Tutkimusryhmät
Julkaisut
9/9 kappaletta-
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L. 2024. European journal of medicinal chemistry. 271: -
Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy
Lobertti, Carlos A; Gizzi, Fernán O; Magni, Christian; Rial, Analía; Chabalgoity, José A; Yim, Lucía; Blancato, Víctor S; Asquith, Christopher R M; García Véscovi, Eleonora. 2024. Scientific reports. 14: . 5148 -
The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold
Kalogirou, Andreas S; Oh, Hans J; Asquith, Christopher RM. 2023. Molecules. 28: -
Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles
Bieberich, Andrew A; Asquith, Christopher RM. 2023. International journal of molecular sciences. 24: -
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
Karim, Marwah; Saul, Sirle; Ghita, Luca; Sahoo, Malaya Kumar; Ye, Chengjin; Bhalla, Nishank; Lo, Chieh-Wen; Jin, Jing; Park, Jun-Gyu; Martinez-Gualda, Belén; East, Michael Patrick; Johnson, Gary L; Pinsky, Benjamin A; Martinez-Sobrido, Luis; Asquith, Christopher RM; Narayanan, Aarthi; De Jonghe, Steven; Einav, Shirit. 2022. Antiviral research. 204: -
Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
Bieberich, Andrew A; Laitinen, Tuomo; Maffuid, Kaitlyn; Fatig, Raymond O; Torrice, Chad D; Morris, David C; Crona, Daniel J; Asquith, Christopher RM. 2022. Scientific reports. 12: . 12820 -
PKN3: a target in cancer metastasis
Temme, Louisa; Laitinen, Tuomo; Asquith, Christopher RM. 2022. Nature reviews drug discovery. 21: -
Small-molecule inhibition of the archetypal UbiB protein COQ8
Murray, Nathan H.; Asquith, Christopher R. M.; Fang, Zixiang; East, Michael P.; Ptak, Naomi; Smith, Robert W.; Vasta, James D.; Zimprich, Chad A.; Corona, Cesear R.; Robers, Matthew B.; Johnson, Gary L.; Bingman, Craig A.; Pagliarini, David J.. 2022. Nature chemical biology. 2023; 19: 230-238 -
Synthesis and evaluation of 1,2,3-dithiazole inhibitors of the nucleocapsid protein of feline immunodeficiency virus (FIV) as a model for HIV infection
Laitinen, Tuomo; Meili, Theres; Koyioni, Maria; Koutentis, Panayiotis A; Poso, Antti; Hofmann-Lehmann, Regina; Asquith, Christopher RM. 2022. Bioorganic and medicinal chemistry. 68: