Asla Pitkänen
Professori
A.I. Virtanen -instituutti, Terveystieteiden tiedekunta
[email protected] | 050 517 2091
Tutkimusryhmät
Projektit
Julkaisut
339/339 kappaletta-
Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy
Puhakka, Noora; Cifelli, Pierangelo; Ruffolo, Gabriele; Gaeta, Alessandro; Roseti, Cristina; De Iacovo, Angela; Tiilikainen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Pitkänen, Asla; Palma, Eleonora. 2025. Experimental neurology. 387: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury
Kyyriäinen, Jenni; Andrade, Pedro; Ekolle Ndode-Ekane, Xavier; Manninen, Eppu; Hämäläinen, Elina; Rauramaa, Tuomas; Heiskanen, Mette; Puhakka, Noora; Immonen, Riikka; Pitkänen, Asla. 2024. Epilepsy research. 200: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
van Vliet, Erwin A; Scheper, Mirte; Mills, James D; Puhakka, Noora; Szydlowska, Kinga; Ferracin, Manuela; Lovisari, Francesca; Soukupova, Marie; Zucchini, Silvia; Srivastava, Prashant K; Johnson, Michael R; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Simonato, Michele. 2024. Epilepsia. 65: 3406-3420 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study
Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla. 2024. Epilepsia. [First published: 11 December 2024]: 1-16 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury
Heiskanen, Mette; Banuelos, Ivette; Manninen, Eppu; Andrade, Pedro; Hämäläinen, Elina; Puhakka, Noora; Pitkänen, Asla. 2024. Epilepsia. 65: 3703-3716 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort
Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla. 2023. Epilepsia. 2024; 65: 511-526 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Gene Expression Profile as a Predictor of Seizure Liability
Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Highlights From the Annual Meeting of the American Epilepsy Society 2022
Valencia, Ignacio; Alexander, Allyson L.; Andrade, Danielle M.; Arevalo-Astrada, Miguel; Rubiños, Clio; Auer, Nancy; Bainbridge, Jacquelyn L.; Baxendale, Sallie A.; Bartolomei, Fabrice; Becker, Danielle A.; Berg, Anne T.; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Bhatnagar, Shivani; Blümcke, Ingmar; Blumenfeld, Hal; Buchanan, Gordon F.; Burdette, David E.; Burneo, Jorge G.; Busch, Robyn M.; Chauvel, Patrick; Chin, Jeannie; Clifford, Lisa; Conner, Kelly R.; Cook, Mark J.; Conway, Je. 2023. Epilepsy currents. [Epub ahead of print 16 Aug 2023]: 1-36 B1 Kirjoitus tieteellisessä aikakauslehdessä -
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury
Puhakka, Noora; Das Gupta, Shalini; Leskinen, Sara; Heiskanen, Mette; Nattinen, Janika; Aapola, Ulla; Uusitalo, Hannu; Pitkanen, Asla. 2023. Neurotrauma reports. 4: 359-366 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Sleep Disturbance and Severe Hydrocephalus in a Normally Behaving Wistar Rat With Traumatic Brain Injury
Kyyriäinen, Jenni; Andrade, Pedro; Hämäläinen, Elina; Pitkänen, Asla. 2023. Neurotrauma reports. 4: 384-395 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla. 2023. Epilepsy research. 2024; 199: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology
Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: . 14049 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury
Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat
Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury
De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Frontiers in neurology. 13: . 820267 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons
Karttunen, Jenni; Heiskanen, Mette; Joki, Tiina; Hyysalo, Anu; Navarro-Ferrandis, Vicente; Miettinen, Susanna; Narkilahti, Susanna; Pitkänen, Asla. 2022. European journal of cell biology. 101: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model
De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Epilepsia. 63: 1849-1861 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra, Nishant K.; Engel, Jerome; Liebeskind, David S.; Sharma, Vijay K.; Hirsch, Lawrence J.; Kasner, Scott E; French, Jacqueline A.; Devinsky, Orrin; Friedman, Alon; Dawson, Jesse; Quinn, Terence J.; Selim, Magdy; de Havenon, Adam; Yasuda, Clarissa L.; Cendes, Fernando; Benninger, Felix; Zaveri, Hitten P.; Burneo, Jorge G.; Srivastava, Padma; Bhushan Singh, Mamta; Bhatia, Rohit; Vishnu, V.Y.; Bentes, Carla; Ferro, Jose; Weiss, Shennan; Sivaraju, Adithya; Kim, Jennifer A.; Galovic, Marian; Gil. 2022. Epilepsy and behavior. 127: B1 Kirjoitus tieteellisessä aikakauslehdessä -
MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains
Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI
Andrade, Pedro; Lara-Valderrábano, Leonardo; Manninen, Eppu; Ciszek, Robert; Tapiala, Jesse; Ndode-Ekane, Xavier Ekolle; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER
Henshall, David C.; Arzimanoglou, Alexis; Dedeurwaerdere, Stefanie; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Lerche, Holger; Pitkänen, Asla; Ryvlin, Philippe; Simonato, Michele; Sisodiya, Sanjay M.. 2022. Epilepsy research. 2023; 189: B1 Kirjoitus tieteellisessä aikakauslehdessä -
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology
Puhakka, Noora; Das Gupta, Shalini; Vuokila, Niina; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Ultrasonic vocalizations – Novel seizure-related manifestation in rats
Lara-Valderrábano, Leonardo; Ciszek, Robert; Bañuelos-Cabrera, Ivette; Andrade, Pedro; Pitkänen, Asla. 2022. Epilepsy research. 183: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis
Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Epilepsia -
Biomarkers for posttraumatic epilepsy
Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Epilepsy and behavior -
Climate change and epilepsy: Insights from clinical and basic science studies
Gulcebi, Medine I; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S; Jimenez-Jimenez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E; Thijs, Roland D; Zuberi, Sameer M; Blenkinsop, Stephen; Fowler, Hayley J; Foley, Aideen; Sisodiya, Sanjay M; Balestrini, Simona et al. [incl. Pitkänen, Asla]. 2021. Epilepsy and behavior -
Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap
Simonato, Michele; Agoston, Denes V; Brooks-Kayal, Amy; Dulla, Chris; Fureman, Brandy; Henshall, David C; Pitkänen, Asla; Theodore, William H; Twyman, Roy E; Kobeissy, Firas H; Wang, Kevin K; Whittemore, Vicky; Wilcox, Karen S. 2021. Nature reviews neurology -
Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances
Henshall, David C.; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Pitkanen, Asla; Sisodiya, Sanjay; Simonato, Michele; Cross, J. Helen; Ryvlin, Philippe; Brodie, Martin J.; Trinka, Eugen; Sofia, Francesca. 2021. Epilepsy research -
Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury
Dulla, Chris G.; Pitkänen, Asla. 2021. Neurotherapeutics -
Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus
Wang, Ying; Andrade, Pedro; Pitkänen Asta. 2021. Biomedicines -
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences -
Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury
Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Brain structure and function -
Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury
Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Neuroscience -
Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury
Ndode-Ekane, Xavier Ekolle; Puigferrat Pérez, Maria del Mar; Di Sapia, Rossella; Lapinlampi, Niina; Pitkänen, Asla. 2021. International journal of molecular sciences -
Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury
Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla. 2021. International journal of molecular sciences -
Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla?
Pitkänen, Asla. 2021. Duodecim -
A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis
Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W. 2020. IEEE -
Biomarkers For Epileptogenesis And Its Treatment
Engel, Jerome Jr; Pitkänen, Asla. 2020. Neuropharmacology -
Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI
Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. International journal of molecular sciences -
Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization
Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Scientific reports -
Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury
Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Journal of neurotrauma -
Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury
Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Neuroscience -
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Brain pathology -
Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala
Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari. 2020. eLife -
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville]. 2020. Nature -
Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Neurobiology of disease -
Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury
Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla. 2020. Neuroscience letters -
Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats
Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Epilepsia -
Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury
Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Journal of neurotrauma -
Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats
Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Journal of neurotrauma -
Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy
Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J. 2019. Epilepsia -
Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force
Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E. 2019. Epilepsia open -
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility
Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Epilepsy research -
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury
Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Scientific reports -
Epilepsy biomarkers - Toward etiology and pathology specificity
Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Neurobiology of disease -
Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies
Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. International journal of molecular sciences -
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)
Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Neuroscience -
Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Epilepsy research -
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis
Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Epilepsy research -
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research -
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis
Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Epilepsy research -
In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned
Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. International journal of molecular sciences -
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports -
MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study
Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience -
Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative
Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C. 2019. Epilepsia open -
Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium
Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Epilepsy research -
Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury
Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D. 2019. Neuroimage -
Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice
Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE. 2019. Neuroinformatics -
A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats
Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. Journal of neuroscience methods -
Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy
Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Journal of neuroscience methods -
Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients
Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W. 2018. Frontiers in neuroscience -
Big data sharing and analysis to advance research in post-traumatic epilepsy
Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Neurobiology of disease -
Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury
Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Journal of neurotrauma -
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study
Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla). 2018. Neurobiology of disease -
Epilepsy in neuropathologically verified Alzheimer's disease
Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Seizure: european journal of epilepsy -
Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis
Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Epilepsy research -
Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Epilepsy research -
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Journal of extracellular vesicles -
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology -
T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury
Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. Restorative neurology and neuroscience -
Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Acta neuropathologica communications -
miR-124-3p is a chronic regulator of gene expression after brain injury
Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. Cellular and molecular life sciences -
Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. PLoS ONE -
Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE
Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. 2017. Epilepsia -
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Epilepsia -
Decreased levels of active uPA and KLK8 assessed by [111In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy
Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S. 2017. Epilepsia -
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research -
Epilepsy After Traumatic Brain Injury
Pitkänen Asla, Kyyriäinen Jenni, Andrade Pedro, Pasanen Lotta, Ndode-Ekane Xavier Ekolle. 2017. Elsevier -
Epilepsy in Models of Alzheimer's Disease
Tanila H, Pitkänen A. 2017. Elsevier -
Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep
Andrade Pedro, Nissinen Jari, Pitkanen Asla. 2017. Journal of neurotrauma -
Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy
Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele. 2017. eNeuro -
Models of Seizures and Epilepsy (Second Edition)
Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL. 2017. Elsevier -
Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs
van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Epilepsia -
Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models
Dingledine Raymond, Coulter Douglas A, Fritsch Brita, Gorter Jan A, Lelutiu Nadia, McNamara James, Nadler J Victor, Pitkänen Asla, Rogawski Michael A, Skene Pate, Sloviter Robert S, Wang Yu, Wadman Wytse J, Wasterlain Claude, Roopra Avtar. 2017. Scientific data -
Unfolded Maps for Quantitative Analysis of Cortical Lesion Location and Extent after Traumatic Brain Injury
Ndode-Ekane Xavier Ekolle, Kharatishvili Irina, Pitkänen Asla. 2017. Journal of neurotrauma -
What Can We Model?
Pitkänen A, Galanopoulou AS, Moshé SL, Buckmaster PS. 2017. Elsevier -
What Do Models Model? What Needs to Be Modeled?
Galanopoulou AS, Pitkänen A, Buckmaster PS, Moshé SL. 2017. Elsevier -
Advances in the development of biomarkers for epilepsy
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. The Lancet Neurology -
Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets
Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Scientific reports -
Common data elements and data management: Remedy to cure underpowered preclinical studies
Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Epilepsy research -
Dynamics of PDGFRß Expression in Different Cell Types After Brain Injury
Kyyriäinen Jenni, Ndode-Ekane Xavier Ekkolle, Pitkänen Asla. 2016. Glia -
Epileptogenesis after traumatic brain injury in Plaur-deficient mice
Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epilepsy and behavior -
Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy
Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Scientific reports -
Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography
López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M. 2016. Journal of nuclear medicine -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods -
Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease
Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Current alzheimer research -
WONOEP appraisal: Imaging biomarkers in epilepsy
van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P. 2016. Epilepsia -
Development of epilepsy after ischaemic stroke
Pitkänen Asla, Roivainen Reina, Luasiuk Katarzyna. 2015. The Lancet Neurology -
Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat
Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Frontiers in neuroscience -
Epilepsy biomarkers
Engel Jerome Jr, Pitkänen Asla. 2015. Wiley-Blackwell -
Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force
Baulac Michel, de Boer Hanneke, Elger Christian, Glynn Mike, Kälviäinen Reetta, Little Ann, Mifsud Janet, Perucca Emilio, Pitkänen Asla, Ryvlin Philippe. 2015. Epilepsia -
Epileptogenesis
Pitkänen Asla, Lukasiuk Katarzyna, Dudek F Edward, Staley Kevin J. 2015. Cold Spring Harbor perspectives in medicine -
Epileptogenesis after traumatic brain injury in Plau-deficient mice
Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epilepsy and behavior -
Expression of PDGFR-beta positive NG2 cells in the hippocampus after status epilepticus
Kyyriäinen J., Ndode-Ekane X. E., Pitkänen A.. 2015. Glia -
Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis
Sierra A, Gröhn O, Pitkänen A. 2015. Neuroscience -
Opportunities for improving animal welfare in rodent models of epilepsy and seizures
Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. 2015. Journal of neuroscience methods -
Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation
Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Epilepsy research -
Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease
Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Molecular neurobiology -
Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice
Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Epilepsy and behavior -
A common SCN1A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability--a pharmacogenetic transcranial magnetic stimulation study
Menzler K, Hermsen A, Balkenhol K, Duddek C, Bugiel H, Bauer S, Schorge S, Reif PS, Klein KM, Haag A, Oertel WH, Hamer HM, Knake S, Trucks H, Sander T, Rosenow F; EPICURE-Consortium. 2014. Epilepsia -
Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?
Powell Kim L, Lukasiuk Katarzyna, O'Brien Terence J, Pitkänen Asla. 2014. Advances in experimental medicine and biology -
Brain Extracellular Matrix in Health and Disease
Dityatev A, Wehrle-Haller B, Pitkänen A. 2014. Elsevier -
Decreased resting functional connectivity after traumatic brain injury in the rat
Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. PLoS ONE -
Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research -
Epilepsy related to traumatic brain injury
Pitkänen Asla, Immonen Riitta. 2014. Neurotherapeutics -
Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury
Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Neuropharmacology -
Gender issues in antiepileptogenic treatments
Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Neurobiology of disease -
In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2014. Epilepsia -
Neural ECM and epilepsy
Pitkänen A, Ndode-Ekane XE, Lukasiuk K, Wilczynski GM, Dityatev A, Walker MC, Chabrol E, Dedeurwaerdere S, Vazquez N, Powell EM. 2014. Progress in brain research -
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI
Huusko N, Pitkänen A. 2014. Neuroscience -
Past and Present Definitions of Epileptogenesis and Its Biomarkers
Pitkänen A, Engel J Jr. 2014. Neurotherapeutics -
Posttraumatic epilepsy - Disease or comorbidity?
Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior -
The challenge and promise of anti-epileptic therapy development in animal models
Simonato Michele, Brooks-Kayal Amy R, Engel Jr Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O'Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A. 2014. The Lancet Neurology -
Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2013. Epilepsia -
Diffusion tensor imaging of hippocampal network plasticity
Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Brain structure and function -
Epilepsy biomarkers
Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. 2013. Epilepsia -
Epilepsy on the horizon
Epilepsy Advocacy Europe, Sheanon E, Pitkänen A. 2013. Epilepsia -
Epilepsy therapy development: Technical and methodologic issues in studies with animal models
Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Edward Dudek F. 2013. Epilepsia -
Issues related to development of antiepileptogenic therapies
Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. 2013. Epilepsia -
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Brain structure and function -
MRI biomarkers for post-traumatic epileptogenesis.
Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. Journal of neurotrauma -
Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI
Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma -
Targets for antiepileptogenesis: Overview
Pitkänen Asla. 2013. Uni-Med Verlag AG -
Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT
Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Neuroimage -
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease
Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Journal of neurochemistry -
Finding a better drug for epilepsy: Antiepileptogenesis targets
Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. 2012. Epilepsia -
Head Trauma and Epilepsy
Pitkänen Asla, Bolkvadze Tamuna. 2012. Oxford University Press -
Identification of new epilepsy treatments: issues in preclinical methodology
Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. 2012. Epilepsia -
Molecular Basis of Acquired Epileptogenesis
Lukasiuk K, Pitkänen A. 2012. Handbook of Clinical Neurology -
New Insight on the Mechanisms of Epileptogenesis in the Developing Brain
Kubova H, Lukasiuk K, Pitkänen A. 2012. Advances and Technical Standards in Neurosurgery -
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures
Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Epilepsia -
The Written Declaration on Epilepsy: An important achievement for Europe and beyond
Baulac M, De Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A. 2012. Seizure: european journal of epilepsy -
Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy
Ndode-Ekane XE, Pitkänen A. 2012. Molecular neurobiology -
Anti-epileptogenesis in rodent post-traumatic epilepsy models
Pitkänen Asla, Bolkvadze Tamuna, Immonen Riikka. 2011. Neuroscience letters -
Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat
Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Brain structure and function -
Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats
Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Journal of cerebral blood flow and metabolism -
Mechanisms of epileptogenesis and potential treatment targets
Pitkänen Asla, Lukasiuk Katarzyna. 2011. The Lancet Neurology -
Molecular biomarkers of epileptogenesis
Pitkänen A, Lukasiuk K. 2011. Biomarkers in medicine -
Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain
Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Epilepsia -
Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats
Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Neuroscience -
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Epilepsy research -
Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy
Kharatishvili I & Pitkänen A. 2010. Epilepsy research -
Diffusion tensor MRI of axonal plasticity in the rat hippocampus
Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Neuroimage -
Posttraumatic epilepsy
Kharatishvili I & Pitkänen A. 2010. Current opinion in neurology -
Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus
Lahtinen L, Ndode-Ekane XE, Barinka F, Akamine Y, Esmaeili MH, Rantala J & Pitkänen A. 2010. Neurobiology of disease -
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy
Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Neuroscience -
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Journal of neuroscience -
Commentary: the prospect of cell-based therapy for epilepsy
Kriegstein AR, Pitkänen A. 2009. Neurotherapeutics -
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up
Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Experimental neurology -
Epilepsy: Neuronal Death
Pitkänen A, Lukasiuk K. 2009. Academid Press -
Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning
Majak K, Dabrowski M, Pitkänen A. 2009. Neuroscience -
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Neuroscience -
From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options
Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. EPILEPSIA. SUPPLEMENT -
Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK. 2009. Neuroscience -
Genes relevant to epileptogenic mechanisms
Maja K, Pitkänen A. 2009. John Libbey Eurotext -
Molecular and cellular basis of epileptogenesis in symptomatic epilepsy
Pitkänen A, Lukasiuk K. 2009. Epilepsy and behavior -
Neuropeptide Y overexpression using recombinant adeno-associated viral vectors
Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A. 2009. Neurotherapeutics -
Posttraumatic models
Kharatishvili I, Pitkänen A. 2009. Academic Preess -
Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury
Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Neuroimage -
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Experimental neurology -
Seizure-induced gene expression
Pitkänen A, Lukasiuk K. 2009. Academic Press -
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus
Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Neuroimage -
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A. 2008. Brain -
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
Goffin K, Nissinen J, Van Laere K, Pitkänen A. 2007. Experimental neurology -
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning
Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H. 2007. Molecular and cellular neuroscience -
Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
Nissinen J, Pitkänen A. 2007. Epilepsy research -
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat
Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J. 2007. Epilepsy research -
Epileptogenesis after cortical photothrombotic brain lesion in rats
Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Neuroscience -
Epileptogenesis in experimental models
Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. EPILEPSIA. SUPPLEMENT -
Gene therapy in epilepsy: The focus on NPY
Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A. 2007. Peptides -
Genetics of epilepsy: epilepsy research foundation workshop report
Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C. 2007. Epileptic disorders -
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy
Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A. 2007. Neuromolecular medicine -
Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations
Gröhn O, Pitkänen A. 2007. EPILEPSIA. SUPPLEMENT -
Mechanisms of emotional learning in normal and epileptic brain
Majak K, Pitkänen A. 2007. International Congress Series -
Neuroprotection with anti-epileptic drugs: state of the evidence
Pitkänen A. 2007. Clarius Press -
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Brain -
The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury
Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK. 2007. Restorative neurology and neuroscience -
A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats
Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. Epilepsy research -
A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A. 2006. Neuroscience -
Animal models of post-traumatic epilepsy
Pitkänen A, Mcintosh TK. 2006. Journal of neurotrauma -
Change over of the baton
Pitkänen A, Gilliam F. 2006. Epilepsy research -
Chapter 11 Epileptogenesis-related genes revisited
Lukasiuk K, Dabrowski M, Adach A, Pitkänen A. 2006. Progress in brain research -
Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat
Pirttilä TJ, Pitkänen A. 2006. Neuroscience letters -
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy
Kemppainen EJS, Nissinen J, Pitkänen A. 2006. Epilepsia -
Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis
Lahtinen L, Lukasiuk K, Pitkänen A. 2006. European journal of neuroscience -
Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo
Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Neuroimage -
New data suggest that discontinuation of status epilepticus is not necessary for antiepileptogenic effect in immature brain
Pitkänen A. 2006. Epilepsy currents -
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: A histologic and MRI study
Nairismägi J, Pitkänen A, Kettunen MI, Kauppinen RA, Kubova H. 2006. Epilepsia -
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat
Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J. 2005. Epilepsy research -
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy
Narkilahti S, Pitkänen A. 2005. Neuroscience -
Cystatin C expression is associated with granule cell dispersion in epilepsy
Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. 2005. Annals of neurology -
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
Pirttilä TJ, Lukasiuk K, Håkansson K, Grubb A, Abrahamson M, Pitkänen A. 2005. Neurobiology of disease -
Epileptic seizure detection: A nonlinear viewpooint
Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T. 2005. Computer methods and programs in biomedicine -
Epileptogenesis after experimental focal cerebral ischemia
Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Neurochemical research -
Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain
Pitkänen A, Gröhn O. 2005. Epilepsy currents -
Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?
Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK. 2005. Neuroscience -
Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study
Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R, Könönen M. 2005. Neurology -
MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy
Goncalves Pereira PM, Insausti R, Artacho-Pérula E, Salmenperä T, Kälviäinen R, Pitkänen A. 2005. American journal of neuroradiology -
Antiepileptic drugs in neuroprotections
Pitkänen A, Kubova H. 2004. Expert opinion on pharmacotherapy -
Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats
Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. 2004. Epilepsy research -
Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice
Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E. 2004. European journal of neuroscience -
Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: A tract-tracing study in chronic epileptic rats
Kemppainen S, Pitkänen A. 2004. Neuroscience -
Denervation and reinnervation of amygdaloid neurons in drug-refratory temporal lobe epilepsy
Pitkänen A. 2004. Epilepsy currents -
Do seizures cause irreversible cognitive damage? Evidence from animal studies
Majak K, Pitkänen A. 2004. EPILEPSY & BEHAVIOR. SUPPLEMENT -
Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat
Nissinen J, Large CH, Stratton SC, Pitkänen A. 2004. Epilepsy research -
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats
Niittykoski M, Nissinen J, Penttonen M, Pitkänen A. 2004. Neuroscience -
Large-scale analysis of gene expression in epilepsy reseach: is synthesis alreasy possible?
Lukasiuk K, Pitkänen A. 2004. Neurochemical research -
New pharmacotherapy for epilepsy
Pitkänen A. 2004. Idrugs -
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy
Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia -
Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat
Majak K, Rönkkö S, Kemppainen S, Pitkänen A. 2004. Journal of comparative neurology -
Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
Kubová H, Mares P, Suchomelová L, Brozek G, Druga R, Pitkänen A. 2004. European journal of neuroscience -
Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat
Majak K, Pitkänen A. 2003. European journal of neuroscience -
Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis
Narkilahti S, Nissinen J, Pitkänen A. 2003. Neuropharmacology -
American Epilepsy Society - 56th Annual Meeting
Pitkänen A. 2003. Idrugs -
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death
Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Cancer research -
Clinical trials in neuroprotection
Pitkänen A. 2003. Idrugs -
Do epileptic seizures damage the brain?
Sutula TP, Hagen J, Pitkänen A. 2003. Current opinion in neurology -
Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling
Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E. 2003. Neuroscience -
Expression and activation of caspase 3 following status epilepticus in the rat
Narkilahti S, Pirttilä TJ, Lukasiuk K, Tuunanen J, Pitkänen A. 2003. European journal of neuroscience -
Intrinsic synaptic circuitry of the amygdala
Pitkänen A, Savander M, Nurminen N, Ylinen A. 2003. Annals of the New York Academy of Sciences -
Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits
Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Epilepsy research -
Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: A PHA-L study in the rat
Majak K, Pitkänen A. 2003. Hippocampus -
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy
Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE. 2003. Neuroscience letters -
The Amygdala in Brain Function: Basic and Clinical Approaches
Shinnick-Gallagher P, Pitkänen A, Shekhar A, Cahill L. 2003. Annals of the New York Academy of Sciences -
Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop
Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. 2003. Epilepsia -
Tunteiden neurobiologiaa
Pitkänen A. 2003. Duodecim -
cDNA profiling of epileptogenesis in the rat brain
Lukasiuk K, Kontula L, Pitkänen A. 2003. European journal of neuroscience -
Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala
Pitkänen A, Kemppainen S. 2002. Pharmacology biochemistry and behavior -
Decreased BDNF signalling in transgenic mice reduces epileptogenesis
Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E. 2002. European journal of neuroscience -
Drug-mediated neuroprotection and anti-epileptogenesis
Pitkänen A. 2002. NEUROLOGY. SUPPLEMENT -
Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat
Kubová H, Druga R, Haugvicová R, Suchomelová L, Pitkanen A. 2002. EPILEPSIA. SUPPLEMENT -
Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models
Pitkänen A. 2002. Epilepsy research -
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
Pitkänen A, Sutula TP. 2002. The Lancet Neurology -
Neurobiology of epileptogenesis in the temporal lobe
Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2002. Advances and Technical Standards in Neurosurgery -
Prevention of epileptogenesis
Pitkänen A. 2002. Lippincott -
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. 2002. Progress in Brain Research -
Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat
Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Journal of comparative neurology -
Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat
Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A. 2002. Neuroscience -
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey
Pitkanen A, Kelly JL, Amaral DG. 2002. Hippocampus -
Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat
Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Hippocampus -
Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
Lukasiuk K, Pirttilä TJ, Pitkänen A. 2002. EPILEPSIA. SUPPLEMENT -
Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats
Halonen T, Nissinen J, Pitkänen A. 2001. Neuropharmacology -
Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
Halonen T, Nissinen J, Pitkanen A. 2001. Epilepsy research -
Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology
Pirttilä T-RM, Pitkänen A, Tuunanen J, Kauppinen RA. 2001. Magnetic resonance in medicine -
Hippocampal and amygdaloid damage in partial epilepsy A cross-sectional MRI study of 241 patients
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2001. Epilepsy research -
Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat
Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A. 2001. Journal of comparative neurology -
Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?
Nissinen J, Lukasiuk K, Pitkänen A. 2001. Hippocampus -
MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy
Jutila L, Ylinen A, Partanen K, Alafuzoff I, Mervaala E, Partanen J, Vapalahti M, Vainio P, Pitkänen A. 2001. American journal of neuroradiology -
More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy?
Sutula TP, Pitkänen A. 2001. Neurology -
Neurobiology of epileptogenesis in the temporal lobe
Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2001. Springer -
Projections from the amygdalo-piriform transition area to the amygdaloid coplex: A PHA-L study in rat
Jolkkonen E, Miettinen R, Pitkänen A. 2001. Journal of comparative neurology -
Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat
Pikkarainen M, Pitkanen A. 2001. Cerebral cortex -
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats
Kubová H, Druga R, Lukasiuk K, Suchomelová L, Haugvicová R, Jirmanová I, Pitkänen A. 2001. Journal of neuroscience -
Time course and mechanisms of amygdaloid damage after kainate-induced status epilepticus in rat
Lukasiuk K, Tuunanen J, Halonen T, Pitkänen A. 2001. Biomedical and Health Research -
A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat
Nissinen J, Halonen T, Koivisto E, Pitkänen A. 2000. Epilepsy research -
Anatomic heterogeneity of the rat amygdaloid complex
Pitkänen A, Jolkkonen E, Kemppainen S. 2000. Folia morphologica -
Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy
Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A. 2000. EPILEPSIA. SUPPLEMENT -
Connectivity of the rat amygdaloid complex
Pitkänen A. 2000. Oxford University Press -
Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid
Kemppainen S, Pitkänen A. 2000. Journal of comparative neurology -
Do seizures cause neuronal damage in rat amygdala kindling?
Tuunanen J, Pitkänen A. 2000. Epilepsy research -
Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho
Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism -
GABA(A)-mediated toxicity of hippocampal neurons in vitro
Lukasiuk K, Pitkänen A. 2000. Journal of neurochemistry -
MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus
Salmenperä T, Kälviäinen R, Partanen K, Mervaala E, Pitkänen A. 2000. Epilepsy research -
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow
Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Neuroscience -
Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat
Liubashina O, Jolkkonen E, Pitkänen A. 2000. Neuroscience letters -
Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2000. Seizure: european journal of epilepsy -
Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review
Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Annals of the New York Academy of Sciences -
[11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology
Lamusuo S, Pitkänen A, Jutila L, Ylinen A, Partanen K, Kälviäinen R, Ruottinen H-M, Oikonen V, Någren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO. 2000. Neurology -
Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study
Jongen-Rêlo AL, Pitkänen A, Amaral DG. 1999. Journal of comparative neurology -
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Pitkänen A, Jolkkonen J. 1999. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT -
Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T. 1999. Epilepsy research -
Epilepsian geenit ja neurobiologia
Lehesjoki A-E, Pitkänen A. 1999. Duodecim -
Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
Halonen T, Nissinen J, Pitkänen A. 1999. Epilepsy research -
Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications
Kälviäinen R, Pitkänen A. 1999. Wrightson Biomedical Publishing -
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat
Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A. 1999. Journal of comparative neurology -
Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame
Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Magnetic resonance in medicine -
Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy
Pitkänen A, Salmenperä T, Äikiä M, Partanen K, Kälviäinen R. 1999. Wrightson Biomedical Publishing -
Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms
Tuunanen J, Lukasiuk K, Halonen T, Pitkänen A. 1999. Neuroscience -
Amygdala damage in experimental and human temporal lobe epilepsy
Pitkänen A, Tuunanen J, Kälviäinen R, Partanen K, Salmenperä T. 1998. Epilepsy research -
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala
Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Brain research -
Hippocampal damage caused by seizures in temporal lobe epilepsy
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 1998. The Lancet -
Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus
Jolkkonen E, Pitkänen A. 1998. Journal of comparative neurology -
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices
Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. American journal of neuroradiology -
Mantelitumake
Pitkänen A. 1998. Duodecim -
Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus
Pitkänen A, Amaral DG. 1998. Journal of comparative neurology -
Prevention of epilepsy
Pitkänen A, Halonen T. 1998. Trends in pharmacological sciences -
Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy
Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1998. Neurology -
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex
Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Annals of neurology -
Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease
Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Neurobiology of aging -
Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus
Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Neuroscience -
Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy
Tuunanen J, Halonen T, Pitkänen A. 1997. Epilepsy research -
Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA
Miettinen M, Pitkänen A, Miettinen R. 1997. Journal of comparative neurology -
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex
Mikkonen M, Soininen H, Pitkänen A. 1997. Journal of comparative neurology -
Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex
Savander V, Ledoux JE, Pitkänen A. 1997. Neuroscience -
Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study
Savander V, Miettinen R, Ledoux JE, Pitkänen A. 1997. Neuroscience -
MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy
Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1997. Epilepsy research -
MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus
Kälviäinen R, Partanen K, Äikiä M, Mervaala E, Vainio P, Riekkinen PJ Sr, Pitkänen A. 1997. Neurology -
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala
Pitkänen A, Savander V, Ledoux JE. 1997. Trends in neurosciences -
Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection
Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Experimental neurology -
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A. 1996. Neuroscience -
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A. 1996. Journal of comparative neurology -
Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus
Savander V, Go C-G, Ledoux JE, Pitkänen A. 1996. Journal of comparative neurology -
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study
Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Neuroscience letters -
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system
Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Neuroreport -
Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease
Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Neurology -
Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex
Tuunanen J, Halonen T, Pitkänen A. 1996. European journal of neuroscience -
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus
Halonen T, Nissinen J, Jansen JA, Pitkänen A. 1996. European journal of pharmacology -
Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat
Savander V, LeDoux JE, Pitkänen A. 1996. Neuroscience letters -
Treatment with antiepileptic drugs: Possible neuroprotective effects
Pitkänen A. 1996. NEUROLOGY. SUPPLEMENT -
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
Pitkänen A, Tuunanen J, Halonen T. 1996. Epilepsy research -
Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder
Kuikka JT, Pitkänen A, Lepola U, Partanen K, Vainio P, Bergström KA, Wieler HJ, Kaiser KP, Mittelbach L, Koponen H, Leinonen E, Riekkinen PJ. 1995. Nuclear medicine communications -
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele
Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Neurology -
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Journal of comparative neurology -
Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus
Savander V, Go C-G, LeDoux JE, Pitkänen A. 1995. Journal of comparative neurology -
Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus
Pitkänen A, Stefanacci L, Farb CR, Go GG, LeDoux JE, Amaral DG. 1995. Journal of comparative neurology -
Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat
Pitkänen A, Tuunanen J, Halonen T. 1995. Neuroscience letters