Virpi Tiitu

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Linus, Awuniji; Tanska, Petri; Nippolainen, Ervin; Tiitu, Virpi; Töyras, Juha; Korhonen, Rami K; Afara, Isaac O; Mononen, Mika E. 2024. Journal of biomechanics. 169: . 112135

Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

Linus, Awuniji; Tanska, Petri; Sarin, Jaakko K.; Nippolainen, Ervin; Tiitu, Virpi; Mäkelä, Janne T.A.; Töyräs, Juha; Korhonen, Rami K.; Mononen, Mika E.; Afara, Isaac O.. 2023. Annals of biomedical engineering. 51: 2245-2257

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Sarin, JK; Nykänen, O; Tiitu, V; Mancini, IAD; Brommer, H; Visser, J; Malda, J; van Weeren, PR; Afara, IO; Töyräs, J. 2019. Annals of biomedical engineering. 47: 1815-1826

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Saukko, AEA; Turunen, MJ; Honkanen, MKM; Lovric, G; Tiitu, V; Honkanen, JTJ; Grinstaff, MW; Jurvelin, JS; Töyräs, J. 2019. Scientific reports. 9: 7118

Association between subchondral bone structure and osteoarthritis histopathological grade

Finnilä MA, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P, Saarakkala S. 2016. Journal of orthopaedic research. 2017; 35: 785-792

Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Stewart Rachel C, Honkanen Juuso TJ, Kokkonen Harri T, Tiitu Virpi, Saarakkala Simo, Joukainen Antti, Snyder Brian D, Jurvelin Jukka S, Grinstaff Mark W, Töyräs Juha. 2016. Cartilage. 8: 391-399

Early in situ changes in chondrocyte biomechanical responses due to a partial meniscectomy in the lateral compartment of the mature rabbit knee joint

Fick JM, Ronkainen AP, Madden R, Sawatsky A, Tiitu V, Herzog W, Korhonen RK. 2016. Journal of biomechanics. 49: 4057-4064

Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound

Puhakka PH, te Moller NCR, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2016. Acta orthopaedica. 87: 418-424

Contrast Enhanced Imaging of Human Meniscus Using Cone Beam CT

Honkanen JTJ, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS, Töyräs J. 2015. Osteoarthritis and cartilage. 23: 1367-1376

Control of swelling properties of polyvinyl alcohol/hyaluronic acid hydrogels for the encapsulation of chondrocyte cells

Pirinen Sami, Karvinen Jennika, Tiitu Virpi, Suvanto Mika, Pakkanen Tuula T. 2015. Journal of applied polymer science. 132: 6 p

Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity

Ilves Tiina, Tiitu Virpi, Suttle Mireille-Maria, Saarinen Jari Vilho, Harvima Ilkka Tapani. 2015. Dermatitis. 26: 260-267

Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal

Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2015. Osteoarthritis and cartilage. 23: 2206-2213

Multi-parametric MRI characterization of enzymatically degraded articular cartilage

Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Liimatainen Timo, Michaeli Shalom, Mangia Silvia, Ellermann Jutta, Nieminen Miika T. 2015. Journal of orthopaedic research. 2016; 34: 1111-1120

Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament

Arokoski Mikko EA, Tiitu Virpi, Jurvelin Jukka S, Korhonen Rami K, Fick James M. 2015. Journal of orthopaedic research. 33: 1278-1286

Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds

Puhakka PH, Ylärinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kröger H, Virén T, Jurvelin JS, Töyräs J. 2014. Physics in medicine and biology. 59: 6537-48

Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage

Qu Chengjuan, Hirviniemi Mikko, Tiitu Virpi, Jurvelin Jukka S, Töyräs Juha, Lammi Mikko J. 2014. Cartilage. 5: 97-106

Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties

Rautiainen Jari, Nissi Mikko J, Salo Elli-Noora, Tiitu Virpi, Finnilä Mikko AJ, Aho Olli-Matti, Saarakkala Simo, Lehenkari Petri, Ellermann Jutta, Nieminen Miika T. 2014. Magnetic resonance in medicine. Epub ahead of print: -

Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking-contribution of steric and electrostatic effects

Kulmala KAM, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK, Töyräs J. 2013. Medical engineering and physics. 35: 1415-1420

Osteochondral Repair: Evaluation with Sweep Imaging with Fourier Transform in an Equine Model

Jari Rautiainen; Lauri J. Lehto; Virpi Tiitu; Outi Kiekara; Hertta Pulkkinen; Anne Brünott; René van Weeren; Harold Brommer; Pieter A. J. Brama; Jutta Ellermann; Ilkka Kiviranta; Miika T. Nieminen; Mikko J. Nissi. 2013. Radiology. epub ahead of print: epub ahead of print

Ultrasound speed varies in articulaar cartilage under indentation loading

Lötjönen J, Julkunen P, Tiitu V, Jurvelin JS, Töyräs J. 2013. IEEE transactions on ultrasonics ferroelectrics and frequency control. 58: 2772-2780

Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro

Silvast Tuomo, Jurvelin Jukka, Tiitu Virpi, Quinn Thomas, Töyräs Juha. 2012. Cartilage. 2013; 4: 42-51

Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage

Kobrina Y, Rieppo L, Saarakkala S, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Jurvelin JS, Isaksson H. 2012. Osteoarthritis and cartilage. : --

Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

Virén T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brünott A, Van Weeren R, Brama PAJ, Zheng YP, Jurvelin JS, Töyräs J. 2012. Journal of medical engineering and technology. 36: 185-192

Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage

K.A.M. Kulmala, H.J. Pulkkinen, L. Rieppo, V. Tiitu, I. Kiviranta, A. Brünott, H. Brommer, R. van Weeren, P.A.J. Brama, M.T. Mikkola, R.K. Korhonen, J.S. Jurvelin, J.Töyräs. 2012. Cartilage. 3: 235-244

Diffusion of Gd-DTPA2- into articular cartilage

Salo E-N, Nissi MJ, Kulmala KAM, Tiitu V, Töyräs J, Nieminen MT. 2012. Osteoarthritis and cartilage. 20: 117-126

Effects of Medium and Temperature on Cellular Responses in the Superficial Zone of Hypo-Osmotically Challenged Articular Cartilage

Huttu Mari, Turunen Siru, Sokolinski Viktoria, Tiitu Virpi, Lammi Mikko, Korhonen Rami K. 2012. Journal of functional biomaterials. 3: 544-555

Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage

Huttu Mari, Puhakka Jani, Mäkelä Janne, Takakubo Yuya, Tiitu Virpi, Saarakkala Simo, Konttinen Yrjö, Kiviranta Ilkka, Korhonen Rami K. Teoksessa: ORS(toim.) , 2012. Transactions of the Orthopaedic Research Society. s. 1823.

Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Töyräs J, Silvast TS, Lammi MJ, Kiviranta I. 2012. Osteoarthritis and cartilage. : --

Ultrasonic evaluation of acute impact injury of articular cartilage in vitro

Virén T, Timonen M, Tyrväinen H, Tiitu V, Jurvelin JS, Töyräs J. 2012. Osteoarthritis and cartilage. 20: 719-726

Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage

Kokkonen HT, Mäkelä J, Kulmala KAM, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V, Töyräs J. 2011. Osteoarthritis and cartilage. 19: 1190-1198

Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair

Kulmala K.A.M, Pulkkinen H.J, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama P.A.J, Mikkola M.T, Korhonen R.K, Jurvelin J.S, Töyräs J.. 2011.

Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography

Kokkonen HT, Jurvelin JS, Tiitu V, Töyräs J. 2011. Osteoarthritis and cartilage. 19: 297-301

Effects of medium and temperature on cell mechanics in osmotically challenged articular cartilage

Huttu MRJ, Turunen SM, Sokolinski V, Tiitu V, Lammi MJ, Korhonen RK. 2011.

Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control

Virén Tuomas, Saarakkala Simo, Tiitu Virpi, Puhakka Jani, Kiviranta Ilkka, Jurvelin Jukka S, Töyräs Juha. 2011. IEEE transactions on ultrasonics ferroelectrics and frequency control. 58: 148-154

Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Lammi MJ & Kiviranta I. 2010. Osteoarthritis and cartilage. 18: 1077-1087

Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ

Virén T, Saarakkala S, Jurvelin JS, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Lammi MJ & Töyräs J. 2010. Ultrasound in medicine and biology. 36: 833-839

Simultaneous ultrasound measurement of articular cartilage and subchondral bone

Aula AS, Töyräs J, Tiitu V, Jurvelin JS. 2010. Osteoarthritis and cartilage. 18: 1570-1576

Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films

Myllymaa S, Myllymaa K, Korhonen H, Lammi MJ, Tiitu V & Reijo Lappalainen. 2010. Colloids and surfaces b: biointerfaces. 76: 505-511

Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating

Myllymaa K, Myllymaa S, Korhonen H, Lammi MJ, Saarenpää H, Suvanto M, Pakkanen TA, Tiitu V, Lappalainen R. 2009. Journal of materials science: materials in medicine. : 2337-2347

Bioreactor improves the growth and viability of chondrocytes in the knitted Poly-L,D-Lactide scaffold

V. Tiitu, H. Pulkkinen, P. Valonen, O. Pulliainen, M. Kellomäki, M. J. Lammi, I. Kiviranta. 2008. Biorheology. 45: 539-546

Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold

Tiitu V, Pulkkinen HJ, Valonen P, Pulliainen O, Kellomäki M, Lammi MJ, Kiviranta I. 2008. Biorheology. 45: 539-546

Recombinant human collagens as scaffold materials for chondrocyte cultures

Tiitu V, Pulkkinen HJ, Valonen P, Kiviranta O, Kiekara T, Kiviranta I, Lammi MJ. 2008. Bio-medical materials and engineering. 18: 225-229

Recombinant human type II collagen as a material for cartilage tissue engineering

Pulkkinen HJ, Tiitu V, Valonen P, Hamalainen E-R, Lammi MJ, Kiviranta I. 2008. International journal of artificial organs. 31: 960-969

Poly-L-D-Lactic acid scaffold in the repair of porcine knee cartilage lesions

Pullinen O, Vasara AI, Hyttinen MM, Tiitu V, Valonen P, Kellomäki M, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I, Lammi MJ. 2007. Tissue engineering. 13: 1347-1355

Cellulose sponge as a scaffold for cartilage tissue engineering

Pulkkinen H, Tiitu V, Lammentausta E, Hämäläinen E-R, Kiviranta I, Lammi MJ. 2006. BIO-MEDICAL MATERIALS AND ENGINEERING SUPPLEMENT. 16: S29-S35

Tarkenna hakuasi

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Association between subchondral bone structure and osteoarthritis histopathological grade

Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Early in situ changes in chondrocyte biomechanical responses due to a partial meniscectomy in the lateral compartment of the mature rabbit knee joint

Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound

Contrast Enhanced Imaging of Human Meniscus Using Cone Beam CT

Control of swelling properties of polyvinyl alcohol/hyaluronic acid hydrogels for the encapsulation of chondrocyte cells

Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity

Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal

Multi-parametric MRI characterization of enzymatically degraded articular cartilage

Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament

Transport of Iodine Is Different in Cartilage and Meniscus

Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage

Cell-tissue interactions in osteoarthritic human hip joint articular cartilage

Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds

Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage

Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties

Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking-contribution of steric and electrostatic effects

Osteochondral Repair: Evaluation with Sweep Imaging with Fourier Transform in an Equine Model

Ultrasound speed varies in articulaar cartilage under indentation loading

Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro

Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage

Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage

Diffusion of Gd-DTPA2- into articular cartilage

Effects of Medium and Temperature on Cellular Responses in the Superficial Zone of Hypo-Osmotically Challenged Articular Cartilage

Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage

Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit

Ultrasonic evaluation of acute impact injury of articular cartilage in vitro

Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage

Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair

Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography

Effects of medium and temperature on cell mechanics in osmotically challenged articular cartilage

Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control

Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo

Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ

Simultaneous ultrasound measurement of articular cartilage and subchondral bone

Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films

Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating

Bioreactor improves the growth and viability of chondrocytes in the knitted Poly-L,D-Lactide scaffold

Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold

Recombinant human collagens as scaffold materials for chondrocyte cultures

Recombinant human type II collagen as a material for cartilage tissue engineering

Poly-L-D-Lactic acid scaffold in the repair of porcine knee cartilage lesions

Cellulose sponge as a scaffold for cartilage tissue engineering