Eva del Amo Páez - UEFConnect

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M. 2024. European journal of pharmaceutics and biopharmaceutics. 198:

Mass spectrometry in ocular drug research

del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183

Towards a population pharmacokinetic/pharmacodynamic model of anti-VEGF therapy in patients with age-related macular degeneration

del Amo, Eva M; Bishop, Paul N; Godia, Pere; Aarons, Leon. 2023. European journal of pharmaceutics and biopharmaceutics. 188: 78-88

Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”

del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247

Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization

Tavakoli, Shirin; Puranen, Jooseppi; Bahrpeyma, Sina; Lautala, Veera E.; Karumo, Suvi; Lajunen, Tatu; del Amo, Eva M.; Ruponen, Marika; Urtti, Arto. 2022. International journal of pharmaceutics. 620:

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613:

Pharmacokinetic Models: Indispensable Tools for Ophthalmic Drug Development

Del Amo, Eva M. 2022. ONdrugDelivery. 2022: 59-63

Topical ophthalmic administration: Can a drug instilled onto the ocular surface exert an effect at the back of the eye?

del Amo, Eva M.. 2022. Frontiers in drug delivery. 2: . 954771

Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison

Naageshwaran, Vatsala; Ranta, Veli-Pekka; Toropainen, Elisa; Tuomainen, Marjo; Gum, Glenwood; Xie, Enli; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2022. International journal of pharmaceutics. 615:

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Balla, Anusha; Ruponen, Marika; Valtari, Annika; Toropainen, Elisa; Tuomainen, Marjo; Alvarez-Lorenzo, Carmen; del Amo, Eva M.; Urtti, Arto; Vellonen, Kati-Sisko. 2022. European journal of pharmaceutics and biopharmaceutics. 172: 53-60

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452

Current Situation and Challenges in Vitreous Substitutes

Mondelo-García, C; Bandín-Vilar, E; García-Quintanilla, L; Castro-Balado, A; Del Amo, EM; Gil-Martínez, M; Blanco-Teijeiro, MJ; González-Barcia, M; Zarra-Ferro, I; Fernández-Ferreiro, A; Otero-Espinar, FJ. 2021. Macromolecular bioscience. 21: 2100066

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu. 2021. Scientific reports. 11: 980

Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration

Naageshwaran, Vatsala; Ranta, Veli-Pekka; Gum, Glenwood; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2020. Journal of pharmaceutical sciences. 2021; 110: 529-535

Intravitreal Pharmacokinetic Study of the Antiangiogenic Glycoprotein Opticin

del Amo, Eva M; Griffiths, John R; Klaska, Izabela P; Hoke, Justin; White, Anne; Aarons, Leon; Cooper, Garth JS; Bainbridge, James; Bishop, Paul N; Unwin, Richard D. 2020. Molecular pharmaceutics. [Epub ahead of print 21 May 2020]: -

Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface

Tavakoli, Shirin; Peynshaert, Karen; Lajunen, Tatu; Devoldere, Joke; Del Amo, Eva M; Ruponen, Marika; De Smedt, Stefaan C; Remaut, Katrien; Urtti, Arto. 2020. Journal of controlled release. 328: 952-961

PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats

Luaces-Rodríguez, Andrea; del Amo, Eva M; Mondelo-García, Cristina; Gómez-Lado, Noemí; Gonzalez, Francisco; Ruibal, Álvaro; González-Barcia, Miguel; Zarra-Ferro, Irene; Otero-Espinar, Francisco J; Fernández-Ferreiro, Anxo; Aguiar, Pablo. 2020. European journal of pharmaceutics and biopharmaceutics. 154: 330-337

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. European journal of pharmaceutical sciences. 155: 105553

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Drug discovery today. 24: 1446-1457

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 143: 18-23

Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye

Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 119: 83-89

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model

Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Journal of pharmaceutical sciences. 106: 2463-2471

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. European journal of pharmaceutical sciences. 109: 162-168

Pharmacokinetic aspects of retinal drug delivery

del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185

HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo

Trifunovic Dragana, Arango-Gonzalez Blanca, Comitato Antonella, Barth Melanie, Del Amo Eva M, Kulkarni Manoj, Sahaboglu Ayse, Hauck Stefanie M, Urtti Arto, Arsenijevic Yvan, Ueffing Marius, Marigo Valeria, Paquet-Durand Francois. 2016. Human molecular genetics. 25: 4462-4472

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

Sahaboglu Ayse, Barth Melanie, Secer Enver, del Amo Eva M, Urtti Arto, Arsenijevic Yvan, Zrenner Eberhart, Paquet-Durand Francois. 2016. Scientific reports. 6: 39537

Preservatives in Ocular Medications and Nutraceuticals

Immonen Annamari, Immonen Mikko, Hakalehto Elias, del Amo Eva M. Teoksessa: Hakalehto Eino Elias(toim.) , 2016. Microbiological Industrial Hygiene. s. 59-79. Nova science publishers

Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug

Del Amo, EM; Ghemtio, L; Xhaard, H; Yliperttula, M; Urtti, A; Kidron, H. 2015. PLoS ONE. 10: e74758

Drug Development Regarding the Digestive Microbiota [Chapter 12]

Del Amo Eva M, Hakalehto Elias. Teoksessa: Hakalehto Elias(toim.) , 2015. Microbiological Clinical Hygiene. s. 177-192. Nova science publishers

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 95: 215-226

Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology

Andrés-Guerrero Vanessa, Zong Mengmeng, Ramsay Eva, Rojas Blanca, Sarkhel Sanjay, Gallego Beatriz, de Hoz Rosa, Ramírez Ana I, Salazar Juan J, Triviño Alberto, Ramírez José M, Del Amo Eva M, Cameron Neil, de-Las-Heras Beatriz, Urtti Arto, Mihov George, Dias Aylvin, Herrero-Vanrell Rocío. 2015. Journal of controlled release. 211: 105-117

Ocular and Systemic Pharmacokinetic Models for Drug Discovery and Development

Del Amo Páez, Eva Maria. 2015. University of Helsinki

Prediction of ocular drug distribution from systemic blood circulation

Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Molecular pharmaceutics. 13 (2016): 2906-2911

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

Del Amo Eva M, Urtti Arto. 2015. Experimental eye research. 137: 111-124

Bacterial interactions in the small intestine and their contribution to host nutrient uptake

Hakalehto, Elias;Pesola, Jouni; Del Amo, Eva; Hänninen, Osmo. Teoksessa: Hakalehto, Elias(toim.) , 2012. Alimentary Microbiome: A PMEU Approach. s. 61-94. Nova science publishers

Prediction of the vitreal half-life of small molecular drug-like compounds

Kidron, Heidi; del Amo, Eva M; Vellonen, Kati-Sisko; Urtti, Arto. 2012. Pharmaceutical research. 29: 3302-3311

Prediction of the corneal permeability of drug-like compounds

Kidron, H; Vellonen, K-S; del Amo, EM; Tissari, A; Urtti, A. 2010. Pharmaceutical research. 27: 1398-1407

In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

del Amo EM, Heikkinen AT, Mönkkönen J. 2009. European journal of pharmaceutical sciences. 36: 200-211

Current and future ophthalmic drug delivery systems: A shift to the posterior segment

Del Amo, Eva M; Urtti, Arto. 2008. Drug discovery today. 13: 135-143

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

del Amo EM, Urtti A, Yliperttula M. 2008. European journal of pharmaceutical sciences. 35: 161-174

Tarkenna hakuasi

Eva Maria del Amo Páez

Tutkimusryhmät

Avainsanat

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Mass spectrometry in ocular drug research

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

Towards a population pharmacokinetic/pharmacodynamic model of anti-VEGF therapy in patients with age-related macular degeneration

Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”

Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

Pharmacokinetic Models: Indispensable Tools for Ophthalmic Drug Development

Topical ophthalmic administration: Can a drug instilled onto the ocular surface exert an effect at the back of the eye?

Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Current Situation and Challenges in Vitreous Substitutes

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration

Intravitreal Pharmacokinetic Study of the Antiangiogenic Glycoprotein Opticin

Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface

PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye

Esterase activity in porcine and albino rabbit ocular tissues

Implications of melanin binding in ocular drug delivery

Silmän biofarmasia [Ocular biopharmacy]

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pharmacokinetic aspects of retinal drug delivery

HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

Preservatives in Ocular Medications and Nutraceuticals

Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug

Drug Development Regarding the Digestive Microbiota [Chapter 12]

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology

Ocular and Systemic Pharmacokinetic Models for Drug Discovery and Development

Prediction of ocular drug distribution from systemic blood circulation

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

Bacterial interactions in the small intestine and their contribution to host nutrient uptake

Prediction of the vitreal half-life of small molecular drug-like compounds

Prediction of the corneal permeability of drug-like compounds

In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

Current and future ophthalmic drug delivery systems: A shift to the posterior segment

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2