Dorota Kaminska

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

Talari, Noble Kumar; Mattam, Ushodaya; Kaminska, Dorota; Sotomayor-Rodriguez, Irene; Rahman, Afra P.; Péterfy, Miklós; Pajukanta, Päivi; Pihlajamäki, Jussi; Chella Krishnan, Karthickeyan. 2024. iScience. 27: . 109709

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Iannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka. 2023. Molecular metabolism. 78:

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92:

Hyperinsulinemia is Highly Associated with Markers of Hepatocytic Senescence in Two Independent Cohorts

Meijnikman, Abraham S; van Olden, Casper C; Aydin, Omrum; Herrema, Hilde; Kaminska, Dorota; Lappa, Dimitra; Männistö, Ville; Tremaroli, Valentina; Olofsson, Louise E; de Brauw, Maurits; van de Laar, Arnold; Verheij, Joanne; Gerdes, Victor EA; Schwartz, Thue W; Nielsen, Jens; Bäckhed, Fredrik; Pajukanta, Päivi; Pihlajamäki, Jussi; Tchkonia, Tamar; Kirkland, James L; Kuipers, Folkert; Nieuwdorp, Max; Groen, Albert K. 2022. Diabetes. 71: 1929-1936

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

van der Kolk, Birgitta; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel; Männistö, Ville; Saris, Wim; Astrup, Arne; Rydén, Mikael; Blaak, Ellen; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H. 2021. Journal of clinical endocrinology and metabolism. 106: 1312-1324

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Pan, David Z; Miao, Zong; Comenho, Caroline; Rajkumar, Sandhya; Koka, Amogha; Lee, Seung Hyuk T; Alvarez, Marcus; Kaminska, Dorota; Ko, Arthur; Sinsheimer, Janet S; Mohlke, Karen L; Mancuso, Nicholas; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Tusié-Luna, Maria Teresa; Aguilar-Salinas, Carlos; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Laakso, Markku; Garske, Kristina M; et al.. 2021. Genome medicine. 13: 123

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D.. 2021. Nutrients. 13: 3509

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. American journal of human genetics. 108: 411-430

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

De Jesus, Dario; Orime, Kazuki; Kaminska, Dorota; Kimura, Tomohiko; Basile, Giorgio; Wang, Chih-Hao; Haertle, Larissa; Riemens, Renzo; Brown, Natalie; Hu, Jiang; Männistö, Ville; Silva, Amélia; Dirice, Ercument; Tseng, Yu-Hua; Haaf, Thomas; Pihlajamäki, Jussi; Kulkarni, Rohit. 2020. Journal of clinical investigation. 130: 2391-2407

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Männistö, Ville; Kaminska, Dorota; Käkelä, Pirjo; Neuvonen, Mikko; Niemi, Mikko; Alvarez, Marcus; Pajukanta, Päivi; Romeo, Stefano; Nieuwdorp, Max; Groen, Albert K; Pihlajamäki, Jussi. 2020. Hepatology communications. 2021; 5: 244-257

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. 2020. Liver international. 2021; 41: 754-763

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA

Benhammou, Jihane N; Ko, Arthur; Alvarez, Marcus; Kaikkonen, Minna U; Rankin, Carl; Garske, Kristina M; Padua, David; Bhagat, Yash; Kaminska, Dorota; Karja, Vesa; Pihlajamäki, Jussi; Pisegna, Joseph R; Pajukanta, Päivi. 2019. Hepatology communications. 3: 1356-1372

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Liver international. 39: 1895-1905

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. 2018. Bioscience reports. 38: 1-9

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. 2017. Genome medicine. 9: 63

Regulation of alternative splicing in human obesity loci

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Obesity. 24: 2033-2037

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Genes and nutrition. 10: 43

Regulation of Alternative Splicing in Obesity and Weight Loss

Kaminska Dorota. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Statin use and non-alcoholic steatohepatitis in at risk individuals

Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. 2015. Journal of hepatology. 63: 705-712

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. 2015. Metabolism: clinical and experimental. 64: 793-796

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. 2014. Pediatric obesity. -:

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861

Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis

Männistö Ville T, Simonen Marko, Soininen Pasi, Tiainen Mika, Kangas Antti J, Kaminska Dorota, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Gylling Helena, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Journal of lipid research. 55: 2676-2684

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition

Aikio Mari, Elamaa Harri, Vicente David, Izzi Valerio, Kaur Inderjeet, Seppinen Lotta, Speedy Helen E, Kaminska Dorota, Kuusisto Sanna, Sormunen Raija, Heijasvaara Ritva, Jones Emma L, Muilu Mikko, Jauhiainen Matti, Pihlajamäki Jussi, Savolainen Markku J, Shoulders Carol C, Pihlajaniemi Taina. 2014. Proceedings of the National Academy of Sciences of the United States of America. 111: E3043-52

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Dongiovanni Paola, Petta Salvatore, Maglio Cristina, Fracanzani Anna Ludovica, Pipitone Rosaria, Mozzi Enrico, Motta Benedetta Maria, Kaminska Dorota, Rametta Raffaela, Grimaudo Stefania, Pelusi Serena, Montalcini Tiziana, Alisi Anna, Maggioni Marco, Kärjä Vesa, Borén Jan, Käkelä Pirjo, Di Marco Vito, Xing Chao, Nobili Valerio et.al.. 2014. Hepatology. Epub ahead of print: -

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Diabetologia. Epub 2013 Nov 7.: 1-5

Desmosterol in human nonalcoholic steatohepatitis

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L. 2013. Diabetes. 62: 3747-3750

Regulation of alternative splicing in obesity and weight loss

Kaminska D, Pihlajamäki J. 2013. Adipocytes. 2: 143-7

The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts

Belt H, Huusko N, Kaminska D, Munoz Ruiz M, Paasonen J, Pellinen R. 2013. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Diabetes. 61: 2807-2813

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Obesity surgery. 22: 1473-1480

Response to Brosch et al.

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. 2012. Cell metabolism. 15: 267-269

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Journal of hepatology. 56: 663-670

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Journal of hepatology. 56: 663-670

Tarkenna hakuasi

Julkaisut

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Hyperinsulinemia is Highly Associated with Markers of Hepatocytic Senescence in Two Independent Cohorts

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

Regulation of alternative splicing in human obesity loci

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Regulation of Alternative Splicing in Obesity and Weight Loss

Statin use and non-alcoholic steatohepatitis in at risk individuals

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Desmosterol in human nonalcoholic steatohepatitis

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Regulation of alternative splicing in obesity and weight loss

The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Response to Brosch et al.

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans