Risto Juvonen

Šadibolová, Michaela; Juvonen, Risto O.; Auriola, Seppo; Boušová, Iva. 2022. In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity Archives of toxicology 96: 793-808. 2022

Laitinen, Heikki; Juvonen, Risto O; Saarti, Jarmo. 2021. Information literacy skills are required in finding reliable toxicological information resources Journal of the European association for health information and libraries 17 3: 23-28. 2021

Juvonen, Risto O; Ahinko, Mira; Jokinen, Elmeri M; Huuskonen, Juhani; Raunio, Hannu; Pentikäinen, Olli T. 2021. Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling ACS omega 6 17: 11286-11296. 2021

Juvonen, Risto O; Jokinen, Elmeri M; Huuskonen, Juhani; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T. 2021. Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A1 Xenobiotica 51 11: 1207-1216. 2021

Jalkanen, Aaro; Lassheikki, Veera; Torsti, Tommi; Gharib, Elham; Lehtonen, Marko; Juvonen, Risto O. 2020. Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone Xenobiotica 2021; 51 3: 268-278. 2020

Juvonen, RO; Jokinen, EM; Javaid, A; Lehtonen, M; Raunio, H; Pentikäinen, OT. 2020. Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study Chemical biology and drug design 95 5: 520-533. 2020

Juvonen, RO; Pentikäinen, O; Huuskonen, J; Timonen, J; Kärkkäinen, O; Heikkinen, A; Fashe, M; Raunio, H. 2020. In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species Xenobiotica 50 8: 885-893. 2020

Mohammed, Ali Mustafa; Huuskonen, Pasi; Juvonen, Risto; Sahlman, Heidi; Repo, Jenni; Myöhänen, Kirsi; Myllynen, Päivi; Woo, Chit-Shing Jackson; Karttunen, Vesa; Vähäkangas, Kirsi. 2020. Activities of metabolizing enzymes in human placenta Toxicology letters 326: 70-77. 2020

Physiological and toxicological considerations. Berglund, Larry G; Rissanen, Sirkka; Jussila, Kirsi; Kaufman, Jonathan W; Piirilä, Päivi; Savolainen, Kai M; Kalliokoski, Pentti; Pasanen, Pertti; Viluksela, Matti; Landström, Ulf; Saarinen, Pekka; Rysä, Jaana; Juvonen, Risto / Industrial Ventilation Design Guidebook Volume 1: Fundamentals. 2020. 2020

Raunio, Hannu; Pentikäinen, Olli; Juvonen, Risto O. 2020. Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro International journal of molecular sciences 21 13: E4708. 2020

Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N. 2019. In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes Molecules 24 11: 2191. 2019

Metanolimyrkytys. Juvonen, Risto; Savolainen, Kai / Lääketieteellinen farmakologia ja toksikologia. 2019. 2019

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Metabolism of Scoparone in Experimental Animals and Humans Planta medica 85 06: 453-464. 2019

Etyleeniglykolimyrkytys. Juvonen, Risto; Savolainen, Kai / Lääketieteellinen farmakologia ja toksikologia. 2019. 2019

Etanolimyrkytys. Juvonen, Risto; Savolainen, Kai / Lääketieteellinen farmakologia ja toksikologia. 2019. 2019

Alkoholimyrkytyskuolemat ja alkoholille altistuminen. Juvonen, Risto; Savolainen, Kai / Lääketieteellinen farmakologia ja toksikologia. 2019. 2019

Alkoholien toksikokinetiikka. Juvonen, Risto; Savolainen, Kai / Lääketieteellinen farmakologia ja toksikologia. 2019. 2019

Juvonen, Risto O; Heikkinen, Aki T; Kärkkäinen, Olli; Jehangir, Rabia; Huuskonen, Juhani; Troberg, Johanna; Raunio, Hannu; Pentikäinen, Olli T; Finel, Moshe. 2019. In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs European journal of pharmaceutical sciences 141: 105118. 2019

Juvonen, Risto O; Ahinko, Mira; Huuskonen, Juhani; Raunio, Hannu; Pentikäinen, Olli T. 2018. Development of New Coumarin-Based Profluorescent Substrates for Human Cytochrome P450 Enzymes Xenobiotica 49 9: 1015-1024. 2018

Juvonen, RO; Rauhamäki, S; Kortet, S; Niinivehmas, S; Troberg, J; Petsalo, A; Huuskonen, J; Raunio, H; Finel, M; Pentikäinen, OT. 2018. Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 Molecular pharmaceutics 15 3: 923-933. 2018

Making it Together: Information Specialist and Toxicologist Developing Students' Professional Information Skills (Abstract). Laitinen, Heikki; Juvonen, Risto O; Saarti, Jarmo / The Sixth European Conference on Information Literacy (ECIL) September 24th - 27th, 2018 , Oulu, Finland, Abstracts. 2018. 2018

Muluneh, Fashe; Häkkinen, Merja R; El Dairi, Rami; Pasanen, Markku; Juvonen, Risto O. 2018. New glutathione conjugate of the pyrrolizidine alkaloids produced by human cytosolic enzyme dependent reactions in vitro Rapid communications in mass spectrometry 32 16: 1344-1352. 2018

Niinivehmas, S; Postila, PA; Rauhamäki, S; Manivannan, E; Kortet, S; Ahinko, M; Huuskonen, P; Nyberg, N; Koskimies, P; Lätti, S; Multamäki, E; Juvonen, RO; Raunio, H; Pasanen, M; Huuskonen, J; Pentikäinen, OT. 2018. Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives Journal of Enzyme Inhibition and Medicinal Chemistry 33 1: 743-754. 2018

Rauhamaki, Sanna; Postila, Pekka A; Niinivehmas, Sanna; Kortet, Sami; Schildt, Emmi; Pasanen, Mira; Manivannan, Elangovan; Ahinko, Mira; Koskimies, Pasi; Nyberg, Niina; Huuskonen, Pasi; Multamaki, Elina; Pasanen, Markku; Juvonen, Risto O; Raunio, Hannu; Huuskonen, Juhani; Pentikainen, Olli T. 2018. Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors. Frontiers in chemistry 6: 41. 2018

Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. 2017. Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals Planta Medica 2018; 84 5: 320-328. 2017

Raunio Hannu, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija, Rahnasto-Rilla Minna. 2016. Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes. Drug Metabolism Letters 10 1: 56-64. 2016

Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. 2015. Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites. Toxicology Reports 2: 1024-1032. 2015

Raunio Hannu, Kuusisto Mira, Juvonen Risto O, Pentikäinen Olli T. 2015. Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes. FRONTIERS IN PHARMACOLOGY 6: 123. 2015

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna. 2015. In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids. CHEMICAL RESEARCH IN TOXICOLOGY 28 4: 702-710. 2015

Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes. XENOBIOTICA (LONDON) 2016; 46 1: 14-24. 2015

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Räsänen Juha, Pasanen Markku. 2015. Species-specific differences in the in vitro metabolism of lasiocarpine. CHEMICAL RESEARCH IN TOXICOLOGY 28 10: 2034-2044. 2015

Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling. Molecular Nutrition & Food Research [epub ahead of print 10 SEP 2015]: -. 2015

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1950-1957. 2014

Heikkinen Aki T, Friedlein Arno, Matondo Mariette, Hatley Oliver J, Petsalo Aleksanteri, Juvonen Risto, Galetin Aleksandra, Rostami-Hodjegan Amin, Aebersold Ruedi, Lamerz Jens, Dunkley Tom, Cutler Paul, Parrott Neil. 2014. Quantitative ADME Proteomics - CYP and UGT Enzymes in the Beagle Dog Liver and Intestine. PHARMACEUTICAL RESEARCH 2015; 32: 74-90. 2014

Juvonen Risto, Savolainen Kai, Vähäkangas Kirsi. 2014. Alkoholimyrkytykset ja alkoholin krooniset haitat [Luku 43]: Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, Lääketieteellinen farmakologia ja toksikologia. 1044-1054. 2014

Keinonen Tuula, Hartikainen-Ahia Anu, Hokkanen Johanna, Hämeen-Anttila Katri, Juvonen Risto, Kosonen Anna-Liisa, Kärkkäinen Sirpa, Siitonen Piia, Vainio Kirsti. 2014. Lasten lääkekasvatus. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 237. 2014

Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. 2014. Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 2015; 22: 538-550. 2014

Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi. 2014. Chloropicrin-induced toxic responses in human lung epithelial cells. TOXICOLOGY LETTERS 226: 236-244. 2014

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. MOLECULAR AND CELLULAR ENDOCRINOLOGY 387: 8-18. 2014

Raunio Hannu, Pasanen Markku, Juvonen Risto, Rahnasto-Rilla Minna, Tani Niina, Hukkanen Kaisa, Huuskonen Pasi, Muluneh Fashe. 2014. Vierasaineiden metabolia. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 208. 2014

Tani Niina, Juvonen Risto O, Raunio Hannu, Fashe Muluneh, Leppänen Jukka, Zhao Bin, Tyndale Rachel F, Rahnasto-Rilla Minna. 2014. Rational design of novel CYP2A6 inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 22 23: 6655-6664. 2014

Vähäkangas Kirsi, Pasanen Markku, Raunio Hannu, Mensalo Päivi, Juvonen Risto, Loikkanen Jarkko. 2013. Yleisen toksikologian kansainvälisen maisteriohjelman kehittyminen - tieteellinen tutkimus opetuksen perustana: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim)., Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. Publications of the University of Eastern Finland. General Series 13. 48-53. 2013

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013

Rahikainen Tuomas, Häkkinen Merja R, Finel Moshe, Pasanen Markku, Juvonen Risto O. 2013. A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. XENOBIOTICA (LONDON) 43 10: 853-861. 2013

Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A. 2012. Metabolism of bilirubin by human cytochrome P450 2A6. TOXICOLOGY AND APPLIED PHARMACOLOGY 261: 50-58. 2012

Abu-Bakar A'edah, Hakkola Jukka, Juvonen Risto, Rahnasto-Rilla Minna, Raunio Hannu, Lang Matti A. 2012. Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver. CURRENT DRUG METABOLISM 2013:14: 137-150. 2012

Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012

Huttunen Kristiina M, Tani Niina, Juvonen Risto O, Raunio Hannu, Rautio Jarkko. 2012. Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome P450-activated prodrugs. Molecular Pharmaceutics 2013:10: 532-537. 2012

Koppaka Vindhya, Thompson David C, Chen Ying, Ellermann Manuel, Nicolaou Kyriacos C, Juvonen Risto O, Petersen Dennis, Deitrich Richard A, Hurley Thomas D, Vasiliou Vasilis. 2012. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application PHARMACOLOGICAL REVIEWS [ONLINE] 64 3: 520-539. 2012

Martikainen Laura E, Rahnasto-Rilla Minna, Neshybova Silvie, Lahtela-Kakkonen Maija, Raunio Hannu, Juvonen Risto O. 2012. Interactions of inhibitor molecules with the human CYP2E1 enzyme active site. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 47 5: 996-1005. 2012

Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS 437 1-2: 29-41. 2012

Mulik Rohit S, Mönkkönen Jukka, Juvonen Risto O, Mahadik Kakasaheb R, Paradkar Anant R. 2012. Apoptosis-induced anticancer effect of transferrinconjugated solid lipid nanoparticles of curcumin. Cancer Nanotechnology 3 1-6: 65-81. 2012

Tani Niina, Rahnasto-Rilla Minna, Wittekindt Carsten, Salminen Kaisa A, Ritvanen Anniina, Ollakka Riina, Koskiranta Jenna, Raunio Hannu, Juvonen Risto O. 2012. Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 47: 270-277. 2012

Salminen Kaisa A, Meyer Achim, Jerabkova Lenka, Korhonen Laura E, Rahnasto Minna, Juvonen Risto O, Imming Peter, Raunio Hannu. 2011. Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids. PHYTOMEDICINE 18: 533 - 538. 2011

Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics. DRUG METABOLISM AND DISPOSITION 39 3: 412 - 418. 2011

Rahnasto Minna K, Raunio Hannu A, Wittekindt Carsten, Salminen Kaisa A, Leppänen Jukka, Juvonen Risto O, Poso Antti, Lahtela-Kakkonen Maija K. 2011. Identification of novel CYP2A6 inhibitors by virtual screening BIOORGANIC AND MEDICINAL CHEMISTRY 19: 7186-7193. 2011

Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. 2011. 2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites TOXICOLOGY LETTERS 207: 34-41. 2011

Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. 2011. d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry TOXICOLOGY IN VITRO 25: 411 - 425. 2011

Juvonen R. 2010. Mitä haittoja sienet voivat aiheuttaa? (Kuukauden kysymys). APTEEKKARI: SUOMEN APTEEKKARILEHTI 9: 26-28. 2010

Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxity using in vitro cell culture model. Molecular Pharmaceutics 7 3: 815-825. 2010

Mulik RS, Mönkkönen J, Juvonen RO, Mahadik KR & Paradkar AR. 2010. Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis INTERNATIONAL JOURNAL OF PHARMACEUTICS 398: 190-203. 2010

Kärkkäinen S, Keinonen T, Juvonen R. 2009. Teaching about intoxicating substances in primary school: teacher students' thoughts on the subject 11: 78-85. 2009

Laine JE, Auriola S, Pasanen M, Juvonen RO. 2009. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes XENOBIOTICA (LONDON) 39 1: 11-21. 2009

Rahnasto M, Wittekindt C, Juvonen RO, Turpeinen M, Petsalo A, Pelkonen O, Poso A, Stahl G, Höltje H-D, Raunio H. 2008. Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme-an in silico approach PHARMACOGENOMICS JOURNAL 8 5: 328-338. 2008

Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo XENOBIOTICA (LONDON) 38 1: 34-47. 2008

Gratz S, Wu QK, El-Nezami H, Juvonen RO, Mykkänen H, Turner PC, Gratz S, WU QK, El-Nezami H. 2007. Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells APPLIED AND ENVIRONMENTAL MICROBIOLOGY 73 12: 3958-3964. 2007

Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J. 2007. Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality PHARMACEUTICAL RESEARCH 24 4: 679-687. 2007

Korhonen LE, Turpeinen M, Rahnasto M, Wittekindt C, Poso A, Pelkonen O, Raunio H, Juvonen RO. 2007. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. BRITISH JOURNAL OF PHARMACOLOGY 150: 932-942. 2007

Saario SM, Poso A, Juvonen RO, Järvinen T, Salo-Ahen OMH. 2006. Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. JOURNAL OF MEDICINAL CHEMISTRY 49: 4650-4656. 2006

Turpeinen M, Korhonen LE, Tolonen A, Uusitalo J, Juvonen R, Raunio H, Pelkonen O. 2006. Cytochrome P450 (CYP) inhibition screening: Comparison of three tests. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 29: 130-138. 2006

Gratz S, Täubel M, Juvonen RO, Viluksela M, Turner PC, Mykkänen H, El-Nezami H, Gratz S, Täubel M, El-Nezami H. 2006. Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B1 in rats. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 72 11: 7398-7400. 2006

Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J. 2006. Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure. JOURNAL OF MEDICINAL CHEMISTRY 49: 1207-1211. 2006

El-Nezami HS, Polychronaki NN, Ma J, Zhu H, Ling W, Salminen EK, Juvonen RO, Salminen SJ, Poussa T, Mykkänen HM, El-Nezami HS, Polychronaki NN, Mykkänen HM. 2006. Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China. AMERICAN JOURNAL OF CLINICAL NUTRITION 83: 1199-1203. 2006

Korhonen LE, Rahnasto M, Mähönen N J, Wittekindt C, Poso A, Juvonen RO, Raunio H. 2005. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 48: 3808-3815. 2005

Mykkänen H, Zhu H, Salminen E, Juvonen RO, Ling W, Ma J, Polychronaki N, Kemiläinen H, Mykkänen O, Salminen S, El-Nezami H, Mykkänen H, Polychronaki, Kemiläinen H, Mykkänen O, El-Nezami H. 2005. Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males. INTERNATIONAL JOURNAL OF CANCER 115: 879-884. 2005

Rahnasto M, Raunio H, Poso A, Wittekindt C, Juvonen RO. 2005. Quantitative structure - activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. JOURNAL OF MEDICINAL CHEMISTRY 48: 440-449. 2005

Seppänen J, Juvonen R. 2005. Suippumyrkkyseitikkimyrkytys SIENILEHTI 57 4: 108-116. 2005

Forsberg MM, Juvonen RO, Helisalmi P, Leppänen J, Gogos JA, Karayiorgou M, Männistö PT. 2004. Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 370: 279-289. 2004

Gratz S, Mykkänen H, Ouwehand AC, Juvonen R, Salminen S, El-Nezami H, Gratz S, El-Nezami H. 2004. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 70 10: 6306-6308. 2004

Raunio H, Taavitsainen P, Honkakoski P, Juvonen R, Pelkonen O. 2004. In vitro methods in the prediction of kinetics of drugs: focus on drug metabolism. ATLA : ALTERNATIVES TO LABORATORY ANIMALS 32: 425-430. 2004

Turrek M, Juvonen RO, Ripatti I, Männistö PT, Raasmaja A. 2004. Interaktiivisen opetuksen kehittämisestä systemaattisen farmakologian ja lääkeainetoksikologian kurssilla. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 20 3: 201-208. 2004

Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallen EAA, Christiaans JAM, Jarho EM, Gynther J, Männistö PT. 2004. Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site. BIOCHEMICAL JOURNAL 382: 1003-1008. 2004

Venäläinen JI, Juvonen RO, Männistö PT. 2004. Evolutionary relationships of the prolyl oligopeptidase family enzymes FEBS JOURNAL 271: 2705-2715. 2004

Rahnasto M, Raunio H, Poso A, Juvonen RO. 2003. More potent inhibition of human CYP2A6 than mouse CYP2A5 enzyme activities by derivatives of phenylethylamine and benzaldehyde. XENOBIOTICA (LONDON) 33 5: 529-539. 2003

Myöhänen T, Juvonen R. 2003. Psilosybiini huumaavien sienten vaikuttava myrkky. SIENILEHTI 55 2: 36-46. 2003

Asikainen A, Tarhanen J, Poso A, Pasanen M, Alhava E, Juvonen RO. 2003. Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes TOXICOLOGY IN VITRO 17: 449-455. 2003

Odlind C, Reenilä I, Männistö PT, Juvonen R, Uhlén S, Gogos JA, Karayiorgou M, Hansell P. 2002. Reduced natriuretic response to acute sodium loading in COMT gene deleted mice [online] BMC PHYSIOLOGY [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCPHYSIOL/] 2. 2002

Pohjanvirta R, Korkalainen M, McGuire J, Simanainen U, Juvonen R, Tuomisto JT, Unkila M, Viluksela M, Bergman J, Poellinger L, Tuomisto J. 2002. Comparison of acute toxicities of indolo(3,2-b)carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive rats. FOOD AND CHEMICAL TOXICOLOGY 40: 1023-1032. 2002

Venäläinen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EAA, Gynther J, Männistö PT. 2002. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. BIOCHEMICAL PHARMACOLOGY 64: 463-471. 2002

Poso A, Gynther J, Juvonen R. 2001. A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 15: 195-202. 2001

Taavitsainen P, Juvonen R, Pelkonen O. 2001. In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. DRUG METABOLISM AND DISPOSITION 29: 217-222. 2001

Juvonen RO, Gynther J, Pasanen M, Alhava E, Poso A. 2000. Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6). XENOBIOTICA (LONDON) 30 1: 81-92. 2000

Niemelä O, Parkkila S, Juvonen RO, Viitala K, Gelboin HV, Pasanen M. 2000. Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. JOURNAL OF HEPATOLOGY 33: 893-901. 2000

Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. 2000. Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes ARCHIVES OF TOXICOLOGY 74: 511-520. 2000

Kojo A, Viitala P, Pasanen M, Pelkonen O, Raunio H, Juvonen R. 1998. Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes. ARCHIVES OF TOXICOLOGY 72: 336-341. 1998

Raunio H, Juvonen R, Pasanen M, Pelkonen O, Pääkkö P, Soini Y. 1998. Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma. HEPATOLOGY 27: 427-432. 1998

Juvonen RO, Pennanen S, Pasanen M. 1997. A convenient laboratory experiment for teaching the fundamentals of drug metabolism. AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION 61: 314-317. 1997

Pelkonen P, Lang MA, Negishi M, Wild CP, Juvonen RO. 1997. Interaction of Aflatoxin B1 with cytochrome P450 2A5 and its mutants: Correlation with metabolic activation and toxicity. CHEMICAL RESEARCH IN TOXICOLOGY 10 1: 85-90. 1997

Pennanen S, Kojo A, Pasanen M, Liesivuori J, Juvonen RO, Komulainen H. 1996. CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. HUMAN AND EXPERIMENTAL TOXICOLOGY 15: 435-442. 1996

Kojo A, Pellinen P, Juvonen R, Raunio H, Pelkonen O, Pasanen M. 1996. Distinct responses of mouse hepatic CYP enzymes to corn oil and peroxisome proliferators. BIOCHEMICAL PHARMACOLOGY 51: 1137-1143. 1996

Negishi M, Iwasaki M, Juvonen RO, Sueyoshi T, Darden TA, Pedersen LG. 1996. Structural flexibility and functional versatility of cytrochrome P450 and rapid evolution. MUTATION RESEARCH. FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 350: 43-50. 1996

Asikainen J, Pasanen M, Juvonen RO. 1996. Inhibition of mice coumarin 7-hydroxylase by undecanoic Ù-lactone, benzoxazole and 2H-pyran-2-one, Proceedings of the 15th European Workshop on Drug Metabolism.Gustav Fischer. Experimental and Toxicologic Pathology. Supplement. 13-17. 1996

Kinonen T, Pasanen M, Gynther J, Poso A, Järvinen T, Alhava E, Juvonen RO. 1995. Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6. BRITISH JOURNAL OF PHARMACOLOGY 116: 2625-2630. 1995

Laitinen JT, Juvonen RO. 1995. A sensitive microassay reveals marked regional differences in the capacity of rat brain to generate carbon monoxide. BRAIN RESEARCH 694: 246-252. 1995

Pasanen M, Pellinen P, Stenbäck F, Juvonen RO, Raunio H, Pelkonen O. 1995. The role of CYP enzymes in cocaine-induced liver damage. ARCHIVES OF TOXICOLOGY 69: 287-290. 1995

Poso A, Juvonen R, Gynther J. 1995. Comparative molecular field analysis of compounds with CYP2A5 binding affinity. QSAR AND COMBINATORIAL SCIENCE 14: 507-511. 1995

Sueyoshi T, Park LJ, Moore R, Juvonen RO, Negishi M. 1995. Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 322 1: 265-271. 1995

Juvonen R, Iwasaki M, Negishi M. 1994. Function of residue-365 in mouse P4502A5 (P450coh): site directed mutagenesis, spectral and enzymatic properties: Lechner MC, Cytochrome P450. 8th International Conference.John Libbey. 801-803. 1994

Kojo A, Laitinen S, Pellinen P, Juvonen R, Raunio H, Pelkonen O, Pasanen M. 1994. Clofibrate decreases CYP2A5 in male DBA/2N mice: Lechner MC, Cytochrome P450. 8th International Conference.John Libbey. 511-514. 1994

Mäenpää J, Juvonen R, Raunio H, Rautio A, Pelkonen O. 1994. Coumarin and methoxsalen metabolism by CYP2A6 and CYP2a-5 isoforms in man and mouse: Lechner MC, Cytochrome P450. 8th International Conference.John Libbey. 631-634. 1994

Mäenpää J, Juvonen R, Raunio H, Rautio A, Pelkonen O. 1994. Metabolic interactions of methoxsalen and coumarin in humans and mice BIOCHEMICAL PHARMACOLOGY 48: 1363-1369. 1994

Pelkonen P, Juvonen R. 1994. Transgeenisillä hiivoilla testataan aflatoksiinien myrkyllisyyttä. APTEEKKARI: SUOMEN APTEEKKARILEHTI 4: 6-7. 1994

Pelkonen P, Lang MA, Wild CP, Negishi M, Juvonen RO. 1994. Activation of aflatoxin B1 by mouse CYP2A enzymes and cytotoxicity in recombinant yeast cells EUROPEAN JOURNAL OF PHARMACOLOGY 292: 67-73. 1994

Yhteystiedot

Organisaatio

Sähköposti

Puhelin

Tutkimusryhmät - UEF

Julkaisut