Nieuwdorp, Max; Groen, Albert K; Pihlajamäki, Jussi. 2020. Hepatology communications. 2021; 5: 244-257

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Basic and clinical pharmacology and toxicology. 125: 123-132

Evaluation of the effect of bariatric surgery-induced weight loss on knee gait and cartilage degeneration

Liukkonen, MK; Mononen, ME; Vartiainen, P; Kaukinen, P; Bragge, T; Suomalainen, JS; Malo, MKH; Venesmaa, S; Käkelä, P; Pihlajamäki, J; Karjalainen, PA; Arokoski, JP; Korhonen, R. 2018. Journal of biomechanical engineering: transactions of the ASME. 14: 41008

Impact of obesity and Roux-en-Y gastric bypass on comorbidities with special emphasis on cholecystolithiasis and related lipid metabolism

Käkelä, Pirjo. 2018. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. 2018. Bioscience reports. 38: 1-9

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi. 2018. Obesity surgery. 28: 3969-3975

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J. 2017. Nutrition and diabetes. 7: e285

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

de Mello VD, Matte A, Perfilyev A, Männistö V, Rönn T, Nilsson E, Käkelä P, Ling C, Pihlajamäki J. 2017. Epigenetics. [Epub 2017 Feb 23]: 287-295

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J. 2017. Obesity. 25: 545-552

Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2017. Sleep medicine. 35: 85-90

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666

Regulation of alternative splicing in human obesity loci

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Obesity. 24: 2033-2037

Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease

Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J. 2016. Obesity surgery. 27: 1284-1291

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tizian, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville et al. 2016. Gastroenterology. 150: 1219-1230

Adipose Tissue Splicing in Human Obesity Loci, conference paper

Dorota Kaminska, Pirjo Käkelä, Pekka Miettinen, Sari Venesmaa, Imre Ilves, Marjukka Kolehmainen, Leila Karhunen, Johanna Kuusisto, Helena Gylling, Markku Laakso, Jussi Pihlajamäki. 2015.

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels

Nilsson Emma, Matte Ashok, Perfilyev Alexander, de Mello Vanessa D, Käkelä Pirjo, Pihlajamäki Jussi, Ling Charlotte. 2015. Journal of clinical endocrinology and metabolism. [epub ahead of p rint Sep 29, 2015]: -

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi. 2015. Journal of lipid research. 2016; 57: 56-65

Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery: A Prospective Multicentre Trial

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2015. Obesity surgery. 2016; 26: 1384-1390

Statin use and non-alcoholic steatohepatitis in at risk individuals

Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. 2015. Journal of hepatology. 63: 705-712

Adipose Tissue INSR Splicing Is Regulated by Weight Loss and Associates With Insulin Levels

Dorota Kaminska, Pirjo Käkelä, Sari Venesmaa, Maija Hämäläinen, Leila Karhunen, Helena Gylling, Markku Laakso, Jussi Pihlajamäki. 2014.

Effect of statin use on outcome of symptomatic cholelithiasis: a case-control study

Pulkkinen J, Eskelinen M, Kiviniemi V, Kotilainen T, Pöyhönen M, Kilpeläinen L, Käkelä P, Kastarinen H, Paajanen H. 2014. Bmc gastroenterology. 14: 1-7

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861

Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis

Männistö Ville T, Simonen Marko, Soininen Pasi, Tiainen Mika, Kangas Antti J, Kaminska Dorota, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Gylling Helena, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Journal of lipid research. 55: 2676-2684

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Dongiovanni Paola, Petta Salvatore, Maglio Cristina, Fracanzani Anna Ludovica, Pipitone Rosaria, Mozzi Enrico, Motta Benedetta Maria, Kaminska Dorota, Rametta Raffaela, Grimaudo Stefania, Pelusi Serena, Montalcini Tiziana, Alisi Anna, Maggioni Marco, Kärjä Vesa, Borén Jan, Käkelä Pirjo, Di Marco Vito, Xing Chao, Nobili Valerio et.al.. 2014. Hepatology. Epub ahead of print: -

A population-based study on the prevalence of NASH using scores validated against liver histology

Hyysalo J, Männistö VT, Zhou Y, Arolad J, Kärjä V, Leivonen M, Juut A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valentik L, Fargionk S, Pihlajamäki J,Peltoneng M, Yki-Järvinena H. 2013. Journal of hepatology. Available online 12 December 2013: -

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Diabetologia. Epub 2013 Nov 7.: 1-5

Desmosterol in human nonalcoholic steatohepatitis

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L. 2013. Diabetes. 62: 3747-3750

Genetic risk score does not predict the outcome of obesity surgery

Käkelä P, Jääskeläinen T, Torpström J, Ilves I, Venesmaa S, Pääkkönen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamäki J. 2013. Obesity surgery. online: -

Mahalaukun ohitus lihavuusleikkauksena: yhden keskuksen kymmenen vuoden kokemukset ja seurannan haasteet

Käkelä P, Torpström J, Venesmaa S, Ilves I, Junnila EL, Penttinen K, Martikainen T, Gylling H, Pääkkönen M, Pihlajamäki J. 2013. Duodecim. 129: 756-764

Regulation of alternative splicing in human obesity loci

Dorota Kaminska, Pirjo Käkelä, Sari Venesmaa, Helena Gylling, Markku Laakso, Jussi Pihlajamäki. 2013.

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Diabetes. 61: 2807-2813

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

Dorota Kaminska, Pirjo Käkelä, Sari Venesmaa, Tiina Kuulasmaa, Maija Vaittinen, Leena Pulkkinen, Matti Pääkkönen, Helena Gylling, Markku Laakso, Jussi Pihlajamäki. 2012.

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Obesity surgery. 22: 1473-1480

Impact of Obesity and Associated Diseases on Outcome After Laparoscopic Cholecystectomy

Paajanen, Hannu; Käkelä, Pirjo; Suuronen, Satu; Paajanen, Juuso; Juvonen, Petri; Pihlajamäki, Jussi. 2012. Surgical laparoscopy endoscopy and percutaneous techniques. 22: 509-513

Lihavuusleikkauksen jälkeen

Torpström, Jaana; Käkelä, Pirjo; Pihlajamäki, Jussi. 2012. DIABETES JA LÄÄKÄRI. 41: 29-33

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Journal of hepatology. 56: 663-670

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Journal of hepatology. 56: 663-670

Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding

Pihlajamäki J, Grönlund S, Simonen M, Käkelä P, Moilanen L, Pääkkönen M, Pirinen E, Kolehmainen M, Kärjä V, Kainulainen S, Uusitupa M, Alhava E, Miettinen TA, Gylling H. 2010. Metabolism: clinical and experimental. 59: 866-872

Tutkimusryhmät

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

How Often Occult Inguinal or Spigelian Hernias Detected during Laparoscopy of Other Reasons Are Later Operated?

Incidence of acute diverticulitis compared to appendicitis in emergency wards: a 10-year nationwide register and cohort study from Finland

Lihavuusleikkaus on tehokas apu - muutos voi kuitenkin altistaa puutoksille ravitsemuksessa

Robotic versus hybrid assisted ventral hernia repair: a prospective one-year comparative study of clinical outcomes

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Fatal complications after an interrupted gastric bypass operation in a patient with non-alcoholic fatty liver disease and massive obesity: a case report

The Importance of Intestinal Length in Triglyceride Metabolism and in Predicting the Outcomes of Comorbidities in Laparoscopic Roux-en-Y Gastric Bypass-a Narrative Review

Vatsanpeitteiden tyrän robottiavusteinen leikkaushoito: Viiden vuoden kokemuksen Kuopion yliopistollisessa sairaalassa

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Evaluation of the effect of bariatric surgery-induced weight loss on knee gait and cartilage degeneration

Impact of obesity and Roux-en-Y gastric bypass on comorbidities with special emphasis on cholecystolithiasis and related lipid metabolism

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Regulation of alternative splicing in human obesity loci

Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Adipose Tissue Splicing in Human Obesity Loci, conference paper

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery: A Prospective Multicentre Trial

Statin use and non-alcoholic steatohepatitis in at risk individuals

Adipose Tissue INSR Splicing Is Regulated by Weight Loss and Associates With Insulin Levels

Effect of statin use on outcome of symptomatic cholelithiasis: a case-control study

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

A population-based study on the prevalence of NASH using scores validated against liver histology

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Desmosterol in human nonalcoholic steatohepatitis

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Genetic risk score does not predict the outcome of obesity surgery

Mahalaukun ohitus lihavuusleikkauksena: yhden keskuksen kymmenen vuoden kokemukset ja seurannan haasteet

Regulation of alternative splicing in human obesity loci

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Impact of Obesity and Associated Diseases on Outcome After Laparoscopic Cholecystectomy

Lihavuusleikkauksen jälkeen

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding