Tiit Örd

Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

Aherrahrou, Rédouane; Baig, Ferheen; Theofilatos, Konstantinos; Lue, Dillon; Beele, Alicia; Örd, Tiit; Kaikkonen, Minna U; Aherrahrou, Zouhair; Cheng, Qi; Ghosh, Saikat Kumar B; Karnewar, Santosh; Karnewar, Vaishnavi; Finn, Aloke V; Owens, Gary K; Joner, Michael; Mayr, Manuel; Civelek, Mete. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 898-914

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Babu, Mohan; Devi, Durga; Mäkinen, Petri; Örd, Tiit; Aavik, Einari; Kaikkonen, Minna; Ylä-Herttuala, Seppo. 2023. Arteriosclerosis, thrombosis, and vascular biology. 43: e46–e61

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92:

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Örd, Tiit; Suoranta, Tuisku; Heikkilä, Janne; Kaikkonen, Minna U.; Laham-Karam, Nihay; Ylä-Herttuala, Seppo. 2023. Frontiers in cardiovascular medicine. 10: . 1113890

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

Örd, Tiit; Lönnberg, Tapio; Nurminen, Valtteri; Ravindran, Aarthi; Niskanen, Henri; Kiema, Miika; Õunap, Kadri; Maria, Maleeha; Moreau, Pierre R; Mishra, Pashupati P; Palani, Senthil; Virta, Jenni; Liljenbäck, Heidi; Aavik, Einari; Roivainen, Anne; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Lehtimäki, Terho; Kaikkonen, Minna U. 2023. American journal of human genetics. 110: 722-740

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Jauhiainen, Suvi; Ilmonen, Henna; Vuola, Pia; Rasinkangas, Heta; Pulkkinen, Heidi H; Keränen, Sara; Kiema, Miika; Liikkanen, Jade J; Laham Karam, Nihay; Laidinen, Svetlana; Beter, Mustafa; Aavik, Einari; Lappalainen, Kimmo; Lohi, Jouko; Aronniemi, Johanna; Örd, Tiit; Kaikkonen, Minna U; Salminen, Päivi; Tukiainen, Erkki; Ylä-Herttuala, Seppo; Laakkonen, Johanna P. 2023. eLife. 12:

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Aherrahrou, Rédouane; Lue, Dillon; Perry, R Noah; Aberra, Yonathan Tamrat; Khan, Mohammad Daud; Soh, Joon Yuhl; Örd, Tiit; Singha, Prosanta; Yang, Qianyi; Gilani, Huda; Benavente, Ernest Diez; Wong, Doris; Hinkle, Jameson; Ma, Lijiang; Sheynkman, Gloria M; den Ruijter, Hester M; Miller, Clint L; Björkegren, Johan LM; Kaikkonen, Minna U; Civelek, Mete. 2023. Circulation research. 132: 323-338

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

Örd, Tiit; Örd, Daima; Adler, Priit; Örd, Tõnis. 2023. PLoS genetics. 19: . e1011014

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Anisimov, Andrey; Fang, Shentong; Hemanthakumar, Karthik Amudhala; Örd, Tiit; van Avondt, Kristof; Chevre, Raphael; Toropainen, Anu; Singha, Prosanta; Gilani, Huda; Nguyen, Su D; Karaman, Sinem; Korhonen, Emilia A; Adams, Ralf H.; Augustin, Hellmut G; Öörni, Katariina; Soehnlein, Oliver; Kaikkonen, Minna U; Alitalo, Kari. 2023. Nature cardiovascular research. 2: 307-321

Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine

Palani, Senthil; Miner, Maxwell WG; Virta, Jenni; Liljenbäck, Heidi; Eskola, Olli; Örd, Tiit; Ravindran, Aarthi; Kaikkonen, Minna U; Knuuti, Juhani; Li, Xiang-Guo; Saraste, Antti; Roivainen, Anne. 2022. Frontiers in immunology. 13: . 821423

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations

Toropainen, Anu; Stolze, Lindsey K; Örd, Tiit; Whalen, Michael B; Torrell, Paula Martí; Link, Verena M; Kaikkonen, Minna U; Romanoski, Casey E. 2022. Genome research. 32: 409-424

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M. 2022. Cells. 11:

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Maria, Maleeha; Pouyanfar, Negar; Örd, Tiit; Kaikkonen, Minna U. 2022. Genes. 13:

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. American journal of human genetics. 108: 411-430

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Conklin, Austin C.; Nishi, Hitoo; Schlamp, Florencia; Örd, Tiit; Õunap, Kadri; Kaikkonen, Minna U.; Fisher, Edward A.; Romanoski, Casey E.. 2021. Immunometabolism. 3: e210022

Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

Örd, Tiit; Örd, Daima; Kaikkonen, Minna U.; Örd, Tõnis. 2021. Cancers. 13: 2341

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. 2021. Arteriosclerosis, thrombosis, and vascular biology. 41: 2149-2167

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Örd, Tiit; Õunap, Kadri; Stolze, Lindsey; Aherrahrou, Rédouane; Nurminen, Valtteri; Selvarajan, Ilakya; Toropainen, Anu; Lönnberg, Tapio; Aavik, Einari; Yla-Herttuala, Seppo; Civelek, Mete; Romanoski, Casey E; Kaikkonen, Minna U. 2021. Circulation research. 129: 240-258

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt, Marie Ac; Prange, Koen Hm; Slenders, Lotte; Örd, Tiit; Elbersen, Danny; Boltjes, Arjan; de Jager, Saskia Ca; Asselbergs, Folkert W; de Borst, Gert J; Aavik, Einari; Lönnberg, Tapio; Lutgens, Esther; Glass, Christopher K; den Ruijter, Hester M; Kaikkonen, Minna U; Bot, Ilze; Slütter, Bram; van der Laan, Sander W; Ylä-Herttuala, Seppo; Mokry, Michal; et al. 2020. Circulation research. 127: 1437-1455

Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages

Moisio, Olli; Palani, Senthil; Virta, Jenni; Elo, Petri; Liljenbäck, Heidi; Tolvanen, Tuula; Käkelä, Meeri; Miner, Maxwell G; Herre, Erika Atencio; Marjamäki, Päivi; Örd, Tiit; Heinäniemi, Merja; Kaikkonen, Minna U; Zhang, Fenghua; Srinivasarao, Madduri; Knuuti, Juhani; Low, Philip S; Saraste, Antti; Li, Xiang-Guo; Roivainen, Anne. 2020. Scientific reports. 10: 13593

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Stolze, Lindsey; Conklin, Austin; Whalen, Michael; López Rodríguez, Maykel; Õunap, Kadri; Selvarajan, Ilakya; Toropainen, Anu; Örd, Tiit; Li, Jin; Eshghi, Anna; Solomon, Alice; Fang, Yun; Kaikkonen, Minna; Romanoski, Casey. 2020. American journal of human genetics. 106: P748-763

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells

Moreau, Pierre R; Örd, Tiit; Downes, Nicholas L; Niskanen, Henri; Bouvy-Liivrand, Maria; Aavik, Einari; Ylä-Herttuala, Seppo; Kaikkonen, Minna U. 2018. Frontiers in cardiovascular medicine. 5: 12

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Julkaisut

Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells