Sanna Oikari

Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis

Mustonen, Anne-Mari; Lehmonen, Nina; Oikari, Sanna; Capra, Janne; Raekallio, Marja; Mykkänen, Anna; Paakkonen, Tommi; Rilla, Kirsi; Niemelä, Tytti; Nieminen, Petteri. 2022. Scientific reports. 12: . 17550

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes

Mustonen, Anne-Mari; Paakkonen, Tommi; Matilainen, Johanna; Rilla, Kirsi; Käkelä, Reijo; Malinen, Marjo; Takabe, Piia; Oikari, Sanna; Capra, Janne; Sihvo, Sanna P; Ryökäs, Pauliina; Nieminen, Petteri. 2022. International journal of molecular sciences. 23:

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna. 2022. Journal of investigative dermatology. 1412: 3041-3051.e10

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Aaltonen, Niina; Kyykallio, Heikki; Tollis, Sylvain; Capra, Janne; Hartikainen, Jaana M.; Matilainen, Johanna; Oikari, Sanna; Rilla, Kirsi. 2022. Frontiers in oncology. 12: . 869417

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid

Mustonen, Anne-Mari; Capra, Janne; Rilla, Kirsi; Lehenkari, Petri; Oikari, Sanna; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Matilainen, Johanna; Nieminen, Petteri. 2021. Bmc musculoskeletal disorders. 22: 247

The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells

Kyykallio, Heikki; Oikari, Sanna; Álvez, María Bueno; Dodd, Carlos José Gallardo; Capra, Janne; Rilla, Kirsi. 2020. Cancers. 12: 1908

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype

Tiainen, Satu; Rilla, Kirsi; Hämäläinen, Kirsi; Oikari, Sanna; Auvinen, Päivi. 2020. Breast cancer research and treatment. 2021; 185: 63-72

Activated hyaluronan metabolism in the tumor matrix - Causes and consequences

Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H. 2019. Matrix biology. 78-79: 147-164

Analysis of UDP-Sugars from Cultured Cells and Small Tissue Samples

Oikari, Sanna; Tammi, Markku I. Teoksessa: Vigetti, D; Theocharis, A(toim.) , 2019. The Extracellular Matrix. s. 81-89. Humana press

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. Cells. 8: 276

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Melero-Fernandez de Mera, RM; Arasu, UT; Kärnä, R; Oikari, S; Rilla, K; Vigetti, D; Passi, A; Heldin, P; Tammi, MI; Deen, AJ. 2019. Matrix biology. 80: 85-103

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23

Metformin decreases hyaluronan synthesis by vascular smooth muscle cells

Sainio, A; Takabe, P; Oikari, S; Salomäki-Myftari, H; Koulu, M; Söderström, M; Pasonen-Seppänen, S; Järveläinen, H. 2019. Journal of investigative medicine. 68: 383-391

Peritumoral ADC values in breast cancer: region of interest selection, associations with hyaluronan intensity, and prognostic significance

Kettunen, T; Okuma, H; Auvinen, P; Sudah, M; Tiainen, S; Sutela, A; Masarwah, A; Tammi, M; Tammi, R; Oikari, S; Vanninen, R. 2019. European radiology. 2020; 30: 38-46

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis

Tiainen, S; Masarwah, A; Oikari, S; Rilla, K; Hämäläinen, K; Sudah, M; Sutela, A; Vanninen, R; Ikonen, J; Tammi, R; Tammi, M; Auvinen, P. 2019. Breast cancer research and treatment. 2020; 179: 565-575

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways

Rauhala, L; Jokela, T; Kärnä, R; Bart, G; Takabe, P: Oikari, S; Tammi, MI; Pasonen-Seppänen, S; Tammi, RH. 2018. Biochemical journal. 475: 1755-1772

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

Hämäläinen, L; Kärkkäinen, E; Takabe, P; Rauhala, L; Bart, G; Kärnä, R; Pasonen-Seppänen, S; Oikari, S; Tammi, MI; Tammi, RH. 2018. British journal of dermatology. 179: 651-661

UDP-sugar accumulation drives hyaluronan synthesis in breast cancer

Oikari, S; Kettunen, T; Tiainen, S; Häyrinen, J; Masarwah, A; Sudah, M; Sutela, A; Vanninen, R; Tammi, M; Auvinen, P. 2018. Matrix biology. 67: 63-74

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Koistinen Ville, Härkönen Kai, Kärnä Riikka, Arasu Uma Thanigi, OIkari Sanna, Rilla Kirsi. 2017. Matrix biology. 63: 38-54

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. 2017. Matrix biology. 64: 54-68

Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis

Oikari Sanna, Makkonen Katri, Deen Ashik Jawahar, Tyni Ilari, Kärnä Riikka, Tammi Raija H, Tammi Markku I. 2016. Glycobiology. 26: 710-722

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

Tiainen Satu, Oikari Sanna, Tammi Markku, Rilla Kirsi, Hämäläinen Kirsi, Tammi Raija, Kosma Veli-Matti, Auvinen Päivi. 2016. Breast cancer research and treatment. 160: 237-247

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

Koistinen Ville, Jokela Tiina, Oikari Sanna, Kärnä Riikka, Tammi Markku, Rilla Kirsi. 2016. Histochemistry and cell biology. 145: 531-544

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

Masarwah Amro, Auvinen Päivi, Sudah Mazen, Dabravolskaite Vaiva, Arponen Otso, Sutela Anna, Oikari Sanna, Kosma Veli-Matti, Vanninen Ritva. 2016. Bmc cancer. 16: 833

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. 2016. Cellular and molecular life sciences. 73: 3183-3204

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Siiskonen Hanna, Oikari Sanna, Pasonen-Seppänen Sanna, Rilla Kirsi. 2015. Frontiers in immunology. epub:

Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Jokela Tiina, Oikari Sanna, Takabe Piia, Rilla Kirsi, Kärnä Riikka, Tammi Markku, Tammi Raija. 2015. Journal of biological chemistry. 290: 12379-12393

The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome

Masarwah Amro, Tammi Markku, Sudah Mazen, Sutela Anna, Oikari Sanna, Kosma Veli-Matti, Tammi Raija, Vanninen R, Auvinen Päivi. 2015. Breast cancer research and treatment. 153: 625-634

Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer

Masarwah Amro, Auvinen Päivi, Sudah Mazen, Rautiainen Suvi, Sutela Anna, Pelkonen Outi, Oikari Sanna, Kosma Veli-Matti, Vanninen Ritva. 2015. European radiology. 25: 1875-1882

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. Histopathology. 2014; 66: 873-883

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

Deen Ashik Jawahar, Rilla Kirsi, Oikari Sanna, Kärnä Riikka, Bart Genevieve, Häyrinen Jukka, Bathina Avinash Rahul, Ropponen Antti, Makkonen Katri, Tammi Raija H, Tammi Markku I. 2014. Journal of biological chemistry. 289: 8375-89

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Hascall Vincent C, Wang Aimin, Tammi Markku, Oikari Sanna, Tammi Raija, Passi Alberto, Vigetti Davide, Hanson Richard W, Hart Gerald W. 2014. Matrix biology. 35: 14-17

Borate-aided anion exchange high-performance liquid chromatography of uridine diphosphate-sugars in brain, heart, adipose and liver tissues

Oikari S, Venäläinen T, Tammi M. 2013. Journal of chromatography a. 1323: 82-86

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. 2013. Experimental cell research. 319: 2006-2018

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Journal of biological chemistry. 288: 5973-5983

Multiple roles of hyaluronan as a target and modifier of the inflammatory response

Oikari S, Jokela TA, Tammi RH, Tammi MI. Teoksessa: Karamanos NK(toim.) , 2012. Extracellular matrix: pathobiology and signaling. s. 39-65. De Gruyter

Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1

Jokela Tiina A, Makkonen Katri M, Oikari Sanna, Kärnä Riikka, Koli Elina, Hart Gerald W, Tammi Raija H, Tammi Markku I. 2011. Journal of biological chemistry. 289: 33632-33640

Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats

Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH. 2008. Pflugers archiv: european journal of physiology. 456: 369-377

Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats

Oikari S, Ahtialansaari T, Huotari A, Kiehne K, Fölsch UR, Wolffram S, Jänne J, Alhonen L, Herzig KH. 2008. Acta physiologica. 194: 57-65

Evaluation of Phenotypic Changes of Acyl-CoA Binding Protein / Diazepam Binding Inhibitor Overexpression in Transgenic Mice and Rats

Oikari S. 2008. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning

Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H. 2007. Molecular and cellular neuroscience. 34: 199-208

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A

Bengtsson MW, Mäkelä K, Sjöblom M, Uotila S, Åkerman KEO, Herzig K-H, Flemström G. 2007. American journal of physiology : gastrointestinal and liver physiology. 293: G501-G509

Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis

Räty S, Piironen A, Babu M, Pelli H, Sand J, Uotila S, Nordback I, Herzig K-H. 2007. Scandinavian journal of gastroenterology. 42: 1000-1005

Duodenal diazepam-binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

Pelli H, Herzig K-H, Uotila S, Räty S, Laine S, Sand J, Nordback I. 2006. Scandinavian journal of clinical and laboratory investigation. 66: 677-684

VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumäki J, Laakso M, Herzig K-H, Ylä-Herttuala S. 2006. Faseb journal. 20: 2159-2161

Introduction of histidine residues into avidin subunit interfaces allows pH-dependet regulation of quaternary structure and biotin binding

Nordlund HR, Hytönen VP, Laitinen OH, Uotila STH, Niskanen EA, Savolainen J, Porkka E, Kulomaa MS. 2003. Febs letters. 555: 449-454

The STC-1 cells express functional orexin-A receptors coupled to CCK release

Larsson KP, Åkerman KE, Magga J, Uotila S, Kukkonen JP, Näsman J, Herzig KH. 2003. Biochemical and biophysical research communications. 309: 209-216

Tarkenna hakuasi

Tutkimusryhmät

Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid

The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype

Activated hyaluronan metabolism in the tumor matrix - Causes and consequences

Analysis of UDP-Sugars from Cultured Cells and Small Tissue Samples

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Metformin decreases hyaluronan synthesis by vascular smooth muscle cells

Peritumoral ADC values in breast cancer: region of interest selection, associations with hyaluronan intensity, and prognostic significance

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

UDP-sugar accumulation drives hyaluronan synthesis in breast cancer

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome

Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Borate-aided anion exchange high-performance liquid chromatography of uridine diphosphate-sugars in brain, heart, adipose and liver tissues

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Multiple roles of hyaluronan as a target and modifier of the inflammatory response

Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1

Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats

Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats

Evaluation of Phenotypic Changes of Acyl-CoA Binding Protein / Diazepam Binding Inhibitor Overexpression in Transgenic Mice and Rats

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A

Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis

Duodenal diazepam-binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

Introduction of histidine residues into avidin subunit interfaces allows pH-dependet regulation of quaternary structure and biotin binding

The STC-1 cells express functional orexin-A receptors coupled to CCK release