Virpi Tiitu

Saukko, AEA; Turunen, MJ; Honkanen, MKM; Lovric, G; Tiitu, V; Honkanen, JTJ; Grinstaff, MW; Jurvelin, JS; Töyräs, J. 2019. Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging Scientific reports 9 1: 7118. 2019

Sarin, JK; Nykänen, O; Tiitu, V; Mancini, IAD; Brommer, H; Visser, J; Malda, J; van Weeren, PR; Afara, IO; Töyräs, J. 2019. Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy Annals of biomedical engineering 47 8: 1815-1826. 2019

Fick JM, Ronkainen AP, Madden R, Sawatsky A, Tiitu V, Herzog W, Korhonen RK. 2016. Early in situ changes in chondrocyte biomechanical responses due to a partial meniscectomy in the lateral compartment of the mature rabbit knee joint. JOURNAL OF BIOMECHANICS 49 16: 4057-4064. 2016

Finnilä MA, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P, Saarakkala S. 2016. Association between subchondral bone structure and osteoarthritis histopathological grade. JOURNAL OF ORTHOPAEDIC RESEARCH 2017; 35 4: 785-792. 2016

Puhakka PH, te Moller NCR, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2016. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. ACTA ORTHOPAEDICA 87 4: 418-424. 2016

Stewart Rachel C, Honkanen Juuso TJ, Kokkonen Harri T, Tiitu Virpi, Saarakkala Simo, Joukainen Antti, Snyder Brian D, Jurvelin Jukka S, Grinstaff Mark W, Töyräs Juha. 2016. Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage. Cartilage 8 4: 391-399. 2016

Inkinen Satu I, Liukkonen Jukka, Tiitu Virpi, Viren Tuomas, Jurvelin Jukka S, Töyräs Juha. 2015. Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage. ULTRASOUND IN MEDICINE AND BIOLOGY 41 7: 1958-1966. 2015

Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2015. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. OSTEOARTHRITIS AND CARTILAGE 23 12: 2206-2213. 2015

Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Liimatainen Timo, Michaeli Shalom, Mangia Silvia, Ellermann Jutta, Nieminen Miika T. 2015. Multi-parametric MRI characterization of enzymatically degraded articular cartilage. JOURNAL OF ORTHOPAEDIC RESEARCH 2016; 34 7: 1111-1120. 2015

Pirinen Sami, Karvinen Jennika, Tiitu Virpi, Suvanto Mika, Pakkanen Tuula T. 2015. Control of swelling properties of polyvinyl alcohol/hyaluronic acid hydrogels for the encapsulation of chondrocyte cells. JOURNAL OF APPLIED POLYMER SCIENCE 132 28: 6 p. 2015

Ilves Tiina, Tiitu Virpi, Suttle Mireille-Maria, Saarinen Jari Vilho, Harvima Ilkka Tapani. 2015. Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity. Dermatitis 26 6: 260-267. 2015

Honkanen Juuso, Turunen Mikael, Tiitu Virpi, Jurvelin Jukka, Töyräs Juha. 2015. Transport of Iodine Is Different in Cartilage and Meniscus. ANNALS OF BIOMEDICAL ENGINEERING 2016; 44 7: 2114-2122. 2015

Honkanen JTJ, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS, Töyräs J. 2015. Contrast Enhanced Imaging of Human Meniscus Using Cone Beam CT. OSTEOARTHRITIS AND CARTILAGE 23 8: 1367-1376. 2015

Arokoski Mikko EA, Tiitu Virpi, Jurvelin Jukka S, Korhonen Rami K, Fick James M. 2015. Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament. JOURNAL OF ORTHOPAEDIC RESEARCH 33 9: 1278-1286. 2015

Huttu Mari RJ, Puhakka Jani, Mäkelä Janne TA, Takakubo Yuya, Tiitu Virpi, Saarakkala Simo, Konttinen Yrjö T, Kiviranta Ilkka, Korhonen Rami K. 2014. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. CONNECTIVE TISSUE RESEARCH 55 4: 282-91. 2014

Puhakka PH, Ylärinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kröger H, Virén T, Jurvelin JS, Töyräs J. 2014. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds. PHYSICS IN MEDICINE AND BIOLOGY 59 21: 6537-48. 2014

Qu Chengjuan, Hirviniemi Mikko, Tiitu Virpi, Jurvelin Jukka S, Töyräs Juha, Lammi Mikko J. 2014. Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage. Cartilage 5 2: 97-106. 2014

Rautiainen Jari, Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Finnilä Mikko AJ, Aho Olli-Matti, Saarakkala Simo, Lehenkari Petri, Ellermann Jutta, Nieminen Miika T. 2014. Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties. MAGNETIC RESONANCE IN MEDICINE Epub ahead of print: -. 2014

Jari Rautiainen; Lauri J. Lehto; Virpi Tiitu; Outi Kiekara; Hertta Pulkkinen; Anne Brünott; René van Weeren; Harold Brommer; Pieter A. J. Brama; Jutta Ellermann; Ilkka Kiviranta; Miika T. Nieminen; Mikko J. Nissi. 2013. Osteochondral Repair: Evaluation with Sweep Imaging with Fourier Transform in an Equine Model. RADIOLOGY epub ahead of print: epub ahead of print. 2013

Kulmala KAM, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK, Töyräs J. 2013. Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking-contribution of steric and electrostatic effects. MEDICAL ENGINEERING & PHYSICS 35 10: 1415-1420. 2013

Lötjönen J, Julkunen P, Tiitu V, Jurvelin JS, Töyräs J. 2013. Ultrasound speed varies in articulaar cartilage under indentation loading. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 58 12: 2772-2780. 2013

Salo E-N, Nissi MJ, Kulmala KAM, Tiitu V, Töyräs J, Nieminen MT. 2012. Diffusion of Gd-DTPA2- into articular cartilage. OSTEOARTHRITIS AND CARTILAGE 20 2: 117-126. 2012

Virén T, Timonen M, Tyrväinen H, Tiitu V, Jurvelin JS, Töyräs J. 2012. Ultrasonic evaluation of acute impact injury of articular cartilage in vitro OSTEOARTHRITIS AND CARTILAGE 20: 719-726. 2012

Virén T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brünott A, Van Weeren R, Brama PAJ, Zheng YP, Jurvelin JS, Töyräs J. 2012. Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY 36 3: 185-192. 2012

Silvast Tuomo, Jurvelin Jukka, Tiitu Virpi, Quinn Thomas, Töyräs Juha. 2012. Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro Cartilage 2013; 4 1: 42-51. 2012

K.A.M. Kulmala, H.J. Pulkkinen, L. Rieppo, V. Tiitu, I. Kiviranta, A. Brünott, H. Brommer, R. van Weeren, P.A.J. Brama, M.T. Mikkola, R.K. Korhonen, J.S. Jurvelin, J.Töyräs. 2012. Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage. Cartilage 3 3: 235-244. 2012

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Töyräs J, Silvast TS, Lammi MJ, Kiviranta I. 2012. Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit. OSTEOARTHRITIS AND CARTILAGE 2012 Dec 17. pii: S1063-4584(12)01049-7.: --. 2012

Kobrina Y, Rieppo L, Saarakkala S, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Jurvelin JS, Isaksson H. 2012. Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage. OSTEOARTHRITIS AND CARTILAGE 2012 Dec 23. pii: S1063-4584(12)01050-3.: --. 2012

Huttu Mari, Turunen Siru, Sokolinski Viktoria, Tiitu Virpi, Lammi Mikko, Korhonen Rami K. 2012. Effects of Medium and Temperature on Cellular Responses in the Superficial Zone of Hypo-Osmotically Challenged Articular Cartilage. Journal of Functional Biomaterials 3 3: 544-555. 2012

Huttu Mari, Puhakka Jani, Mäkelä Janne, Takakubo Yuya, Tiitu Virpi, Saarakkala Simo, Konttinen Yrjö, Kiviranta Ilkka, Korhonen Rami K. 2012. Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage: ORS, Transactions of the Orthopaedic Research Society. 1823. 2012

Huttu MRJ, Turunen SM, Sokolinski V, Tiitu V, Lammi MJ, Korhonen RK. 2011. Effects of medium and temperature on cell mechanics in osmotically challenged articular cartilage: Van Sint Jan S, Feipel V, Aerenhouts D, Baeyens J-P, Carpentier A, Cattrysse E, Clarys J-P, Duchateau J, Guissard N, Leloup T, Provyn S, Rooze M, Scafoglieri A, Schuind F, Van Roy P, Warzée N, ISB 2011 Brussels Conference book Program & Abstracts. 143-144. 2011

Kokkonen HT, Jurvelin JS, Tiitu V, Töyräs J. 2011. Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography OSTEOARTHRITIS AND CARTILAGE 19: 297-301. 2011

Kokkonen HT, Mäkelä J, Kulmala KAM, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V, Töyräs J. 2011. Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage OSTEOARTHRITIS AND CARTILAGE 19: 1190-1198. 2011

Kulmala K.A.M, Pulkkinen H.J, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama P.A.J, Mikkola M.T, Korhonen R.K, Jurvelin J.S, Töyräs J.. 2011. Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair. Teoksessa: (toim.), 5th Osteoarthritis Imaging Workshop. ss. 6. 2011

Virén Tuomas, Saarakkala Simo, Tiitu Virpi, Puhakka Jani, Kiviranta Ilkka, Jurvelin Jukka S, Töyräs Juha. 2011. Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 58 1: 148-154. 2011

Virén T, Saarakkala S, Jurvelin JS, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Lammi MJ & Töyräs J. 2010. Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ. ULTRASOUND IN MEDICINE AND BIOLOGY 36 5: 833-839. 2010

Myllymaa S, Myllymaa K, Korhonen H, Lammi MJ, Tiitu V & Reijo Lappalainen. 2010. Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films COLLOIDS AND SURFACES B: BIOINTERFACES 76 2: 505-511. 2010

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Lammi MJ & Kiviranta I. 2010. Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo. OSTEOARTHRITIS AND CARTILAGE 18 8: 1077-1087. 2010

Aula AS, Töyräs J, Tiitu V, Jurvelin JS. 2010. Simultaneous ultrasound measurement of articular cartilage and subchondral bone. OSTEOARTHRITIS AND CARTILAGE 18 12: 1570-1576. 2010

Myllymaa K, Myllymaa S, Korhonen H, Lammi MJ, Saarenpää H, Suvanto M, Pakkanen TA, Tiitu V, Lappalainen R. 2009. Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE 20: 2337-2347. 2009

Pulkkinen HJ, Tiitu V, Valonen P, Hamalainen E-R, Lammi MJ, Kiviranta I. 2008. Recombinant human type II collagen as a material for cartilage tissue engineering INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 31 11: 960-969. 2008

Tiitu V, Pulkkinen HJ, Valonen P, Kiviranta O, Kiekara T, Kiviranta I, Lammi MJ. 2008. Recombinant human collagens as scaffold materials for chondrocyte cultures. BIO-MEDICAL MATERIALS AND ENGINEERING 18 4-5: 225-229. 2008

Tiitu V, Pulkkinen HJ, Valonen P, Pulliainen O, Kellomäki M, Lammi MJ, Kiviranta I. 2008. Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold. BIORHEOLOGY 45 3-4: 539-546. 2008

V. Tiitu, H. Pulkkinen, P. Valonen, O. Pulliainen, M. Kellomäki, M. J. Lammi, I. Kiviranta. 2008. Bioreactor improves the growth and viability of chondrocytes in the knitted Poly-L,D-Lactide scaffold BIORHEOLOGY 45 3-4: 539-546. 2008

Pullinen O, Vasara AI, Hyttinen MM, Tiitu V, Valonen P, Kellomäki M, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I, Lammi MJ. 2007. Poly-L-D-Lactic acid scaffold in the repair of porcine knee cartilage lesions. TISSUE ENGINEERING 13 6: 1347-1355. 2007

Pulkkinen H, Tiitu V, Lammentausta E, Hämäläinen E-R, Kiviranta I, Lammi MJ. 2006. Cellulose sponge as a scaffold for cartilage tissue engineering. BIO-MEDICAL MATERIALS AND ENGINEERING SUPPLEMENT 16: S29-S35. 2006

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