Mika Ala-Korpela
Tutkimusjohtaja
Farmasian laitos, Terveystieteiden tiedekunta
mika.ala-korpela@uef.fi
Julkaisut
128/128 kappaletta-
Genome-wide characterization of circulating metabolic biomarkers
Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartson. 2024. Nature. [Epub ahead of print 06 March 2024]: 1-21 -
Influence of age and sex on longitudinal metabolic profiles and body weight trajectories in the UK Biobank
Mäkinen, Ville-Petteri; Ala-Korpela, Mika. 2024. International journal of epidemiology. 53: . dyae055 -
NMR metabolomic modeling of age and lifespan: A multicohort analysis
Lau, Chung-Ho E.; Manou, Maria; Markozannes, Georgios; Ala-Korpela, Mika; Ben-Shlomo, Yoav; Chaturvedi, Nish; Engmann, Jorgen; Gentry-Maharaj, Aleksandra; Herzig, Karl-Heinz; Hingorani, Aroon; Jaervelin, Marjo-Riitta; Kaehoenen, Mika; Kivimaeki, Mika; Lehtimaeki, Terho; Marttila, Saara; Menon, Usha; Munroe, Patricia B.; Palaniswamy, Saranya; Providencia, Rui; Raitakari, Olli; Schmidt, Amand Floriaan; Sebert, Sylvain; Wong, Andrew; Vineis, Paolo; Tzoulaki, Ioanna; Robinson, Oliver. 2024. Aging cell. [Epub ahead of print 18 April 2024]: -
Short-Term Metabolic Changes and Their Physiological Mediators in the Roux-en-Y Gastric Bypass Bariatric Surgery
Zhao, Siyu; Hörkkö, Sohvi; Savolainen, Markku J; Koivukangas, Vesa; Mäkinen, Ville-Petteri; Ala-Korpela, Mika; Hukkanen, Janne. 2024. Obesity surgery. 34: 625-634 -
Association of Tobacco Smoke Exposure with Metabolic Profile from Childhood to Early Adulthood: The Special Turku Coronary Risk Factor Intervention Project (STRIP)
Lehtovirta, Miia; Pahkala, Katja; Rovio, Suvi P; Magnussen, Costan G; Laitinen, Tomi T; Niinikoski, Harri; Lagström, Hanna; Viikari, Jorma S A; Rönnemaa, Tapani; Jula, Antti; Ala-Korpela, Mika; Raitakari, Olli T. 2023. European journal of preventive cardiology. 31: 103–115 -
Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers
Li, Tianqi; Ihanus, Andrei; Ohukainen, Pauli; Järvelin, Marjo-Riitta; Kähönen, Mika; Kettunen, Johannes; Raitakari, Olli T; Lehtimäki, Terho; Mäkinen, Ville-Petteri; Tynkkynen, Tuulia; Ala-Korpela, Mika. 2023. International journal of epidemiology. 2024; 53: -
Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes—Support for Stratified Aging Models
Ala-Korpela, Mika; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Perola, Markus; Salomaa, Veikko; Kettunen, Johannes; Raitakari, Olli T; Mäkinen, Ville-Petteri. 2023. Journal of clinical endocrinology and metabolism. 108: 2099-2104 -
Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
Mäkinen, Ville-Petteri; Kettunen, Johannes; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Perola, Markus; Salomaa, Veikko; Järvelin, Marjo-Riitta; Raitakari, Olli T.; Ala-Korpela, Mika. 2023. International journal of obesity. 47: 453-462 -
A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation
Wang, Qin; Richardson, Tom G.; Sanderson, Eleanor; Tudball, Matthew J.; Ala-Korpela, Mika; Davey Smith, George; Holmes, Michael V.. 2022. International journal of epidemiology. 51: 1153-1166 -
Association of Physical Activity with Metabolic Profile from Adolescence to Adulthood
Lehtovirta, Miia; Wu, Feitong; Rovio, Suvi P.; Heinonen, Olli J.; Laitinen, Tomi T.; Niinikoski, Harri; Lagström, Hanna; Viikari, Jorma S. A.; Rönnemaa, Tapani; Jula, Antti; Ala‐Korpela, Mika; Raitakari, Olli T.; Pahkala, Katja. 2022. Scandinavian journal of medicine and science in sports. 2023; 33: 307-318 -
Characteristics of Normalization Methods in Quantitative Urinary Metabolomics — Implications for Epidemiological Applications and Interpretations
Li, Tianqi; Tynkkynen, Tuulia; Ihanus, Andrei; Zhao, Siyu; Mäkinen, Ville-Petteri; Ala-Korpela, Mika. 2022. Biomolecules. 12: -
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics
Kananen, Laura; Hurme, Mikko; Bürkle, Alexander; Moreno-Villanueva, Maria; Bernhardt, Jürgen; Debacq-Chainiaux, Florence; Grubeck-Loebenstein, Beatrix; Malavolta, Marco; Basso, Andrea; Piacenza, Francesco; Collino, Sebastiano; Gonos, Efstathios S.; Sikora, Ewa; Gradinaru, Daniela; Jansen, Eugene H. J. M.; Dollé, Martijn E. T.; Salmon, Michel; Stuetz, Wolfgang; Weber, Daniela; Grune, Tilman; Breusing, Nicolle; Simm, Andreas; Capri, Miriam; Franceschi, Claudio; Slagboom, Eline; Talbot, Duncan; Lib. 2022. GeroScience. 2023; 45: 85-103 -
Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals
Palmu, Joonatan; Tikkanen, Emmi; Havulinna, Aki S; Vartiainen, Erkki; Lundqvist, Annamari; Ruuskanen, Matti O; Perola, Markus; Ala-Korpela, Mika; Jousilahti, Pekka; Würtz, Peter; Salomaa, Veikko; Lahti, Leo; Niiranen, Teemu. 2022. Journal of hypertension. 40: 579 - 587 -
Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank
Mulugeta, Anwar; Hyppönen, Elina; Ala-Korpela, Mika; Mäkinen, Ville-Petteri. 2022. Scientific reports. 12: . 8590 -
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Luukkonen, Panu K; Qadri, Sami; Ahlholm, Noora; Porthan, Kimmo; Männistö, Ville; Sammalkorpi, Henna; Penttilä, Anne K; Hakkarainen, Antti; Lehtimäki, Tiina E; Gaggini, Melania; Gastaldelli, Amalia; Ala-Korpela, Mika; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Pihlajamäki, Jussi; Hodson, Leanne; Yki-Järvinen, Hannele. 2022. Journal of hepatology. 76: 526-535 -
Genetic and observational evidence: No independent role for cholesterol efflux over static high‐density lipoprotein concentration measures in coronary heart disease risk assessment
Kuusisto, Sanna; Karjalainen, Minna K.; Tillin, Therese; Kangas, Antti J.; Holmes, Michael V.; Kähönen, Mika; Lehtimäki, Terho; Viikari, Jorma; Perola, Markus; Chaturvedi, Nishi; Salomaa, Veikko; Raitakari, Olli T.; Järvelin, Marjo‐Riitta; Kettunen, Johannes; Ala‐Korpela, Mika. 2022. Journal of internal medicine. 292: 146-153 -
Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young
Chiesa, Scott T.; Charakida, Marietta; Georgiopoulos, Georgios; Roberts, Justin D.; Stafford, Simon J.; Park, Chloe; Mykkänen, Juha; Kähönen, Mika; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli; Pietiäinen, Milla; Pussinen, Pirkko; Muthurangu, Vivek; Hughes, Alun D.; Sattar, Naveed; Timpson, Nicholas J.; Deanfield, John E.. 2022. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 11: . e024380 -
Longitudinal profiling of metabolic ageing trends in two population cohorts of young adults
Makinen, Ville-Petteri; Karsikas, Mari; Kettunen, Johannes; Lehtimaki, Terho; Kahonen, Mika; Viikari, Jorma; Perola, Markus; Salomaa, Veikko; Jarvelin, Marjo-Riitta; Raitakari, Olli T.; Ala-Korpela, Mika. 2022. International journal of epidemiology. 51: 1970-1983 -
Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity
Kujala, Urho M; Leskinen, Tuija; Rottensteiner, Mirva; Aaltonen, Sari; Ala‐Korpela, Mika; Waller, Katja; Kaprio, Jaakko. 2022. Scandinavian journal of medicine and science in sports. 32: 1316-1323 -
The epidemiological quest for the role of vitamin D turned non-linear—and simply made sense
Ala-Korpela, Mika. 2022. International journal of epidemiology. 2023; 52: 1-4 -
There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate
Li, Tianqi; Ihanus, Andrei; Ohukainen, Pauli; Järvelin, Marjo-Riitta; Kettunen, Johannes; Mäkinen, Ville-Petteri; Tynkkynen, Tuulia; Ala-Korpela, Mika. 2022. International journal of epidemiology. 51: 2022-2025 -
A computationally efficient Bayesian seemingly unrelated regressions model for high-dimensional quantitative trait loci discovery
Bottolo, Leonardo; Banterle, Marco; Richardson, Sylvia; Ala-Korpela, Mika; Järvelin, Marjo-Riitta; Lewin, Alex. 2021. Journal of the royal statistical society series c: applied statistics. 70: 886-908 -
Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention - Association with Metabolic Profile from Childhood to Adulthood
Lehtovirta, Miia; Matthews, Laurie A.; Laitinen, Tomi T.; Nuotio, Joel; Niinikoski, Harri; Rovio, Suvi P.; Lagström, Hanna; Viikari, Jorma S. A.; Rönnemaa, Tapani; Jula, Antti; Ala-Korpela, Mika; Raitakari, Olli T.; Pahkala, Katja. 2021. Nutrients. 13: 533 -
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism
Karpale, Mikko; Karajamäki, Aki Juhani; Kummu, Outi; Gylling, Helena; Hyötyläinen, Tuulia; Oresic, Matej; Tolonen, Ari; Hautajärvi, Heidi; Savolainen, Markku J; Ala-Korpela, Mika; Hukkanen, Janne; Hakkola, Jukka. 2021. British journal of pharmacology. 178: 2461-2481 -
Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health
Marttila, Saara; Rovio, Suvi; Mishra, Pashupati P.; Seppälä, Ilkka; Lyytikäinen, Leo-Pekka; Juonala, Markus; Waldenberger, Melanie; Oksala, Niku; Ala-Korpela, Mika; Harville, Emily; Hutri-Kähönen, Nina; Kähönen, Mika; Raitakari, Olli; Lehtimäki, Terho; Raitoharju, Emma. 2021. Scientific reports. 11: 9203 -
Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology: disclosure of fundamental structural and metabolic relationships
Ala-Korpela, M; Zhao, S; Järvelin, MR; Mäkinen, VP; Ohukainen, P. 2021. International journal of epidemiology. [Published: 18 August 2021]: 1-16 -
Big data bring big controversies: HDL cholesterol and mortality
Ala-Korpela, Mika; Kuusisto, Sanna; Holmes, Michael V. 2021. International journal of epidemiology. 50: 913-915 -
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures
Gomez-Alonso, Monica; del C. Kretschmer, Anja; Wilson, Rory; Pfeiffer, Liliane; Karhunen, Ville; Seppälä, Ilkka; Zhang, Weihua; Mittelstraß, Kirstin; Wahl, Simone; Matias-Garcia, Pamela R; Prokisch, Holger; Horn, Sacha; Meitinger, Thomas; Serrano-Garcia, Luis R; Sebert, Sylvain; Raitakari, Olli; Loh, Marie; Rathmann, Wolfgang; Müller-Nurasyid, Martina; Herder, Christian; et al. [incl. Ala-Korpela, Mika]. 2021. Clinical epigenetics. 13: 7 -
Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives
Richardson, Tom G; Wang, Qin; Sanderson, Eleanor; Mahajan, Anubha; McCarthy, Mark I; Frayling, Timothy M; Ala-Korpela, Mika; Sniderman, Allan; Davey Smith, George; Holmes, Michael V. 2021. The Lancet healthy longevity. 2: e317-e326 -
Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis
Richardson, Tom G; Mykkänen, Juha; Pahkala, Katja; Ala-Korpela, Mika; Bell, Joshua A; Taylor, Kurt; Viikari, Jorma; Lehtimäki, Terho; Raitakari, Olli; Davey Smith, George. 2021. International journal of epidemiology. 50: 1580-1592 -
HDL-Mediated Cholesterol Efflux Associates with Incident Kidney Disease
Kuusisto, Sanna; Kostara, Christina; Kangas, Antti J; Perola, Markus; Salomaa, Veikko; Kettunen, Johannes; Ala-Korpela, Mika. 2021. Clinical chemistry. 67: 689-691 -
Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts
Tikkanen, Emmi; Jägerroos, Vilma; Holmes, Michael V; Sattar, Naveed; Ala-Korpela, Mika; Jousilahti, Pekka; Lundqvist, Annamari; Perola, Markus; Salomaa, Veikko; Würtz, Peter. 2021. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 10: e021995 -
Polygenic risk for breast cancer: in search for potential clinical utility
Wang, Tingting; Ala-Korpela, Mika. 2021. International journal of epidemiology. 50: 1911-1913 -
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
Auvinen, J; Tapio, J; Karhunen, V; Kettunen, J; Serpi, R; Dimova, EY; Gill, D; Soininen, P; Tammelin, T; Mykkänen, J; Puukka, K; Kähönen, M; Raitoharju, E; Lehtimäki, T; Ala-Korpela, M; Raitakari, OT; Keinänen-Kiukaanniemi, S; Järvelin, MR; Koivunen, P. 2021. Science advances. 7: eabi4822 -
The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions. The Cardiovascular Risk in Young Finns Study
Kresanov, Petri; Mykkänen, Juha; Ahotupa, Markku; Ala-Korpela, Mika; Juonala, Markus; Kaikkonen, Jari; Kähönen, Mika; Lehtimäki, Terho; Vasankari, Tommi; Viikari, Jorma; Raitakari, Olli T. 2021. Free radical biology and medicine. 162: 225-232 -
Vexed causal inferences in nutritional epidemiology-call for genetic help
Ohukainen, P; Virtanen, JK; Ala-Korpela, M. 2021. International journal of epidemiology. 2022; 51: 6-15 -
A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease.
Prokic, Ivana; Lahousse, Lies; de Vries, Maaike; Liu, Jun; Kalaoja, Marita; Vonk, Judith M; van der Plaat, Diana A; van Diemen, Cleo C; van der Spek, Ashley; Zhernakova, Alexandra; Fu, Jingyuan; Ghanbari, Mohsen; Ala-Korpela, Mika; Kettunen, Johannes; Havulinna, Aki S; Perola, Markus; Salomaa, Veikko; Lind, Lars; Ärnlöv, Johan; Stricker, Bruno H C et al.. 2020. Bmc pulmonary medicine. 20: 193 -
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study
Karjalainen, Minna; Holmes, Michael; Wang, Qin; Anufrieva, Olga; Kähönen, Mika; Lehtimäki, Terho; Havulinna, Aki; Kristiansson, Kati; Salomaa, Veikko; Perola, Markus; Viikari, Jorma; Raitakari, Olli; Järvelin, Marjo-Riitta; Ala-Korpela, Mika; Kettunen, Johannes. 2020. Atherosclerosis. 299: 56-63 -
Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts
Vojinovic, Dina; Kalaoja, Marita; Trompet, Stella; Fischer, Krista; Shipley, Martin J; Li, Shuo; Havulinna, Aki S; Perola, Markus; Salomaa, Veikko; Yang, Qiong; Sattar, Naveed; Jousilahti, Pekka; Amin, Najaf; Satizabal, Claudia L; Taba, Nele; Sabayan, Behnam; Vasan, Ramachandran S; Ikram, M Arfan; Stott, David J; Ala-Korpela, Mika; et al.. 2020. Neurology. 2021; 96: e1110-e1123 -
Commentary: The Unbelievable Impediment to Understanding Causality of Risk Factors: Case Prostate Cancer
Ohukainen, P; Ala-Korpela, M. 2020. International journal of epidemiology. 49: 597-598 -
Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease
Ohukainen, P; Kuusisto, S; Kettunen, J; Perola, M; Järvelin, MR; Mäkinen, VP; Ala-Korpela, M. 2020. Atherosclerosis. 294: 10-15 -
Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
Robinson, Oliver; Chadeau Hyam, Marc; Karaman, Ibrahim; Climaco Pinto, Rui; Ala-Korpela, Mika; Handakas, Evangelos; Fiorito, Giovanni; Gao, He; Heard, Andy; Jarvelin, Marjo-Riitta; Lewis, Matthew; Pazoki, Raha; Polidoro, Silvia; Tzoulaki, Ioanna; Wielscher, Matthias; Elliott, Paul; Vineis, Paolo. 2020. Aging cell. 19: e13149 -
Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models
Mefford, Joel; Park, Danny; Zheng, Zhili; Ko, Arthur; Ala-Korpela, Mika; Laakso, Markku; Pajukanta, Päivi; Yang, Jian; Witte, John; Zaitlen, Noah. 2020. Journal of computational biology. 27: 599-612 -
EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics
Ekholm, J; Ohukainen, P; Kangas, AJ; Kettunen, J; Wang, Q; Karsikas, M; Khan, AA; Kingwell, BA; Kähönen, M; Lehtimäki, T; Raitakari, OT; Järvelin, MR; Meikle, PJ; Ala-Korpela, M. 2020. International journal of epidemiology. 49: 1075-1081 -
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
Richardson, Tom; Sanderson, Eleanor; Palmer, Tom; Ala-Korpela, Mika; Ference, Brian; Davey Smith, George; Holmes, Michael. 2020. PLoS medicine. 17: e1003062 -
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen, Lasse; Gustafsson, Stefan; Wang, Qin; Hansen, Daniel Hvidberg; Hedman, Åsa K; Schork, Andrew; Page, Karen; Zhernakova, Daria V; Wu, Yang; Peters, James; Eriksson, Niclas; Bergen, Sarah E; Boutin, Thibaud S; Bretherick, Andrew D; Enroth, Stefan; Kalnapenkis, Anette; Gådin, Jesper R; Suur, Bianca E; Chen, Yan; Matic, Ljubica; et al. incl. [Ala-Korpela, Mika]. 2020. Nature metabolism. 2: 1135-1148 -
High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
Zuber, Verena; Gill, Dipender; Ala-Korpela, Mika; Langenberg, Claudia; Butterworth, Adam; Bottolo, Leonardo; Burgess, Stephen. 2020. International journal of epidemiology. 2021; 50: 893-901 -
Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.
Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Journal of Alzheimer's disease. 74: 277-286 -
Metabolic profiles of socio-economic position: a multi-cohort analysis
Robinson, Oliver; Carter, Alice R; Ala-Korpela, Mika; Casas, Juan P; Chaturvedi, Nishi; Engmann, Jorgen; Howe, Laura D; Hughes, Alun D; Järvelin, Marjo-Riitta; Kähönen, Mika; Karhunen, Ville; Kuh, Diana; Shah, Tina; Ben-Shlomo, Yoav; Sofat, Reecha; Lau, Chung-Ho E; Lehtimäki, Terho; Menon, Usha; Raitakari, Olli; Ryan, Andy; et al.. 2020. International journal of epidemiology. 2021; 50: 768-782 -
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis
Wang, Qin; Oliver-Williams, Clare; Raitakari, Olli T; Viikari, Jorma; Lehtimäki, Terho; Kähönen, Mika; Järvelin, Marjo-Riitta; Salomaa, Veikko; Perola, Markus; Danesh, John; Kettunen, Johannes; Butterworth, Adam S; Holmes, Michael V; Ala-Korpela, Mika. 2020. European heart journal. 2021; 42: 1160-1169 -
Novel biomarkers associated with incident heart failure in 10 106 Finnish men
Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. 2020. ESC heart failure. 2021; 8: 605-614 -
The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study
Zheng, Jie; Brion, Marie-Jo; Kemp, John; Warrington, Nicole; Borges, Maria-Carolina; Hemani, Gibran; Richardson, Tom; Rasheed, Humaira; Qiao, Zhen; Haycock, Philip; Ala-Korpela, Mika; Davey Smith, George; Tobias, Jon; Evans, David. 2020. Journal of bone and mineral research. 35: 1224-1235 -
A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density
Kemp, JP; Sayers, A; Fraser, WD; Davey Smith, G; Ala-Korpela, M; Evans, DM; Tobias, JH. 2019. Journal of bone and mineral research. 34: 1306-1313 -
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context
Gallois, A; Mefford, J; Ko, A; Vaysse, A; Julienne, H; Ala-Korpela, M; Laakso, M; Zaitlen, N; Pajukanta, P; Aschard, H. 2019. Nature communications. 10: 4788 -
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
Deelen, J; Kettunen, J; Fischer, K; van der Spek, A; Trompet, S; Kastenmüller, G; Boyd, A; Zierer, J; van den Akker, EB; Ala-Korpela, M; Amin, N; Demirkan, A; Ghanbari, M; van Heemst, D; Ikram, MA; van Klinken, JB; Mooijaart, SP; Peters, A; Salomaa, V; Sattar, N; et al.. 2019. Nature communications. 10: 3346 -
Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.
Ahola-Olli, AV; Mustelin, L; Kalimeri, M; Kettunen, J; Jokelainen, J; Auvinen, J; Puukka, K; Havulinna, AS; Lehtimäki, T; Kähönen, M; Juonala, M; Keinänen-Kiukaanniemi, S; Salomaa, V; Perola, M; Järvelin, MR; Ala-Korpela, M; Raitakari, O; Würtz, P. 2019. Diabetologia. 62: 2298-2309 -
Commentary: Data-driven subgrouping in epidemiology and medicine
Ala-Korpela, Mika. 2019. International journal of epidemiology. 48: 374-376 -
Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity From Serum
Kuusisto, S; Holmes, MV; Ohukainen, P; Kangas, AJ; Karsikas, M; Tiainen, M; Perola, M; Salomaa, V; Kettunen, J; Ala-Korpela, M. 2019. Clinical chemistry. 65: 1042-1050 -
Elevated serum α-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
Ritchie, SC; Kettunen, J; Brozynska, M; Nath, AP; Havulinna, AS; Männistö, S; Perola, M; Salomaa, V; Ala-Korpela, M; Abraham, G; Würtz, P; Inouye, M. 2019. PLoS ONE. 14: e0223692 -
Exome sequencing of Finnish isolates enhances rare-variant association power
Locke, AE; Steinberg, KM; Chiang, CWK; Service, SK; Havulinna, AS; Stell, L; Pirinen, M; Abel, HJ; Chiang, CC; Fulton, RS; Jackson, AU; Kang, CJ; Kanchi, KL; Koboldt, DC; Larson, DE; Nelson, J; Nicholas, TJ; Pietilä, A; Ramensky, V; Ray, D; et al. (incl. Laakso, M; Ala-Korpela, M; Vangipurapu, J). 2019. Nature. 572: 323-328 -
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease
Jia, Q; Han, Y; Huang, P; Woodward, NC; Gukasyan, J; Kettunen, J; Ala-Korpela, M; Anufrieva, O; Wang, Q; Perola, M; Raitakari, O; Lehtimäki, T; Viikari, J; Järvelin, M-R; Boehnke, M; Laakso, M; Mohlke, KL; Fiehn, O; Wang, Z; Tang, WHW; et al.. 2019. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 8: e011922 -
Genetic and environmental perturbations lead to regulatory decoherence
Lea, A; Subramaniam, M; Ko, A; Lehtimäki, T; Raitoharju, E; Kähönen, M; Seppälä, I; Mononen, N; Raitakari, OT; Ala-Korpela, M; Pajukanta, P; Zaitlen, N; Ayroles, JF. 2019. eLife. 8: e40538 -
Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study
Wang, Q; Jokelainen, J; Auvinen, J; Puukka, K; Keinänen-Kiukaanniemi, S; Järvelin, MR; Kettunen, J; Mäkinen, VP; Ala-Korpela, M. 2019. Bmc medicine. 17: 217 -
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Kettunen, J; Holmes, MV; Allara, E; Anufrieva, O; Ohukainen, P; Oliver-Williams, C; Wang, Q; Tillin, T; Hughes, AD; Kähönen, M; Lehtimäki, T; Viikari, J; Raitakari, OT; Salomaa, V; Järvelin, MR; Perola, M; Davey Smith, G; Chaturvedi, N; Danesh, J; Di Angelantonio, E; et al [incl. Ala-Korpela, M]. 2019. PLoS biology. 17: e3000572 -
Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients
Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137 -
Polygenic risk scores and the prediction of common diseases
Ala-Korpela, Mika; Holmes, Michael V. 2019. International journal of epidemiology. 2020; 49: 1-3 -
Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics
Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M. 2019. International journal of epidemiology. 48: 978-993 -
The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease
Ala-Korpela, Mika. 2019. International journal of epidemiology. 48: 1389-1392 -
The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study
Karjalainen, JP; Mononen, N; Hutri-Kähönen, N; Lehtimäki, M; Juonala, M; Ala-Korpela, M; Kähönen, M; Raitakari, O; Lehtimäki, T. 2019. Scientific reports. 9: 458 -
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression
Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Liver international. 39: 1895-1905 -
What is 'LDL cholesterol'?
Holmes, Michael V; Ala-Korpela, Mika. 2019. Nature reviews cardiology. 16: 198-198 -
Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts
Tynkkynen, J; Chouraki, V; van der Lee, SJ; Hernesniemi, J; Yang, Q; Li, S; Beiser, A; Larson, MG; Sääksjärvi, K; Shipley, MJ; Singh-Manoux, A; Gerszten, RE; Wang, TJ; Havulinna, AS; Würtz, P; Fischer, K; Demirkan, A; Ikram, MA; Amin, N; Lehtimäki, T; et al [ Incl Soininen, Pasi; Ala-Korpela, Mika]. 2018. Alzheimer's & dementia. 14: 723-733 -
Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies
Akbaraly, T; Würtz, P; Singh-Manoux, A; Shipley, MJ; Haapakoski, R; Lehto, M; Desrumaux, C; Kähönen, M; Lehtimäki, T; Mikkilä, V; Hingorani, A; Humphries, SE; Kangas, AJ; Soininen, P; Raitakari, O; Ala-Korpela, M; Kivimäki, M. 2018. Scientific reports. 8: 8620 -
Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients
Kettunen, Johannes; Ritchie, Scott C; Anufrieva, Olga; Lyytikainen, Leo-Pekka; Hernesniemi, Jussi; Karhunen, Pekka J; Kuukasjärvi, Pekka; Laurikka, Jari; Kähönen, Mika; Lehtimäki, Terho; Havulinna, Aki S; Salomaa, Veikko; Mannistö, Satu; Ala-Korpela, Mika; Perola, Markus; Inouye, Michael; Würtz, Peter. 2018. Circulation. Genomic and precision medicine. 11: e002234 -
Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial
Welsh, P; Rankin, N; Li, Q; Mark, PB; Würtz, P; Ala-Korpela, M; Marre, M; Poulter, N; Hamet, P; Chalmers, J; Woodward, M; Sattar, N. 2018. Diabetologia. 61: 1581-1591 -
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
Barrios, C; Zierer, J; Würtz, P; Haller, T; Metspalu, A; Gieger, C; Thorand, B; Meisinger, C; Waldenberger, M; Raitakari, O; Lehtimäki, T; Otero, S; Rodríguez, E; Pedro-Botet, J; Kähönen, M; Ala-Korpela, M; Kastenmüller, G; Spector, TD; Pascual, J; Menni, C. 2018. Scientific reports. 8: 15249 -
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts
Ramsay, Hugh; Barnett, Jennifer H; Murray, Graham K; Miettunen, Jouko; Mäki, Pirjo; Järvelin, Marjo-Riitta; Smith, George Davey; Ala-Korpela, Mika; Veijola, Juha. 2018. Psychological medicine. 48: 2609-2623 -
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study
Teslovich, Tanya M; Kim, Daniel Seung; Yin, Xianyong; Stancakova, Alena; Jackson, Anne U; Wielscher, Matthias; Naj, Adam; Perry, John R B; Huyghe, Jeroen R; Stringham, Heather M; Davis, James P; Raulerson, Chelsea K; Welch, Ryan P; Fuchsberger, Christian; Locke, Adam E; Sim, Xueling; Chines, Peter S; Narisu, Narisu; Kangas, Antti J; Soininen, Pasi; et al (incl. Yaluri, Alena; Ala-Korpela, Mika; Kuusisto, Johanna; Laakso, Markku; Soininen, Pasi). 2018. Human molecular genetics. 27: 1664-1674 -
Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled tria
Beynon, R; Richmond, RC; Santos Ferreira, DL; Ness, AR; May, M; Davey Smith, G; Vincent, EE; Adams, C; Ala-Korpela, M; Würtz, P; Soidinsalo, S; Metcalfe, C; Donovan, JL; Lane, AJ; Martin, RM. 2018. International journal of cancer. 2019; 144: 1918-1928 -
Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke
Holmes, MV; Millwood, IY; Kartsonaki, C; Hill, MR; Bennett, DA; Boxall, R; Guo, Y; Xu, X; Bian, Z; Hu, R; Walters, RG; Chen, J; Ala-Korpela, M; Parish, S; Clarke, RJ; Peto, R; Collins, R; Li, L; Chen, Z. 2018. Journal of the american college of cardiology. 71: 620-632 -
Metabolic characterization of menopause: cross-sectional and longitudinal evidence
Wang, Q; Ferreira, DLS; Nelson, SM; Sattar, N; Ala-Korpela, M; Lawlor, DA. 2018. Bmc medicine. 16: 17 -
Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment
Sliz, E; Kettunen, J; Holmes, MV; Williams, CO; Boachie, C; Wang, Q; Mannikko, M; Sebert, S; Walters, R; Lin, K; Millwood, IY; Clarke, R; Li, L; Rankin, N; Welsh, P; Delles, C; Jukema, JW; Trompet, S; Ford, I; Perola, M et al. [Incl. Ala-Korpela, M]. 2018. Circulation. 138: 2499-2512 -
NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects
Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes. 2018. Human molecular genetics. 27: 2214-2223 -
Objective Metabolomics Research
Ala-Korpela, Mika. 2018. Clinical chemistry. 64: 30-33 -
Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood
Lehtovirta, M; Pahkala, K; Niinikoski, H; Kangas, AJ; Soininen, P; Lagström, H; Viikari, JSA; Rönnemaa, T; Jula, A; Ala-Korpela,, M; Würtz, P; Raitakari, OT. 2017. Journal of pediatrics. 2018; 195: 190-198.e3 -
Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
Tillin Therese, Hughes Alun D, Wang Qin, Würtz Peter, Ala-Korpela Mika, Sattar Naveed, Forouhi Nita G, Godsland Ian F, Eastwood Sophie V, McKeigue Paul M, Chaturvedi Nish. 2015. Diabetologia. 58: 968-979 -
A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs
Korsoff Pirkko, Bogl Leonie H, Korhonen Päivi, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Rose Richard J, Kaaja Risto, Kaprio Jaakko. 2014. Frontiers in endocrinology. 5: 28 -
A metabolic view on menopause and ageing
Auro Kirsi, Joensuu Anni, Fischer Krista, Kettunen Johannes, Salo Perttu, Mattsson Hannele, Niironen Marjo, Kaprio Jaakko, Eriksson Johan G, Lehtimäki Terho, Raitakari Olli, Jula Antti, Tiitinen Aila, Jauhiainen Matti, Soininen Pasi, Kangas Antti J, Kähönen Mika, Havulinna Aki S, Ala-Korpela Mika, Salomaa Veikko et al. 2014. Nature communications. 5: 4708 -
Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression
Marttinen Pekka, Pirinen Matti, Sarin Antti-Pekka, Gillberg Jussi, Kettunen Johannes, Surakka Ida, Kangas Antti J, Soininen Pasi, O'Reilly Paul, Kaakinen Marika, Kähönen Mika, Lehtimäki Terho, Ala-Korpela Mika, Raitakari Olli T, Salomaa Veikko, Järvelin Marjo-Riitta, Ripatti Samuli, Kaski Samuel. 2014. Bioinformatics. 30: 2026-2034 -
Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors
Jelenkovic Aline, Bogl Leonie H, Rose Richard J, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kaprio Jaakko, Silventoinen Karri. 2014. Atherosclerosis. 233: 394-402 -
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons
Fischer Krista, Kettunen Johannes, Würtz Peter, Haller Toomas, Havulinna Aki S, Kangas Antti J, Soininen Pasi, Esko Tõnu, Tammesoo Mari-Liis, Mägi Reedik, Smit Steven, Palotie Aarno, Ripatti Samuli, Salomaa Veikko, Ala-Korpela Mika, Perola Markus, Metspalu Andres. 2014. PLoS medicine. 11: e1001606 -
Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: The cardiovascular risk in Young Finns Study
Raitoharju Emma, Seppälä Ilkka, Oksala Niku, Lyytikäinen Leo-Pekka, Raitakari Olli, Viikari Jorma, Ala-Korpela Mika, Soininen Pasi, Kangas Antti J, Waldenberger Melanie, Klopp Norman, Illig Thomas, Leiviskä Jaana, Loo Britt-Marie, Hutri-Kähönen Nina, Kähönen Mika, Laaksonen Reijo, Lehtimäki Terho. 2014. Molecular and cellular endocrinology. 391: 41-49 -
Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up
Mäntyselkä Pekka, Niskanen Leo, Kautiainen Hannu, Saltevo Juha, Würtz Peter, Soininen Pasi, Kangas Antti J, Ala-Korpela Mika, Vanhala Mauno. 2014. Lipids in health and disease. 13: 28 -
Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet)
Lankinen Maria, Kolehmainen Marjukka, Jääskeläinen Tiina, Paananen Jussi, Joukamo Laura, Kangas Antti J, Soininen Pasi, Poutanen Kaisa, Mykkänen Hannu, Gylling Helena, Ore¨ic Matej, Jauhiainen Matti, Ala-Korpela Mika, Uusitupa Matti, Schwab Ursula. 2014. PLoS ONE. 9: e90352 -
Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity
Valcárcel Beatriz, Ebbels Timothy M, Kangas Antti J, Soininen Pasi, Elliot Paul, Ala-Korpela Mika, Järvelin Marjo-Riitta, de Iorio Maria. 2014. Journal of the royal society interface. 11: 20130908 -
Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change
Würtz Peter, Wang Qin, Kangas Antti J, Richmond Rebecca C, Skarp Joni, Tiainen Mika, Tynkkynen Tuulia, Soininen Pasi, Havulinna Aki S, Kaakinen Marika, Viikari Jorma S, Savolainen Markku J, Kähönen Mika, Lehtimäki Terho, Männistö Satu, Blankenberg Stefan, Zeller Tanja, Laitinen Jaana, Pouta Anneli, Mäntyselkä Pekka et al. 2014. PLoS medicine. 11: e1001765 -
Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals
Lassenius Mariann I, Mäkinen Ville-Petteri, Fogarty Christopher L, Peräneva Lina, Jauhiainen Matti, Pussinen Pirkko J, Taskinen Marja-Riitta, Kirveskari Juha, Vaarala Outi, Nieminen Janne K, Hörkkö Sohvi, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Gordin Daniel, Ahola Aila J, Forsblom Carol, Groop Per-Henrik, Lehto Markku. 2014. Nutrition and metabolism. 11: 28 -
Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque
Fan Yue-Mei, Hernesniemi Jussi, Oksala Niku, Levula Mari, Raitoharju Emma, Collings Auni, Hutri-Kähönen Nina, Juonala Markus, Marniemi Jukka, Lyytikäinen Leo-Pekka, Seppälä Ilkka, Mennander Ari, Tarkka Matti, Kangas Antti J, Soininen Pasi, Salenius Juha P, Klopp Norman, Illig Thomas, Laitinen Tomi, Ala-Korpela Mika et al. 2014. Scientific reports. 4 :4650: 1-8 -
Association of height and pubertal timing with lipoprotein subclass profile: Exploring the role of genetic and environmental effects
Jelenkovic Aline, Bogl Leonie H, Rose Richard J, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kaprio Jaakko, Silventoinen Karri. 2013. American journal of human biology. 25: 465-472 -
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626 -
Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial
Erkkilä AT, Schwab US, Lehto S, de Mello VD, Kangas AJ, Soininen P, Ala-Korpela M, Uusitupa MIJ. 2013. Journal of clinical lipidology. online: - -
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men
Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Diabetes care. 36: 3732-3738 -
Lipoprotein subclass profiles in young adults born preterm at very low birth weight
Hovi Petteri, Kajantie Eero, Soininen Pasi, Kangas Antti J, Järvenpää Anna-Liisa, Andersson Sture, Eriksson Johan G, Ala-Korpela Mika, Wehkalampi Karoliina. 2013. Lipids in health and disease. 12: 57 -
Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease - a note on Mendelian randomization studies
Würtz Peter, Kangas Antti J, Soininen Pasi, Lehtimäki Terho, Kähönen Mika, Viikari Jorma S, Raitakari Olli T, Järvelin Marjo-Riitta, Smith George D, Ala-Korpela Mika. 2013. Journal of the american college of cardiology. 62: 1906-1908 -
Rasvainen kala muokkaa HDL-hiukkaskokoa ja lipidipitoisuuksia
Joukamo L, Lankinen M, Schwab U, Soininen P, Kangas AJ, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Oresic M, Ala-Korpela M, Uusitupa M. 2013. Duodecim. 129: 2661-70 -
Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study
Koskinen Juha, Magnussen Costan G, Würtz Peter, Soininen Pasi, Kangas Antti J, Viikari Jorma S, Kähönen Mika, Loo Britt-Marie, Jula Antti, Ahotupa Markku, Lehtimäki Terho, Ala-Korpela Mika, Juonala Markus, Raitakari Olli T. 2012. European journal of preventive cardiology. 19: 1296-1303 -
Association between liver insulin resistance and cardiovascular risk factors
Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Journal of internal medicine. 272: 402-408 -
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults
Würtz Peter, Soininen Pasi, Kangas Antti J, Rönnemaa Tapani, Lehtimäki Terho, Kähönen Mika, Viikari Jorma S, Raitakari Olli T, Ala-Korpela Mika. 2012. Diabetes care. 2013:36: 648-655 -
Fetal growth, omega-3 (n-3) fatty acids, and progression of subclinical atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in Young Finns Study1-3
Skilton Michael R, Mikkilä Vera, Würtz Peter, Ala-Korpela Mika, Sim Kyra A, Soininen Pasi, Kangas Antti J, Viikari Jorma S, Juonala Markus, Laitinen Tomi, Lehtimäki Terho, Taittonen Leena, Kähönen Mika, Celermajer David S, Raitakari Olli T. 2012. American journal of clinical nutrition. 2013:97: 58-65 -
Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics
Szymańska Ewa, Bouwman Jildau, Strassburg Katrin, Vervoort Jacques, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Westerhuis Johan, van Duynhoven John P, Mela David J, Macdonald Ian A, Vreeken Rob J, Smilde Age K, Jacobs Doris M. 2012. Omics: a journal of integrative biology. 16: 652-667 -
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. 2012. Circulation: cardiovascular genetics. 5: 242-249 -
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis
Würtz Peter, Raiko Juho R, Magnussen Costan G, Soininen Pasi, Kangas Antti J, Tynkkynen Tuulia, Thomson Russell, Laatikainen Reino, Savolainen Markku J, Laurikka Jari, Kuukasjärvi Pekka, Tarkka Matti, Karhunen Pekka J, Jula Antti, Viikari Jorma S, Kähönen Mika, Lehtimäki Terho, Juonala Markus, Ala-Korpela Mika, Raitakari Olli T. 2012. European heart journal. 33: 2307-2316 -
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Diabetes. 61: 1895-1902 -
Long-term leisure-time physical activity and serum metabolome
Kujala Urho M, Mäkinen Ville-Petteri, Heinonen Ilkka, Soininen Pasi, Kangas Antti J, Leskinen Tuija H, Rahkila Paavo, Würtz Peter, Kovanen Vuokko, Cheng Sulin, Sipilä Sarianna, Hirvensalo Mirja, Telama Risto, Tammelin Tuija, Savolainen Markku J, Pouta Anneli, O'Reilly Paul F, Mäntyselkä Pekka, Viikari Jorma, Kähönen Mika et.al. 2012. Circulation. 2013:127: 340-348 -
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 -
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis
Inouye Michael, Ripatti Samuli, Kettunen Johannes, Lyytikäinen Leo-Pekka, Oksala Niku, Laurila Pirkka-Pekka, Kangas Antti J, Soininen Pasi, Savolainen Markku J, Viikari Jorma, Kähönen Mika, Perola Markus, Salomaa Veikko, Raitakari Olli, Lehtimäki Terho, Taskinen Marja-Riitta, Järvelin Marjo-Riitta, Ala-Korpela Mika, Palotie Aarno, de Bakker Paul. 2012. PLoS genetics. 8: e1002907 -
Serum omega-6 polyunsaturated fatty acids and the metabolic syndrome: a longitudinal population-based cohort study
Vanhala Mauno, Saltevo Juha, Soininen Pasi, Kautiainen Hannu, Kangas Antti J, Ala-Korpela Mika, Mäntyselkä Pekka. 2012. American journal of epidemiology. 176: 253-260 -
Weight change and lipoprotein particle concentration and particle size: A cohort study with 6.5-year follow-up
Mäntyselkä Pekka, Kautiainen Hannu, Saltevo Juha, Würtz Peter, Soininen Pasi, Kangas Antti J, Ala-Korpela Mika, Vanhala Mauno. 2012. Atherosclerosis. 223: 239-243 -
High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up
Vanhala M, Kumpula LS, Soininen P, Kangas AJ, Ala-Korpela M, Kautiainen H, Mäntyselkä P & Saltevo J. 2011. European journal of endocrinology. 164: 549-552 -
1H NMR and prior knowledge based lineshape fitting analysis: a powerful combination for quantitative biochemistry of plasma and lipoproteins
Ala-Korpela M, Korhonen A, Liinamaa MJ, Savolainen MJ, Jokisaari J, Kesäniemi YA. 1997. JOURNAL OF MAGNETIC RESONANCE ANALYSIS. 3: 15-20 -
1H nuclear magnetic resonance spectroscopy: noninvasive neurochemistry for basic research and clinical applications
Hakumäki JM, Ala-Korpela M, Kauppinen RA. Teoksessa: (toim.) , 1997. Current Topics in Neurochemistry. s. 59-85. Research Trends -
Assessment of cholesteryl ester transfer protein function in lipoprotein mixtures by 1H NMR spectroscopy
Korhonen A, Ala-Korpela M, Liinamaa MJ, Jokisaari J. 1997. Nmr in biomedicine. 10: 303-308 -
Assessment of quantitative artificial neural network analysis in a metabolically dynamic ex vivo 31P NMR pig liver study
Ala-Korpela M, Changani KK, Hiltunen Y, Bell JD, Fuller BJ, Bryant DJ, Taylor-Robinson SD, Davidson BR. 1997. Magnetic resonance in medicine. 38: 840-844 -
Evidence for distinct behaviour of phosphatidylcholine and sphingomyelin at low density lipoprotein surface
Murphy HC, Ala-Korpela M, White JJ, Raoof A, Bell JD, Barnard ML, Burns SP, Iles RA. 1997. Biochemical and biophysical research communications. 234: 733-737 -
Inequivalence of single CHa and CHb methylene bonds in the interior of a diunsaturated lipid bilayer from a molecular dynamics simulation
Hyvönen M, Ala-Korpela M, Vaara J, Rantala TT, Jokisaari J. 1997. Chemical physics letters. 268: 55-60 -
Structure and dynamic properties of diunsaturated 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine lipid bilayer from molecular dynamics simulation
Hyvönen MT, Rantala TT, Ala-Korpela M. 1997. Biophysical journal. 73: 2907-2923 -
Absolute quantification of phospholipid metabolites in brain-tissue extracts by 1H NMR spectroscopy
Ala-Korpela M, Posio P, Mattila S, Korhonen A, Williams SR. 1996. JOURNAL OF MAGNETIC RESONANCE (B). 113: 184-189 -
Automated classification of human brain tumours by neural network analysis using in vivo 1H magnetic resonance spectroscopic metabolite phenotypes
Usenius J-P, Tuohimetsä S, Vainio P, Ala-Korpela M, Hiltunen Y, Kauppinen RA. 1996. Neuroreport. 7: 1597-1600